{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T08:00:07Z","timestamp":1793260807637,"version":"4.5.0"},"reference-count":175,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Curr Cardiol Rep"],"DOI":"10.1007\/s11886-026-02382-4","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T08:24:44Z","timestamp":1784103884000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Epigenetic Control of Mammalian Cardiomyocyte Proliferation"],"prefix":"10.1007","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6606-4678","authenticated-orcid":false,"given":"Francesca","family":"Butera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Elliott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enzo R.","family":"Porrello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"issue":"6","key":"2382_CR1","doi-asserted-by":"publisher","first-page":"4444","DOI":"10.1002\/ehf2.13646","volume":"8","author":"A Abdin","year":"2021","unstructured":"Abdin A, Anker SD, Butler J, Coats AJS, Kindermann I, Lainscak M, et al. \u2018Time is prognosis\u2019 in heart failure: time-to-treatment initiation as a modifiable risk factor. ESC Heart Fail. 2021;8(6):4444\u201353. https:\/\/doi.org\/10.1002\/ehf2.13646.","journal-title":"ESC Heart Fail"},{"issue":"9","key":"2382_CR2","doi-asserted-by":"publisher","first-page":"1001002","DOI":"10.3389\/fcvm.2022.1001002","volume":"17","author":"M Cameli","year":"2022","unstructured":"Cameli M, Pastore MC, Campora A, Lisi M, Mandoli GE. Donor shortage in heart transplantation: How can we overcome this challenge? Front Cardiovasc Med. 2022;17(9):1001002. https:\/\/doi.org\/10.3389\/fcvm.2022.1001002.","journal-title":"Front Cardiovasc Med"},{"issue":"20","key":"2382_CR3","doi-asserted-by":"publisher","first-page":"e618","DOI":"10.1161\/CIR.0000000000000617","volume":"138","author":"K Thygesen","year":"2018","unstructured":"Thygesen K, Alpert JS, Jaffe AS, Chaitman BR, Bax JJ, Morrow DA, et al. Fourth universal definition of myocardial infarction (2018). Circulation. 2018;138(20):e618\u201351. https:\/\/doi.org\/10.1161\/CIR.0000000000000617.","journal-title":"Circulation"},{"issue":"7","key":"2382_CR4","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1016\/j.cell.2015.05.026","volume":"161","author":"O Bergmann","year":"2015","unstructured":"Bergmann O, Zdunek S, Felker A, Salehpour M, Alkass K, Bernard S, et al. Dynamics of cell generation and turnover in the human heart. Cell. 2015;161(7):1566\u201375. https:\/\/doi.org\/10.1016\/j.cell.2015.05.026.","journal-title":"Cell"},{"issue":"9","key":"2382_CR5","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1161\/01.RES.85.9.856","volume":"85","author":"S Guerra","year":"1999","unstructured":"Guerra S, Leri A, Wang X, Finato N, Di Loreto C, Beltrami CA, et al. Myocyte death in the failing human heart is gender dependent. Circ Res. 1999;85(9):856\u201366. https:\/\/doi.org\/10.1161\/01.RES.85.9.856.","journal-title":"Circ Res"},{"issue":"7","key":"2382_CR6","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1161\/01.RES.0000067471.95890.5C","volume":"92","author":"S Kostin","year":"2003","unstructured":"Kostin S, Pool L, Els\u00e4sser A, Hein S, Drexler HCA, Arnon E, et al. Myocytes die by multiple mechanisms in failing human hearts. Circ Res. 2003;92(7):715\u201324. https:\/\/doi.org\/10.1161\/01.RES.0000067471.95890.5C.","journal-title":"Circ Res"},{"issue":"3","key":"2382_CR7","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.devcel.2006.12.011","volume":"12","author":"J Grego-Bessa","year":"2007","unstructured":"Grego-Bessa J, Luna-Zurita L, del Monte G, Bol\u00f3s V, Melgar P, Arandilla A, et al. Notch signaling is essential for ventricular chamber development. Dev Cell. 2007;12(3):415\u201329. https:\/\/doi.org\/10.1016\/j.devcel.2006.12.011.","journal-title":"Dev Cell"},{"issue":"6028","key":"2382_CR8","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1126\/science.1199010","volume":"332","author":"T Heallen","year":"2011","unstructured":"Heallen T, Zhang M, Wang J, Bonilla-Claudio M, Klysik E, Johnson RL, et al. Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size. Science. 2011;332(6028):458\u201361. https:\/\/doi.org\/10.1126\/science.1199010.","journal-title":"Science"},{"issue":"11","key":"2382_CR9","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1038\/s41569-018-0063-3","volume":"15","author":"J Wang","year":"2018","unstructured":"Wang J, Liu S, Heallen T, Martin JF. The Hippo pathway in the heart: pivotal roles in development, disease, and regeneration. Nat Rev Cardiol. 2018;15(11):672\u201384. https:\/\/doi.org\/10.1038\/s41569-018-0063-3.","journal-title":"Nat Rev Cardiol"},{"issue":"16","key":"2382_CR10","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1161\/CIRCULATIONAHA.120.051921","volume":"143","author":"CB Sim","year":"2021","unstructured":"Sim CB, Phipson B, Ziemann M, Rafehi H, Mills RJ, Watt KI, et al. Sex-specific control of human heart maturation by the progesterone receptor. Circulation. 2021;143(16):1614\u201328. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.120.051921.","journal-title":"Circulation"},{"issue":"12","key":"2382_CR11","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1161\/CIRCULATIONAHA.117.028252","volume":"136","author":"GA Quaife-Ryan","year":"2017","unstructured":"Quaife-Ryan GA, Sim CB, Ziemann M, Kaspi A, Rafehi H, Ramialison M, et al. Multicellular Transcriptional Analysis of Mammalian Heart Regeneration. Circulation. 2017;136(12):1123\u201339. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.117.028252.","journal-title":"Circulation"},{"issue":"6020","key":"2382_CR12","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1126\/science.1200708","volume":"331","author":"ER Porrello","year":"2011","unstructured":"Porrello ER, Mahmoud AI, Simpson E, Hill JA, Richardson JA, Olson EN, et al. Transient regenerative potential of the neonatal mouse heart. Science. 2011;331(6020):1078\u201380. https:\/\/doi.org\/10.1126\/science.1200708.","journal-title":"Science"},{"issue":"8","key":"2382_CR13","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1006\/jmcc.1996.0163","volume":"28","author":"F Li","year":"1996","unstructured":"Li F, Wang X, Capasso JM, Gerdes AM. Rapid transition of cardiac myocytes from hyperplasia to hypertrophy during postnatal development. J Mol Cell Cardiol. 1996;28(8):1737\u201346. https:\/\/doi.org\/10.1006\/jmcc.1996.0163.","journal-title":"J Mol Cell Cardiol"},{"issue":"1","key":"2382_CR14","doi-asserted-by":"publisher","first-page":"H220","DOI":"10.1152\/ajpheart.1997.272.1.H220","volume":"272","author":"MH Soonpaa","year":"1997","unstructured":"Soonpaa MH, Field LJ. Assessment of cardiomyocyte DNA synthesis in normal and injured adult mouse hearts. Am J Physiol-Heart Circulatory Physiol. 1997;272(1):H220\u20136. https:\/\/doi.org\/10.1152\/ajpheart.1997.272.1.H220.","journal-title":"Am J Physiol-Heart Circulatory Physiol"},{"issue":"3","key":"2382_CR15","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1093\/cvr\/cvq005","volume":"86","author":"S Walsh","year":"2010","unstructured":"Walsh S, Pont\u00e9n A, Fleischmann BK, Jovinge S. Cardiomyocyte cell cycle control and growth estimation in vivo\u2014an analysis based on cardiomyocyte nuclei. Cardiovasc Res. 2010;86(3):365\u201373. https:\/\/doi.org\/10.1093\/cvr\/cvq005.","journal-title":"Cardiovasc Res"},{"issue":"4","key":"2382_CR16","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1016\/j.cell.2015.10.035","volume":"163","author":"K Alkass","year":"2015","unstructured":"Alkass K, Panula J, Westman M, Wu TD, Guerquin-Kern JL, Bergmann O. No Evidence for Cardiomyocyte Number Expansion in Preadolescent Mice. Cell. 2015;163(4):1026\u201336. https:\/\/doi.org\/10.1016\/j.cell.2015.10.035.","journal-title":"Cell"},{"issue":"2827","key":"2382_CR17","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1126\/science.109.2827.227","volume":"109","author":"WF Libby","year":"1949","unstructured":"Libby WF, Anderson EC, Arnold JR. Age determination by radiocarbon content: world-wide assay of natural radiocarbon. Science. 1949;109(2827):227\u20138. https:\/\/doi.org\/10.1126\/science.109.2827.227.","journal-title":"Science"},{"issue":"5923","key":"2382_CR18","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1126\/science.1164680","volume":"324","author":"O Bergmann","year":"2009","unstructured":"Bergmann O, Bhardwaj RD, Bernard S, Zdunek S, Barnab\u00e9-Heider F, Walsh S, et al. Evidence for cardiomyocyte renewal in humans. Science. 2009;324(5923):98\u2013102. https:\/\/doi.org\/10.1126\/science.1164680.","journal-title":"Science"},{"issue":"4","key":"2382_CR19","doi-asserted-by":"publisher","first-page":"1446","DOI":"10.1073\/pnas.1214608110","volume":"110","author":"M Mollova","year":"2013","unstructured":"Mollova M, Bersell K, Walsh S, Savla J, Das LT, Park SY, et al. Cardiomyocyte proliferation contributes to heart growth in young humans. Proc Natl Acad Sci U S A. 2013;110(4):1446\u201351. https:\/\/doi.org\/10.1073\/pnas.1214608110.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"2382_CR20","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1016\/0092-8674(91)90557-F","volume":"65","author":"SP Chellappan","year":"1991","unstructured":"Chellappan SP, Hiebert S, Mudryj M, Horowitz JM, Nevins JR. The E2F transcription factor is a cellular target for the RB protein. Cell. 1991;65(6):1053\u201361. https:\/\/doi.org\/10.1016\/0092-8674(91)90557-F.","journal-title":"Cell"},{"issue":"10","key":"2382_CR21","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1161\/01.RES.0000020201.44772.67","volume":"90","author":"KBS Pasumarthi","year":"2002","unstructured":"Pasumarthi KBS, Field LJ. Cardiomyocyte cell cycle regulation. Circ Res. 2002;90(10):1044\u201354. https:\/\/doi.org\/10.1161\/01.RES.0000020201.44772.67.","journal-title":"Circ Res"},{"issue":"2","key":"2382_CR22","doi-asserted-by":"publisher","first-page":"e017839","DOI":"10.1161\/JAHA.120.017839","volume":"10","author":"SP Bishop","year":"2021","unstructured":"Bishop SP, Zhou Y, Nakada Y, Zhang J. Changes in cardiomyocyte cell cycle and hypertrophic growth during fetal to adult in Mammals. J Am Heart Assoc. 2021;10(2):e017839. https:\/\/doi.org\/10.1161\/JAHA.120.017839.","journal-title":"J Am Heart Assoc"},{"issue":"11","key":"2382_CR23","doi-asserted-by":"publisher","first-page":"2644","DOI":"10.1172\/JCI119453","volume":"99","author":"MH Soonpaa","year":"1997","unstructured":"Soonpaa MH, Koh GY, Pajak L, Jing S, Wang H, Franklin MT, et al. Cyclin D1 overexpression promotes cardiomyocyte DNA synthesis and multinucleation in transgenic mice. J Clin Invest. 1997;99(11):2644\u201354. https:\/\/doi.org\/10.1172\/JCI119453.","journal-title":"J Clin Invest"},{"issue":"26","key":"2382_CR24","doi-asserted-by":"publisher","first-page":"18033","DOI":"10.1074\/jbc.M113.541953","volume":"289","author":"S Tane","year":"2014","unstructured":"Tane S, Kubota M, Okayama H, Ikenishi A, Yoshitome S, Iwamoto N, et al. Repression of Cyclin D1 Expression Is Necessary for the Maintenance of Cell Cycle Exit in Adult Mammalian Cardiomyocytes*. J Biol Chem. 2014;289(26):18033\u201344. https:\/\/doi.org\/10.1074\/jbc.M113.541953.","journal-title":"J Biol Chem"},{"issue":"1","key":"2382_CR25","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1161\/CIRCRESAHA.117.311504","volume":"122","author":"W Zhu","year":"2018","unstructured":"Zhu W, Zhao M, Mattapally S, Chen S, Zhang J. CCND2 overexpression enhances the regenerative potency of human induced pluripotent stem cell-derived cardiomyocytes. Circ Res. 2018;122(1):88\u201396. https:\/\/doi.org\/10.1161\/CIRCRESAHA.117.311504.","journal-title":"Circ Res"},{"issue":"6","key":"2382_CR26","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1161\/CIRCRESAHA.123.322929","volume":"133","author":"J Sun","year":"2023","unstructured":"Sun J, Wang L, Matthews RC, Walcott GP, Lu YA, Wei Y, et al. CCND2 modified mRNA activates cell cycle of cardiomyocytes in hearts with myocardial infarction in mice and pigs. Circ Res. 2023;133(6):484\u2013504. https:\/\/doi.org\/10.1161\/CIRCRESAHA.123.322929.","journal-title":"Circ Res"},{"issue":"34","key":"2382_CR27","doi-asserted-by":"publisher","first-page":"35858","DOI":"10.1074\/jbc.M404975200","volume":"279","author":"HW Chaudhry","year":"2004","unstructured":"Chaudhry HW, Dashoush NH, Tang H, Zhang L, Wang X, Wu EX, et al. Cyclin A2 mediates cardiomyocyte mitosis in the postmitotic myocardium. J Biol Chem. 2004;279(34):35858\u201366. https:\/\/doi.org\/10.1074\/jbc.M404975200.","journal-title":"J Biol Chem"},{"issue":"12","key":"2382_CR28","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1161\/CIRCRESAHA.107.153544","volume":"100","author":"RK Cheng","year":"2007","unstructured":"Cheng RK, Asai T, Tang H, Dashoush NH, Kara RJ, Costa KD, et al. Cyclin A2 induces cardiac regeneration after myocardial infarction and prevents heart failure. Circ Res. 2007;100(12):1741\u20138. https:\/\/doi.org\/10.1161\/CIRCRESAHA.107.153544.","journal-title":"Circ Res"},{"issue":"224","key":"2382_CR29","doi-asserted-by":"publisher","first-page":"224ra27","DOI":"10.1126\/scitranslmed.3007668","volume":"6","author":"SD Shapiro","year":"2014","unstructured":"Shapiro SD, Ranjan AK, Kawase Y, Cheng RK, Kara RJ, Bhattacharya R, et al. Cyclin A2 induces cardiac regeneration after myocardial infarction through cytokinesis of adult cardiomyocytes. Sci Transl Med. 2014;6(224):224ra27. https:\/\/doi.org\/10.1126\/scitranslmed.3007668.","journal-title":"Sci Transl Med"},{"issue":"1","key":"2382_CR30","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/s41536-025-00438-7","volume":"10","author":"E Bouhamida","year":"2025","unstructured":"Bouhamida E, Vadakke-Madathil S, Mathiyalagan P, Ranjan AK, Khan A, Sherman CD, et al. Cyclin A2 induces cytokinesis in human adult cardiomyocytes and drives reprogramming in mice. npj Regen Med. 2025;10(1):47. https:\/\/doi.org\/10.1038\/s41536-025-00438-7.","journal-title":"npj Regen Med"},{"issue":"4","key":"2382_CR31","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1161\/01.res.88.4.443","volume":"88","author":"HS Liao","year":"2001","unstructured":"Liao HS, Kang PM, Nagashima H, Yamasaki N, Usheva A, Ding B, et al. Cardiac-specific overexpression of cyclin-dependent kinase 2 increases smaller mononuclear cardiomyocytes. Circ Res. 2001;88(4):443\u201350. https:\/\/doi.org\/10.1161\/01.res.88.4.443.","journal-title":"Circ Res"},{"issue":"1","key":"2382_CR32","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.cell.2018.02.014","volume":"173","author":"TMA Mohamed","year":"2018","unstructured":"Mohamed TMA, Ang YS, Radzinsky E, Zhou P, Huang Y, Elfenbein A, et al. Regulation of Cell cycle to stimulate adult cardiomyocyte proliferation and cardiac regeneration. Cell. 2018;173(1):104-116.e12. https:\/\/doi.org\/10.1016\/j.cell.2018.02.014.","journal-title":"Cell"},{"issue":"17","key":"2382_CR33","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1161\/CIRCULATIONAHA.121.057641","volume":"145","author":"RRE Abouleisa","year":"2022","unstructured":"Abouleisa RRE, Salama ABM, Ou Q, Tang XL, Solanki M, Guo Y, et al. Transient cell cycle induction in cardiomyocytes to treat subacute ischemic heart failure. Circulation. 2022;145(17):1339\u201355. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.121.057641.","journal-title":"Circulation"},{"issue":"Pt 2","key":"2382_CR34","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1042\/BJ20031481","volume":"382","author":"KA Bicknell","year":"2004","unstructured":"Bicknell KA, Coxon CH, Brooks G. Forced expression of the cyclin B1-CDC2 complex induces proliferation in adult rat cardiomyocytes. Biochem J. 2004;382(Pt 2):411\u20136. https:\/\/doi.org\/10.1042\/BJ20031481.","journal-title":"Biochem J"},{"issue":"10","key":"2382_CR35","doi-asserted-by":"publisher","first-page":"8644","DOI":"10.1074\/jbc.M110.184549","volume":"286","author":"VD Stefano","year":"2011","unstructured":"Stefano VD, Giacca M, Capogrossi MC, Crescenzi M, Martelli F. Knockdown of Cyclin-dependent kinase inhibitors induces cardiomyocyte re-entry in the cell cycle. J Biol Chem. 2011;286(10):8644\u201354. https:\/\/doi.org\/10.1074\/jbc.M110.184549.","journal-title":"J Biol Chem"},{"issue":"3","key":"2382_CR36","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1016\/j.bbrc.2013.12.109","volume":"443","author":"S Tane","year":"2014","unstructured":"Tane S, Ikenishi A, Okayama H, Iwamoto N, Nakayama KI, Takeuchi T. CDK inhibitors, p21(Cip1) and p27(Kip1), participate in cell cycle exit of mammalian cardiomyocytes. Biochem Biophys Res Commun. 2014;443(3):1105\u20139. https:\/\/doi.org\/10.1016\/j.bbrc.2013.12.109.","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"2382_CR37","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1083\/jcb.201012049","volume":"194","author":"P Sdek","year":"2011","unstructured":"Sdek P, Zhao P, Wang Y, Huang CJ, Ko CY, Butler PC, et al. Rb and p130 control cell cycle gene silencing to maintain the postmitotic phenotype in cardiac myocytes. J Cell Biol. 2011;194(3):407\u201323. https:\/\/doi.org\/10.1083\/jcb.201012049.","journal-title":"J Cell Biol"},{"issue":"11","key":"2382_CR38","doi-asserted-by":"publisher","first-page":"2722","DOI":"10.1172\/JCI119817","volume":"100","author":"R Agah","year":"1997","unstructured":"Agah R, Kirshenbaum LA, Abdellatif M, Truong LD, Chakraborty S, Michael LH, et al. Adenoviral delivery of E2F\u20131 directs cell cycle reentry and p53-independent apoptosis in postmitotic adult myocardium in vivo. J Clin Invest. 1997;100(11):2722\u20138. https:\/\/doi.org\/10.1172\/JCI119817.","journal-title":"J Clin Invest"},{"issue":"2","key":"2382_CR39","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1093\/cvr\/cvn194","volume":"80","author":"H Ebelt","year":"2008","unstructured":"Ebelt H, Zhang Y, Kampke A, Xu J, Schlitt A, Buerke M, et al. E2F2 expression induces proliferation of terminally differentiated cardiomyocytes in vivo. Cardiovasc Res. 2008;80(2):219\u201326. https:\/\/doi.org\/10.1093\/cvr\/cvn194.","journal-title":"Cardiovasc Res"},{"issue":"1","key":"2382_CR40","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1093\/cvr\/cvp383","volume":"86","author":"MJ van Amerongen","year":"2010","unstructured":"van Amerongen MJ, Diehl F, Novoyatleva T, Patra C, Engel FB. E2F4 is required for cardiomyocyte proliferation. Cardiovasc Res. 2010;86(1):92\u2013102. https:\/\/doi.org\/10.1093\/cvr\/cvp383.","journal-title":"Cardiovasc Res"},{"issue":"4","key":"2382_CR41","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/j.yjmcc.2006.06.012","volume":"41","author":"FB Engel","year":"2006","unstructured":"Engel FB, Schebesta M, Keating MT. Anillin localization defect in cardiomyocyte binucleation. J Mol Cell Cardiol. 2006;41(4):601\u201312. https:\/\/doi.org\/10.1016\/j.yjmcc.2006.06.012.","journal-title":"J Mol Cell Cardiol"},{"issue":"24","key":"2382_CR42","doi-asserted-by":"publisher","first-page":"2798","DOI":"10.1161\/CIRCULATIONAHA.117.031542","volume":"138","author":"L Ye","year":"2018","unstructured":"Ye L, D\u2019Agostino G, Loo SJ, Wang CX, Su LP, Tan SH, et al. Early regenerative capacity in the porcine heart. Circulation. 2018;138(24):2798\u2013808. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.117.031542.","journal-title":"Circulation"},{"key":"2382_CR43","doi-asserted-by":"publisher","unstructured":"Zhu W, Zhang E, Zhao M, Chong Z, Fan C, Tang Y, et al. Regenerative potential of neonatal porcine hearts. Circulation. 2018 Dec 11. Located at: Hagerstown, MD. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.118.034886.","DOI":"10.1161\/CIRCULATIONAHA.118.034886"},{"key":"2382_CR44","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.yjmcc.2020.07.004","volume":"146","author":"N Velayutham","year":"2020","unstructured":"Velayutham N, Alfieri CM, Agnew EJ, Riggs KW, Baker RS, Ponny SR, et al. Cardiomyocyte cell cycling, maturation, and growth by multinucleation in postnatal swine. J Mol Cell Cardiol. 2020;146:95\u2013108. https:\/\/doi.org\/10.1016\/j.yjmcc.2020.07.004.","journal-title":"J Mol Cell Cardiol"},{"issue":"9","key":"2382_CR45","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.1038\/ng.3929","volume":"49","author":"M Patterson","year":"2017","unstructured":"Patterson M, Barske L, Van Handel B, Rau CD, Gan P, Sharma A, et al. Frequency of mononuclear diploid cardiomyocytes underlies natural variation in heart regeneration. Nat Genet. 2017;49(9):1346\u201353. https:\/\/doi.org\/10.1038\/ng.3929.","journal-title":"Nat Genet"},{"issue":"2","key":"2382_CR46","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.cell.2009.04.060","volume":"138","author":"K Bersell","year":"2009","unstructured":"Bersell K, Arab S, Haring B, K\u00fchn B. Neuregulin1\/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury. Cell. 2009;138(2):257\u201370. https:\/\/doi.org\/10.1016\/j.cell.2009.04.060.","journal-title":"Cell"},{"issue":"8","key":"2382_CR47","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1038\/nm1619","volume":"13","author":"B K\u00fchn","year":"2007","unstructured":"K\u00fchn B, del Monte F, Hajjar RJ, Chang YS, Lebeche D, Arab S, et al. Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair. Nat Med. 2007;13(8):962\u20139. https:\/\/doi.org\/10.1038\/nm1619.","journal-title":"Nat Med"},{"issue":"9","key":"2382_CR48","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1161\/CIRCULATIONAHA.116.024307","volume":"136","author":"WE Wang","year":"2017","unstructured":"Wang WE, Li L, Xia X, Fu W, Liao Q, Lan C, et al. Dedifferentiation, Proliferation, and Redifferentiation of Adult Mammalian Cardiomyocytes After Ischemic Injury. Circulation. 2017;136(9):834\u201348. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.116.024307.","journal-title":"Circulation"},{"issue":"9","key":"2382_CR49","doi-asserted-by":"publisher","first-page":"3105","DOI":"10.1016\/j.celrep.2020.02.034","volume":"30","author":"R Windmueller","year":"2020","unstructured":"Windmueller R, Leach JP, Babu A, Zhou S, Morley MP, Wakabayashi A, et al. Direct comparison of mononucleated and binucleated cardiomyocytes reveals molecular mechanisms underlying distinct proliferative competencies. Cell Rep. 2020;30(9):3105-3116.e4. https:\/\/doi.org\/10.1016\/j.celrep.2020.02.034.","journal-title":"Cell Rep"},{"issue":"2","key":"2382_CR50","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1161\/CIRCULATIONAHA.122.061018","volume":"147","author":"Z Yu","year":"2023","unstructured":"Yu Z, Zhang L, Cattaneo P, Guimar\u00e3es-Camboa N, Fang X, Gu Y, et al. Increasing mononuclear diploid cardiomyocytes by loss of E2F transcription factor 7\/8 fails to improve cardiac regeneration after infarct. Circulation. 2023;147(2):183\u20136. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.122.061018.","journal-title":"Circulation"},{"issue":"5","key":"2382_CR51","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1007\/s00395-019-0744-z","volume":"114","author":"M Yekelchyk","year":"2019","unstructured":"Yekelchyk M, Guenther S, Preussner J, Braun T. Mono- and multi-nucleated ventricular cardiomyocytes constitute a transcriptionally homogenous cell population. Basic Res Cardiol. 2019;114(5):36. https:\/\/doi.org\/10.1007\/s00395-019-0744-z.","journal-title":"Basic Res Cardiol"},{"key":"2382_CR52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41569-025-01145-y","volume":"7","author":"T Koopmans","year":"2025","unstructured":"Koopmans T, van Rooij E. Molecular gatekeepers of endogenous adult mammalian cardiomyocyte proliferation. Nat Rev Cardiol. 2025;7:1\u201326. https:\/\/doi.org\/10.1038\/s41569-025-01145-y.","journal-title":"Nat Rev Cardiol"},{"issue":"Pt 15","key":"2382_CR53","doi-asserted-by":"publisher","first-page":"3295","DOI":"10.1242\/jcs.01159","volume":"117","author":"P Ahuja","year":"2004","unstructured":"Ahuja P, Perriard E, Perriard JC, Ehler E. Sequential myofibrillar breakdown accompanies mitotic division of mammalian cardiomyocytes. J Cell Sci. 2004;117(Pt 15):3295\u2013306. https:\/\/doi.org\/10.1242\/jcs.01159.","journal-title":"J Cell Sci"},{"issue":"1","key":"2382_CR54","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1073\/pnas.1208863110","volume":"110","author":"ER Porrello","year":"2013","unstructured":"Porrello ER, Mahmoud AI, Simpson E, Johnson BA, Grinsfelder D, Canseco D, et al. Regulation of neonatal and adult mammalian heart regeneration by the miR-15 family. Proc Natl Acad Sci U S A. 2013;110(1):187\u201392. https:\/\/doi.org\/10.1073\/pnas.1208863110.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"2382_CR55","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1161\/CIRCULATIONAHA.123.066004","volume":"151","author":"Y Morikawa","year":"2025","unstructured":"Morikawa Y, Kim JH, Li RG, Liu L, Liu S, Deshmukh V, et al. YAP overcomes mechanical barriers to induce mitotic rounding and adult cardiomyocyte division. Circulation. 2025;151(1):76\u201393. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.123.066004.","journal-title":"Circulation"},{"issue":"6","key":"2382_CR56","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1007\/s11886-022-01682-9","volume":"24","author":"AM Pettinato","year":"2022","unstructured":"Pettinato AM, Ladha FA, Hinson JT. The cardiac sarcomere and cell cycle. Curr Cardiol Rep. 2022;24(6):623\u201330. https:\/\/doi.org\/10.1007\/s11886-022-01682-9.","journal-title":"Curr Cardiol Rep"},{"key":"2382_CR57","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.125.326522","author":"S Lee","year":"2025","unstructured":"Lee S, Heinrich P, Lee D, Kang Y, Robinson H, Humphrey SJ, et al. IGFBP2 mediates human iPSC-Cardiomyocyte proliferation in a cellular contact-dependent manner. Circ Res. 2025. https:\/\/doi.org\/10.1161\/CIRCRESAHA.125.326522.","journal-title":"Circ Res"},{"issue":"6","key":"2382_CR58","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1016\/j.stem.2019.03.009","volume":"24","author":"RJ Mills","year":"2019","unstructured":"Mills RJ, Parker BL, Quaife-Ryan GA, Voges HK, Needham EJ, Bornot A, et al. Drug screening in human PSC-cardiac organoids identifies pro-proliferative compounds acting via the mevalonate pathway. Cell Stem Cell. 2019;24(6):895-907.e6. https:\/\/doi.org\/10.1016\/j.stem.2019.03.009.","journal-title":"Cell Stem Cell"},{"issue":"14","key":"2382_CR59","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1161\/CIRCULATIONAHA.124.065763","volume":"151","author":"NT Lam","year":"2025","unstructured":"Lam NT, Nguyen NUN, Elhelaly WM, Hsu CC, Menendez-Montes I, Xiao F, et al. Induced cytokinesis generates highly proliferative mononuclear cardiomyocytes at the expense of contractility. Circulation. 2025;151(14):1009\u201323. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.124.065763.","journal-title":"Circulation"},{"issue":"7432","key":"2382_CR60","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/nature11682","volume":"493","author":"SE Senyo","year":"2013","unstructured":"Senyo SE, Steinhauser ML, Pizzimenti CL, Yang VK, Cai L, Wang M, et al. Mammalian heart renewal by pre-existing cardiomyocytes. Nature. 2013;493(7432):433\u20136. https:\/\/doi.org\/10.1038\/nature11682.","journal-title":"Nature"},{"issue":"2","key":"2382_CR61","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1161\/CIRCULATIONAHA.114.011490","volume":"132","author":"AC Sturzu","year":"2015","unstructured":"Sturzu AC, Rajarajan K, Passer D, Plonowska K, Riley A, Tan TC, et al. Fetal mammalian heart generates a robust compensatory response to cell loss. Circulation. 2015;132(2):109\u201321. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.114.011490.","journal-title":"Circulation"},{"issue":"12","key":"2382_CR62","doi-asserted-by":"publisher","first-page":"966","DOI":"10.18632\/aging.100526","volume":"4","author":"BJ Haubner","year":"2012","unstructured":"Haubner BJ, Adamowicz-Brice M, Khadayate S, Tiefenthaler V, Metzler B, Aitman T, et al. Complete cardiac regeneration in a mouse model of myocardial infarction. Aging (Albany NY). 2012;4(12):966\u201377. https:\/\/doi.org\/10.18632\/aging.100526.","journal-title":"Aging (Albany NY)"},{"issue":"6","key":"2382_CR63","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/j.ejcts.2010.03.049","volume":"38","author":"BJ Herdrich","year":"2010","unstructured":"Herdrich BJ, Danzer E, Davey MG, Allukian M, Englefield V, Gorman JH, et al. Regenerative healing following fetal myocardial infarction. Eur J Cardiothorac Surg. 2010;38(6):691\u20138. https:\/\/doi.org\/10.1016\/j.ejcts.2010.03.049.","journal-title":"Eur J Cardiothorac Surg"},{"key":"2382_CR64","doi-asserted-by":"publisher","first-page":"208","DOI":"10.3389\/fphys.2019.00208","volume":"10","author":"MC Lock","year":"2019","unstructured":"Lock MC, Darby JRT, Soo JY, Brooks DA, Perumal SR, Selvanayagam JB, et al. Differential response to injury in fetal and adolescent sheep hearts in the immediate post-myocardial infarction period. Front Physiol. 2019;10:208. https:\/\/doi.org\/10.3389\/fphys.2019.00208.","journal-title":"Front Physiol"},{"issue":"10","key":"2382_CR65","doi-asserted-by":"publisher","first-page":"4346","DOI":"10.1096\/fj.15-272013","volume":"29","author":"SS Jonker","year":"2015","unstructured":"Jonker SS, Louey S, Giraud GD, Thornburg KL, Faber JJ. Timing of cardiomyocyte growth, maturation, and attrition in perinatal sheep. FASEB J. 2015;29(10):4346\u201357. https:\/\/doi.org\/10.1096\/fj.15-272013.","journal-title":"FASEB J"},{"issue":"14","key":"2382_CR66","doi-asserted-by":"publisher","first-page":"103622","DOI":"10.1016\/j.jaccas.2025.103622","volume":"30","author":"J Gur","year":"2025","unstructured":"Gur J, Devanagondi R, Pratt R, Smith F, Mandell J, Martin S, et al. A case of complete functional myocardial regeneration in a human neonate. JACC: Case Reports. 2025;30(14):103622. https:\/\/doi.org\/10.1016\/j.jaccas.2025.103622.","journal-title":"JACC: Case Reports."},{"issue":"2","key":"2382_CR67","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1161\/CIRCRESAHA.115.307017","volume":"118","author":"BJ Haubner","year":"2016","unstructured":"Haubner BJ, Schneider J, Schweigmann U, Schuetz T, Dichtl W, Velik-Salchner C, et al. Functional recovery of a human neonatal heart after severe myocardial infarction. Circ Res. 2016;118(2):216\u201321. https:\/\/doi.org\/10.1161\/CIRCRESAHA.115.307017.","journal-title":"Circ Res"},{"issue":"3","key":"2382_CR68","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1038\/ng.759","volume":"43","author":"S John","year":"2011","unstructured":"John S, Sabo PJ, Thurman RE, Sung MH, Biddie SC, Johnson TA, et al. Chromatin accessibility pre-determines glucocorticoid receptor binding patterns. Nat Genet. 2011;43(3):264\u20138. https:\/\/doi.org\/10.1038\/ng.759.","journal-title":"Nat Genet"},{"issue":"7","key":"2382_CR69","doi-asserted-by":"publisher","first-page":"2626","DOI":"10.1073\/pnas.72.7.2626","volume":"72","author":"JO Thomas","year":"1975","unstructured":"Thomas JO, Kornberg RD. An octamer of histones in chromatin and free in solution. Proc Natl Acad Sci U S A. 1975;72(7):2626\u201330. https:\/\/doi.org\/10.1073\/pnas.72.7.2626.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"2382_CR70","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.cell.2012.02.013","volume":"149","author":"P Filippakopoulos","year":"2012","unstructured":"Filippakopoulos P, Picaud S, Mangos M, Keates T, Lambert JP, Barsyte-Lovejoy D, et al. Histone recognition and large-scale structural analysis of the human Bromodomain Family. Cell. 2012;149(1):214\u201331. https:\/\/doi.org\/10.1016\/j.cell.2012.02.013.","journal-title":"Cell"},{"issue":"19","key":"2382_CR71","doi-asserted-by":"publisher","first-page":"7357","DOI":"10.1073\/pnas.0401866101","volume":"101","author":"G Liang","year":"2004","unstructured":"Liang G, Lin JCY, Wei V, Yoo C, Cheng JC, Nguyen CT, et al. Distinct localization of histone H3 acetylation and H3\u2013K4 methylation to the transcription start sites in the human genome. Proc Natl Acad Sci U S A. 2004;101(19):7357\u201362. https:\/\/doi.org\/10.1073\/pnas.0401866101.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"2382_CR72","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1074\/jbc.M509266200","volume":"281","author":"SB Hake","year":"2006","unstructured":"Hake SB, Garcia BA, Duncan EM, Kauer M, Dellaire G, Shabanowitz J, et al. Expression patterns and post-translational modifications associated with mammalian histone H3 variants. J Biol Chem. 2006;281(1):559\u201368. https:\/\/doi.org\/10.1074\/jbc.M509266200.","journal-title":"J Biol Chem"},{"issue":"5","key":"2382_CR73","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1016\/j.cell.2012.06.051","volume":"150","author":"BD Towbin","year":"2012","unstructured":"Towbin BD, Gonz\u00e1lez-Aguilera C, Sack R, Gaidatzis D, Kalck V, Meister P, et al. Step-Wise methylation of histone H3K9 positions heterochromatin at the nuclear periphery. Cell. 2012;150(5):934\u201347. https:\/\/doi.org\/10.1016\/j.cell.2012.06.051.","journal-title":"Cell"},{"key":"2382_CR74","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.ceb.2015.10.003","volume":"37","author":"E Conway","year":"2015","unstructured":"Conway E, Healy E, Bracken AP. PRC2 mediated H3K27 methylations in cellular identity and cancer. Curr Opinion Cell Biol. 2015;37:42\u20138. https:\/\/doi.org\/10.1016\/j.ceb.2015.10.003.","journal-title":"Curr Opinion Cell Biol"},{"issue":"12","key":"2382_CR75","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1038\/s41580-021-00398-y","volume":"22","author":"NP Blackledge","year":"2021","unstructured":"Blackledge NP, Klose RJ. The molecular principles of gene regulation by Polycomb repressive complexes. Nat Rev Mol Cell Biol. 2021;22(12):815\u201333. https:\/\/doi.org\/10.1038\/s41580-021-00398-y.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"2382_CR76","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1038\/s41467-017-02762-z","volume":"9","author":"R Gilsbach","year":"2018","unstructured":"Gilsbach R, Schwaderer M, Preissl S, Gr\u00fcning BA, Kranzh\u00f6fer D, Schneider P, et al. Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo. Nat Commun. 2018;9(1):391. https:\/\/doi.org\/10.1038\/s41467-017-02762-z.","journal-title":"Nat Commun"},{"issue":"3","key":"2382_CR77","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1038\/s41569-025-01205-3","volume":"23","author":"ER Porrello","year":"2026","unstructured":"Porrello ER, Lee CJM, Foo RSY, Elliott DA. Transcriptional regulation in heart development, disease and regeneration: reassessing the fetal gene hypothesis. Nat Rev Cardiol. 2026;23(3):183\u201396. https:\/\/doi.org\/10.1038\/s41569-025-01205-3.","journal-title":"Nat Rev Cardiol"},{"issue":"4","key":"2382_CR78","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1096\/fj.14-264093","volume":"29","author":"CB Sim","year":"2015","unstructured":"Sim CB, Ziemann M, Kaspi A, Harikrishnan KN, Ooi J, Khurana I, et al. Dynamic changes in the cardiac methylome during postnatal development. FASEB J. 2015;29(4):1329\u201343. https:\/\/doi.org\/10.1096\/fj.14-264093.","journal-title":"FASEB J"},{"issue":"1","key":"2382_CR79","doi-asserted-by":"publisher","first-page":"5288","DOI":"10.1038\/ncomms6288","volume":"5","author":"R Gilsbach","year":"2014","unstructured":"Gilsbach R, Preissl S, Gr\u00fcning BA, Schnick T, Burger L, Benes V, et al. Dynamic DNA methylation orchestrates cardiomyocyte development, maturation and disease. Nat Commun. 2014;5(1):5288. https:\/\/doi.org\/10.1038\/ncomms6288.","journal-title":"Nat Commun"},{"issue":"39","key":"2382_CR80","doi-asserted-by":"publisher","first-page":"26484","DOI":"10.1074\/jbc.M803686200","volume":"283","author":"CM Trivedi","year":"2008","unstructured":"Trivedi CM, Lu MM, Wang Q, Epstein JA. Transgenic overexpression of hdac3 in the heart produces increased postnatal cardiac myocyte proliferation but does not induce hypertrophy. J Biol Chem. 2008;283(39):26484\u20139. https:\/\/doi.org\/10.1074\/jbc.M803686200.","journal-title":"J Biol Chem"},{"issue":"3","key":"2382_CR81","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1016\/j.devcel.2010.08.012","volume":"19","author":"CM Trivedi","year":"2010","unstructured":"Trivedi CM, Zhu W, Wang Q, Jia C, Kee HJ, Li L, et al. Hopx and Hdac2 interact to modulate Gata4 acetylation and embryonic cardiac myocyte proliferation. Dev Cell. 2010;19(3):450\u20139. https:\/\/doi.org\/10.1016\/j.devcel.2010.08.012.","journal-title":"Dev Cell"},{"issue":"11","key":"2382_CR82","doi-asserted-by":"publisher","first-page":"e1009890","DOI":"10.1371\/journal.pgen.1009890","volume":"17","author":"A B\u00fchler","year":"2021","unstructured":"B\u00fchler A, Gahr BM, Park DD, Bertozzi A, Boos A, Dalvoy M, et al. Histone deacetylase 1 controls cardiomyocyte proliferation during embryonic heart development and cardiac regeneration in zebrafish. PLoS Genet. 2021;17(11):e1009890. https:\/\/doi.org\/10.1371\/journal.pgen.1009890.","journal-title":"PLoS Genet"},{"issue":"2","key":"2382_CR83","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1161\/CIRCRESAHA.122.320785","volume":"131","author":"J Jang","year":"2022","unstructured":"Jang J, Song G, Pettit SM, Li Q, Song X, Cai CL, et al. Epicardial HDAC3 promotes myocardial growth through a novel MicroRNA pathway. Circ Res. 2022;131(2):151\u201364. https:\/\/doi.org\/10.1161\/CIRCRESAHA.122.320785.","journal-title":"Circ Res"},{"issue":"7","key":"2382_CR84","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1161\/CIRCRESAHA.115.304517","volume":"115","author":"G Felician","year":"2014","unstructured":"Felician G, Collesi C, Lusic M, Martinelli V, Ferro MD, Zentilin L, et al. Epigenetic modification at Notch responsive promoters blunts efficacy of inducing notch pathway reactivation after myocardial infarction. Circ Res. 2014;115(7):636\u201349. https:\/\/doi.org\/10.1161\/CIRCRESAHA.115.304517.","journal-title":"Circ Res"},{"issue":"3","key":"2382_CR85","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1161\/CIRCRESAHA.111.252205","volume":"110","author":"A He","year":"2012","unstructured":"He A, Ma Q, Cao J, von Gise A, Zhou P, Xie H, et al. Polycomb repressive complex 2 regulates normal development of the mouse heart. Circ Res. 2012;110(3):406\u201315. https:\/\/doi.org\/10.1161\/CIRCRESAHA.111.252205.","journal-title":"Circ Res"},{"issue":"2","key":"2382_CR86","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1161\/CIRCRESAHA.117.311212","volume":"121","author":"S Ai","year":"2017","unstructured":"Ai S, Yu X, Li Y, Peng Y, Li C, Yue Y, et al. Divergent requirements for EZH1 in heart development versus regeneration. Circ Res. 2017;121(2):106\u201312. https:\/\/doi.org\/10.1161\/CIRCRESAHA.117.311212.","journal-title":"Circ Res"},{"issue":"4","key":"2382_CR87","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1016\/j.celrep.2019.06.065","volume":"28","author":"Z Yue","year":"2019","unstructured":"Yue Z, Chen J, Lian H, Pei J, Li Y, Chen X, et al. PDGFR-\u03b2 Signaling regulates cardiomyocyte proliferation and myocardial regeneration. Cell Rep. 2019;28(4):966-978.e4. https:\/\/doi.org\/10.1016\/j.celrep.2019.06.065.","journal-title":"Cell Rep"},{"issue":"158","key":"2382_CR88","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.yjmcc.2021.05.018","volume":"1","author":"K Davis","year":"2021","unstructured":"Davis K, Azarcon P, Hickenlooper S, Bia R, Horiuchi E, Szulik MW, et al. The role of demethylases in cardiac development and disease. J Mol Cell Cardiol. 2021;1(158):89\u2013100. https:\/\/doi.org\/10.1016\/j.yjmcc.2021.05.018.","journal-title":"J Mol Cell Cardiol"},{"issue":"21","key":"2382_CR89","doi-asserted-by":"publisher","first-page":"eadt9446","DOI":"10.1126\/sciadv.adt9446","volume":"11","author":"N Liu","year":"2025","unstructured":"Liu N, Pei J, Xie Y, Xuan H, Jiang N, Wang J, et al. PTMA controls cardiomyocyte proliferation and cardiac repair by enhancing STAT3 acetylation. Sci Adv. 2025;11(21):eadt9446. https:\/\/doi.org\/10.1126\/sciadv.adt9446.","journal-title":"Sci Adv"},{"issue":"2","key":"2382_CR90","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/0092-8674(91)90181-w","volume":"67","author":"DW Goodrich","year":"1991","unstructured":"Goodrich DW, Wang NP, Qian YW, Lee EY, Lee WH. The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle. Cell. 1991;67(2):293\u2013302. https:\/\/doi.org\/10.1016\/0092-8674(91)90181-w.","journal-title":"Cell"},{"issue":"12","key":"2382_CR91","doi-asserted-by":"publisher","first-page":"7813","DOI":"10.1128\/mcb.13.12.7813-7825.1993","volume":"13","author":"JA Lees","year":"1993","unstructured":"Lees JA, Saito M, Vidal M, Valentine M, Look T, Harlow E, et al. The retinoblastoma protein binds to a family of E2F transcription factors. Mol Cell Biol. 1993;13(12):7813\u201325. https:\/\/doi.org\/10.1128\/mcb.13.12.7813-7825.1993.","journal-title":"Mol Cell Biol"},{"issue":"6667","key":"2382_CR92","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1038\/35404","volume":"391","author":"A Brehm","year":"1998","unstructured":"Brehm A, Miska EA, McCance DJ, Reid JL, Bannister AJ, Kouzarides T. Retinoblastoma protein recruits histone deacetylase to repress transcription. Nature. 1998;391(6667):597\u2013601. https:\/\/doi.org\/10.1038\/35404.","journal-title":"Nature"},{"issue":"6","key":"2382_CR93","doi-asserted-by":"publisher","first-page":"2486","DOI":"10.1128\/MCB.25.6.2486-2497.2005","volume":"25","author":"WR MacLellan","year":"2005","unstructured":"MacLellan WR, Garcia A, Oh H, Frenkel P, Jordan MC, Roos KP, et al. Overlapping roles of pocket proteins in the myocardium are unmasked by germ line deletion of p130 plus heart-specific deletion of Rb. Mol Cell Biol. 2005;25(6):2486\u201397. https:\/\/doi.org\/10.1128\/MCB.25.6.2486-2497.2005.","journal-title":"Mol Cell Biol"},{"key":"2382_CR94","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.yjmcc.2018.05.013","volume":"121","author":"D El-Nachef","year":"2018","unstructured":"El-Nachef D, Oyama K, Wu YY, Freeman M, Zhang Y, MacLellan WR. Repressive histone methylation regulates cardiac myocyte cell cycle exit. J Mol Cell Cardiol. 2018;121:1\u201312. https:\/\/doi.org\/10.1016\/j.yjmcc.2018.05.013.","journal-title":"J Mol Cell Cardiol"},{"issue":"2","key":"2382_CR95","doi-asserted-by":"publisher","first-page":"e0281610","DOI":"10.1371\/journal.pone.0281610","volume":"18","author":"Z Zhang","year":"2023","unstructured":"Zhang Z, Freeman M, Zhang Y, El-Nachef D, Davenport G, Williams A, et al. Hippo signaling and histone methylation control cardiomyocyte cell cycle re-entry through distinct transcriptional pathways. PLoS One. 2023;18(2):e0281610. https:\/\/doi.org\/10.1371\/journal.pone.0281610.","journal-title":"PLoS One"},{"issue":"23","key":"2382_CR96","doi-asserted-by":"publisher","first-page":"4683","DOI":"10.1242\/dev.102798","volume":"140","author":"T Heallen","year":"2013","unstructured":"Heallen T, Morikawa Y, Leach J, Tao G, Willerson JT, Johnson RL, et al. Hippo signaling impedes adult heart regeneration. Development. 2013;140(23):4683\u201390. https:\/\/doi.org\/10.1242\/dev.102798.","journal-title":"Development"},{"issue":"34","key":"2382_CR97","doi-asserted-by":"publisher","first-page":"13839","DOI":"10.1073\/pnas.1313192110","volume":"110","author":"M Xin","year":"2013","unstructured":"Xin M, Kim Y, Sutherland LB, Murakami M, Qi X, McAnally J, et al. Hippo pathway effector Yap promotes cardiac regeneration. Proc Natl Acad Sci. 2013;110(34):13839\u201344. https:\/\/doi.org\/10.1073\/pnas.1313192110.","journal-title":"Proc Natl Acad Sci"},{"issue":"12","key":"2382_CR98","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1161\/hh2401.100742","volume":"89","author":"G Xiao","year":"2001","unstructured":"Xiao G, Mao S, Baumgarten G, Serrano J, Jordan MC, Roos KP, et al. Inducible activation of c-Myc in adult myocardium in vivo provokes cardiac myocyte hypertrophy and reactivation of DNA synthesis. Circ Res. 2001;89(12):1122\u20139. https:\/\/doi.org\/10.1161\/hh2401.100742.","journal-title":"Circ Res"},{"issue":"1","key":"2382_CR99","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1038\/s41467-020-15552-x","volume":"11","author":"MJ Bywater","year":"2020","unstructured":"Bywater MJ, Burkhart DL, Straube J, Sab\u00f2 A, Pendino V, Hudson JE, et al. Reactivation of Myc transcription in the mouse heart unlocks its proliferative capacity. Nat Commun. 2020;11(1):1827. https:\/\/doi.org\/10.1038\/s41467-020-15552-x.","journal-title":"Nat Commun"},{"issue":"27","key":"2382_CR100","doi-asserted-by":"publisher","first-page":"E1848","DOI":"10.1073\/pnas.1200250109","volume":"109","author":"X Lian","year":"2012","unstructured":"Lian X, Hsiao C, Wilson G, Zhu K, Hazeltine LB, Azarin SM, et al. Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling. Proc Natl Acad Sci U S A. 2012;109(27):E1848-1857. https:\/\/doi.org\/10.1073\/pnas.1200250109.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"47","key":"2382_CR101","doi-asserted-by":"publisher","first-page":"18531","DOI":"10.1073\/pnas.0703113104","volume":"104","author":"A Klaus","year":"2007","unstructured":"Klaus A, Saga Y, Taketo MM, Tzahor E, Birchmeier W. Distinct roles of Wnt\/\u03b2-catenin and Bmp signaling during early cardiogenesis. Proc Natl Acad Sci. 2007;104(47):18531\u20136. https:\/\/doi.org\/10.1073\/pnas.0703113104.","journal-title":"Proc Natl Acad Sci"},{"issue":"13","key":"2382_CR102","doi-asserted-by":"publisher","first-page":"3797","DOI":"10.1093\/emboj\/16.13.3797","volume":"16","author":"H Aberle","year":"1997","unstructured":"Aberle H, Bauer A, Stappert J, Kispert A, Kemler R. beta-catenin is a target for the ubiquitin-proteasome pathway. EMBO J. 1997;16(13):3797\u2013804. https:\/\/doi.org\/10.1093\/emboj\/16.13.3797.","journal-title":"EMBO J"},{"issue":"6592","key":"2382_CR103","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1038\/382638a0","volume":"382","author":"J Behrens","year":"1996","unstructured":"Behrens J, von Kries JP, K\u00fchl M, Bruhn L, Wedlich D, Grosschedl R, et al. Functional interaction of \u03b2-catenin with the transcription factor LEF-1. Nature. 1996;382(6592):638\u201342. https:\/\/doi.org\/10.1038\/382638a0.","journal-title":"Nature"},{"issue":"3","key":"2382_CR104","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/s0092-8674(00)80112-9","volume":"86","author":"M Molenaar","year":"1996","unstructured":"Molenaar M, van de Wetering M, Oosterwegel M, Peterson-Maduro J, Godsave S, Korinek V, et al. XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos. Cell. 1996;86(3):391\u20139. https:\/\/doi.org\/10.1016\/s0092-8674(00)80112-9.","journal-title":"Cell"},{"issue":"5382","key":"2382_CR105","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1126\/science.281.5382.1509","volume":"281","author":"TC He","year":"1998","unstructured":"He TC, Sparks AB, Rago C, Hermeking H, Zawel L, da Costa LT, et al. Identification of c-MYC as a target of the APC pathway. Science. 1998;281(5382):1509\u201312. https:\/\/doi.org\/10.1126\/science.281.5382.1509.","journal-title":"Science"},{"issue":"10","key":"2382_CR106","doi-asserted-by":"publisher","first-page":"5522","DOI":"10.1073\/pnas.96.10.5522","volume":"96","author":"M Shtutman","year":"1999","unstructured":"Shtutman M, Zhurinsky J, Simcha I, Albanese C, D\u2019Amico M, Pestell R, et al. The cyclin D1 gene is a target of the \u03b2-catenin\/LEF-1 pathway. Proc Natl Acad Sci U S A. 1999;96(10):5522\u20137. https:\/\/doi.org\/10.1073\/pnas.96.10.5522.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"22","key":"2382_CR107","doi-asserted-by":"publisher","first-page":"dev193417","DOI":"10.1242\/dev.193417","volume":"147","author":"GA Quaife-Ryan","year":"2020","unstructured":"Quaife-Ryan GA, Mills RJ, Lavers G, Voges HK, Vivien CJ, Elliott DA, et al. \u03b2-Catenin drives distinct transcriptional networks in proliferative and nonproliferative cardiomyocytes. Development. 2020;147(22):dev193417. https:\/\/doi.org\/10.1242\/dev.193417.","journal-title":"Development"},{"issue":"6","key":"2382_CR108","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1097\/FJC.0000000000000429","volume":"68","author":"S Wang","year":"2016","unstructured":"Wang S, Ye L, Li M, Liu J, Jiang C, Hong H, et al. GSK-3\u03b2 Inhibitor CHIR-99021 promotes proliferation through upregulating \u03b2-catenin in neonatal atrial human cardiomyocytes. J Cardiovasc Pharmacol. 2016;68(6):425\u201332. https:\/\/doi.org\/10.1097\/FJC.0000000000000429.","journal-title":"J Cardiovasc Pharmacol"},{"issue":"9","key":"2382_CR109","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1016\/j.chembiol.2006.08.004","volume":"13","author":"AS Tseng","year":"2006","unstructured":"Tseng AS, Engel FB, Keating MT. The GSK-3 inhibitor BIO promotes proliferation in Mammalian cardiomyocytes. Chem Biol. 2006;13(9):957\u201363. https:\/\/doi.org\/10.1016\/j.chembiol.2006.08.004.","journal-title":"Chem Biol"},{"issue":"40","key":"2382_CR110","doi-asserted-by":"publisher","first-page":"E8372","DOI":"10.1073\/pnas.1707316114","volume":"114","author":"RJ Mills","year":"2017","unstructured":"Mills RJ, Titmarsh DM, Koenig X, Parker BL, Ryall JG, Quaife-Ryan GA, et al. Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest. Proc Natl Acad Sci U S A. 2017;114(40):E8372\u201381. https:\/\/doi.org\/10.1073\/pnas.1707316114.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"17","key":"2382_CR111","doi-asserted-by":"publisher","first-page":"6071","DOI":"10.1128\/MCB.21.17.6071-6079.2001","volume":"21","author":"T Iso","year":"2001","unstructured":"Iso T, Sartorelli V, Chung G, Shichinohe T, Kedes L, Hamamori Y. HERP, a new primary target of Notch regulated by ligand binding. Mol Cell Biol. 2001;21(17):6071\u20139. https:\/\/doi.org\/10.1128\/MCB.21.17.6071-6079.2001.","journal-title":"Mol Cell Biol"},{"issue":"6","key":"2382_CR112","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1101\/gad.8.6.707","volume":"8","author":"PJ Swiatek","year":"1994","unstructured":"Swiatek PJ, Lindsell CE, del Amo FF, Weinmaster G, Gridley T. Notch1 is essential for postimplantation development in mice. Genes Dev. 1994;8(6):707\u201319. https:\/\/doi.org\/10.1101\/gad.8.6.707.","journal-title":"Genes Dev"},{"issue":"4","key":"2382_CR113","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1242\/dev.128.4.491","volume":"128","author":"B McCright","year":"2001","unstructured":"McCright B, Gao X, Shen L, Lozier J, Lan Y, Maguire M, et al. Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation. Development. 2001;128(4):491\u2013502. https:\/\/doi.org\/10.1242\/dev.128.4.491.","journal-title":"Development"},{"issue":"9","key":"2382_CR114","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1242\/dev.02344","volume":"133","author":"Y Watanabe","year":"2006","unstructured":"Watanabe Y, Kokubo H, Miyagawa-Tomita S, Endo M, Igarashi K, Kichi A, et al. Activation of Notch1 signaling in cardiogenic mesoderm induces abnormal heart morphogenesis in mouse. Development. 2006;133(9):1625\u201334. https:\/\/doi.org\/10.1242\/dev.02344.","journal-title":"Development"},{"issue":"12","key":"2382_CR115","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1161\/01.RES.0000226497.52052.2a","volume":"98","author":"M Nemir","year":"2006","unstructured":"Nemir M, Croquelois A, Pedrazzini T, Radtke F. Induction of cardiogenesis in embryonic stem cells via downregulation of Notch1 signaling. Circ Res. 2006;98(12):1471\u20138. https:\/\/doi.org\/10.1161\/01.RES.0000226497.52052.2a.","journal-title":"Circ Res"},{"issue":"1","key":"2382_CR116","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1083\/jcb.200806104","volume":"183","author":"VM Campa","year":"2008","unstructured":"Campa VM, Guti\u00e9rrez-Lanza R, Cerignoli F, D\u00edaz-Trelles R, Nelson B, Tsuji T, et al. Notch activates cell cycle reentry and progression in quiescent cardiomyocytes. J Cell Biol. 2008;183(1):129\u201341. https:\/\/doi.org\/10.1083\/jcb.200806104.","journal-title":"J Cell Biol"},{"issue":"1","key":"2382_CR117","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1093\/cvr\/cvx228","volume":"114","author":"C Collesi","year":"2018","unstructured":"Collesi C, Felician G, Secco I, Gutierrez MI, Martelletti E, Ali H, et al. Reversible Notch1 acetylation tunes proliferative signalling in cardiomyocytes. Cardiovasc Res. 2018;114(1):103\u201322. https:\/\/doi.org\/10.1093\/cvr\/cvx228.","journal-title":"Cardiovasc Res"},{"issue":"9","key":"2382_CR118","doi-asserted-by":"publisher","first-page":"2551","DOI":"10.1093\/emboj\/18.9.2551","volume":"18","author":"R Yagi","year":"1999","unstructured":"Yagi R, Chen LF, Shigesada K, Murakami Y, Ito Y. A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator. EMBO J. 1999;18(9):2551\u201362. https:\/\/doi.org\/10.1093\/emboj\/18.9.2551.","journal-title":"EMBO J"},{"issue":"24","key":"2382_CR119","doi-asserted-by":"publisher","first-page":"6778","DOI":"10.1093\/emboj\/19.24.6778","volume":"19","author":"F Kanai","year":"2000","unstructured":"Kanai F, Marignani PA, Sarbassova D, Yagi R, Hall RA, Donowitz M, et al. TAZ: a novel transcriptional co-activator regulated by interactions with 14\u20133-3 and PDZ domain proteins. EMBO J. 2000;19(24):6778\u201391. https:\/\/doi.org\/10.1093\/emboj\/19.24.6778.","journal-title":"EMBO J"},{"issue":"1","key":"2382_CR120","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1101\/gad.1843810","volume":"24","author":"B Zhao","year":"2010","unstructured":"Zhao B, Li L, Tumaneng K, Wang CY, Guan KL. A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF\u03b2-TRCP. Genes Dev. 2010;24(1):72\u201385. https:\/\/doi.org\/10.1101\/gad.1843810.","journal-title":"Genes Dev"},{"issue":"14","key":"2382_CR121","doi-asserted-by":"publisher","first-page":"1962","DOI":"10.1101\/gad.1664408","volume":"22","author":"B Zhao","year":"2008","unstructured":"Zhao B, Ye X, Yu J, Li L, Li W, Li S, et al. TEAD mediates YAP-dependent gene induction and growth control. Genes Dev. 2008;22(14):1962\u201371. https:\/\/doi.org\/10.1101\/gad.1664408.","journal-title":"Genes Dev"},{"issue":"7","key":"2382_CR122","doi-asserted-by":"publisher","first-page":"2394","DOI":"10.1073\/pnas.1116136109","volume":"109","author":"A von Gise","year":"2012","unstructured":"von Gise A, Lin Z, Schlegelmilch K, Honor LB, Pan GM, Buck JN, et al. YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy. Proc Natl Acad Sci. 2012;109(7):2394\u20139. https:\/\/doi.org\/10.1073\/pnas.1116136109.","journal-title":"Proc Natl Acad Sci"},{"issue":"29","key":"2382_CR123","doi-asserted-by":"publisher","first-page":"24255","DOI":"10.1074\/jbc.M112.365080","volume":"287","author":"I Lei","year":"2012","unstructured":"Lei I, Gao X, Sham MH, Wang Z. SWI\/SNF protein component BAF250a regulates cardiac progenitor cell differentiation by modulating chromatin accessibility during second heart field development. J Biol Chem. 2012;287(29):24255\u201362. https:\/\/doi.org\/10.1074\/jbc.M112.365080.","journal-title":"J Biol Chem"},{"issue":"7730","key":"2382_CR124","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1038\/s41586-018-0658-1","volume":"563","author":"L Chang","year":"2018","unstructured":"Chang L, Azzolin L, Di Biagio D, Zanconato F, Battilana G, Lucon Xiccato R, et al. The SWI\/SNF complex is a mechanoregulated inhibitor of YAP and TAZ. Nature. 2018;563(7730):265\u20139. https:\/\/doi.org\/10.1038\/s41586-018-0658-1.","journal-title":"Nature"},{"issue":"1","key":"2382_CR125","doi-asserted-by":"publisher","first-page":"4716","DOI":"10.1038\/s41467-023-40203-2","volume":"14","author":"CJ Boogerd","year":"2023","unstructured":"Boogerd CJ, Perini I, Kyriakopoulou E, Han SJ, La P, van der Swaan B, et al. Cardiomyocyte proliferation is suppressed by ARID1A-mediated YAP inhibition during cardiac maturation. Nat Commun. 2023;14(1):4716. https:\/\/doi.org\/10.1038\/s41467-023-40203-2.","journal-title":"Nat Commun"},{"issue":"3","key":"2382_CR126","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1161\/CIRCRESAHA.115.303632","volume":"115","author":"Z Lin","year":"2014","unstructured":"Lin Z, von Gise A, Zhou P, Gu F, Ma Q, Jiang J, et al. Cardiac-specific YAP activation improves cardiac function and survival in an experimental murine MI model. Circ Res. 2014;115(3):354\u201363. https:\/\/doi.org\/10.1161\/CIRCRESAHA.115.303632.","journal-title":"Circ Res"},{"issue":"12","key":"2382_CR127","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1101\/gad.264234.115","volume":"29","author":"Q Chen","year":"2015","unstructured":"Chen Q, Zhang N, Xie R, Wang W, Cai J, Choi KS, et al. Homeostatic control of Hippo signaling activity revealed by an endogenous activating mutation in YAP. Genes Dev. 2015;29(12):1285\u201397. https:\/\/doi.org\/10.1101\/gad.264234.115.","journal-title":"Genes Dev"},{"issue":"6","key":"2382_CR128","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1016\/j.devcel.2019.01.017","volume":"48","author":"TO Monroe","year":"2019","unstructured":"Monroe TO, Hill MC, Morikawa Y, Leach JP, Heallen T, Cao S, et al. YAP partially reprograms chromatin accessibility to directly induce adult cardiogenesis In Vivo. Dev Cell. 2019;48(6):765-779.e7. https:\/\/doi.org\/10.1016\/j.devcel.2019.01.017.","journal-title":"Dev Cell"},{"key":"2382_CR129","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.125.074956","author":"L Liu","year":"2026","unstructured":"Liu L, Steimle JD, Tsai CR, Meng F, Morikawa Y, Zhao Y, et al. YAP Induces a Prorenewal Metabolic State in Cardiomyocytes. Circulation. 2026. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.125.074956.","journal-title":"Circulation"},{"issue":"7675","key":"2382_CR130","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1038\/nature24045","volume":"550","author":"JP Leach","year":"2017","unstructured":"Leach JP, Heallen T, Zhang M, Rahmani M, Morikawa Y, Hill MC, et al. Hippo pathway deficiency reverses systolic heart failure after infarction. Nature. 2017;550(7675):260\u20134. https:\/\/doi.org\/10.1038\/nature24045.","journal-title":"Nature"},{"issue":"600","key":"2382_CR131","doi-asserted-by":"publisher","first-page":"eabd6892","DOI":"10.1126\/scitranslmed.abd6892","volume":"13","author":"S Liu","year":"2021","unstructured":"Liu S, Li K, Wagner Florencio L, Tang L, Heallen TR, Leach JP, et al. Gene therapy knockdown of Hippo signaling induces cardiomyocyte renewal in pigs after myocardial infarction. Sci Transl Med. 2021;13(600):eabd6892. https:\/\/doi.org\/10.1126\/scitranslmed.abd6892.","journal-title":"Sci Transl Med"},{"issue":"14","key":"2382_CR132","doi-asserted-by":"publisher","first-page":"1892","DOI":"10.1161\/01.CIR.99.14.1892","volume":"99","author":"B Bartelds","year":"1999","unstructured":"Bartelds B, Knoester H, Beaufort-Krol GCM, Smid GB, Takens J, Zijlstra WG, et al. Myocardial lactate metabolism in fetal and newborn lambs. Circulation. 1999;99(14):1892\u20137. https:\/\/doi.org\/10.1161\/01.CIR.99.14.1892.","journal-title":"Circulation"},{"issue":"7964","key":"2382_CR133","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1038\/s41586-023-06068-7","volume":"618","author":"A Paredes","year":"2023","unstructured":"Paredes A, Justo-M\u00e9ndez R, Jim\u00e9nez-Blasco D, N\u00fa\u00f1ez V, Calero I, Villalba-Orero M, et al. \u03b3-Linolenic acid in maternal milk drives cardiac metabolic maturation. Nature. 2023;618(7964):365\u201373. https:\/\/doi.org\/10.1038\/s41586-023-06068-7.","journal-title":"Nature"},{"issue":"Pt 2","key":"2382_CR134","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1113\/jphysiol.2003.049478","volume":"552","author":"JF Turrens","year":"2003","unstructured":"Turrens JF. Mitochondrial formation of reactive oxygen species. J Physiol. 2003;552(Pt 2):335\u201344. https:\/\/doi.org\/10.1113\/jphysiol.2003.049478.","journal-title":"J Physiol"},{"issue":"3","key":"2382_CR135","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.cell.2014.03.032","volume":"157","author":"BN Puente","year":"2014","unstructured":"Puente BN, Kimura W, Muralidhar SA, Moon J, Amatruda JF, Phelps KL, et al. The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response. Cell. 2014;157(3):565\u201379. https:\/\/doi.org\/10.1016\/j.cell.2014.03.032.","journal-title":"Cell"},{"issue":"5930","key":"2382_CR136","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1126\/science.1160809","volume":"324","author":"MG Vander Heiden","year":"2009","unstructured":"Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg Effect: The metabolic requirements of cell proliferation. Science. 2009;324(5930):1029\u201333. https:\/\/doi.org\/10.1126\/science.1160809.","journal-title":"Science"},{"issue":"6","key":"2382_CR137","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/j.cmet.2015.05.014","volume":"21","author":"F Pietrocola","year":"2015","unstructured":"Pietrocola F, Galluzzi L, Bravo-San Pedro JM, Madeo F, Kroemer G. Acetyl Coenzyme A: A central metabolite and second messenger. Cell Metab. 2015;21(6):805\u201321. https:\/\/doi.org\/10.1016\/j.cmet.2015.05.014.","journal-title":"Cell Metab"},{"issue":"11","key":"2382_CR138","doi-asserted-by":"publisher","first-page":"5807","DOI":"10.1073\/pnas.110148297","volume":"97","author":"J Landry","year":"2000","unstructured":"Landry J, Sutton A, Tafrov ST, Heller RC, Stebbins J, Pillus L, et al. The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases. Proc Natl Acad Sci. 2000;97(11):5807\u201311. https:\/\/doi.org\/10.1073\/pnas.110148297.","journal-title":"Proc Natl Acad Sci"},{"issue":"7078","key":"2382_CR139","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1038\/nature04433","volume":"439","author":"Y Tsukada","year":"2006","unstructured":"Tsukada Y, Fang J, Erdjument-Bromage H, Warren ME, Borchers CH, Tempst P, et al. Histone demethylation by a family of JmjC domain-containing proteins. Nature. 2006;439(7078):811\u20136. https:\/\/doi.org\/10.1038\/nature04433.","journal-title":"Nature"},{"issue":"3","key":"2382_CR140","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1038\/ncomms1755","volume":"27","author":"S Hino","year":"2012","unstructured":"Hino S, Sakamoto A, Nagaoka K, Anan K, Wang Y, Mimasu S, et al. FAD-dependent lysine-specific demethylase-1 regulates cellular energy expenditure. Nat Commun. 2012;27(3):758. https:\/\/doi.org\/10.1038\/ncomms1755.","journal-title":"Nat Commun"},{"issue":"4","key":"2382_CR141","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1096\/fasebj.10.4.8647346","volume":"10","author":"PK Chiang","year":"1996","unstructured":"Chiang PK, Gordon RK, Tal J, Zeng GC, Doctor BP, Pardhasaradhi K, et al. S-Adenosylmetliionine and methylation. FASEB J. 1996;10(4):471\u201380. https:\/\/doi.org\/10.1096\/fasebj.10.4.8647346.","journal-title":"FASEB J"},{"issue":"9","key":"2382_CR142","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1038\/s44161-024-00531-y","volume":"3","author":"Y Shi","year":"2024","unstructured":"Shi Y, Tian M, Zhao X, Tang L, Wang F, Wu H, et al. \u03b1-Ketoglutarate promotes cardiomyocyte proliferation and heart regeneration after myocardial infarction. Nat Cardiovasc Res. 2024;3(9):1083\u201397. https:\/\/doi.org\/10.1038\/s44161-024-00531-y.","journal-title":"Nat Cardiovasc Res"},{"issue":"7983","key":"2382_CR143","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1038\/s41586-023-06585-5","volume":"622","author":"X Li","year":"2023","unstructured":"Li X, Wu F, G\u00fcnther S, Looso M, Kuenne C, Zhang T, et al. Inhibition of fatty acid oxidation enables heart regeneration in adult mice. Nature. 2023;622(7983):619\u201326. https:\/\/doi.org\/10.1038\/s41586-023-06585-5.","journal-title":"Nature"},{"issue":"2","key":"2382_CR144","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1038\/s42255-020-0169-x","volume":"2","author":"AC Cardoso","year":"2020","unstructured":"Cardoso AC, Lam NT, Savla JJ, Nakada Y, Pereira AHM, Elnwasany A, et al. Mitochondrial substrate utilization regulates cardiomyocyte cell-cycle progression. Nat Metab. 2020;2(2):167\u201378. https:\/\/doi.org\/10.1038\/s42255-020-0169-x.","journal-title":"Nat Metab"},{"issue":"7527","key":"2382_CR145","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1038\/nature13909","volume":"515","author":"ET Chouchani","year":"2014","unstructured":"Chouchani ET, Pell VR, Gaude E, Aksentijevi\u0107 D, Sundier SY, Robb EL, et al. Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS. Nature. 2014;515(7527):431\u20135. https:\/\/doi.org\/10.1038\/nature13909.","journal-title":"Nature"},{"issue":"20","key":"2382_CR146","doi-asserted-by":"publisher","first-page":"1973","DOI":"10.1161\/CIRCULATIONAHA.120.049952","volume":"143","author":"J Bae","year":"2021","unstructured":"Bae J, Salamon RJ, Brandt EB, Paltzer WG, Zhang Z, Britt EC, et al. Malonate promotes adult cardiomyocyte proliferation and heart regeneration. Circulation. 2021;143(20):1973\u201386. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.120.049952.","journal-title":"Circulation"},{"issue":"15","key":"2382_CR147","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1161\/CIRCULATIONAHA.119.043067","volume":"141","author":"A Magadum","year":"2020","unstructured":"Magadum A, Singh N, Kurian AA, Munir I, Mehmood T, Brown K, et al. Pkm2 regulates cardiomyocyte cell cycle and promotes cardiac regeneration. Circulation. 2020;141(15):1249\u201365. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.119.043067.","journal-title":"Circulation"},{"issue":"1","key":"2382_CR148","doi-asserted-by":"publisher","first-page":"8669","DOI":"10.1038\/s41598-021-88159-x","volume":"11","author":"VM Fajardo","year":"2021","unstructured":"Fajardo VM, Feng I, Chen BY, Perez-Ramirez CA, Shi B, Clark P, et al. GLUT1 overexpression enhances glucose metabolism and promotes neonatal heart regeneration. Sci Rep. 2021;11(1):8669. https:\/\/doi.org\/10.1038\/s41598-021-88159-x.","journal-title":"Sci Rep"},{"key":"2382_CR149","doi-asserted-by":"publisher","first-page":"102446","DOI":"10.1016\/j.redox.2022.102446","volume":"56","author":"Y Chen","year":"2022","unstructured":"Chen Y, Wu G, Li M, Hesse M, Ma Y, Chen W, et al. LDHA-mediated metabolic reprogramming promoted cardiomyocyte proliferation by alleviating ROS and inducing M2 macrophage polarization. Redox Biol. 2022;56:102446. https:\/\/doi.org\/10.1016\/j.redox.2022.102446.","journal-title":"Redox Biol"},{"issue":"4","key":"2382_CR150","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.stem.2022.03.009","volume":"29","author":"J Du","year":"2022","unstructured":"Du J, Zheng L, Gao P, Yang H, Yang WJ, Guo F, et al. A small-molecule cocktail promotes mammalian cardiomyocyte proliferation and heart regeneration. Cell Stem Cell. 2022;29(4):545-558.e13. https:\/\/doi.org\/10.1016\/j.stem.2022.03.009.","journal-title":"Cell Stem Cell"},{"key":"2382_CR151","doi-asserted-by":"publisher","first-page":"102094","DOI":"10.1016\/j.redox.2021.102094","volume":"46","author":"RRE Abouleisa","year":"2021","unstructured":"Abouleisa RRE, McNally L, Salama ABM, Hammad SK, Ou Q, Wells C, et al. Cell cycle induction in human cardiomyocytes is dependent on biosynthetic pathway activation. Redox Biol. 2021;46:102094. https:\/\/doi.org\/10.1016\/j.redox.2021.102094.","journal-title":"Redox Biol"},{"issue":"6562","key":"2382_CR152","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1126\/science.abg5159","volume":"373","author":"Y Chen","year":"2021","unstructured":"Chen Y, L\u00fcttmann FF, Schoger E, Sch\u00f6ler HR, Zelaray\u00e1n LC, Kim KP, et al. Reversible reprogramming of cardiomyocytes to a fetal state drives heart regeneration in mice. Science. 2021;373(6562):1537\u201340. https:\/\/doi.org\/10.1126\/science.abg5159.","journal-title":"Science"},{"issue":"5","key":"2382_CR153","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1038\/ncb3149","volume":"17","author":"G D\u2019Uva","year":"2015","unstructured":"D\u2019Uva G, Aharonov A, Lauriola M, Kain D, Yahalom-Ronen Y, Carvalho S, et al. ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation. Nat Cell Biol. 2015;17(5):627\u201338. https:\/\/doi.org\/10.1038\/ncb3149.","journal-title":"Nat Cell Biol"},{"issue":"8","key":"2382_CR154","doi-asserted-by":"publisher","first-page":"e50163","DOI":"10.7554\/eLife.50163","volume":"23","author":"H Honkoop","year":"2019","unstructured":"Honkoop H, de Bakker DE, Aharonov A, Kruse F, Shakked A, Nguyen PD, et al. Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart. Elife. 2019;23(8):e50163. https:\/\/doi.org\/10.7554\/eLife.50163.","journal-title":"Elife"},{"key":"2382_CR155","doi-asserted-by":"publisher","first-page":"CD008950","DOI":"10.1002\/14651858.CD008950.pub2","volume":"7","author":"S Bontekoe","year":"2012","unstructured":"Bontekoe S, Mantikou E, van Wely M, Seshadri S, Repping S. Mastenbroek S 2012 Low oxygen concentrations for embryo culture in assisted reproductive technologies. Cochr Database Syst Rev. 2012;7:CD008950. https:\/\/doi.org\/10.1002\/14651858.CD008950.pub2.","journal-title":"Cochr Database Syst Rev"},{"issue":"11","key":"2382_CR156","doi-asserted-by":"publisher","first-page":"1140021","DOI":"10.3389\/fped.2023.1140021","volume":"21","author":"L Filippi","year":"2023","unstructured":"Filippi L, Scaramuzzo RT, Pascarella F, Pini A, Morganti R, Cammalleri M, et al. Fetal oxygenation in the last weeks of pregnancy evaluated through the umbilical cord blood gas analysis. Front Pediatr. 2023;21(11):1140021. https:\/\/doi.org\/10.3389\/fped.2023.1140021.","journal-title":"Front Pediatr"},{"issue":"1","key":"2382_CR157","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1097\/00003081-199203000-00015","volume":"35","author":"RN Pollack","year":"1992","unstructured":"Pollack RN, Divon MY. Intrauterine growth retardation: definition, classification, and etiology. Clin Obstet Gynecol. 1992;35(1):99\u2013107. https:\/\/doi.org\/10.1097\/00003081-199203000-00015.","journal-title":"Clin Obstet Gynecol"},{"issue":"7636","key":"2382_CR158","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1038\/nature20173","volume":"541","author":"Y Nakada","year":"2017","unstructured":"Nakada Y, Canseco DC, Thet S, Abdisalaam S, Asaithamby A, Santos CX, et al. Hypoxia induces heart regeneration in adult mice. Nature. 2017;541(7636):222\u20137. https:\/\/doi.org\/10.1038\/nature20173.","journal-title":"Nature"},{"issue":"6","key":"2382_CR159","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1161\/CIRCRESAHA.122.321604","volume":"132","author":"J Johnson","year":"2023","unstructured":"Johnson J, Yang Y, Bian Z, Schena G, Li Y, Zhang X, et al. Systemic hypoxemia induces cardiomyocyte hypertrophy and right ventricular specific induction of proliferation. Circ Res. 2023;132(6):723\u201340. https:\/\/doi.org\/10.1161\/CIRCRESAHA.122.321604.","journal-title":"Circ Res"},{"issue":"11","key":"2382_CR160","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.4187\/respcare.11928","volume":"69","author":"L Berra","year":"2024","unstructured":"Berra L, Medeiros KJ, Marrazzo F, Patel S, Imber D, Rezoagli E, et al. Feasibility of delivering 5-Day normobaric hypoxia breathing in a hospital setting. Respir Care. 2024;69(11):1400\u20138. https:\/\/doi.org\/10.4187\/respcare.11928.","journal-title":"Respir Care"},{"issue":"9","key":"2382_CR161","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1161\/CIRCRESAHA.122.322334","volume":"132","author":"JN H\u00f6nemann","year":"2023","unstructured":"H\u00f6nemann JN, Gerlach D, Hoffmann F, Kramer T, Weis H, Hellweg CE, et al. Hypoxia and cardiac function in patients with prior myocardial infarction. Circ Res. 2023;132(9):1165\u20137. https:\/\/doi.org\/10.1161\/CIRCRESAHA.122.322334.","journal-title":"Circ Res"},{"issue":"36","key":"2382_CR162","doi-asserted-by":"publisher","first-page":"22642","DOI":"10.1074\/jbc.272.36.22642","volume":"272","author":"S Salceda","year":"1997","unstructured":"Salceda S, Caro J. Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes. J Biol Chem. 1997;272(36):22642\u20137. https:\/\/doi.org\/10.1074\/jbc.272.36.22642.","journal-title":"J Biol Chem"},{"issue":"3","key":"2382_CR163","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.cmet.2006.01.012","volume":"3","author":"I Papandreou","year":"2006","unstructured":"Papandreou I, Cairns RA, Fontana L, Lim AL, Denko NC. HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab. 2006;3(3):187\u201397. https:\/\/doi.org\/10.1016\/j.cmet.2006.01.012.","journal-title":"Cell Metab"},{"issue":"5","key":"2382_CR164","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.devcel.2015.04.021","volume":"33","author":"N Guimar\u00e3es-Camboa","year":"2015","unstructured":"Guimar\u00e3es-Camboa N, Stowe J, Aneas I, Sakabe N, Cattaneo P, Henderson L, et al. HIF1\u03b1 represses cell stress pathways to allow proliferation of hypoxic fetal cardiomyocytes. Dev Cell. 2015;33(5):507\u201321. https:\/\/doi.org\/10.1016\/j.devcel.2015.04.021.","journal-title":"Dev Cell"},{"issue":"1","key":"2382_CR165","doi-asserted-by":"publisher","first-page":"2877","DOI":"10.1038\/s41467-025-57996-z","volume":"16","author":"D Cai","year":"2025","unstructured":"Cai D, Liu C, Li H, Wang C, Bai L, Feng J, et al. Foxk1 and Foxk2 promote cardiomyocyte proliferation and heart regeneration. Nat Commun. 2025;16(1):2877. https:\/\/doi.org\/10.1038\/s41467-025-57996-z.","journal-title":"Nat Commun"},{"issue":"7559","key":"2382_CR166","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1038\/nature14582","volume":"523","author":"W Kimura","year":"2015","unstructured":"Kimura W, Xiao F, Canseco DC, Muralidhar S, Thet S, Zhang HM, et al. Hypoxia fate mapping identifies cycling cardiomyocytes in the adult heart. Nature. 2015;523(7559):226\u201330. https:\/\/doi.org\/10.1038\/nature14582.","journal-title":"Nature"},{"issue":"1","key":"2382_CR167","doi-asserted-by":"publisher","first-page":"5784","DOI":"10.1038\/s41467-021-25933-5","volume":"12","author":"X Liu","year":"2021","unstructured":"Liu X, Pu W, He L, Li Y, Zhao H, Li Y, et al. Cell proliferation fate mapping reveals regional cardiomyocyte cell-cycle activity in subendocardial muscle of left ventricle. Nat Commun. 2021;12(1):5784. https:\/\/doi.org\/10.1038\/s41467-021-25933-5.","journal-title":"Nat Commun"},{"key":"2382_CR168","doi-asserted-by":"publisher","unstructured":"Rigaud VOC, Zarka C, Kurian J, Harlamova D, Elia A, Kasatkin N, et al. UCP2 modulates cardiomyocyte cell cycle activity, acetyl-CoA, and histone acetylation in response to moderate hypoxia. JCI Insight. 2022;7(15). https:\/\/doi.org\/10.1172\/jci.insight.155475.","DOI":"10.1172\/jci.insight.155475"},{"issue":"1","key":"2382_CR169","doi-asserted-by":"publisher","first-page":"10354","DOI":"10.1038\/s41467-025-65344-4","volume":"16","author":"J Sun","year":"2025","unstructured":"Sun J, Wu Y, Adjmi M, Matthews RC, Kurian AA, \u017bak MM, et al. Transient overexpression of hPKM2 in porcine cardiomyocytes prevents heart failure after myocardial infarction. Nat Commun. 2025;16(1):10354. https:\/\/doi.org\/10.1038\/s41467-025-65344-4.","journal-title":"Nat Commun"},{"issue":"1","key":"2382_CR170","doi-asserted-by":"publisher","first-page":"47341","DOI":"10.31083\/RCM47341","volume":"27","author":"F Sedaghat-Hamedani","year":"2026","unstructured":"Sedaghat-Hamedani F, Kayvanpour E, Meder B. Targeting the sarcomere: Myosin inhibitors as the revolutionary game changer in hypertrophic cardiomyopathy. Rev Cardiovasc Med. 2026;27(1):47341. https:\/\/doi.org\/10.31083\/RCM47341.","journal-title":"Rev Cardiovasc Med"},{"issue":"9","key":"2382_CR171","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1016\/j.jacc.2014.12.027","volume":"65","author":"DC Canseco","year":"2015","unstructured":"Canseco DC, Kimura W, Garg S, Mukherjee S, Bhattacharya S, Abdisalaam S, et al. Human ventricular unloading induces cardiomyocyte proliferation. J Am Coll Cardiol. 2015;65(9):892\u2013900. https:\/\/doi.org\/10.1016\/j.jacc.2014.12.027.","journal-title":"J Am Coll Cardiol"},{"issue":"Supplement_1","key":"2382_CR172","doi-asserted-by":"publisher","first-page":"cvae088.019","DOI":"10.1093\/cvr\/cvae088.019","volume":"120","author":"G Ciucci","year":"2024","unstructured":"Ciucci G, Colliva A, Vodret S, Texler B, Cardini B, Oberhuber R, et al. Mechanical load regulates the proliferation of multiple cell types in the heart. Cardiovasc Res. 2024;120(Supplement_1):cvae088.019. https:\/\/doi.org\/10.1093\/cvr\/cvae088.019.","journal-title":"Cardiovasc Res"},{"issue":"10","key":"2382_CR173","doi-asserted-by":"publisher","first-page":"240167","DOI":"10.1098\/rsob.240167","volume":"14","author":"R Salmenov","year":"2024","unstructured":"Salmenov R, Mummery C, ter Huurne M. Cell cycle visualization tools to study cardiomyocyte proliferation in real-time. Open Biol. 2024;14(10):240167. https:\/\/doi.org\/10.1098\/rsob.240167.","journal-title":"Open Biol"},{"issue":"1","key":"2382_CR174","doi-asserted-by":"publisher","first-page":"82","DOI":"10.3390\/biology12010082","volume":"12","author":"D Li","year":"2023","unstructured":"Li D, Son Y, Jang M, Wang S, Zhu W. Nanoparticle based cardiac specific drug delivery. Biology (Basel). 2023;12(1):82. https:\/\/doi.org\/10.3390\/biology12010082.","journal-title":"Biology (Basel)"},{"issue":"11","key":"2382_CR175","doi-asserted-by":"publisher","first-page":"3845","DOI":"10.1038\/s41591-025-04011-z","volume":"31","author":"TD Henry","year":"2025","unstructured":"Henry TD, Chung ES, Alvisi M, Sethna F, Murray DR, Traverse JH, et al. Cardiotropic AAV gene therapy for heart failure: a phase 1 trial. Nat Med. 2025;31(11):3845\u201352. https:\/\/doi.org\/10.1038\/s41591-025-04011-z.","journal-title":"Nat Med"}],"container-title":["Current Cardiology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11886-026-02382-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11886-026-02382-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11886-026-02382-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T08:24:49Z","timestamp":1784103889000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11886-026-02382-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,15]]},"references-count":175,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2382"],"URL":"https:\/\/doi.org\/10.1007\/s11886-026-02382-4","relation":{},"ISSN":["1534-3170"],"issn-type":[{"value":"1534-3170","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,15]]},"assertion":[{"value":"16 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This article does not contain any studies with human or animal subjects performed by any of the authors.","order":1,"name":"Ethics","label":"Human and Animal Rights and Informed Consent","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"David A. Elliott reports a patent: Elliott DA, McNamara JW, Porrello ER. 2024. Treatment methods for muscle associated diseases. PCT application no. PCT\/AU2025\/050228 filed in 2025. Enzo R. Porrello reports travel support for the Novo Nordisk Foundation Science Cluster Conference: Engineering Stem Cells and Stem Cell Niches. He reports two patents: Elliott DA, McNamara JW, Porrello ER. 2024. Treatment methods for muscle associated diseases. PCT application no. PCT\/AU2025\/050228 filed in 2025. Porrello ER, Brizard C, Hudson JE, Mathieson EF, Laskary A, Reynolds L. 2022. Engineered human cardiac tissue. PCT\/AU2023\/050668 entered National Phase in 2025 in Australia, Europe, Japan, US. He reports being Co-Founder and Scientific Advisory Board, Dynomics Inc., San Francisco, USA, Chair of SAB. And he also reports being a Co-founder and stockholder of Dynomics Inc. and Ibnova Therapeutics. Francesca Butera has no conflicts of interest.","order":2,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"69"}}