{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T22:53:11Z","timestamp":1770072791404,"version":"3.49.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2009,4,18]],"date-time":"2009-04-18T00:00:00Z","timestamp":1240012800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Curr Atheroscler Rep"],"published-print":{"date-parts":[[2009,5]]},"DOI":"10.1007\/s11883-009-0030-x","type":"journal-article","created":{"date-parts":[[2009,4,17]],"date-time":"2009-04-17T12:13:20Z","timestamp":1239970400000},"page":"188-195","source":"Crossref","is-referenced-by-count":33,"title":["Proteomics of acute coronary syndromes"],"prefix":"10.1007","volume":"11","author":[{"given":"Athanasios","family":"Didangelos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Simper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Monaco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Mayr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,4,18]]},"reference":[{"key":"30_CR1","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.1161\/01.CIR.91.11.2844","volume":"91","author":"P. Libby","year":"1995","unstructured":"Libby P: Molecular bases of the acute coronary syndromes. Circulation 1995, 91:2844\u20132850.","journal-title":"Circulation"},{"key":"30_CR2","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1136\/hrt.2004.041798","volume":"90","author":"F.D. Kolodgie","year":"2004","unstructured":"Kolodgie FD, Virmani R, Burke AP, et al.: Pathologic assessment of the vulnerable human coronary plaque. Heart 2004, 90:1385\u20131391.","journal-title":"Heart"},{"key":"30_CR3","doi-asserted-by":"crossref","first-page":"C13","DOI":"10.1016\/j.jacc.2005.10.065","volume":"47","author":"R. Virmani","year":"2006","unstructured":"Virmani R, Burke AP, Farb A, Kolodgie FD: Pathology of the vulnerable plaque. J Am Coll Cardiol 2006, 47:C13\u201318.","journal-title":"J Am Coll Cardiol"},{"key":"30_CR4","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1161\/01.CIR.104.3.365","volume":"104","author":"P. Libby","year":"2001","unstructured":"Libby P: Current concepts of the pathogenesis of the acute coronary syndromes. Circulation 2001, 104:365\u2013372.","journal-title":"Circulation"},{"key":"30_CR5","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1161\/01.CIR.89.1.36","volume":"89","author":"A.C. Wal van der","year":"1994","unstructured":"van der Wal AC, Becker AE, van der Loos CM, Das PK: Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology. Circulation 1994, 89:36\u201344.","journal-title":"Circulation"},{"key":"30_CR6","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1161\/01.ATV.11.5.1223","volume":"11","author":"E.P. Amento","year":"1991","unstructured":"Amento EP, Ehsani N, Palmer H, Libby P: Cytokines and growth factors positively and negatively regulate interstitial collagen gene expression in human vascular smooth muscle cells. Arterioscler Thromb 1991, 11:1223\u20131230.","journal-title":"Arterioscler Thromb"},{"key":"30_CR7","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1161\/01.RES.81.3.448","volume":"81","author":"U. Schonbeck","year":"1997","unstructured":"Schonbeck U, Mach F, Sukhova GK, et al.: Regulation of matrix metalloproteinase expression in human vascular smooth muscle cells by T lymphocytes: a role for CD40 signaling in plaque rupture? Circ Res 1997, 81:448\u2013454.","journal-title":"Circ Res"},{"key":"30_CR8","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1177\/1753425908091246","volume":"14","author":"H. Loppnow","year":"2008","unstructured":"Loppnow H, Werdan K, Buerke M: Vascular cells contribute to atherosclerosis by cytokine- and innateimmunity-related inflammatory mechanisms. Innate Immun 2008, 14:63\u201387.","journal-title":"Innate Immun"},{"key":"30_CR9","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1600-065X.2007.00554.x","volume":"219","author":"Z.Q. Yan","year":"2007","unstructured":"Yan ZQ, Hansson GK: Innate immunity, macrophage activation, and atherosclerosis. Immunol Rev 2007, 219:187\u2013203.","journal-title":"Immunol Rev"},{"key":"30_CR10","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1172\/JCI117619","volume":"94","author":"Z.S. Galis","year":"1994","unstructured":"Galis ZS, Sukhova GK, Lark MW, Libby P: Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques. J Clin Invest 1994, 94:2493\u20132503.","journal-title":"J Clin Invest"},{"key":"30_CR11","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.cardiores.2005.12.002","volume":"69","author":"H. Nagase","year":"2006","unstructured":"Nagase H, Visse R, Murphy G: Structure and function of matrix metalloproteinases and TIMPs. Cardiovasc Res 2006, 69:562\u2013573.","journal-title":"Cardiovasc Res"},{"key":"30_CR12","doi-asserted-by":"crossref","first-page":"3751","DOI":"10.1002\/pmic.200400947","volume":"4","author":"M. Mayr","year":"2004","unstructured":"Mayr M, Mayr U, Chung YL, et al.: Vascular proteomics: linking proteomic and metabolomic changes. Proteomics 2004, 4:3751\u20133761.","journal-title":"Proteomics"},{"key":"30_CR13","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s11883-008-0033-z","volume":"10","author":"R. Martinez-Pinna","year":"2008","unstructured":"Martinez-Pinna R, Martin-Ventura JL, Mas S, et al.: Proteomics in atherosclerosis. Curr Atheroscler Rep 2008, 10:209\u2013215.","journal-title":"Curr Atheroscler Rep"},{"key":"30_CR14","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1161\/01.ATV.0000183928.25844.f6","volume":"25","author":"M. Mayr","year":"2005","unstructured":"Mayr M, Chung YL, Mayr U, et al.: Proteomic and metabolomic analyses of atherosclerotic vessels from apolipoprotein E-deficient mice reveal alterations in inflammation, oxidative stress, and energy metabolism. Arterioscler Thromb Vasc Biol 2005, 25:2135\u20132142.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"30_CR15","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1002\/elps.1150181133","volume":"18","author":"M. Unlu","year":"1997","unstructured":"Unlu M, Morgan ME, Minden JS: Difference gel electrophoresis: a single gel method for detecting changes in protein extracts. Electrophoresis 1997, 18:2071\u20132077.","journal-title":"Electrophoresis"},{"key":"30_CR16","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1152\/physiolgenomics.00124.2002","volume":"13","author":"S.A. You","year":"2003","unstructured":"You SA, Archacki SR, Angheloiu G, et al.: Proteomic approach to coronary atherosclerosis shows ferritin light chain as a significant marker: evidence consistent with iron hypothesis in atherosclerosis. Physiol Genomics 2003, 13:25\u201330.","journal-title":"Physiol Genomics"},{"key":"30_CR17","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1074\/mcp.M600259-MCP200","volume":"6","author":"C. Bagnato","year":"2007","unstructured":"Bagnato C, Thumar J, Mayya V, et al.: Proteomics analysis of human coronary atherosclerotic plaque: a feasibility study of direct tissue proteomics by liquid chromatography and tandem mass spectrometry. Mol Cell Proteomics 2007, 6:1088\u20131102.","journal-title":"Mol Cell Proteomics"},{"key":"30_CR18","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1161\/01.CIR.0000136814.87170.B1","volume":"110","author":"J.L. Martin-Ventura","year":"2004","unstructured":"Martin-Ventura JL, Duran MC, Blanco-Colio LM, et al.: Identification by a differential proteomic approach of heat shock protein 27 as a potential marker of atherosclerosis. Circulation 2004, 110:2216\u20132219.","journal-title":"Circulation"},{"key":"30_CR19","doi-asserted-by":"crossref","unstructured":"Lepedda AJ, Cigliano A, Cherchi GM, et al.: A proteomic approach to differentiate histologically classified stable and unstable plaques from human carotid arteries. Atherosclerosis 2008 Jul 12 (Epub ahead of print).","DOI":"10.1016\/j.atherosclerosis.2008.07.001"},{"key":"30_CR20","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1016\/j.jacc.2004.06.073","volume":"44","author":"P.J. Mateos-Caceres","year":"2004","unstructured":"Mateos-Caceres PJ, Garcia-Mendez A, Lopez Farre A, et al.: Proteomic analysis of plasma from patients during an acute coronary syndrome. J Am Coll Cardiol 2004, 44:1578\u20131583.","journal-title":"J Am Coll Cardiol"},{"key":"30_CR21","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1080\/07853890701288760","volume":"39","author":"I. Eberini","year":"2007","unstructured":"Eberini I, Gianazza E, Breghi L, et al.: Apolipoprotein A-I breakdown is induced by thrombolysis in coronary patients. Ann Med 2007, 39:306\u2013311.","journal-title":"Ann Med"},{"key":"30_CR22","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1021\/pr0601990","volume":"6","author":"M.G. Barderas","year":"2007","unstructured":"Barderas MG, Tunon J, Darde VM, et al.: Circulating human monocytes in the acute coronary syndrome express a characteristic proteomic profile. J Proteome Res 2007, 6:876\u2013886.","journal-title":"J Proteome Res"},{"key":"30_CR23","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.1172\/JCI35111","volume":"118","author":"G.D. Lewis","year":"2008","unstructured":"Lewis GD, Wei R, Liu E, et al.: Metabolite profiling of blood from individuals undergoing planned myocardial infarction reveals early markers of myocardial injury. J Clin Invest 2008, 118:3503\u20133512.","journal-title":"J Clin Invest"},{"key":"30_CR24","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1161\/01.CIR.0000031525.61826.A8","volume":"106","author":"D. Simper","year":"2002","unstructured":"Simper D, Stalboerger PG, Panetta CJ, et al.: Smooth muscle progenitor cells in human blood. Circulation 2002, 106:1199\u20131204.","journal-title":"Circulation"},{"key":"30_CR25","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1515\/BC.2008.093","volume":"389","author":"M. Hristov","year":"2008","unstructured":"Hristov M, Zernecke A, Schober A, Weber C: Adult progenitor cells in vascular remodeling during atherosclerosis. Biol Chem 2008, 389:837\u2013844.","journal-title":"Biol Chem"},{"key":"30_CR26","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/nm1182","volume":"11","author":"C. Urbich","year":"2005","unstructured":"Urbich C, Heeschen C, Aicher A, et al.: Cathepsin L is required for endothelial progenitor cell-induced neovascularization. Nat Med 2005, 11:206\u2013213.","journal-title":"Nat Med"},{"key":"30_CR27","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1161\/CIRCRESAHA.108.182261","volume":"104","author":"G. Pula","year":"2009","unstructured":"Pula G, Mayr U, Evans C, et al.: Proteomics identifies thymidine phosphorylase as a key regulator of the angiogenic potential of colony-forming units and endothelial progenitor cell cultures. Circ Res 2009, 104:32\u201340.","journal-title":"Circ Res"},{"key":"30_CR28","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1161\/01.ATV.0000188554.49745.9e","volume":"25","author":"J. George","year":"2005","unstructured":"George J, Afek A, Abashidze A, et al.: Transfer of endothelial progenitor and bone marrow cells influences atherosclerotic plaque size and composition in apolipoprotein E knockout mice. Arterioscler Thromb Vasc Biol 2005, 25:2636\u20132641.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"30_CR29","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1093\/cvr\/cvm034","volume":"77","author":"J. Zoll","year":"2008","unstructured":"Zoll J, Fontaine V, Gourdy P, et al.: Role of human smooth muscle cell progenitors in atherosclerotic plaque development and composition. Cardiovasc Res 2008, 77:471\u2013480.","journal-title":"Cardiovasc Res"},{"key":"30_CR30","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1172\/JCI19628","volume":"113","author":"Y. Hu","year":"2004","unstructured":"Hu Y, Zhang Z, Torsney E, et al.: Abundant progenitor cells in the adventitia contribute to atherosclerosis of vein grafts in ApoE-deficient mice. J Clin Invest 2004, 113:1258\u20131265.","journal-title":"J Clin Invest"},{"key":"30_CR31","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1161\/CIRCRESAHA.108.174623","volume":"102","author":"M. Mayr","year":"2008","unstructured":"Mayr M, Zampetaki A, Sidibe A, et al.: Proteomic and metabolomic analysis of smooth muscle cells derived from the arterial media and adventitial progenitors of apolipoprotein E-deficient mice. Circ Res 2008, 102:1046\u20131056.","journal-title":"Circ Res"},{"key":"30_CR32","first-page":"79","volume":"114","author":"R. Ross","year":"1984","unstructured":"Ross R, Wight TN, Strandness E, Thiele B: Human atherosclerosis. I. Cell constitution and characteristics of advanced lesions of the superficial femoral artery. Am J Pathol 1984, 114:79\u201393.","journal-title":"Am J Pathol"},{"key":"30_CR33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0021-9150(01)00766-3","volume":"166","author":"G.A. Plenz","year":"2003","unstructured":"Plenz GA, Deng MC, Robenek H, Volker W: Vascular collagens: spotlight on the role of type VIII collagen in atherogenesis. Atherosclerosis 2003, 166:1\u201311.","journal-title":"Atherosclerosis"},{"key":"30_CR34","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/978-3-642-76849-1_6","volume":"87","author":"J. Rauterberg","year":"1993","unstructured":"Rauterberg J, Jaeger E, Althaus M: Collagens in atherosclerotic vessel wall lesions. Curr Top Pathol 1993, 87:163\u2013192.","journal-title":"Curr Top Pathol"},{"key":"30_CR35","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1161\/01.ATV.19.10.2395","volume":"19","author":"G. Plenz","year":"1999","unstructured":"Plenz G, Dorszewski A, Volker W, et al.: Cholesterol-induced changes of type VIII collagen expression and distribution in carotid arteries of rabbit. Arterioscler Thromb Vasc Biol 1999, 19:2395\u20132404.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"30_CR36","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1749-6632.1985.tb11844.x","volume":"454","author":"W.D. Wagner","year":"1985","unstructured":"Wagner WD: Proteoglycan structure and function as related to atherosclerosis. Ann N Y Acad Sci 1985, 454:52\u201368.","journal-title":"Ann N Y Acad Sci"},{"key":"30_CR37","first-page":"381","volume":"44","author":"T.N. Wight","year":"1985","unstructured":"Wight TN: Proteoglycans in pathological conditions: atherosclerosis. Fed Proc 1985, 44:381\u2013385.","journal-title":"Fed Proc"},{"key":"30_CR38","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1161\/01.CIR.98.6.519","volume":"98","author":"K.D. O\u2019Brien","year":"1998","unstructured":"O\u2019Brien KD, Olin KL, Alpers CE, et al.: Comparison of apolipoprotein and proteoglycan deposits in human coronary atherosclerotic plaques: colocalization of biglycan with apolipoproteins. Circulation 1998, 98:519\u2013527.","journal-title":"Circulation"},{"key":"30_CR39","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0021-9150(89)90206-2","volume":"75","author":"W.D. Wagner","year":"1989","unstructured":"Wagner WD, Edwards IJ, St Clair RW, Barakat H: Low density lipoprotein interaction with artery derived proteoglycan: the influence of LDL particle size and the relationship to atherosclerosis susceptibility. Atherosclerosis 1989, 75:49\u201359.","journal-title":"Atherosclerosis"},{"key":"30_CR40","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1161\/01.ATV.0000034021.92658.4C","volume":"22","author":"F.D. Kolodgie","year":"2002","unstructured":"Kolodgie FD, Burke AP, Farb A, et al.: Differential accumulation of proteoglycans and hyaluronan in culprit lesions: insights into plaque erosion. Arterioscler Thromb Vasc Biol 2002, 22:1642\u20131648.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"30_CR41","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.4049\/jimmunol.177.2.1272","volume":"177","author":"K.A. Scheibner","year":"2006","unstructured":"Scheibner KA, Lutz MA, Boodoo S, et al.: Hyaluronan fragments act as an endogenous danger signal by engaging TLR2. J Immunol 2006, 177:1272\u20131281.","journal-title":"J Immunol"},{"key":"30_CR42","doi-asserted-by":"crossref","first-page":"10229","DOI":"10.1074\/jbc.M100099200","volume":"276","author":"Y. Okamura","year":"2001","unstructured":"Okamura Y, Watari M, Jerud ES, et al.: The extra domain A of fibronectin activates Toll-like receptor 4. J Biol Chem 2001, 276:10229\u201310233.","journal-title":"J Biol Chem"},{"key":"30_CR43","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.cardiores.2005.11.003","volume":"69","author":"C.M. Dollery","year":"2006","unstructured":"Dollery CM, Libby P: Atherosclerosis and proteinase activation. Cardiovasc Res 2006, 69:625\u2013635.","journal-title":"Cardiovasc Res"},{"key":"30_CR44","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1161\/01.CIR.99.19.2503","volume":"99","author":"G.K. Sukhova","year":"1999","unstructured":"Sukhova GK, Schonbeck U, Rabkin E, et al.: Evidence for increased collagenolysis by interstitial collagenases-1 and -3 in vulnerable human atheromatous plaques. Circulation 1999, 99:2503\u20132509.","journal-title":"Circulation"},{"key":"30_CR45","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1161\/01.CIR.91.8.2125","volume":"91","author":"D.L. Brown","year":"1995","unstructured":"Brown DL, Hibbs MS, Kearney M, et al.: Identification of 92-kD gelatinase in human coronary atherosclerotic lesions. Association of active enzyme synthesis with unstable angina. Circulation 1995, 91:2125\u20132131.","journal-title":"Circulation"},{"key":"30_CR46","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1161\/res.90.3.251","volume":"90","author":"Z.S. Galis","year":"2002","unstructured":"Galis ZS, Khatri JJ: Matrix metalloproteinases in vascular remodeling and atherogenesis: the good, the bad, and the ugly. Circ Res 2002, 90:251\u2013262.","journal-title":"Circ Res"},{"key":"30_CR47","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1172\/JCI181","volume":"102","author":"G.K. Sukhova","year":"1998","unstructured":"Sukhova GK, Shi GP, Simon DI, et al.: Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells. J Clin Invest 1998, 102:576\u2013583.","journal-title":"J Clin Invest"},{"key":"30_CR48","doi-asserted-by":"crossref","first-page":"9748","DOI":"10.1073\/pnas.93.18.9748","volume":"93","author":"I. Halpert","year":"1996","unstructured":"Halpert I, Sires UI, Roby JD, et al.: Matrilysin is expressed by lipid-laden macrophages at sites of potential rupture in atherosclerotic lesions and localizes to areas of versican deposition, a proteoglycan substrate for the enzyme. Proc Natl Acad Sci U S A 1996, 93:9748\u20139753.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"30_CR49","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1161\/01.ATV.0000150045.27127.37","volume":"25","author":"A.C. Jonsson-Rylander","year":"2005","unstructured":"Jonsson-Rylander AC, Nilsson T, Fritsche-Danielson R, et al.: Role of ADAMTS-1 in atherosclerosis: remodeling of carotid artery, immunohistochemistry, and proteolysis of versican. Arterioscler Thromb Vasc Biol 2005, 25:180\u2013185.","journal-title":"Arterioscler Thromb Vasc Biol"}],"container-title":["Current Atherosclerosis Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11883-009-0030-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11883-009-0030-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11883-009-0030-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T21:23:12Z","timestamp":1684963392000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11883-009-0030-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4,18]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["30"],"URL":"https:\/\/doi.org\/10.1007\/s11883-009-0030-x","relation":{},"ISSN":["1523-3804","1534-6242"],"issn-type":[{"value":"1523-3804","type":"print"},{"value":"1534-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4,18]]}}}