{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:58:57Z","timestamp":1792648737195,"version":"4.5.0"},"reference-count":101,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T00:00:00Z","timestamp":1597017600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T00:00:00Z","timestamp":1597017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["787971"],"award-info":[{"award-number":["787971"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["RG\/19\/11\/34633"],"award-info":[{"award-number":["RG\/19\/11\/34633"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Curr Cardiol Rep"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose of Review<\/jats:title><jats:p>Until recently, cardiac regeneration after myocardial infarction has remained a holy grail in cardiology. Failure of clinical trials using adult stem cells and scepticism about the actual existence of such cells has reinforced the notion that the heart is an irreversibly post-mitotic organ. Recent evidence has drastically challenged this conclusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Recent Findings<\/jats:title><jats:p>Cardiac regeneration can successfully be obtained by at least two strategies. First, new cardiomyocytes can be generated from embryonic stem cells or induced pluripotent stem cells and administered to the heart either as cell suspensions or upon ex vivo generation of contractile myocardial tissue. Alternatively, the endogenous capacity of cardiomyocytes to proliferate can be stimulated by the delivery of individual genes or, more successfully, of selected microRNAs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Summary<\/jats:title><jats:p>Recent experimental success in large animals by both strategies now fuels the notion that cardiac regeneration is indeed possible. Several technical hurdles, however, still need to be addressed and solved before broad and successful clinical application is achieved.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s11886-020-01361-7","type":"journal-article","created":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T21:02:54Z","timestamp":1597093374000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Cardiac Regeneration After Myocardial Infarction: an Approachable Goal"],"prefix":"10.1007","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2927-7225","authenticated-orcid":false,"given":"Mauro","family":"Giacca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,8,10]]},"reference":[{"issue":"6","key":"1361_CR1","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1161\/CIRCRESAHA.113.301413","volume":"113","author":"EJ Birks","year":"2013","unstructured":"Birks EJ. Molecular changes after left ventricular assist device support for heart failure. Circ Res. 2013;113(6):777\u201391.","journal-title":"Circ Res"},{"issue":"6","key":"1361_CR2","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1161\/CIRCRESAHA.113.300268","volume":"113","author":"VL Roger","year":"2013","unstructured":"Roger VL. Epidemiology of heart failure. Circ Res. 2013;113(6):646\u201359.","journal-title":"Circ Res"},{"issue":"3","key":"1361_CR3","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1161\/HHF.0b013e318291329a","volume":"6","author":"PA Heidenreich","year":"2013","unstructured":"Heidenreich PA, Albert NM, Allen LA, Bluemke DA, Butler J, Fonarow GC, et al. Forecasting the impact of heart failure in the United States: a policy statement from the American Heart Association. Circ Heart Fail. 2013;6(3):606\u201319.","journal-title":"Circ Heart Fail"},{"issue":"1","key":"1361_CR4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jacc.2017.04.052","volume":"70","author":"GA Roth","year":"2017","unstructured":"Roth GA, Johnson C, Abajobir A, Abd-Allah F, Abera SF, Abyu G, et al. Global, regional, and National Burden of cardiovascular diseases for 10 causes, 1990 to 2015. J Am Coll Cardiol. 2017;70(1):1\u201325.","journal-title":"J Am Coll Cardiol"},{"issue":"21","key":"1361_CR5","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1056\/NEJMoa1911303","volume":"381","author":"JJV McMurray","year":"2019","unstructured":"McMurray JJV, Solomon SD, Inzucchi SE, Kober L, Kosiborod MN, Martinez FA, et al. Dapagliflozin in patients with heart failure and reduced ejection fraction. N Engl J Med. 2019;381(21):1995\u20132008.","journal-title":"N Engl J Med"},{"issue":"4 Pt 1","key":"1361_CR6","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1161\/01.CIR.88.4.1602","volume":"88","author":"SS Gottlieb","year":"1993","unstructured":"Gottlieb SS, Dickstein K, Fleck E, Kostis J, Levine TB, LeJemtel T, et al. Hemodynamic and neurohormonal effects of the angiotensin II antagonist losartan in patients with congestive heart failure. Circulation. 1993;88(4 Pt 1):1602\u20139.","journal-title":"Circulation."},{"issue":"7","key":"1361_CR7","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1093\/eurheartj\/ehu501","volume":"36","author":"RM Califf","year":"2015","unstructured":"Califf RM. LCZ696: too good to be true? Eur Heart J. 2015;36(7):410\u20132.","journal-title":"Eur Heart J"},{"issue":"2","key":"1361_CR8","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/nrd2219","volume":"6","author":"DM Kaye","year":"2007","unstructured":"Kaye DM, Krum H. Drug discovery for heart failure: a new era or the end of the pipeline? Nat Rev Drug Discov. 2007;6(2):127\u201339.","journal-title":"Nat Rev Drug Discov"},{"issue":"1","key":"1361_CR9","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/eurheartj\/ehx745","volume":"39","author":"M Packer","year":"2018","unstructured":"Packer M. The future treatment of heart failure? Eur Heart J. 2018;39(1):5\u20137.","journal-title":"Eur Heart J"},{"issue":"9","key":"1361_CR10","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1016\/j.jacc.2006.02.002","volume":"47","author":"CE Murry","year":"2006","unstructured":"Murry CE, Reinecke H, Pabon LM. Regeneration gaps: observations on stem cells and cardiac repair. J Am Coll Cardiol. 2006;47(9):1777\u201385.","journal-title":"J Am Coll Cardiol"},{"key":"1361_CR11","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1146\/annurev.physiol.010908.163111","volume":"72","author":"RS Whelan","year":"2010","unstructured":"Whelan RS, Kaplinskiy V, Kitsis RN. Cell death in the pathogenesis of heart disease: mechanisms and significance. Annu Rev Physiol. 2010;72:19\u201344.","journal-title":"Annu Rev Physiol"},{"issue":"4","key":"1361_CR12","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/0735-1097(95)00282-8","volume":"26","author":"G Olivetti","year":"1995","unstructured":"Olivetti G, Giordano G, Corradi D, Melissari M, Lagrasta C, Gambert SR, et al. Gender differences and aging: effects on the human heart. J Am Coll Cardiol. 1995;26(4):1068\u201379.","journal-title":"J Am Coll Cardiol"},{"issue":"5923","key":"1361_CR13","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1126\/science.1164680","volume":"324","author":"O Bergmann","year":"2009","unstructured":"Bergmann O, Bhardwaj RD, Bernard S, Zdunek S, Barnabe-Heider F, Walsh S, et al. Evidence for cardiomyocyte renewal in humans. Science. 2009;324(5923):98\u2013102.","journal-title":"Science."},{"issue":"7432","key":"1361_CR14","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/nature11682","volume":"493","author":"SE Senyo","year":"2013","unstructured":"Senyo SE, Steinhauser ML, Pizzimenti CL, Yang VK, Cai L, Wang M, et al. Mammalian heart renewal by pre-existing cardiomyocytes. Nature. 2013;493(7432):433\u20136.","journal-title":"Nature."},{"issue":"1 Pt 2","key":"1361_CR15","first-page":"H220","volume":"272","author":"MH Soonpaa","year":"1997","unstructured":"Soonpaa MH, Field LJ. Assessment of cardiomyocyte DNA synthesis in normal and injured adult mouse hearts. Am J Phys. 1997;272(1 Pt 2):H220\u20136.","journal-title":"Am J Phys"},{"issue":"1","key":"1361_CR16","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1002\/ar.a.10085","volume":"274","author":"D Sedmera","year":"2003","unstructured":"Sedmera D, Reckova M, DeAlmeida A, Coppen SR, Kubalak SW, Gourdie RG, et al. Spatiotemporal pattern of commitment to slowed proliferation in the embryonic mouse heart indicates progressive differentiation of the cardiac conduction system. Anat Rec A Discov Mol Cell Evol Biol. 2003;274(1):773\u20137.","journal-title":"Anat Rec A Discov Mol Cell Evol Biol"},{"issue":"24","key":"1361_CR17","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.1161\/CIRCULATIONAHA.117.031542","volume":"138","author":"L Ye","year":"2018","unstructured":"Ye L, D'Agostino G, Loo SJ, Wang CX, Su LP, Tan SH, et al. Early regenerative capacity in the porcine heart. Circulation. 2018;138(24):2798\u2013808.","journal-title":"Circulation."},{"issue":"2","key":"1361_CR18","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1161\/CIRCRESAHA.115.307017","volume":"118","author":"BJ Haubner","year":"2016","unstructured":"Haubner BJ, Schneider J, Schweigmann U, Schuetz T, Dichtl W, Velik-Salchner C, et al. Functional recovery of a human neonatal heart after severe myocardial infarction. Circ Res. 2016;118(2):216\u201321.","journal-title":"Circ Res"},{"issue":"5601","key":"1361_CR19","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1126\/science.1077857","volume":"298","author":"KD Poss","year":"2002","unstructured":"Poss KD, Wilson LG, Keating MT. Heart regeneration in zebrafish. Science. 2002;298(5601):2188\u201390.","journal-title":"Science."},{"issue":"2","key":"1361_CR20","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/jez.1401870208","volume":"187","author":"JO Oberpriller","year":"1974","unstructured":"Oberpriller JO, Oberpriller JC. Response of the adult newt ventricle to injury. J Exp Zool. 1974;187(2):249\u201353.","journal-title":"J Exp Zool"},{"issue":"7288","key":"1361_CR21","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/nature08804","volume":"464","author":"K Kikuchi","year":"2010","unstructured":"Kikuchi K, Holdway JE, Werdich AA, Anderson RM, Fang Y, Egnaczyk GF, et al. Primary contribution to zebrafish heart regeneration by gata4(+) cardiomyocytes. Nature. 2010;464(7288):601\u20135.","journal-title":"Nature."},{"issue":"7288","key":"1361_CR22","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/nature08899","volume":"464","author":"C Jopling","year":"2010","unstructured":"Jopling C, Sleep E, Raya M, Marti M, Raya A, Izpisua Belmonte JC. Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation. Nature. 2010;464(7288):606\u20139.","journal-title":"Nature."},{"issue":"9","key":"1361_CR23","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.jacc.2014.12.027","volume":"65","author":"DC Canseco","year":"2015","unstructured":"Canseco DC, Kimura W, Garg S, Mukherjee S, Bhattacharya S, Abdisalaam S, et al. Human ventricular unloading induces cardiomyocyte proliferation. J Am Coll Cardiol. 2015;65(9):892\u2013900.","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"1361_CR24","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.cell.2014.03.032","volume":"157","author":"BN Puente","year":"2014","unstructured":"Puente BN, Kimura W, Muralidhar SA, Moon J, Amatruda JF, Phelps KL, et al. The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response. Cell. 2014;157(3):565\u201379.","journal-title":"Cell."},{"issue":"1","key":"1361_CR25","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1038\/s41467-018-04908-z","volume":"9","author":"S Zacchigna","year":"2018","unstructured":"Zacchigna S, Martinelli V, Moimas S, Colliva A, Anzini M, Nordio A, et al. Paracrine effect of regulatory T cells promotes cardiomyocyte proliferation during pregnancy and after myocardial infarction. Nat Commun. 2018;9(1):2432.","journal-title":"Nat Commun"},{"issue":"6436","key":"1361_CR26","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1126\/science.aar2038","volume":"364","author":"K Hirose","year":"2019","unstructured":"Hirose K, Payumo AY, Cutie S, Hoang A, Zhang H, Guyot R, et al. Evidence for hormonal control of heart regenerative capacity during endothermy acquisition. Science. 2019;364(6436):184\u20138.","journal-title":"Science."},{"issue":"2","key":"1361_CR27","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1097\/FJC.0b013e3181e74a14","volume":"56","author":"GD Lopaschuk","year":"2010","unstructured":"Lopaschuk GD, Jaswal JS. Energy metabolic phenotype of the cardiomyocyte during development, differentiation, and postnatal maturation. J Cardiovasc Pharmacol. 2010;56(2):130\u201340.","journal-title":"J Cardiovasc Pharmacol"},{"issue":"5","key":"1361_CR28","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1172\/JCI45529","volume":"121","author":"B Zhou","year":"2011","unstructured":"Zhou B, Honor LB, He H, Ma Q, Oh JH, Butterfield C, et al. Adult mouse epicardium modulates myocardial injury by secreting paracrine factors. J Clin Invest. 2011;121(5):1894\u2013904.","journal-title":"J Clin Invest"},{"key":"1361_CR29","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/1479-5876-11-39","volume":"11","author":"E Przybyt","year":"2013","unstructured":"Przybyt E, Krenning G, Brinker MG, Harmsen MC. Adipose stromal cells primed with hypoxia and inflammation enhance cardiomyocyte proliferation rate in vitro through STAT3 and Erk1\/2. J Transl Med. 2013;11:39.","journal-title":"J Transl Med"},{"issue":"2","key":"1361_CR30","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1080\/08977190701549835","volume":"25","author":"R Hinrichsen","year":"2007","unstructured":"Hinrichsen R, Haunso S, Busk PK. Different regulation of p27 and Akt during cardiomyocyte proliferation and hypertrophy. Growth Factors. 2007;25(2):132\u201340.","journal-title":"Growth Factors"},{"issue":"4\u20136","key":"1361_CR31","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1080\/cac.10.4-6.293.297","volume":"10","author":"E Kardami","year":"2003","unstructured":"Kardami E, Banerji S, Doble BW, Dang X, Fandrich RR, Jin Y, et al. PKC-dependent phosphorylation may regulate the ability of connexin43 to inhibit DNA synthesis. Cell Commun Adhes. 2003;10(4\u20136):293\u20137.","journal-title":"Cell Commun Adhes"},{"issue":"42","key":"1361_CR32","doi-asserted-by":"crossref","first-page":"15546","DOI":"10.1073\/pnas.0607382103","volume":"103","author":"FB Engel","year":"2006","unstructured":"Engel FB, Hsieh PC, Lee RT, Keating MT. FGF1\/p38 MAP kinase inhibitor therapy induces cardiomyocyte mitosis, reduces scarring, and rescues function after myocardial infarction. Proc Natl Acad Sci U S A. 2006;103(42):15546\u201351.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7570","key":"1361_CR33","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/nature15372","volume":"525","author":"K Wei","year":"2015","unstructured":"Wei K, Serpooshan V, Hurtado C, Diez-Cunado M, Zhao M, Maruyama S, et al. Epicardial FSTL1 reconstitution regenerates the adult mammalian heart. Nature. 2015;525(7570):479\u201385.","journal-title":"Nature."},{"issue":"17","key":"1361_CR34","doi-asserted-by":"crossref","first-page":"10261","DOI":"10.1074\/jbc.273.17.10261","volume":"273","author":"YY Zhao","year":"1998","unstructured":"Zhao YY, Sawyer DR, Baliga RR, Opel DJ, Han X, Marchionni MA, et al. Neuregulins promote survival and growth of cardiac myocytes. Persistence of ErbB2 and ErbB4 expression in neonatal and adult ventricular myocytes. J Biol Chem. 1998;273(17):10261\u20139.","journal-title":"J Biol Chem"},{"issue":"2","key":"1361_CR35","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.cell.2009.04.060","volume":"138","author":"K Bersell","year":"2009","unstructured":"Bersell K, Arab S, Haring B, Kuhn B. Neuregulin1\/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury. Cell. 2009;138(2):257\u201370.","journal-title":"Cell."},{"issue":"5","key":"1361_CR36","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/ncb3149","volume":"17","author":"G D'Uva","year":"2015","unstructured":"D'Uva G, Aharonov A, Lauriola M, Kain D, Yahalom-Ronen Y, Carvalho S, et al. ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation. Nat Cell Biol. 2015;17(5):627\u201338.","journal-title":"Nat Cell Biol"},{"issue":"45","key":"1361_CR37","doi-asserted-by":"crossref","first-page":"16029","DOI":"10.1073\/pnas.1406508111","volume":"111","author":"KJ Lavine","year":"2014","unstructured":"Lavine KJ, Epelman S, Uchida K, Weber KJ, Nichols CG, Schilling JD, et al. Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart. Proc Natl Acad Sci U S A. 2014;111(45):16029\u201334.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7662","key":"1361_CR38","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature22978","volume":"547","author":"E Bassat","year":"2017","unstructured":"Bassat E, Mutlak YE, Genzelinakh A, Shadrin IY, Baruch Umansky K, Yifa O, et al. The extracellular matrix protein agrin promotes heart regeneration in mice. Nature. 2017;547(7662):179\u201384.","journal-title":"Nature."},{"issue":"6134","key":"1361_CR39","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1126\/science.1232389","volume":"340","author":"SE Kim","year":"2013","unstructured":"Kim SE, Huang H, Zhao M, Zhang X, Zhang A, Semonov MV, et al. Wnt stabilization of beta-catenin reveals principles for morphogen receptor-scaffold assemblies. Science. 2013;340(6134):867\u201370.","journal-title":"Science."},{"issue":"1","key":"1361_CR40","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1093\/cvr\/cvy255","volume":"115","author":"AP Singh","year":"2019","unstructured":"Singh AP, Umbarkar P, Guo Y, Force T, Gupte M, Lal H. Inhibition of GSK-3 to induce cardiomyocyte proliferation: a recipe for in situ cardiac regeneration. Cardiovasc Res. 2019;115(1):20\u201330.","journal-title":"Cardiovasc Res"},{"issue":"9","key":"1361_CR41","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.chembiol.2006.08.004","volume":"13","author":"AS Tseng","year":"2006","unstructured":"Tseng AS, Engel FB, Keating MT. The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytes. Chem Biol. 2006;13(9):957\u201363.","journal-title":"Chem Biol"},{"issue":"6727","key":"1361_CR42","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/19083","volume":"398","author":"B De Strooper","year":"1999","unstructured":"De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, Mumm JS, et al. A presenilin-1-dependent gamma-secretase-like protease mediates release of notch intracellular domain. Nature. 1999;398(6727):518\u201322.","journal-title":"Nature."},{"issue":"1","key":"1361_CR43","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1083\/jcb.200806091","volume":"183","author":"C Collesi","year":"2008","unstructured":"Collesi C, Zentilin L, Sinagra G, Giacca M. Notch1 signaling stimulates proliferation of immature cardiomyocytes. J Cell Biol. 2008;183(1):117\u201328.","journal-title":"J Cell Biol"},{"issue":"13","key":"1361_CR44","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.1084\/jem.20081427","volume":"205","author":"A Croquelois","year":"2008","unstructured":"Croquelois A, Domenighetti AA, Nemir M, Lepore M, Rosenblatt-Velin N, Radtke F, et al. Control of the adaptive response of the heart to stress via the Notch1 receptor pathway. J Exp Med. 2008;205(13):3173\u201385.","journal-title":"J Exp Med"},{"issue":"1","key":"1361_CR45","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1083\/jcb.200806104","volume":"183","author":"VM Campa","year":"2008","unstructured":"Campa VM, Gutierrez-Lanza R, Cerignoli F, Diaz-Trelles R, Nelson B, Tsuji T, et al. Notch activates cell cycle reentry and progression in quiescent cardiomyocytes. J Cell Biol. 2008;183(1):129\u201341.","journal-title":"J Cell Biol"},{"issue":"6028","key":"1361_CR46","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1126\/science.1199010","volume":"332","author":"T Heallen","year":"2011","unstructured":"Heallen T, Zhang M, Wang J, Bonilla-Claudio M, Klysik E, Johnson RL, et al. Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size. Science. 2011;332(6028):458\u201361.","journal-title":"Science."},{"issue":"10","key":"1361_CR47","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1172\/JCI17459","volume":"111","author":"S Yamamoto","year":"2003","unstructured":"Yamamoto S, Yang G, Zablocki D, Liu J, Hong C, Kim SJ, et al. Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy. J Clin Invest. 2003;111(10):1463\u201374.","journal-title":"J Clin Invest"},{"issue":"11","key":"1361_CR48","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1161\/CIRCRESAHA.108.180042","volume":"103","author":"YY Matsui","year":"2008","unstructured":"Matsui YY, Nakano NN, Shao DD, Gao SS, Luo WW, Hong CC, et al. Lats2 is a negative regulator of myocyte size in the heart. Circ Res. 2008;103(11):1309\u201318.","journal-title":"Circ Res"},{"issue":"196","key":"1361_CR49","first-page":"ra70","volume":"4","author":"M Xin","year":"2011","unstructured":"Xin M, Kim Y, Sutherland LB, Qi X, McAnally J, Schwartz RJ, et al. Regulation of insulin-like growth factor signaling by Yap governs cardiomyocyte proliferation and embryonic heart size. Sci Signal. 2011;4(196):ra70.","journal-title":"Sci Signal"},{"issue":"34","key":"1361_CR50","doi-asserted-by":"crossref","first-page":"13839","DOI":"10.1073\/pnas.1313192110","volume":"110","author":"M Xin","year":"2013","unstructured":"Xin M, Kim Y, Sutherland LB, Murakami M, Qi X, McAnally J, et al. Hippo pathway effector Yap promotes cardiac regeneration. Proc Natl Acad Sci U S A. 2013;110(34):13839\u201344.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"1361_CR51","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/dbio.1996.0270","volume":"179","author":"LA Kirshenbaum","year":"1996","unstructured":"Kirshenbaum LA, Abdellatif M, Chakraborty S, Schneider MD. Human E2F-1 reactivates cell cycle progression in ventricular myocytes and represses cardiac gene transcription. Dev Biol. 1996;179(2):402\u201311.","journal-title":"Dev Biol"},{"issue":"11","key":"1361_CR52","doi-asserted-by":"crossref","first-page":"2722","DOI":"10.1172\/JCI119817","volume":"100","author":"R Agah","year":"1997","unstructured":"Agah R, Kirshenbaum LA, Abdellatif M, Truong LD, Chakraborty S, Michael LH, et al. Adenoviral delivery of E2F-1 directs cell cycle reentry and p53-independent apoptosis in postmitotic adult myocardium in vivo. J Clin Invest. 1997;100(11):2722\u20138.","journal-title":"J Clin Invest"},{"issue":"1","key":"1361_CR53","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1093\/cvr\/cvp383","volume":"86","author":"MJ van Amerongen","year":"2010","unstructured":"van Amerongen MJ, Diehl F, Novoyatleva T, Patra C, Engel FB. E2F4 is required for cardiomyocyte proliferation. Cardiovasc Res. 2010;86(1):92\u2013102.","journal-title":"Cardiovasc Res"},{"issue":"11","key":"1361_CR54","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.1172\/JCI119453","volume":"99","author":"MH Soonpaa","year":"1997","unstructured":"Soonpaa MH, Koh GY, Pajak L, Jing S, Wang H, Franklin MT, et al. Cyclin D1 overexpression promotes cardiomyocyte DNA synthesis and multinucleation in transgenic mice. J Clin Invest. 1997;99(11):2644\u201354.","journal-title":"J Clin Invest"},{"issue":"1","key":"1361_CR55","doi-asserted-by":"crossref","first-page":"e12","DOI":"10.1161\/01.RES.0000049105.15329.1C","volume":"92","author":"M Tamamori-Adachi","year":"2003","unstructured":"Tamamori-Adachi M, Ito H, Sumrejkanchanakij P, Adachi S, Hiroe M, Shimizu M, et al. Critical role of cyclin D1 nuclear import in cardiomyocyte proliferation. Circ Res. 2003;92(1):e12\u20139.","journal-title":"Circ Res"},{"issue":"1","key":"1361_CR56","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.yexcr.2004.10.022","volume":"304","author":"PK Busk","year":"2005","unstructured":"Busk PK, Hinrichsen R, Bartkova J, Hansen AH, Christoffersen TE, Bartek J, et al. Cyclin D2 induces proliferation of cardiac myocytes and represses hypertrophy. Exp Cell Res. 2005;304(1):149\u201361.","journal-title":"Exp Cell Res"},{"issue":"10","key":"1361_CR57","doi-asserted-by":"crossref","first-page":"8644","DOI":"10.1074\/jbc.M110.184549","volume":"286","author":"V Di Stefano","year":"2011","unstructured":"Di Stefano V, Giacca M, Capogrossi MC, Crescenzi M, Martelli F. Knockdown of cyclin-dependent kinase inhibitors induces cardiomyocyte re-entry in the cell cycle. J Biol Chem. 2011;286(10):8644\u201354.","journal-title":"J Biol Chem"},{"issue":"7448","key":"1361_CR58","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/nature12054","volume":"497","author":"AI Mahmoud","year":"2013","unstructured":"Mahmoud AI, Kocabas F, Muralidhar SA, Kimura W, Koura AS, Thet S, et al. Meis1 regulates postnatal cardiomyocyte cell cycle arrest. Nature. 2013;497(7448):249\u201353.","journal-title":"Nature."},{"issue":"34","key":"1361_CR59","doi-asserted-by":"crossref","first-page":"35858","DOI":"10.1074\/jbc.M404975200","volume":"279","author":"HW Chaudhry","year":"2004","unstructured":"Chaudhry HW, Dashoush NH, Tang H, Zhang L, Wang X, Wu EX, et al. Cyclin A2 mediates cardiomyocyte mitosis in the postmitotic myocardium. J Biol Chem. 2004;279(34):35858\u201366.","journal-title":"J Biol Chem"},{"issue":"1 Suppl","key":"1361_CR60","first-page":"I206","volume":"114","author":"YJ Woo","year":"2006","unstructured":"Woo YJ, Panlilio CM, Cheng RK, Liao GP, Atluri P, Hsu VM, et al. Therapeutic delivery of cyclin A2 induces myocardial regeneration and enhances cardiac function in ischemic heart failure. Circulation. 2006;114(1 Suppl):I206\u201313.","journal-title":"Circulation."},{"issue":"4","key":"1361_CR61","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1161\/01.RES.88.4.443","volume":"88","author":"HS Liao","year":"2001","unstructured":"Liao HS, Kang PM, Nagashima H, Yamasaki N, Usheva A, Ding B, et al. Cardiac-specific overexpression of cyclin-dependent kinase 2 increases smaller mononuclear cardiomyocytes. Circ Res. 2001;88(4):443\u201350.","journal-title":"Circ Res"},{"issue":"1","key":"1361_CR62","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1161\/01.RES.0000152326.91223.4F","volume":"96","author":"KB Pasumarthi","year":"2005","unstructured":"Pasumarthi KB, Nakajima H, Nakajima HO, Soonpaa MH, Field LJ. Targeted expression of cyclin D2 results in cardiomyocyte DNA synthesis and infarct regression in transgenic mice. Circ Res. 2005;96(1):110\u20138.","journal-title":"Circ Res"},{"issue":"1","key":"1361_CR63","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1093\/cvr\/cvm101","volume":"78","author":"RJ Hassink","year":"2008","unstructured":"Hassink RJ, Pasumarthi KB, Nakajima H, Rubart M, Soonpaa MH, de la Riviere AB, et al. Cardiomyocyte cell cycle activation improves cardiac function after myocardial infarction. Cardiovasc Res. 2008;78(1):18\u201325.","journal-title":"Cardiovasc Res"},{"issue":"1","key":"1361_CR64","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1161\/01.RES.0000135902.99383.6f","volume":"95","author":"MF Pittenger","year":"2004","unstructured":"Pittenger MF, Martin BJ. Mesenchymal stem cells and their potential as cardiac therapeutics. Circ Res. 2004;95(1):9\u201320.","journal-title":"Circ Res"},{"issue":"7","key":"1361_CR65","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1161\/CIRCRESAHA.110.222703","volume":"107","author":"KE Hatzistergos","year":"2010","unstructured":"Hatzistergos KE, Quevedo H, Oskouei BN, Hu Q, Feigenbaum GS, Margitich IS, et al. Bone marrow mesenchymal stem cells stimulate cardiac stem cell proliferation and differentiation. Circ Res. 2010;107(7):913\u201322.","journal-title":"Circ Res"},{"issue":"6","key":"1361_CR66","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S0092-8674(03)00687-1","volume":"114","author":"AP Beltrami","year":"2003","unstructured":"Beltrami AP, Barlucchi L, Torella D, Baker M, Limana F, Chimenti S, et al. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell. 2003;114(6):763\u201376.","journal-title":"Cell."},{"issue":"9806","key":"1361_CR67","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1016\/S0140-6736(11)61590-0","volume":"378","author":"R Bolli","year":"2011","unstructured":"Bolli R, Chugh AR, D'Amario D, Loughran JH, Stoddard MF, Ikram S, et al. Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial. Lancet. 2011;378(9806):1847\u201357.","journal-title":"Lancet."},{"issue":"1","key":"1361_CR68","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1093\/eurjhf\/hfr148","volume":"14","author":"H Zimmet","year":"2012","unstructured":"Zimmet H, Porapakkham P, Porapakkham P, Sata Y, Haas SJ, Itescu S, et al. Short- and long-term outcomes of intracoronary and endogenously mobilized bone marrow stem cells in the treatment of ST-segment elevation myocardial infarction: a meta-analysis of randomized control trials. Eur J Heart Fail. 2012;14(1):91\u2013105.","journal-title":"Eur J Heart Fail"},{"issue":"8","key":"1361_CR69","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1161\/CIRCRESAHA.116.303614","volume":"116","author":"V Karantalis","year":"2015","unstructured":"Karantalis V, Hare JM. Use of mesenchymal stem cells for therapy of cardiac disease. Circ Res. 2015;116(8):1413\u201330.","journal-title":"Circ Res"},{"issue":"7","key":"1361_CR70","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1161\/CIRCULATIONAHA.117.029343","volume":"136","author":"T Eschenhagen","year":"2017","unstructured":"Eschenhagen T, Bolli R, Braun T, Field LJ, Fleischmann BK, Frisen J, et al. Cardiomyocyte regeneration: a consensus statement. Circulation. 2017;136(7):680\u20136.","journal-title":"Circulation."},{"issue":"7504","key":"1361_CR71","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/nature13233","volume":"510","author":"JJ Chong","year":"2014","unstructured":"Chong JJ, Yang X, Don CW, Minami E, Liu YW, Weyers JJ, et al. Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts. Nature. 2014;510(7504):273\u20137.","journal-title":"Nature."},{"issue":"7","key":"1361_CR72","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nbt.4162","volume":"36","author":"YW Liu","year":"2018","unstructured":"\u2022\u2022 Liu YW, Chen B, Yang X, Fugate JA, Kalucki FA, Futakuchi-Tsuchida A, et al. Human embryonic stem cell-derived cardiomyocytes restore function in infarcted hearts of non-human primates. Nat Biotechnol. 2018;36(7):597\u2013605 This important study shows that the infusion of embryonic stem cells-derived cardiomyocytes into an infarcted heart can lead to cardiac repair in monkeys.","journal-title":"Nat Biotechnol"},{"issue":"19","key":"1361_CR73","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1161\/CIRCULATIONAHA.116.024145","volume":"135","author":"M Tiburcy","year":"2017","unstructured":"\u2022 Tiburcy M, Hudson JE, Balfanz P, Schlick S, Meyer T, Chang Liao ML, et al. Defined engineered human myocardium with advanced maturation for applications in heart failure modeling and repair. Circulation. 2017;135(19):1832\u201347 This study is a recent demonstration that cardiac repair can be achieved through the implantation of in vitro grown, 3D, functional cardiac tissue.","journal-title":"Circulation"},{"issue":"363","key":"1361_CR74","doi-asserted-by":"crossref","first-page":"363ra148","DOI":"10.1126\/scitranslmed.aaf8781","volume":"8","author":"F Weinberger","year":"2016","unstructured":"Weinberger F, Breckwoldt K, Pecha S, Kelly A, Geertz B, Starbatty J, et al. Cardiac repair in guinea pigs with human engineered heart tissue from induced pluripotent stem cells. Sci Transl Med. 2016;8(363):363ra148.","journal-title":"Sci Transl Med"},{"issue":"23","key":"1361_CR75","doi-asserted-by":"crossref","first-page":"4683","DOI":"10.1242\/dev.102798","volume":"140","author":"T Heallen","year":"2013","unstructured":"Heallen T, Morikawa Y, Leach J, Tao G, Willerson JT, Johnson RL, et al. Hippo signaling impedes adult heart regeneration. Development. 2013;140(23):4683\u201390.","journal-title":"Development."},{"issue":"7675","key":"1361_CR76","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/nature24045","volume":"550","author":"JP Leach","year":"2017","unstructured":"\u2022\u2022 Leach JP, Heallen T, Zhang M, Rahmani M, Morikawa Y, Hill MC, et al. Hippo pathway deficiency reverses systolic heart failure after infarction. Nature. 2017;550(7675):260\u20134 This is a very important study showing that cardiac regeneration can be achieved in mice by the activation of the YAP transcriptional cofactor even after post-myocardial heart failure is established.","journal-title":"Nature"},{"issue":"3","key":"1361_CR77","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1161\/CIRCRESAHA.115.303632","volume":"115","author":"Z Lin","year":"2014","unstructured":"Lin Z, von Gise A, Zhou P, Gu F, Ma Q, Jiang J, et al. Cardiac-specific YAP activation improves cardiac function and survival in an experimental murine MI model. Circ Res. 2014;115(3):354\u201363.","journal-title":"Circ Res"},{"key":"1361_CR78","doi-asserted-by":"crossref","first-page":"156","DOI":"10.3389\/fcell.2019.00156","volume":"7","author":"S Kakiuchi-Kiyota","year":"2019","unstructured":"Kakiuchi-Kiyota S, Schutten MM, Zhong Y, Crawford JJ, Dey A. Safety considerations in the development of hippo pathway inhibitors in cancers. Front Cell Dev Biol. 2019;7:156.","journal-title":"Front Cell Dev Biol"},{"issue":"7","key":"1361_CR79","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1161\/CIRCRESAHA.115.304517","volume":"115","author":"G Felician","year":"2014","unstructured":"Felician G, Collesi C, Lusic M, Martinelli V, Ferro MD, Zentilin L, et al. Epigenetic modification at Notch responsive promoters blunts efficacy of inducing Notch pathway reactivation after myocardial infarction. Circ Res. 2014;115(7):636\u201349.","journal-title":"Circ Res"},{"issue":"1","key":"1361_CR80","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.cell.2018.02.014","volume":"173","author":"TMA Mohamed","year":"2018","unstructured":"Mohamed TMA, Ang YS, Radzinsky E, Zhou P, Huang Y, Elfenbein A, et al. Regulation of cell cycle to stimulate adult cardiomyocyte proliferation and cardiac regeneration. Cell. 2018;173(1):104\u201316 e12.","journal-title":"Cell."},{"key":"1361_CR81","doi-asserted-by":"publisher","unstructured":"Braga L, Ali H, Secco I, Giacca M. Non-coding RNA therapeutics for cardiac regeneration. Cardiovasc Res. 2020. https:\/\/doi.org\/10.1093\/cvr\/cvaa071.","DOI":"10.1093\/cvr\/cvaa071"},{"issue":"3","key":"1361_CR82","doi-asserted-by":"crossref","first-page":"394","DOI":"10.4161\/cc.8.3.7554","volume":"8","author":"A Barroso-del Jesus","year":"2009","unstructured":"Barroso-del Jesus A, Lucena-Aguilar G, Menendez P. The miR-302-367 cluster as a potential stemness regulator in ESCs. Cell Cycle. 2009;8(3):394\u20138.","journal-title":"Cell Cycle"},{"issue":"12","key":"1361_CR83","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1038\/ng.250","volume":"40","author":"Y Wang","year":"2008","unstructured":"Wang Y, Baskerville S, Shenoy A, Babiarz JE, Baehner L, Blelloch R. Embryonic stem cell-specific microRNAs regulate the G1-S transition and promote rapid proliferation. Nat Genet. 2008;40(12):1478\u201383.","journal-title":"Nat Genet"},{"issue":"279","key":"1361_CR84","doi-asserted-by":"crossref","first-page":"279ra38","DOI":"10.1126\/scitranslmed.3010841","volume":"7","author":"Y Tian","year":"2015","unstructured":"Tian Y, Liu Y, Wang T, Zhou N, Kong J, Chen L, et al. A microRNA-Hippo pathway that promotes cardiomyocyte proliferation and cardiac regeneration in mice. Sci Transl Med. 2015;7(279):279ra38.","journal-title":"Sci Transl Med"},{"issue":"7","key":"1361_CR85","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1073\/pnas.0510565103","volume":"103","author":"S Volinia","year":"2006","unstructured":"Volinia S, Calin GA, Liu CG, Ambs S, Cimmino A, Petrocca F, et al. A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci U S A. 2006;103(7):2257\u201361.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7043","key":"1361_CR86","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1038\/nature03552","volume":"435","author":"L He","year":"2005","unstructured":"He L, Thomson JM, Hemann MT, Hernando-Monge E, Mu D, Goodson S, et al. A microRNA polycistron as a potential human oncogene. Nature. 2005;435(7043):828\u201333.","journal-title":"Nature."},{"issue":"3","key":"1361_CR87","doi-asserted-by":"crossref","first-page":"879","DOI":"10.3390\/ijms19030879","volume":"19","author":"R Gruszka","year":"2018","unstructured":"Gruszka R, Zakrzewska M. The oncogenic relevance of miR-17-92 cluster and its paralogous miR-106b-25 and miR-106a-363 clusters in brain tumors. Int J Mol Sci. 2018;19(3):879.","journal-title":"Int J Mol Sci"},{"key":"1361_CR88","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/j.biopha.2018.08.097","volume":"107","author":"D Mehlich","year":"2018","unstructured":"Mehlich D, Garbicz F, Wlodarski PK. The emerging roles of the polycistronic miR-106b approximately 25 cluster in cancer\u2014a comprehensive review. Biomed Pharmacother. 2018;107:1183\u201395.","journal-title":"Biomed Pharmacother"},{"issue":"12","key":"1361_CR89","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1161\/CIRCRESAHA.112.300658","volume":"112","author":"J Chen","year":"2013","unstructured":"Chen J, Huang ZP, Seok HY, Ding J, Kataoka M, Zhang Z, et al. Mir-17-92 cluster is required for and sufficient to induce cardiomyocyte proliferation in postnatal and adult hearts. Circ Res. 2013;112(12):1557\u201366.","journal-title":"Circ Res"},{"issue":"1","key":"1361_CR90","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1038\/s41467-019-09530-1","volume":"10","author":"F Gao","year":"2019","unstructured":"Gao F, Kataoka M, Liu N, Liang T, Huang ZP, Gu F, et al. Therapeutic role of miR-19a\/19b in cardiac regeneration and protection from myocardial infarction. Nat Commun. 2019;10(1):1802.","journal-title":"Nat Commun"},{"issue":"7429","key":"1361_CR91","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature11739","volume":"492","author":"A Eulalio","year":"2012","unstructured":"Eulalio A, Mano M, Dal Ferro M, Zentilin L, Sinagra G, Zacchigna S, et al. Functional screening identifies miRNAs inducing cardiac regeneration. Nature. 2012;492(7429):376\u201381.","journal-title":"Nature."},{"issue":"7","key":"1361_CR92","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1016\/j.celrep.2018.04.049","volume":"23","author":"M Diez-Cunado","year":"2018","unstructured":"Diez-Cunado M, Wei K, Bushway PJ, Maurya MR, Perera R, Subramaniam S, et al. miRNAs that induce human cardiomyocyte proliferation converge on the hippo pathway. Cell Rep. 2018;23(7):2168\u201374.","journal-title":"Cell Rep"},{"issue":"8","key":"1361_CR93","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1161\/CIRCRESAHA.116.309589","volume":"120","author":"P Lesizza","year":"2017","unstructured":"Lesizza P, Prosdocimo G, Martinelli V, Sinagra G, Zacchigna S, Giacca M. Single-dose intracardiac injection of pro-regenerative microRNAs improves cardiac function after myocardial infarction. Circ Res. 2017;120(8):1298\u2013304.","journal-title":"Circ Res"},{"issue":"7756","key":"1361_CR94","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/s41586-019-1191-6","volume":"569","author":"K Gabisonia","year":"2019","unstructured":"\u2022\u2022 Gabisonia K, Prosdocimo G, Aquaro GD, Carlucci L, Zentilin L, Secco I, et al. MicroRNA therapy stimulates uncontrolled cardiac repair after myocardial infarction in pigs. Nature. 2019;569(7756):418\u201322 Findings from this study indicate for the first time that cardiac regeneration in a large animal can be obtained after myocardial infarction by the administration of AAV vectors expressing one specific microRNA.","journal-title":"Nature"},{"issue":"11","key":"1361_CR95","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1161\/CIRCRESAHA.114.302331","volume":"114","author":"S Zacchigna","year":"2014","unstructured":"Zacchigna S, Zentilin L, Giacca M. Adeno-associated virus vectors as therapeutic and investigational tools in the cardiovascular system. Circ Res. 2014;114(11):1827\u201346.","journal-title":"Circ Res"},{"issue":"5","key":"1361_CR96","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.stem.2014.10.003","volume":"15","author":"A Aguirre","year":"2014","unstructured":"Aguirre A, Montserrat N, Zacchigna S, Nivet E, Hishida T, Krause MN, et al. In vivo activation of a conserved microRNA program induces mammalian heart regeneration. Cell Stem Cell. 2014;15(5):589\u2013604.","journal-title":"Cell Stem Cell"},{"issue":"6020","key":"1361_CR97","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1126\/science.1200708","volume":"331","author":"ER Porrello","year":"2011","unstructured":"Porrello ER, Mahmoud AI, Simpson E, Hill JA, Richardson JA, Olson EN, et al. Transient regenerative potential of the neonatal mouse heart. Science. 2011;331(6020):1078\u201380.","journal-title":"Science."},{"key":"1361_CR98","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/s41551-017-0157-y","volume":"1","author":"LL Wang","year":"2017","unstructured":"Wang LL, Liu Y, Chung JJ, Wang T, Gaffey AC, Lu M, et al. Local and sustained miRNA delivery from an injectable hydrogel promotes cardiomyocyte proliferation and functional regeneration after ischemic injury. Nat Biomed Eng. 2017;1:983\u201392.","journal-title":"Nat Biomed Eng"},{"issue":"7","key":"1361_CR99","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.7150\/thno.16478","volume":"7","author":"S Deng","year":"2017","unstructured":"Deng S, Zhao Q, Zhen L, Zhang C, Liu C, Wang G, et al. Neonatal heart-enriched miR-708 promotes proliferation and stress resistance of cardiomyocytes in rodents. Theranostics. 2017;7(7):1953\u201365.","journal-title":"Theranostics."},{"issue":"3","key":"1361_CR100","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1089\/nat.2018.0721","volume":"28","author":"JA Kulkarni","year":"2018","unstructured":"Kulkarni JA, Cullis PR, van der Meel R. Lipid nanoparticles enabling gene therapies: from concepts to clinical utility. Nucleic Acid Ther. 2018;28(3):146\u201357.","journal-title":"Nucleic Acid Ther"},{"issue":"1","key":"1361_CR101","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa1716153","volume":"379","author":"D Adams","year":"2018","unstructured":"Adams D, Gonzalez-Duarte A, O'Riordan WD, Yang CC, Ueda M, Kristen AV, et al. Patisiran, an RNAi therapeutic, for hereditary Transthyretin amyloidosis. N Engl J Med. 2018;379(1):11\u201321.","journal-title":"N Engl J Med"}],"container-title":["Current Cardiology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11886-020-01361-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11886-020-01361-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11886-020-01361-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,6]],"date-time":"2022-11-06T12:25:49Z","timestamp":1667737549000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11886-020-01361-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,10]]},"references-count":101,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["1361"],"URL":"https:\/\/doi.org\/10.1007\/s11886-020-01361-7","relation":{},"ISSN":["1523-3782","1534-3170"],"issn-type":[{"value":"1523-3782","type":"print"},{"value":"1534-3170","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,10]]},"assertion":[{"value":"10 August 2020","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The author declares that no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"This article does not contain any studies with human or animal subjects performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and Animal Rights and Informed Consent"}}],"article-number":"122"}}