{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:55:16Z","timestamp":1786982116915,"version":"build-2736575974"},"reference-count":77,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T00:00:00Z","timestamp":1537920000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Curr Cardiol Rep"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1007\/s11886-018-1063-y","type":"journal-article","created":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T04:22:56Z","timestamp":1537935776000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Dangers of Overly Aggressive Blood Pressure Control"],"prefix":"10.1007","volume":"20","author":[{"given":"Faisal","family":"Rahman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"McEvoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,9,26]]},"reference":[{"issue":"4","key":"1063_CR1","doi-asserted-by":"publisher","first-page":"e1000058","DOI":"10.1371\/journal.pmed.1000058","volume":"6","author":"G Danaei","year":"2009","unstructured":"Danaei G, Ding EL, Mozaffarian D, Taylor B, Rehm J, Murray CJ, et al. The preventable causes of death in the United States: comparative risk assessment of dietary, lifestyle, and metabolic risk factors. PLoS Med. 2009;6(4):e1000058.","journal-title":"PLoS Med"},{"issue":"2","key":"1063_CR2","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1001\/jama.2016.19043","volume":"317","author":"MH Forouzanfar","year":"2017","unstructured":"Forouzanfar MH, Liu P, Roth GA, Ng M, Biryukov S, Marczak L, et al. Global burden of hypertension and systolic blood pressure of at least 110 to 115 mm Hg, 1990\u20132015. JAMA. 2017;317(2):165\u201382.","journal-title":"JAMA"},{"issue":"22","key":"1063_CR3","doi-asserted-by":"publisher","first-page":"2103","DOI":"10.1056\/NEJMoa1511939","volume":"373","author":"JT Wright Jr","year":"2015","unstructured":"\u2022\u2022 Group SR, Wright JT Jr, Williamson JD, Whelton PK, Snyder JK, Sink KM, et al. A Randomized trial of intensive versus standard blood-pressure control. N Engl J Med. 2015;373(22):2103\u201316. The largest randomized control trial supporting the benefit of aggressive systolic blood pressure control.","journal-title":"N Engl J Med"},{"issue":"19","key":"1063_CR4","doi-asserted-by":"publisher","first-page":"e127","DOI":"10.1016\/j.jacc.2017.11.006","volume":"71","author":"PK Whelton","year":"2018","unstructured":"Whelton PK, Carey RM, Aronow WS, Casey DE Jr, Collins KJ, Dennison Himmelfarb C, et al. 2017 ACC\/AHA\/AAPA\/ABC\/ACPM\/AGS\/APhA\/ASH\/ASPC\/NMA\/PCNA Guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol. 2018;71(19):e127\u2013248.","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"1063_CR5","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s11906-017-0719-0","volume":"19","author":"JM Flack","year":"2017","unstructured":"Flack JM. Method of blood pressure measurement, interpretation of SPRINT, and the Atlantic divide. Curr Hypertens Rep. 2017;19(3):19.","journal-title":"Curr Hypertens Rep"},{"issue":"5","key":"1063_CR6","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1161\/HYPERTENSIONAHA.117.10479","volume":"71","author":"KC Johnson","year":"2018","unstructured":"Johnson KC, Whelton PK, Cushman WC, Cutler JA, Evans GW, Snyder JK, et al. Blood Pressure measurement in SPRINT (Systolic Blood Pressure Intervention Trial). Hypertension. 2018;71(5):848\u201357.","journal-title":"Hypertension"},{"key":"1063_CR7","doi-asserted-by":"crossref","unstructured":"Muntner P, Carey RM, Gidding S, Jones DW, Taler SJ, Wright JT, et al. Potential US population impact of the 2017 American College of Cardiology\/American Heart Association high blood pressure guideline. J Am Coll Cardiol. 2018;71(2):109\u201318.","DOI":"10.1016\/j.jacc.2017.10.073"},{"issue":"6","key":"1063_CR8","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1056\/NEJMp1716193","volume":"378","author":"G Bakris","year":"2018","unstructured":"Bakris G, Sorrentino M. Redefining hypertension - assessing the new blood-pressure guidelines. N Engl J Med. 2018;378(6):497\u20139.","journal-title":"N Engl J Med"},{"issue":"5","key":"1063_CR9","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1001\/jamainternmed.2018.0126","volume":"178","author":"Jeong Yun Yang","year":"2018","unstructured":"Yang JY, Chiu S, Krouss M. Overtreatment of asymptomatic hypertension\u2014urgency is not an emergency: a teachable moment. JAMA Int Med. 2018;178(5):704\u20135.","journal-title":"JAMA Internal Medicine"},{"issue":"18","key":"1063_CR10","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.1056\/NEJMra1510067","volume":"375","author":"MA Pfeffer","year":"2016","unstructured":"Pfeffer MA, McMurray JJ. Lessons in uncertainty and humility - clinical trials involving hypertension. N Engl J Med. 2016;375(18):1756\u201366.","journal-title":"N Engl J Med"},{"issue":"9080","key":"1063_CR11","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/S0140-6736(97)05381-6","volume":"350","author":"JA Staessen","year":"1997","unstructured":"Staessen JA, Fagard R, Thijs L, Celis H, Arabidze GG, Birkenhager WH, et al. Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension. The Systolic Hypertension in Europe (Syst-Eur) Trial Investigators. Lancet. 1997;350(9080):757\u201364.","journal-title":"Lancet"},{"issue":"18","key":"1063_CR12","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1056\/NEJMoa0801369","volume":"358","author":"NS Beckett","year":"2008","unstructured":"Beckett NS, Peters R, Fletcher AE, Staessen JA, Liu L, Dumitrascu D, et al. Treatment of hypertension in patients 80 years of age or older. N Engl J Med. 2008;358(18):1887\u201398.","journal-title":"N Engl J Med"},{"key":"1063_CR13","doi-asserted-by":"crossref","unstructured":"ALLHAT Collaborative Research Group. Major cardiovascular events in hypertensive patients randomized to doxazosin vs chlorthalidone: the antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT). JAMA. 2000;283(15):1967\u201375.","DOI":"10.1001\/jama.283.15.1967"},{"key":"1063_CR14","doi-asserted-by":"crossref","unstructured":"Effects of treatment on morbidity in hypertension. Results in patients with diastolic blood pressures averaging 115 through 129 mm Hg. JAMA. 1967;202(11):1028\u201334.","DOI":"10.1001\/jama.202.11.1028"},{"key":"1063_CR15","doi-asserted-by":"crossref","unstructured":"Effects of treatment on morbidity in hypertension. II. Results in patients with diastolic blood pressure averaging 90 through 114 mm Hg. JAMA. 1970;213(7):1143\u201352.","DOI":"10.1001\/jama.213.7.1143"},{"key":"1063_CR16","doi-asserted-by":"crossref","unstructured":"Hypertension Detection and Follow-up Program Cooperative Group. Five-year findings of the hypertension detection and follow-up program. I. Reduction in mortality of persons with high blood pressure, including mild hypertension. JAMA. 1979;242(23):2562\u201371.","DOI":"10.1001\/jama.1979.03300230018021"},{"issue":"9349","key":"1063_CR17","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1016\/S0140-6736(02)11911-8","volume":"360","author":"S Lewington","year":"2002","unstructured":"Lewington S, Clarke R, Qizilbash N, Peto R, Collins R, Prospective SC. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet. 2002;360(9349):1903\u201313.","journal-title":"Lancet"},{"key":"1063_CR18","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1186\/1741-7015-11-177","volume":"11","author":"Y Huang","year":"2013","unstructured":"Huang Y, Wang S, Cai X, Mai W, Hu Y, Tang H, et al. Prehypertension and incidence of cardiovascular disease: a meta-analysis. BMC Med. 2013;11:177.","journal-title":"BMC Med"},{"issue":"12","key":"1063_CR19","doi-asserted-by":"publisher","first-page":"2296","DOI":"10.1097\/HJH.0000000000000379","volume":"32","author":"C Thomopoulos","year":"2014","unstructured":"\u2022\u2022 Thomopoulos C, Parati G, Zanchetti A. Effects of blood pressure lowering on outcome incidence in hypertension: 2. Effects at different baseline and achieved blood pressure levels--overview and meta-analyses of randomized trials. J Hypertens. 2014;32(12):2296\u2013304. Meta-analysis using randomized control trial data to compare systolic blood pressure <\u2009130\u00a0mmHg to >\u2009130\u00a0mmHg.","journal-title":"J Hypertens"},{"issue":"9395","key":"1063_CR20","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1016\/S0140-6736(03)14739-3","volume":"362","author":"F Turnbull","year":"2003","unstructured":"Turnbull F, Blood Pressure Lowering Treatment Trialists C. Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials. Lancet. 2003;362(9395):1527\u201335.","journal-title":"Lancet."},{"issue":"11","key":"1063_CR21","doi-asserted-by":"publisher","first-page":"2150","DOI":"10.1097\/HJH.0000000000001547","volume":"35","author":"C Thomopoulos","year":"2017","unstructured":"Thomopoulos C, Parati G, Zanchetti A. Effects of blood-pressure-lowering treatment on outcome incidence. 12. Effects in individuals with high-normal and normal blood pressure: overview and meta-analyses of randomized trials. J Hypertens. 2017;35(11):2150\u201360.","journal-title":"J Hypertens"},{"issue":"7","key":"1063_CR22","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1001\/jamacardio.2017.1421","volume":"2","author":"JD Bundy","year":"2017","unstructured":"Bundy JD, Li C, Stuchlik P, Bu X, Kelly TN, Mills KT, et al. Systolic blood pressure reduction and risk of cardiovascular disease and mortality: a systematic review and network meta-analysis. JAMA Cardiol. 2017;2(7):775\u201381.","journal-title":"JAMA Cardiol"},{"issue":"1","key":"1063_CR23","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1001\/jamainternmed.2017.6015","volume":"178","author":"M Brunstrom","year":"2018","unstructured":"Brunstrom M, Carlberg B. Association of blood pressure lowering with mortality and cardiovascular disease across blood pressure levels: a systematic review and meta-analysis. JAMA Intern Med. 2018;178(1):28\u201336.","journal-title":"JAMA Intern Med"},{"issue":"6","key":"1063_CR24","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1161\/HYPERTENSIONAHA.111.169367","volume":"57","author":"EM Davis","year":"2011","unstructured":"Davis EM, Appel LJ, Wang X, Greene T, Astor BC, Rahman M, et al. Limitations of analyses based on achieved blood pressure: lessons from the African American study of kidney disease and hypertension trial. Hypertension. 2011;57(6):1061\u20138.","journal-title":"Hypertension"},{"issue":"1","key":"1063_CR25","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/hr.2010.183","volume":"34","author":"J Ceral","year":"2011","unstructured":"Ceral J, Habrdova V, Vorisek V, Bima M, Pelouch R, Solar M. Difficult-to-control arterial hypertension or uncooperative patients? The assessment of serum antihypertensive drug levels to differentiate non-responsiveness from non-adherence to recommended therapy. Hypertens Res. 2011;34(1):87\u201390.","journal-title":"Hypertens Res"},{"issue":"12","key":"1063_CR26","doi-asserted-by":"publisher","first-page":"2455","DOI":"10.1097\/HJH.0b013e3283652c61","volume":"31","author":"B Strauch","year":"2013","unstructured":"Strauch B, Petrak O, Zelinka T, Rosa J, Somloova Z, Indra T, et al. Precise assessment of noncompliance with the antihypertensive therapy in patients with resistant hypertension using toxicological serum analysis. J Hypertens. 2013;31(12):2455\u201361.","journal-title":"J Hypertens"},{"issue":"11","key":"1063_CR27","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1136\/heartjnl-2013-305063","volume":"100","author":"M Tomaszewski","year":"2014","unstructured":"Tomaszewski M, White C, Patel P, Masca N, Damani R, Hepworth J, et al. High rates of non-adherence to antihypertensive treatment revealed by high-performance liquid chromatography-tandem mass spectrometry (HP LC-MS\/MS) urine analysis. Heart. 2014;100(11):855\u201361.","journal-title":"Heart"},{"issue":"6","key":"1063_CR28","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1161\/HYPERTENSIONAHA.117.10646","volume":"71","author":"BP Shapiro","year":"2018","unstructured":"Shapiro BP, Ambrosius WT, Blackshear JL, Cushman WC, Whelton PK, Oparil S, et al. Impact of intensive versus standard blood pressure management by tertiles of blood pressure in SPRINT (Systolic Blood Pressure Intervention Trial). Hypertension. 2018;71(6):1064\u201374.","journal-title":"Hypertension"},{"issue":"24","key":"1063_CR29","doi-asserted-by":"publisher","first-page":"2673","DOI":"10.1001\/jama.2016.7050","volume":"315","author":"JD Williamson","year":"2016","unstructured":"Williamson JD, Supiano MA, Applegate WB, Berlowitz DR, Campbell RC, Chertow GM, et al. Intensive vs standard blood pressure control and cardiovascular disease Outcomes in adults aged >\/=75 Years: a randomized clinical trial. JAMA. 2016;315(24):2673\u201382.","journal-title":"JAMA"},{"issue":"33","key":"1063_CR30","doi-asserted-by":"publisher","first-page":"3119","DOI":"10.1093\/eurheartj\/ehy288","volume":"39","author":"Jessica G Abell","year":"2018","unstructured":"Abell JG, Kivim\u00e4ki M, Dugravot A, Tabak AG, Fayosse A, Shipley M et al. Association between systolic blood pressure and dementia in the Whitehall II cohort study: role of age, duration, and threshold used to define hypertension. Eur Heart J. 2018;39(33):3119\u201325.","journal-title":"European Heart Journal"},{"issue":"16","key":"1063_CR31","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1016\/j.jacc.2016.07.754","volume":"68","author":"JW McEvoy","year":"2016","unstructured":"McEvoy JW, Chen Y, Rawlings A, Hoogeveen RC, Ballantyne CM, Blumenthal RS, et al. Diastolic blood pressure, subclinical myocardial damage, and cardiac events: implications for blood pressure control. J Am Coll Cardiol. 2016;68(16):1713\u201322.","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"1063_CR32","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1161\/CIRCULATIONAHA.117.030848","volume":"137","author":"S Beddhu","year":"2018","unstructured":"Beddhu S, Chertow GM, Cheung AK, Cushman WC, Rahman M, Greene T, et al. Influence of baseline diastolic blood pressure on effects of intensive compared with standard blood pressure control. Circulation. 2018;137(2):134\u201343.","journal-title":"Circulation."},{"issue":"17","key":"1063_CR33","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1056\/NEJMoa1001286","volume":"362","author":"WC Cushman","year":"2010","unstructured":"\u2022 Group AS, Cushman WC, Evans GW, Byington RP, Goff DC Jr, Grimm RH Jr, et al. Effects of intensive blood-pressure control in type 2 diabetes mellitus. N Engl J Med. 2010;362(17):1575\u201385. ACCORD is a large trial of BP control among diabetics which, while technically negative, provides tacit support to the findings of SPRINT.","journal-title":"N Engl J Med."},{"issue":"22","key":"1063_CR34","doi-asserted-by":"publisher","first-page":"2175","DOI":"10.1056\/NEJMe1513301","volume":"373","author":"V Perkovic","year":"2015","unstructured":"\u2022 Perkovic V, Rodgers A. Redefining Blood-Pressure Targets--SPRINT Starts the Marathon. N Engl J Med. 2015;373(22):2175\u20138. Pooled analysis of the SPRINT and ACCORD trials showing benefit for aggressive systolic blood pressure control.","journal-title":"N Engl J Med"},{"issue":"21","key":"1063_CR35","doi-asserted-by":"publisher","first-page":"2009","DOI":"10.1056\/NEJMoa1600175","volume":"374","author":"EM Lonn","year":"2016","unstructured":"\u2022\u2022 Lonn EM, Bosch J, Lopez-Jaramillo P, Zhu J, Liu L, Pais P, et al. Blood-pressure lowering in intermediate-risk persons without cardiovascular disease. N Engl J Med. 2016;374(21):2009\u201320. Randomized control trial consistent with the suggestion that benefits of intensive blood pressure control maybe related to patient specific risk.","journal-title":"N Engl J Med"},{"issue":"9943","key":"1063_CR36","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/S0140-6736(14)61212-5","volume":"384","author":"C Blood Pressure Lowering Treatment T","year":"2014","unstructured":"Blood Pressure Lowering Treatment Trialists C, Sundstrom J, Arima H, Woodward M, Jackson R, Karmali K, et al. Blood pressure-lowering treatment based on cardiovascular risk: a meta-analysis of individual patient data. Lancet. 2014;384(9943):591\u20138.","journal-title":"Lancet"},{"issue":"4","key":"1063_CR37","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1097\/HCO.0000000000000179","volume":"30","author":"I Ikonomidis","year":"2015","unstructured":"Ikonomidis I, Makavos G, Lekakis J. Arterial stiffness and coronary artery disease. Curr Opin Cardiol. 2015;30(4):422\u201331.","journal-title":"Curr Opin Cardiol"},{"issue":"3","key":"1063_CR38","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1161\/HYPERTENSIONAHA.109.146290","volume":"55","author":"SJ Lucas","year":"2010","unstructured":"Lucas SJ, Tzeng YC, Galvin SD, Thomas KN, Ogoh S, Ainslie PN. Influence of changes in blood pressure on cerebral perfusion and oxygenation. Hypertension. 2010;55(3):698\u2013705.","journal-title":"Hypertension"},{"issue":"9118","key":"1063_CR39","first-page":"1755","volume":"351","author":"L Hansson","year":"1998","unstructured":"Hansson L, Zanchetti A, Carruthers SG, Dahlof B, Elmfeldt D, Julius S, et al. Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial. HOT Study Group. Lancet. 1998;351(9118):1755\u201362.","journal-title":"HOT Study Group. Lancet"},{"issue":"5","key":"1063_CR40","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1097\/HJH.0b013e32835e831c","volume":"31","author":"SW Rabkin","year":"2013","unstructured":"Rabkin SW, Waheed A, Poulter RS, Wood D. Myocardial perfusion pressure in patients with hypertension and coronary artery disease: implications for DBP targets in hypertension management. J Hypertens. 2013;31(5):975\u201382.","journal-title":"J Hypertens"},{"issue":"4","key":"1063_CR41","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1001\/jama.1991.03460040065031","volume":"265","author":"L Farnett","year":"1991","unstructured":"\u2022\u2022 Farnett L, Mulrow CD, Linn WD, Lucey CR, Tuley MR. The J-curve phenomenon and the treatment of hypertension. Is there a point beyond which pressure reduction is dangerous? JAMA. 1991;265(4):489\u201395. Landmark document on the BP J-curve phenomenon.","journal-title":"JAMA"},{"issue":"10056","key":"1063_CR42","doi-asserted-by":"publisher","first-page":"2142","DOI":"10.1016\/S0140-6736(16)31326-5","volume":"388","author":"E Vidal-Petiot","year":"2016","unstructured":"\u2022\u2022 Vidal-Petiot E, Ford I, Greenlaw N, Ferrari R, Fox KM, Tardif JC, et al. Cardiovascular event rates and mortality according to achieved systolic and diastolic blood pressure in patients with stable coronary artery disease: an international cohort study. Lancet. 2016;388(10056):2142\u201352. A large observational study demonstrating the systolic and diastolic blood pressure J-curve phenomenon where low and high blood pressures are associated with increased cardiovascular events.","journal-title":"Lancet"},{"issue":"4","key":"1063_CR43","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1023\/A:1007856014581","volume":"14","author":"JM Cruickshank","year":"2000","unstructured":"Cruickshank JM. Antihypertensive treatment and the J-curve. Cardiovasc Drugs Ther. 2000;14(4):373\u20139.","journal-title":"Cardiovasc Drugs Ther"},{"issue":"21","key":"1063_CR44","doi-asserted-by":"publisher","first-page":"2805","DOI":"10.1001\/jama.290.21.2805","volume":"290","author":"CJ Pepine","year":"2003","unstructured":"Pepine CJ, Handberg EM, Cooper-DeHoff RM, Marks RG, Kowey P, Messerli FH, et al. A calcium antagonist vs a non-calcium antagonist hypertension treatment strategy for patients with coronary artery disease. The International Verapamil-Trandolapril Study (INVEST): a randomized controlled trial. JAMA. 2003;290(21):2805\u201316.","journal-title":"JAMA."},{"issue":"12","key":"1063_CR45","doi-asserted-by":"publisher","first-page":"884","DOI":"10.7326\/0003-4819-144-12-200606200-00005","volume":"144","author":"FH Messerli","year":"2006","unstructured":"\u2022 Messerli FH, Mancia G, Conti CR, Hewkin AC, Kupfer S, Champion A, et al. Dogma disputed: can aggressively lowering blood pressure in hypertensive patients with coronary artery disease be dangerous? Ann Int Med. 2006;144(12):884\u201393. Landmark document on the BP J-curve phenomenon.","journal-title":"Ann Int Med"},{"key":"1063_CR46","doi-asserted-by":"crossref","unstructured":"\u2022 Bohm M, Schumacher H, Teo KK, Lonn E, Mahfoud F, Mann JFE et al. Achieved diastolic blood pressure and pulse pressure at target systolic blood pressure (120\u2013140\u00a0mmHg) and cardiovascular outcomes in high-risk patients: results from ONTARGET and TRANSCEND trials. Eur Heart J. 2018;39(33):3105\u201314. Post hoc analysis of the ONTARGET and TRANSCEND randomized control trials showing the dangers of low diastolic blood pressure.","DOI":"10.1093\/eurheartj\/ehy287"},{"issue":"3","key":"1063_CR47","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1152\/physrev.00045.2006","volume":"88","author":"DJ Duncker","year":"2008","unstructured":"Duncker DJ, Bache RJ. Regulation of coronary blood flow during exercise. Physiol Rev. 2008;88(3):1009\u201386.","journal-title":"Physiol Rev"},{"key":"1063_CR48","doi-asserted-by":"crossref","unstructured":"Sandesara PB, O\u2019Neal WT, Kelli HM, Topel M, Samman-Tahhan A, Sperling LS. Diastolic Blood Pressure and Adverse Outcomes in the TOPCAT (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist) Trial. J Am Heart Assoc. 2018;7(5).","DOI":"10.1161\/JAHA.117.007475"},{"key":"1063_CR49","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.ijcard.2018.04.031","volume":"263","author":"T Tsujimoto","year":"2018","unstructured":"Tsujimoto T, Kajio H. Low diastolic blood pressure and adverse outcomes in heart failure with preserved ejection fraction. Int J Cardiol. 2018;263:69\u201374.","journal-title":"Int J Cardiol"},{"issue":"10","key":"1063_CR50","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.1016\/j.amjcard.2017.07.094","volume":"120","author":"F Rahman","year":"2017","unstructured":"Rahman F, Al Rifai M, Blaha MJ, Nasir K, Budoff MJ, Psaty BM, et al. Relation of Diastolic Blood Pressure and Coronary Artery Calcium to Coronary Events and Outcomes (From the Multi-Ethnic Study of Atherosclerosis). Am J Cardiol. 2017;120(10):1797\u2013803.","journal-title":"Am J Cardiol"},{"issue":"1","key":"1063_CR51","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1001\/jama.2010.884","volume":"304","author":"RM Cooper-DeHoff","year":"2010","unstructured":"Cooper-DeHoff RM, Gong Y, Handberg EM, Bavry AA, Denardo SJ, Bakris GL, et al. Tight blood pressure control and cardiovascular outcomes among hypertensive patients with diabetes and coronary artery disease. JAMA. 2010;304(1):61\u20138.","journal-title":"JAMA"},{"issue":"7147","key":"1063_CR52","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.1136\/bmj.316.7147.1780","volume":"316","author":"H. C Boshuizen","year":"1998","unstructured":"Boshuizen HC, Izaks GJ, van Buuren S, Ligthart GJ. Blood pressure and mortality in elderly people aged 85 and older: community based study. BMJ. 1998;316(7147):1780\u20131784.","journal-title":"BMJ"},{"issue":"6799","key":"1063_CR53","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1136\/bmj.303.6799.385","volume":"303","author":"RB D\u2019Agostino","year":"1991","unstructured":"D\u2019Agostino RB, Belanger AJ, Kannel WB, Cruickshank JM. Relation of low diastolic blood pressure to coronary heart disease death in presence of myocardial infarction: the Framingham Study. BMJ. 1991;303(6799):385\u20139.","journal-title":"BMJ"},{"issue":"9","key":"1063_CR54","doi-asserted-by":"publisher","first-page":"1936","DOI":"10.1097\/HJH.0000000000001784","volume":"36","author":"Jong-Moo Park","year":"2018","unstructured":"\u2022 Park J-M, Kim BJ, Kwon SU, Hwang Y-H, Heo SH, Rha J-H et al. Intensive blood pressure control may not be safe in subacute ischemic stroke by intracranial atherosclerosis: a result of randomized trial. J Hypertens. 2018;36(9):1936\u201341. Small randomized trial showing risks of aggressive blood pressure control in patients with subacute ischemic stroke with carotid stenosis.","journal-title":"Journal of Hypertension"},{"issue":"9891","key":"1063_CR55","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/S0140-6736(13)60852-1","volume":"382","author":"OR Benavente","year":"2013","unstructured":"Group SPSS, Benavente OR, Coffey CS, Conwit R, Hart RG, McClure LA, et al. Blood-pressure targets in patients with recent lacunar stroke: the SPS3 randomised trial. Lancet. 2013;382(9891):507\u201315.","journal-title":"Lancet"},{"key":"1063_CR56","volume-title":"JAMA Neurol","author":"ID Croall","year":"2018","unstructured":"Croall ID, Tozer DJ, Moynihan B, Khan U, O\u2019Brien JT, Morris RG, et al. Effect of Standard vs Intensive Blood Pressure Control on Cerebral Blood Flow in Small Vessel Disease: The PRESERVE Randomized Clinical Trial. In: JAMA Neurol; 2018."},{"issue":"3","key":"1063_CR57","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1161\/CIRCOUTCOMES.115.002524","volume":"9","author":"D Shimbo","year":"2016","unstructured":"Shimbo D, Barrett Bowling C, Levitan EB, Deng L, Sim JJ, Huang L, et al. Short-Term Risk of Serious Fall Injuries in Older Adults Initiating and Intensifying Treatment With Antihypertensive Medication. Circ Cardiovasc Qual Outcomes. 2016;9(3):222\u20139.","journal-title":"Circ Cardiovasc Qual Outcomes"},{"issue":"4","key":"1063_CR58","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1001\/jamainternmed.2013.14764","volume":"174","author":"ME Tinetti","year":"2014","unstructured":"Tinetti ME, Han L, Lee DS, McAvay GJ, Peduzzi P, Gross CP, et al. Antihypertensive medications and serious fall injuries in a nationally representative sample of older adults. JAMA Intern Med. 2014;174(4):588\u201395.","journal-title":"JAMA Intern Med"},{"issue":"3","key":"1063_CR59","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1111\/j.1532-5415.2011.03317.x","volume":"59","author":"A Gangavati","year":"2011","unstructured":"Gangavati A, Hajjar I, Quach L, Jones RN, Kiely DK, Gagnon P, et al. Hypertension, orthostatic hypotension, and the risk of falls in a community-dwelling elderly population: the maintenance of balance, independent living, intellect, and zest in the elderly of Boston study. J Am Geriatr Soc. 2011;59(3):383\u20139.","journal-title":"J Am Geriatr Soc"},{"issue":"1","key":"1063_CR60","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1161\/HYPERTENSIONAHA.115.05513","volume":"66","author":"LA Lipsitz","year":"2015","unstructured":"Lipsitz LA, Habtemariam D, Gagnon M, Iloputaife I, Sorond F, Tchalla AE, et al. Reexamining the Effect of Antihypertensive Medications on Falls in Old Age. Hypertension. 2015;66(1):183\u20139.","journal-title":"Hypertension."},{"issue":"2","key":"1063_CR61","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1161\/HYPERTENSIONAHA.116.09390","volume":"70","author":"Samantha G. Bromfield","year":"2017","unstructured":"\u2022 Bromfield SG, Ngameni CA, Colantonio LD, Bowling CB, Shimbo D, Reynolds K, et al. Blood pressure, antihypertensive polypharmacy, frailty, and risk for serious fall injuries among older treated adults with hypertension. Hypertension. 2017;70(2):259\u201366. Analysis evaluating the risks of falls among older patients showing that frailty indicators main predictor of fall risk.","journal-title":"Hypertension"},{"issue":"5","key":"1063_CR62","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1097\/EDE.0b013e3181e89905","volume":"21","author":"Silvia Deandrea","year":"2010","unstructured":"Deandrea S, Lucenteforte E, Bravi F, Foschi R, La Vecchia C, Negri E. Risk factors for falls in community-dwelling older people: a systematic review and meta-analysis. Epidemiology 2010;21(5):658\u2013668.","journal-title":"Epidemiology"},{"issue":"12","key":"1063_CR63","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.1007\/s11606-014-2961-3","volume":"29","author":"KL Margolis","year":"2014","unstructured":"Margolis KL, Palermo L, Vittinghoff E, Evans GW, Atkinson HH, Hamilton BP, et al. Intensive blood pressure control, falls, and fractures in patients with type 2 diabetes: the ACCORD trial. J Gen Intern Med. 2014;29(12):1599\u2013606.","journal-title":"J Gen Intern Med"},{"key":"1063_CR64","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.schres.2018.05.010","volume":"201","author":"Brendon Stubbs","year":"2018","unstructured":"Stubbs B, Mueller C, Gaughran F, Lally J, Vancampfort D, Lamb SE, et al. Predictors of falls and fractures leading to hospitalization in people with schizophrenia spectrum disorder: A large representative cohort study. Schizophr Res. 2018. https:\/\/doi.org\/10.1016\/j.schres.2018.05.010 .","journal-title":"Schizophrenia Research"},{"issue":"10017","key":"1063_CR65","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/S0140-6736(15)00805-3","volume":"387","author":"X Xie","year":"2016","unstructured":"Xie X, Atkins E, Lv J, Bennett A, Neal B, Ninomiya T, et al. Effects of intensive blood pressure lowering on cardiovascular and renal outcomes: updated systematic review and meta-analysis. Lancet. 2016;387(10017):435\u201343.","journal-title":"Lancet"},{"issue":"7","key":"1063_CR66","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/S2213-8587(18)30099-8","volume":"6","author":"Srinivasan Beddhu","year":"2018","unstructured":"Beddhu S, Greene T, Boucher R, Cushman WC, Wei G, Stoddard G et al. Intensive systolic blood pressure control and incident chronic kidney disease in people with and without diabetes mellitus: secondary analyses of two randomised controlled trials. Lancet Diabetes Endocrinol. 2018;6(7):555\u201363.","journal-title":"The Lancet Diabetes & Endocrinology"},{"key":"1063_CR67","doi-asserted-by":"crossref","unstructured":"Del Pinto R, Pietropaoli D, Ferri C. Diastolic blood pressure and risk profile in renal and cardiovascular diseases. Results from the SPRINT trial. J Am Soc Hypertens. 2018;12(7)513\u201323.","DOI":"10.1016\/j.jash.2018.04.004"},{"issue":"8","key":"1063_CR68","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1056\/NEJMsa1616035","volume":"377","author":"AP Bress","year":"2017","unstructured":"Bress AP, Bellows BK, King JB, Hess R, Beddhu S, Zhang Z, et al. Cost-Effectiveness of Intensive versus Standard Blood-Pressure Control. N Engl J Med. 2017;377(8):745\u201355.","journal-title":"N Engl J Med"},{"issue":"2","key":"1063_CR69","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.cger.2009.01.005","volume":"25","author":"D Cooney","year":"2009","unstructured":"Cooney D, Pascuzzi K. Polypharmacy in the elderly: focus on drug interactions and adherence in hypertension. Clin Geriatr Med. 2009;25(2):221\u201333.","journal-title":"Clin Geriatr Med"},{"issue":"1","key":"1063_CR70","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1111\/jch.12624","volume":"18","author":"BN Mukete","year":"2016","unstructured":"Mukete BN, Ferdinand KC. Polypharmacy in Older Adults With Hypertension: A Comprehensive Review. J Clin Hypertens (Greenwich). 2016;18(1):10\u20138.","journal-title":"J Clin Hypertens (Greenwich)"},{"issue":"9","key":"1063_CR71","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1007\/s00228-017-2276-5","volume":"73","author":"M Herr","year":"2017","unstructured":"Herr M, Sirven N, Grondin H, Pichetti S, Sermet C. Frailty, polypharmacy, and potentially inappropriate medications in old people: findings in a representative sample of the French population. Eur J Clin Pharmacol. 2017;73(9):1165\u201372.","journal-title":"Eur J Clin Pharmacol"},{"issue":"10137","key":"1063_CR72","doi-asserted-by":"publisher","first-page":"2346","DOI":"10.1016\/S0140-6736(18)30951-6","volume":"391","author":"DE Kandzari","year":"2018","unstructured":"Kandzari DE, Bohm M, Mahfoud F, Townsend RR, Weber MA, Pocock S, et al. Effect of renal denervation on blood pressure in the presence of antihypertensive drugs: 6-month efficacy and safety results from the SPYRAL HTN-ON MED proof-of-concept randomized trial. Lancet. 2018;391(10137):2346\u201355.","journal-title":"Lancet"},{"issue":"10137","key":"1063_CR73","doi-asserted-by":"publisher","first-page":"2335","DOI":"10.1016\/S0140-6736(18)31082-1","volume":"391","author":"M Azizi","year":"2018","unstructured":"Azizi M, Schmieder RE, Mahfoud F, Weber MA, Daemen J, Davies J, et al. Endovascular ultrasound renal denervation to treat hypertension (RADIANCE-HTN SOLO): a multicentre, international, single-blind, randomized, sham-controlled trial. Lancet. 2018;391(10137):2335\u201345.","journal-title":"Lancet"},{"issue":"4","key":"1063_CR74","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.jacc.2015.10.084","volume":"67","author":"S Selvaraj","year":"2016","unstructured":"Selvaraj S, Steg PG, Elbez Y, Sorbets E, Feldman LJ, Eagle KA, et al. Pulse Pressure and Risk for Cardiovascular Events in Patients With Atherothrombosis: From the REACH Registry. J Am Coll Cardiol. 2016;67(4):392\u2013403.","journal-title":"J Am Coll Cardiol"},{"issue":"22","key":"1063_CR75","doi-asserted-by":"publisher","first-page":"2671","DOI":"10.1042\/CS20160407","volume":"131","author":"C Savoia","year":"2017","unstructured":"Savoia C, Volpe M, Grassi G, Borghi C, Agabiti Rosei E, Touyz RM. Personalized medicine-a modern approach for the diagnosis and management of hypertension. Clin Sci (Lond). 2017;131(22):2671\u201385.","journal-title":"Clin Sci (Lond)"},{"issue":"2","key":"1063_CR76","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1161\/CIRCULATIONAHA.116.025471","volume":"135","author":"John W. McEvoy","year":"2017","unstructured":"McEvoy JW, Martin SS, Dardari ZA, Miedema MD, Sandfort V, Yeboah J, et al. Coronary Artery Calcium to Guide a Personalized Risk-Based Approach to Initiation and Intensification of Antihypertensive Therapy. In: Circulation. 2017;135(2):153\u201365.","journal-title":"Circulation"},{"issue":"12","key":"1063_CR77","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1001\/archinternmed.2010.167","volume":"170","author":"Robyn Tamblyn","year":"2010","unstructured":"Tamblyn R, Abrahamowicz M, Dauphinee D, Wenghofer E, Jacques A, Klass D et al. Influence of physicians\u2019 management and communication ability on patients\u2019 persistence with antihypertensive medication. Arch Intern Med 2010;170(12):1064\u20131072.","journal-title":"Archives of Internal Medicine"}],"container-title":["Current Cardiology Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11886-018-1063-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11886-018-1063-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11886-018-1063-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T15:18:10Z","timestamp":1662131890000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11886-018-1063-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,26]]},"references-count":77,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["1063"],"URL":"https:\/\/doi.org\/10.1007\/s11886-018-1063-y","relation":{},"ISSN":["1523-3782","1534-3170"],"issn-type":[{"value":"1523-3782","type":"print"},{"value":"1534-3170","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,26]]},"assertion":[{"value":"26 September 2018","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"Faisal Rahman and John W. McEvoy declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"This article does not contain any studies with human or animal subjects performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and Animal Rights and Informed Consent"}}],"article-number":"108"}}