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This review synthesizes current knowledge, identifies research gaps, and explores how precision medicine can improve diagnosis, treatment, and patient outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Recent Findings<\/jats:title>\n                    <jats:p>SCAD is clinically and biologically heterogeneous, with variation in presentation, etiology, and recurrence risk. Contributing factors include sex-specific hormonal differences, vascular abnormalities, genetic predisposition, psychosocial stressors, and social determinants of health. Despite growing awareness, major gaps persist in risk stratification and tailored care. Emerging tools, including genomics, radiomics, and multiomics, offer opportunities to define SCAD subtypes and personalized management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>A precision medicine framework integrating molecular, imaging, and social data may transform SCAD care. Continued research is essential to improve early detection, optimize therapy, and reduce recurrence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11883-025-01328-5","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T07:04:50Z","timestamp":1755241490000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Spontaneous Coronary Artery Dissection (SCAD): Unveiling the Enigma of the Unexpected Coronary Event"],"prefix":"10.1007","volume":"27","author":[{"given":"Cristiane C.","family":"Singulane","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsey","family":"Watts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Macy E.","family":"Stahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LeAnn","family":"Denlinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Lloyd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pranavi","family":"Pallinti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Preston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Morsy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odayme","family":"Quesada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randy K.","family":"Ramcharitar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mete","family":"Civelek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia F.","family":"Rodriguez-Lozano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,15]]},"reference":[{"issue":"19","key":"1328_CR1","doi-asserted-by":"publisher","first-page":"e523","DOI":"10.1161\/CIR.0000000000000564","volume":"137","author":"SN Hayes","year":"2018","unstructured":"Hayes SN, Kim ESH, Saw J, Adlam D, Arslanian-Engoren C, Economy KE, et al. 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KW is supported by an NHLBI T32 HL007284 and American Heart Association Postdoctoral Fellowship 25POST1357223. MC is supported by an American Heart Association Established Investigator Award 24EIA1258067. MC and PRL are supported by the Leducq AtheroGEN consortium 22CVD04. PRL is supported by NHLBI K01HL17489. OQ is supported by NIH National Heart, Lunch and Blood Institute (K23 23HL151867). All other authors report no disclosures.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Author Disclosures"}},{"value":"No animal or human subjects by the authors were used in this study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and Animal Rights"}}],"article-number":"81"}}