{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T14:45:17Z","timestamp":1784299517231,"version":"3.55.0"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T00:00:00Z","timestamp":1646179200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T00:00:00Z","timestamp":1646179200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Curr Cardiol Rep"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose of Review<\/jats:title>\n                <jats:p>Multivessel coronary artery disease, defined as significant stenosis in two or more major coronary arteries, is associated with high morbidity and mortality. The diagnosis and treatment of multivessel disease have evolved in the PCI era from solely a visual estimation of ischemic risk to a functional evaluation during angiography. This review summarizes the evidence and discusses the commonly used methods of multivessel coronary artery stenosis physiologic assessment.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Recent Findings<\/jats:title>\n                <jats:p>While FFR remains the gold standard in coronary physiologic assessment, several pressure-wire-based non-hyperemic indices of functional stenosis have been developed and validated as well as wire-free angiographically derived quantitative flow ratio. Identifying and treating functionally significant coronary atherosclerotic lesions reduce symptoms and major adverse cardiovascular events.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Summary<\/jats:title>\n                <jats:p>Coronary physiologic assessment in multivessel disease minimizes the observer bias in visual estimates of stenosis, changes clinical management, and improves patient outcomes.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11886-022-01675-8","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T08:05:46Z","timestamp":1646208346000},"page":"541-550","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Physiologic Lesion Assessment to Optimize Multivessel Disease"],"prefix":"10.1007","volume":"24","author":[{"given":"Murtaza","family":"Bharmal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morton J.","family":"Kern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gautam","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0584-1904","authenticated-orcid":false,"given":"Arnold H.","family":"Seto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,3,2]]},"reference":[{"issue":"3","key":"1675_CR1","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.jacc.2010.04.012","volume":"56","author":"NHJ Pijls","year":"2010","unstructured":"Pijls NHJ, Fearon WF, Tonino PAL, et al. Fractional flow reserve versus angiography for guiding percutaneous coronary intervention in patients with multivessel coronary artery disease: 2-year follow-up of the FAME (Fractional Flow Reserve Versus Angiography for Multivessel Evaluation) study. J Am Coll Cardiol. 2010;56(3):177\u201384. https:\/\/doi.org\/10.1016\/j.jacc.2010.04.012.","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"1675_CR2","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1056\/NEJMoa0807611","volume":"360","author":"PAL Tonino","year":"2009","unstructured":"Tonino PAL, De Bruyne B, Pijls NHJ, et al. Fractional flow reserve versus angiography for guiding percutaneous coronary intervention. N Engl J Med. 2009;360(3):213\u201324. https:\/\/doi.org\/10.1056\/NEJMoa0807611.","journal-title":"N Engl J Med"},{"issue":"2","key":"1675_CR3","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1093\/eurheartj\/ehy394","volume":"40","author":"FJ Neumann","year":"2019","unstructured":"Neumann FJ, Sousa-Uva M, Ahlsson A, et al. 2018 ESC\/EACTS Guidelines on myocardial revascularization. Eur Heart J. 2019;40(2):87\u2013165. https:\/\/doi.org\/10.1093\/eurheartj\/ehy394.","journal-title":"Eur Heart J"},{"key":"1675_CR4","doi-asserted-by":"publisher","unstructured":"Zimmermann FM, Omerovic E, Fournier S, et al. Fractional flow reserve-guided percutaneous coronary intervention vs. medical therapy for patients with stable coronary lesions: meta-analysis of individual patient data. Eur Heart J. 2019;40(2):180\u2013186. https:\/\/doi.org\/10.1093\/eurheartj\/ehy812.","DOI":"10.1093\/eurheartj\/ehy812"},{"key":"1675_CR5","doi-asserted-by":"publisher","unstructured":"Zimmermann FM, Ferrara A, Johnson NP, et al. Deferral vs. performance of percutaneous coronary intervention of functionally non-significant coronary stenosis: 15-year follow-up of the DEFER trial. Eur Heart J. 2015;36(45):3182\u20133188. https:\/\/doi.org\/10.1093\/eurheartj\/ehv452.","DOI":"10.1093\/eurheartj\/ehv452"},{"issue":"17","key":"1675_CR6","doi-asserted-by":"publisher","first-page":"2105","DOI":"10.1016\/j.jacc.2017.08.049","volume":"70","author":"Y Kobayashi","year":"2017","unstructured":"Kobayashi Y, Johnson NP, Zimmermann FM, et al. Agreement of the resting distal to aortic coronary pressure with the instantaneous wave-free ratio. J Am Coll Cardiol. 2017;70(17):2105\u201313. https:\/\/doi.org\/10.1016\/j.jacc.2017.08.049.","journal-title":"J Am Coll Cardiol"},{"key":"1675_CR7","doi-asserted-by":"publisher","unstructured":"Maini R, Moscona J, Katigbak P, et al. Instantaneous wave-free ratio as an alternative to fractional flow reserve in assessment of moderate coronary stenoses: a meta-analysis of diagnostic accuracy studies. Cardiovasc Revascularization Med Mol Interv. 2018;19(5 Pt B):613\u2013620. https:\/\/doi.org\/10.1016\/j.carrev.2017.12.014.","DOI":"10.1016\/j.carrev.2017.12.014"},{"issue":"19","key":"1675_CR8","doi-asserted-by":"publisher","first-page":"1824","DOI":"10.1056\/NEJMoa1700445","volume":"376","author":"JE Davies","year":"2017","unstructured":"Davies JE, Sen S, Dehbi HM, et al. Use of the instantaneous wave-free ratio or fractional flow reserve in PCI. N Engl J Med. 2017;376(19):1824\u201334. https:\/\/doi.org\/10.1056\/NEJMoa1700445.","journal-title":"N Engl J Med"},{"issue":"19","key":"1675_CR9","doi-asserted-by":"publisher","first-page":"1813","DOI":"10.1056\/NEJMoa1616540","volume":"376","author":"M G\u00f6tberg","year":"2017","unstructured":"G\u00f6tberg M, Christiansen EH, Gudmundsdottir IJ, et al. Instantaneous wave-free ratio versus fractional flow reserve to guide PCI. N Engl J Med. 2017;376(19):1813\u201323. https:\/\/doi.org\/10.1056\/NEJMoa1616540.","journal-title":"N Engl J Med"},{"issue":"7","key":"1675_CR10","doi-asserted-by":"publisher","first-page":"806","DOI":"10.4244\/EIJ-D-18-00342","volume":"14","author":"J Svanerud","year":"2018","unstructured":"Svanerud J, Ahn JM, Jeremias A, et al. Validation of a novel non-hyperaemic index of coronary artery stenosis severity: the Resting Full-cycle Ratio (VALIDATE RFR) study. EuroIntervention J Eur Collab Work Group Interv Cardiol Eur Soc Cardiol. 2018;14(7):806\u201314. https:\/\/doi.org\/10.4244\/EIJ-D-18-00342.","journal-title":"EuroIntervention J Eur Collab Work Group Interv Cardiol Eur Soc Cardiol"},{"key":"1675_CR11","doi-asserted-by":"publisher","unstructured":"Johnson NP, Li W, Chen X, et al. Diastolic pressure ratio: new approach and validation vs. the instantaneous wave-free ratio. Eur Heart J. 2019;40(31):2585\u20132594. https:\/\/doi.org\/10.1093\/eurheartj\/ehz230.","DOI":"10.1093\/eurheartj\/ehz230"},{"key":"1675_CR12","doi-asserted-by":"publisher","unstructured":"Van\u2019t Veer M, Pijls NHJ, Hennigan B, et al. Comparison of different diastolic resting\u00a0indexes to iFR: are they all equal? J Am Coll Cardiol. 2017;70(25):3088\u20133096. https:\/\/doi.org\/10.1016\/j.jacc.2017.10.066.","DOI":"10.1016\/j.jacc.2017.10.066"},{"issue":"2","key":"1675_CR13","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.nuclcard.2003.12.004","volume":"11","author":"LJ Shaw","year":"2004","unstructured":"Shaw LJ, Iskandrian AE. Prognostic value of gated myocardial perfusion SPECT. J Nucl Cardiol Off Publ Am Soc Nucl Cardiol. 2004;11(2):171\u201385. https:\/\/doi.org\/10.1016\/j.nuclcard.2003.12.004.","journal-title":"J Nucl Cardiol Off Publ Am Soc Nucl Cardiol"},{"issue":"10006","key":"1675_CR14","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.1016\/S0140-6736(15)00057-4","volume":"386","author":"LX van Nunen","year":"2015","unstructured":"Van Nunen LX, Zimmermann FM, Tonino PAL, et al. Fractional flow reserve versus angiography for guidance of PCI in patients with multivessel coronary artery disease (FAME): 5-year follow-up of a randomised controlled trial. Lancet Lond Engl. 2015;386(10006):1853\u201360. https:\/\/doi.org\/10.1016\/S0140-6736(15)00057-4.","journal-title":"Lancet Lond Engl"},{"issue":"13","key":"1675_CR15","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1056\/NEJMoa1408758","volume":"371","author":"B De Bruyne","year":"2014","unstructured":"De Bruyne B, Fearon WF, Pijls NHJ, et al. Fractional flow reserve-guided PCI for stable coronary artery disease. N Engl J Med. 2014;371(13):1208\u201317. https:\/\/doi.org\/10.1056\/NEJMoa1408758.","journal-title":"N Engl J Med"},{"key":"1675_CR16","doi-asserted-by":"publisher","unstructured":"\u2022\u2022 Xaplanteris P, Fournier S, Pijls NHJ, et al. Five-year outcomes with PCI guided by fractional flow reserve. N Engl J Med. 2018;379(3):250-259.\u00a0https:\/\/doi.org\/10.1056\/NEJMoa1803538. Findings from this study demonstrate that FFR-guided PCI is associated with a significantly lower rate of MACE at five years compared medical therapy alone.","DOI":"10.1056\/NEJMoa1803538"},{"issue":"42","key":"1675_CR17","doi-asserted-by":"publisher","first-page":"3124","DOI":"10.1093\/eurheartj\/ehx512","volume":"38","author":"J Escaned","year":"2017","unstructured":"Escaned J, Collet C, Ryan N, et al. Clinical outcomes of state-of-the-art percutaneous coronary revascularization in patients with de novo three vessel disease: 1-year results of the SYNTAX II study. Eur Heart J. 2017;38(42):3124\u201334. https:\/\/doi.org\/10.1093\/eurheartj\/ehx512.","journal-title":"Eur Heart J"},{"key":"1675_CR18","doi-asserted-by":"publisher","unstructured":"\u2022 Van Belle E, Gil R, Klauss V, et al. Impact of routine invasive physiology at\u00a0time of angiography in patients with\u00a0multivessel coronary artery disease\u00a0on reclassification of revascularization strategy: results from the DEFINE REAL Study. JACC Cardiovasc Interv. 2018;11(4):354-365. https:\/\/doi.org\/10.1016\/j.jcin.2017.11.030. Findings from this study demonstrate that invasive physiology at the time of angiography reclassifies the strategy for revascularization in over one-fourth of patients.","DOI":"10.1016\/j.jcin.2017.11.030"},{"issue":"8","key":"1675_CR19","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1016\/j.amjcard.2015.07.028","volume":"116","author":"JM Ahn","year":"2015","unstructured":"Ahn JM, Yoon SH, Roh JH, et al. Trends in outcomes of revascularization for left nain coronary disease or three-vessel disease with the routine incorporation of fractional flow reserve in real practice. Am J Cardiol. 2015;116(8):1163\u201371. https:\/\/doi.org\/10.1016\/j.amjcard.2015.07.028.","journal-title":"Am J Cardiol"},{"key":"1675_CR20","doi-asserted-by":"publisher","unstructured":"Fearon WF, Zimmermann FM, De Bruyne B, et al. Fractional flow reserve-guided PCI as compared with coronary bypass surgery. N Engl J Med.\u00a02021. https:\/\/doi.org\/10.1056\/NEJMoa2112299.","DOI":"10.1056\/NEJMoa2112299"},{"key":"1675_CR21","doi-asserted-by":"publisher","unstructured":"\u2022 Park J, Lee JM, Koo BK, et al. Clinical relevance of functionally insignificant moderate coronary artery stenosis assessed by 3-vessel fractional flow reserve Measurement. J Am Heart Assoc. 2018;7(4):e008055. https:\/\/doi.org\/10.1161\/JAHA.117.008055. Findings from this study demonstrate that moderate multivessel CAD appears to have similar prognostic implications to that of functionally significant CAD.","DOI":"10.1161\/JAHA.117.008055"},{"issue":"11","key":"1675_CR22","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1093\/eurheartj\/ehx458","volume":"39","author":"JM Lee","year":"2018","unstructured":"Lee JM, Koo BK, Shin ES, et al. Clinical implications of three-vessel fractional flow reserve measurement in patients with coronary artery disease. Eur Heart J. 2018;39(11):945\u201351. https:\/\/doi.org\/10.1093\/eurheartj\/ehx458.","journal-title":"Eur Heart J"},{"issue":"8","key":"1675_CR23","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.006071","volume":"6","author":"JM Lee","year":"2017","unstructured":"Lee JM, Koo BK, Shin ES, et al. Clinical outcomes of deferred lesions with angiographically insignificant stenosis but low fractional flow reserve. J Am Heart Assoc. 2017;6(8): e006071. https:\/\/doi.org\/10.1161\/JAHA.117.006071.","journal-title":"J Am Heart Assoc"},{"issue":"24","key":"1675_CR24","doi-asserted-by":"publisher","first-page":"2502","DOI":"10.1016\/j.jcin.2017.07.019","volume":"10","author":"JM Lee","year":"2017","unstructured":"Lee JM, Shin ES, Nam CW, et al. Clinical outcomes according to fractional flow reserve or instantaneous wave-free ratio in deferred lesions. JACC Cardiovasc Interv. 2017;10(24):2502\u201310. https:\/\/doi.org\/10.1016\/j.jcin.2017.07.019.","journal-title":"JACC Cardiovasc Interv"},{"issue":"9994","key":"1675_CR25","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1016\/s0140-6736(15)60648-1","volume":"386","author":"T Engstr\u00f8m","year":"2015","unstructured":"Engstr\u00f8m T, Kelb\u00e6k H, Helqvist S, et al. Complete revascularisation versus treatment of the culprit lesion only in patients with ST-segment elevation myocardial infarction and multivessel disease (DANAMI-3\u2014PRIMULTI): an open-label, randomised controlled trial. Lancet Lond Engl. 2015;386(9994):665\u201371. https:\/\/doi.org\/10.1016\/s0140-6736(15)60648-1.","journal-title":"Lancet Lond Engl"},{"issue":"13","key":"1675_CR26","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1056\/NEJMoa1701067","volume":"376","author":"PC Smits","year":"2017","unstructured":"Smits PC, Abdel-Wahab M, Neumann FJ, et al. Fractional flow reserve-guided multivessel angioplasty in myocardial infarction. N Engl J Med. 2017;376(13):1234\u201344. https:\/\/doi.org\/10.1056\/NEJMoa1701067.","journal-title":"N Engl J Med"},{"issue":"2","key":"1675_CR27","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1093\/eurheartj\/ehx393","volume":"39","author":"B Ibanez","year":"2018","unstructured":"Ibanez B, James S, Agewall S, et al. 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: the Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J. 2018;39(2):119\u201377. https:\/\/doi.org\/10.1093\/eurheartj\/ehx393.","journal-title":"Eur Heart J"},{"issue":"15","key":"1675_CR28","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1056\/NEJMoa1907775","volume":"381","author":"SR Mehta","year":"2019","unstructured":"Mehta SR, Wood DA, Storey RF, et al. Complete revascularization with multivessel PCI for myocardial infarction. N Engl J Med. 2019;381(15):1411\u201321. https:\/\/doi.org\/10.1056\/NEJMoa1907775.","journal-title":"N Engl J Med"},{"issue":"4","key":"1675_CR29","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1056\/NEJMoa2104650","volume":"385","author":"E Puymirat","year":"2021","unstructured":"Puymirat E, Cayla G, Simon T, et al. Multivessel PCI guided by FFR or angiography for myocardial infarction. N Engl J Med. 2021;385(4):297\u2013308. https:\/\/doi.org\/10.1056\/NEJMoa2104650.","journal-title":"N Engl J Med"},{"key":"1675_CR30","doi-asserted-by":"publisher","unstructured":"\u2022 B\u00f6hm F, Mogensen B, \u00d6stlund O, et al. The Full Revasc (Ffr-gUidance for compLete non-cuLprit REVASCularization) Registry-based randomized clinical trial. Am Heart J. 2021;241:92-100. https:\/\/doi.org\/10.1016\/j.ahj.2021.07.007. This clinical trial is designed to evaluate the effect of FFR-guided complete revascularization of non-culprit lesions during index hospitalizations after STEMI on MACE.","DOI":"10.1016\/j.ahj.2021.07.007"},{"key":"1675_CR31","unstructured":"Radboud University. Instantaneous Wave-Free Ratio Guided Multi-Vessel Revascularizati On During Percutaneous Coronary IntervEntion for Acute MyocaRdial INfarction (IMODERN). clinicaltrials.gov.\u00a02020. Accessed 18 Nov\u00a02021."},{"key":"1675_CR32","doi-asserted-by":"publisher","unstructured":"\u2022\u2022 Kikuta Y, Cook CM, Sharp ASP, et al. Pre-angioplasty instantaneous wave-free ratio pullback predicts hemodynamic outcome in humans with\u00a0coronary artery disease: primary results of the international multicenter iFR\u00a0GRADIENT\u00a0registry. JACC Cardiovasc Interv. 2018;11(8):757-767. https:\/\/doi.org\/10.1016\/j.jcin.2018.03.005. Findings from this study elucidate the demonstrated the utility of iFR pullback on revascularization strategy and predicted physiological outcome of PCI.","DOI":"10.1016\/j.jcin.2018.03.005"},{"issue":"8","key":"1675_CR33","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1016\/j.jcin.2018.03.013","volume":"11","author":"MJ Kern","year":"2018","unstructured":"Kern MJ, Seto AH. Instantaneous wave-free ratio pressure pullback with virtual percutaneous coronary intervention planning: seeing the future of coronary interventions? JACC Cardiovasc Interv. 2018;11(8):768\u201370. https:\/\/doi.org\/10.1016\/j.jcin.2018.03.013.","journal-title":"JACC Cardiovasc Interv"},{"key":"1675_CR34","doi-asserted-by":"publisher","unstructured":"\u2022 Warisawa T, Cook CM, Howard JP, et al. Physiological pattern of disease assessed by pressure-wire pullback has an influence on fractional flow reserve\/instantaneous wave-free ratio discordance. Circ Cardiovasc Interv. 2019;12(5):e007494. doi:https:\/\/doi.org\/10.1161\/CIRCINTERVENTIONS.118.007494. Findings from this study elucidate that the physiological pattern of CAD is an important influencing factor for FFR\/iFR discordance.","DOI":"10.1161\/CIRCINTERVENTIONS.118.007494"},{"issue":"14","key":"1675_CR35","doi-asserted-by":"publisher","first-page":"1772","DOI":"10.1016\/j.jacc.2019.07.072","volume":"74","author":"C Collet","year":"2019","unstructured":"Collet C, Sonck J, Vandeloo B, et al. Measurement of hyperemic pullback pressure gradients to characterize patterns of coronary atherosclerosis. J Am Coll Cardiol. 2019;74(14):1772\u201384. https:\/\/doi.org\/10.1016\/j.jacc.2019.07.072.","journal-title":"J Am Coll Cardiol"},{"issue":"20","key":"1675_CR36","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.1016\/j.jcin.2019.05.054","volume":"12","author":"A Jeremias","year":"2019","unstructured":"Jeremias A, Davies JE, Maehara A, et al. Blinded physiological assessment of residual ischemia after successful angiographic percutaneous coronary intervention: the DEFINE PCI study. JACC Cardiovasc Interv. 2019;12(20):1991\u20132001. https:\/\/doi.org\/10.1016\/j.jcin.2019.05.054.","journal-title":"JACC Cardiovasc Interv"},{"issue":"4","key":"1675_CR37","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1001\/jamacardio.2019.0175","volume":"4","author":"S Fournier","year":"2019","unstructured":"Fournier S, Ciccarelli G, Toth GG, et al. Association of improvement in fractional flow reserve with outcomes, including symptomatic relief, after percutaneous coronary intervention. JAMA Cardiol. 2019;4(4):370\u20134. https:\/\/doi.org\/10.1001\/jamacardio.2019.0175.","journal-title":"JAMA Cardiol"},{"issue":"9","key":"1675_CR38","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.120.009232","volume":"13","author":"JM Lee","year":"2020","unstructured":"Lee JM, Hwang D, Choi KH, et al. Prognostic impact of residual anatomic disease burden after functionally complete revascularization. Circ Cardiovasc Interv. 2020;13(9): e009232. https:\/\/doi.org\/10.1161\/CIRCINTERVENTIONS.120.009232.","journal-title":"Circ Cardiovasc Interv"},{"issue":"3","key":"1675_CR39","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.jcin.2017.09.009","volume":"11","author":"KH Choi","year":"2018","unstructured":"Choi KH, Lee JM, Koo BK, et al. Prognostic implication of functional incomplete revascularization and residual functional SYNTAX score in patients with coronary artery disease. JACC Cardiovasc Interv. 2018;11(3):237\u201345. https:\/\/doi.org\/10.1016\/j.jcin.2017.09.009.","journal-title":"JACC Cardiovasc Interv"},{"issue":"41","key":"1675_CR40","doi-asserted-by":"publisher","first-page":"3689","DOI":"10.1093\/eurheartj\/ehy581","volume":"39","author":"C Collet","year":"2018","unstructured":"Collet C, Onuma Y, Andreini D, et al. Coronary computed tomography angiography for heart team decision-making in multivessel coronary artery disease. Eur Heart J. 2018;39(41):3689\u201398. https:\/\/doi.org\/10.1093\/eurheartj\/ehy581.","journal-title":"Eur Heart J"},{"issue":"12","key":"1675_CR41","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.118.007607","volume":"12","author":"D Andreini","year":"2019","unstructured":"Andreini D, Modolo R, Katagiri Y, et al. Impact of fractional flow reserve derived from coronary computed tomography angiography on heart team treatment decision-making in patients with multivessel coronary artery disease: insights from the SYNTAX III REVOLUTION trial. Circ Cardiovasc Interv. 2019;12(12):e007607. https:\/\/doi.org\/10.1161\/CIRCINTERVENTIONS.118.007607.","journal-title":"Circ Cardiovasc Interv"},{"key":"1675_CR42","doi-asserted-by":"publisher","unstructured":"Sonck J, Miyazaki Y, Collet C, et al. Feasibility of planning coronary artery bypass grafting based only on coronary computed tomography angiography and CT-derived fractional flow reserve: a pilot survey of the surgeons involved in the randomized SYNTAX III Revolution trial. Interact Cardiovasc Thorac Surg.\u00a02019:ivz046. https:\/\/doi.org\/10.1093\/icvts\/ivz046.","DOI":"10.1093\/icvts\/ivz046"},{"key":"1675_CR43","doi-asserted-by":"publisher","unstructured":"Cesaro A, Gragnano F, Di Girolamo D, et al. Functional assessment of coronary stenosis: an overview of available techniques. Is quantitative flow ratio a step to the future? Expert Rev Cardiovasc Ther. 2018;16(12):951\u2013962. https:\/\/doi.org\/10.1080\/14779072.2018.1540303.","DOI":"10.1080\/14779072.2018.1540303"},{"issue":"19","key":"1675_CR44","doi-asserted-by":"publisher","first-page":"2024","DOI":"10.1016\/j.jcin.2016.07.013","volume":"9","author":"S Tu","year":"2016","unstructured":"Tu S, Westra J, Yang J, et al. Diagnostic accuracy of fast computational approaches to derive fractional flow reserve from diagnostic coronary angiography: the international multicenter FAVOR pilot study. JACC Cardiovasc Interv. 2016;9(19):2024\u201335. https:\/\/doi.org\/10.1016\/j.jcin.2016.07.013.","journal-title":"JACC Cardiovasc Interv"},{"issue":"3","key":"1675_CR45","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.117.007107","volume":"11","author":"J Westra","year":"2018","unstructured":"Westra J, Tu S, Winther S, et al. Evaluation of coronary artery stenosis by quantitative flow ratio during invasive coronary angiography: the WIFI II study (wire-free functional imaging II). Circ Cardiovasc Imaging. 2018;11(3): e007107. https:\/\/doi.org\/10.1161\/CIRCIMAGING.117.007107.","journal-title":"Circ Cardiovasc Imaging"},{"issue":"25","key":"1675_CR46","doi-asserted-by":"publisher","first-page":"3077","DOI":"10.1016\/j.jacc.2017.10.035","volume":"70","author":"B Xu","year":"2017","unstructured":"Xu B, Tu S, Qiao S, et al. Diagnostic accuracy of angiography-based quantitative flow ratio measurements for online assessment of coronary stenosis. J Am Coll Cardiol. 2017;70(25):3077\u201387. https:\/\/doi.org\/10.1016\/j.jacc.2017.10.035.","journal-title":"J Am Coll Cardiol"},{"issue":"10","key":"1675_CR47","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.120.009155","volume":"13","author":"R Zhang","year":"2020","unstructured":"Zhang R, Song C, Guan C, et al. Prognostic value of quantitative flow ratio based functional SYNTAX score in patients with left main or multivessel coronary artery disease. Circ Cardiovasc Interv. 2020;13(10): e009155. https:\/\/doi.org\/10.1161\/CIRCINTERVENTIONS.120.009155.","journal-title":"Circ Cardiovasc Interv"},{"issue":"2","key":"1675_CR48","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.117.006023","volume":"11","author":"G Spitaleri","year":"2018","unstructured":"Spitaleri G, Tebaldi M, Biscaglia S, et al. Quantitative flow ratio identifies nonculprit coronary lesions requiring revascularization in patients with ST-segment-elevation myocardial infarction and multivessel disease. Circ Cardiovasc Interv. 2018;11(2): e006023. https:\/\/doi.org\/10.1161\/CIRCINTERVENTIONS.117.006023.","journal-title":"Circ Cardiovasc Interv"},{"key":"1675_CR49","doi-asserted-by":"publisher","unstructured":"Zhang J, Yao M, Jia X, et al. The efficacy and safety of quantitative flow ratio-guided complete revascularization in patients with ST-segment elevation myocardial infarction and multivessel disease: a pilot randomized controlled trial. Cardiol J.\u00a02021. https:\/\/doi.org\/10.5603\/CJ.a2021.0111.","DOI":"10.5603\/CJ.a2021.0111"},{"key":"1675_CR50","doi-asserted-by":"publisher","unstructured":"\u2022 Fearon WF, Achenbach S, Engstrom T, et al. Accuracy of fractional flow reserve derived from coronary angiography. Circulation. 2019;139(4):477\u2013484.\u00a0https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.118.037350. Findings from this study demonstrate that angiography derived FFR has a good correlation with pressure-wire-derived FFR.","DOI":"10.1161\/CIRCULATIONAHA.118.037350"},{"key":"1675_CR51","doi-asserted-by":"publisher","unstructured":"Masdjedi K, Tanaka N, Van Belle E, et al. Vessel fractional flow reserve (vFFR) for the assessment of stenosis severity: the FAST II study. EuroIntervention J Eur Collab Work Group Interv Cardiol Eur Soc Cardiol.\u00a02021:EIJ-D-21\u201300471. https:\/\/doi.org\/10.4244\/EIJ-D-21-00471.","DOI":"10.4244\/EIJ-D-21-00471"},{"issue":"14","key":"1675_CR52","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1016\/j.jcin.2019.05.025","volume":"12","author":"CM Cook","year":"2019","unstructured":"Cook CM, Warisawa T, Howard JP, et al. Algorithmic versus expert human interpretation of instantaneous wave-free ratio coronary pressure-wire pull back data. JACC Cardiovasc Interv. 2019;12(14):1315\u201324. https:\/\/doi.org\/10.1016\/j.jcin.2019.05.025.","journal-title":"JACC Cardiovasc Interv"},{"issue":"14","key":"1675_CR53","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1016\/j.jcin.2019.05.039","volume":"12","author":"BK Koo","year":"2019","unstructured":"Koo BK, Samady H. Strap in for the artificial intelligence revolution in interventional cardiology. JACC Cardiovasc Interv. 2019;12(14):1325\u20137. https:\/\/doi.org\/10.1016\/j.jcin.2019.05.039.","journal-title":"JACC Cardiovasc Interv"},{"key":"1675_CR54","doi-asserted-by":"crossref","unstructured":"Kogame N, et al.\u00a0The impact of coronary physiology on contemporary clinical decision making. J Am Coll Cardiol Intv.\u00a0 2020;13:1617-1638.","DOI":"10.1016\/j.jcin.2020.04.040"}],"updated-by":[{"DOI":"10.1007\/s11886-022-01696-3","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T00:00:00Z","timestamp":1649376000000}}],"container-title":["Current Cardiology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11886-022-01675-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11886-022-01675-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11886-022-01675-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T13:30:22Z","timestamp":1651671022000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11886-022-01675-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,2]]},"references-count":54,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["1675"],"URL":"https:\/\/doi.org\/10.1007\/s11886-022-01675-8","relation":{"correction":[{"id-type":"doi","id":"10.1007\/s11886-022-01696-3","asserted-by":"object"}]},"ISSN":["1523-3782","1534-3170"],"issn-type":[{"value":"1523-3782","type":"print"},{"value":"1534-3170","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,2]]},"assertion":[{"value":"9 February 2022","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 March 2022","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 April 2022","order":3,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":4,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":5,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s11886-022-01696-3","URL":"https:\/\/doi.org\/10.1007\/s11886-022-01696-3","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"Morton Kern is a consultant and speaker for Abbott Vascular\/St. Jude, Acist Medical Inc., Philips Inc., and Opsens Inc. Gautam Kumar has received research grants from Acist. Arnold Seto has received research grants from Philips and Acist Medical. The other author declared  no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"This article does not contain any studies with human or animal subjects performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and Animal Rights and Informed Consent"}}]}}