{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:53:16Z","timestamp":1762865596703},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2010,2,24]],"date-time":"2010-02-24T00:00:00Z","timestamp":1266969600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Curr Cardiol Rep"],"published-print":{"date-parts":[[2010,3]]},"DOI":"10.1007\/s11886-010-0090-0","type":"journal-article","created":{"date-parts":[[2010,2,23]],"date-time":"2010-02-23T05:20:42Z","timestamp":1266902442000},"page":"108-115","source":"Crossref","is-referenced-by-count":12,"title":["Low-Flow, Low-Gradient, Normal Ejection Fraction Aortic Stenosis"],"prefix":"10.1007","volume":"12","author":[{"given":"Philippe","family":"Pibarot","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean G.","family":"Dumesnil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,2,24]]},"reference":[{"key":"90_CR1","first-page":"230","volume":"28","author":"A Vahanian","year":"2007","unstructured":"Vahanian A, Baumgartner H, Bax J, et al.: Guidelines on the management of valvular heart disease: the Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology. 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This is the first study to describe this new clinical entity of paradoxical low-flow, low-gradient severe AS with preserved LVEF. This is probably the article in this list that should be read in priority when one wants to learn more about this particular topic.","journal-title":"Circulation"},{"key":"90_CR10","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.jcmg.2008.12.021","volume":"2","author":"D Cramariuc","year":"2009","unstructured":"\u2022 Cramariuc D, Cioffi G, Rieck AE, et al.: Low-flow aortic stenosis in asymptomatic patients: valvular arterial impedance and systolic function from the SEAS substudy. JACC Cardiovasc Imaging 2009, 2:390\u2013399. This is an important study that confirms the results of Hachicha et al. [9\u2022\u2022] in a large prospective series of asymptomatic patients.","journal-title":"JACC Cardiovasc Imaging"},{"key":"90_CR11","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.jcmg.2009.01.004","volume":"2","author":"P Pibarot","year":"2009","unstructured":"Pibarot P, Dumesnil JG: Aortic stenosis: look globally, think globally. JACC Cardiovasc Imaging 2009, 2:400\u2013403.","journal-title":"JACC Cardiovasc Imaging"},{"key":"90_CR12","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1093\/eurheartj\/ehp361","volume":"31","author":"JG Dumesnil","year":"2010","unstructured":"\u2022 Dumesnil JG, Pibarot P, Carabello B: Paradoxical low flow and\/or low gradient severe aortic stenosis despite preserved left ventricular ejection fraction: implications for diagnosis and treatment. Eur Heart J 2010, 31:281\u2013289. This is an interesting viewpoint article of paradoxical low-flow, low-gradient AS. It also provides important additional results of the study by Hachicha et al. [9\u2022\u2022].","journal-title":"Eur Heart J"},{"key":"90_CR13","first-page":"81","volume":"17","author":"E Barasch","year":"2008","unstructured":"\u2022 Barasch E, Fan D, Chukwu EO, et al.: Severe isolated aortic stenosis with normal left ventricular systolic function and low transvalvular gradients: pathophysiologic and prognostic insights. J Heart Valve Dis 2008, 17:81\u201388. This is an important study showing that patients with normal LVEF, low-flow, low-gradient. AS have a 50% lower referral to surgery but a twofold increase in mortality.","journal-title":"J Heart Valve Dis"},{"key":"90_CR14","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1161\/CIRCULATIONAHA.108.847772","volume":"120","author":"F Weidemann","year":"2009","unstructured":"\u2022\u2022 Weidemann F, Herrmann S, Stork S, et al.: Impact of myocardial fibrosis in patients with symptomatic severe aortic stenosis. 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