{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T02:53:51Z","timestamp":1674788031635},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2000,7,1]],"date-time":"2000-07-01T00:00:00Z","timestamp":962409600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Curr Gastroenterol Rep"],"published-print":{"date-parts":[[2000,7]]},"DOI":"10.1007\/s11894-000-0022-z","type":"journal-article","created":{"date-parts":[[2007,5,19]],"date-time":"2007-05-19T19:46:00Z","timestamp":1179603960000},"page":"299-304","source":"Crossref","is-referenced-by-count":3,"title":["Toward a new understanding of Whipple\u2019s disease"],"prefix":"10.1007","volume":"2","author":[{"given":"Mark C.","family":"Flemmer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald W.","family":"Flenner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"22_CR1","first-page":"382","volume":"18","author":"GH Whipple","year":"1907","unstructured":"Whipple GH: A hitherto undescribed disease characterized anatomically by deposits of fat and fatty acids in the intestinal and mesenteric lymphatic tissues. Bull Johns Hopkins Hosp 1907, 18:382\u2013391.","journal-title":"Bull Johns Hopkins Hosp"},{"key":"22_CR2","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3181\/00379727-72-17388","volume":"72","author":"B Black-Schaffer","year":"1949","unstructured":"Black-Schaffer B: The tinctorial demonstration of a glycoprotein in Whipple's disease. Proc Soc Exp Biol Med 1949, 72:225\u2013227.","journal-title":"Proc Soc Exp Biol Med"},{"key":"22_CR3","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/S0016-5085(19)36367-X","volume":"22","author":"JW Paulley","year":"1952","unstructured":"Paulley JW: A case of Whipple's disease. Gastroenterology 1952, 22:128\u2013133.","journal-title":"Gastroenterology"},{"key":"22_CR4","first-page":"80","volume":"109","author":"JH Yardley","year":"1961","unstructured":"Yardley JH, Hendrix TR: Combined electron and light microscopy in Whipple's disease: demonstration of \u2018bacillary bodies\u2019 in the intestine. Bull Johns Hopkins Hosp 1961, 109:80\u201390.","journal-title":"Bull Johns Hopkins Hosp"},{"key":"22_CR5","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1056\/NEJM199207303270501","volume":"327","author":"DA Relman","year":"1992","unstructured":"Relman DA, Schmidt TM, MacDermott RP, Falkow S: Identification of the uncultured bacillus of Whipple's disease. N Engl J Med 1992, 327:293\u2013301.","journal-title":"N Engl J Med"},{"key":"22_CR6","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1056\/NEJM200003023420903","volume":"342","author":"D Raoult","year":"2000","unstructured":"Raoult D, Birg ML, La Scola B, et al.: Cultivation of the bacillus of Whipple's disease. N Engl J Med 2000, 342:620\u2013625. This landmark paper on cultivation of the T. whippelii bacterium could lead to a major increase in understanding.","journal-title":"N Engl J Med"},{"key":"22_CR7","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1097\/00005792-199705000-00003","volume":"6","author":"DV Durand","year":"1997","unstructured":"Durand DV, Lecomte C, Cathebras P, et al.: Whipple's disease: clinical review of 52 cases. Medicine 1997, 6:170\u2013184. Important review of epidemiologic data.","journal-title":"Medicine"},{"key":"22_CR8","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1007\/BF00957912","volume":"336","author":"FM Enzinger","year":"1963","unstructured":"Enzinger FM, Helwig EB: Whipple's disease: a review of the literature and report of 15 patients. Virchows Arch 1963, 336:238\u2013269.","journal-title":"Virchows Arch"},{"key":"22_CR9","volume-title":"Whipple's Disease","author":"WO Dobbins III","year":"1987","unstructured":"Dobbins WO III: Whipple's Disease. Springfield, IL: Charles C. Thomas; 1987."},{"key":"22_CR10","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1097\/00000441-198601000-00011","volume":"291","author":"M Feldman","year":"1986","unstructured":"Feldman M: Whipple's disease. Am J Med Sci 1986, 291:56\u201367.","journal-title":"Am J Med Sci"},{"key":"22_CR11","first-page":"992","volume":"86","author":"JC Bai","year":"1991","unstructured":"Bai JC, Mota AH, Maurino E, et al.: Class 1 and class 2 HLA antigens in a homogenous Argentinian population with Whipple's disease: lack of association with HLA-B-27. Am J Gastroenterol 1991, 86:992\u2013994.","journal-title":"Am J Gastroenterol"},{"key":"22_CR12","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1128\/AEM.64.2.760-762.1998","volume":"64","author":"M Maiwald","year":"1998","unstructured":"Maiwald M, Schumacher F, Ditton HJ, et al.: Environmental occurrence of Whipple's disease bacterium (Tropheryma whippelli). Appl Environ Microbiol 1998, 64:760\u2013762. These authors argue for an oral source of infection.","journal-title":"Appl Environ Microbiol"},{"key":"22_CR13","first-page":"51","volume":"139","author":"DF Keren","year":"1976","unstructured":"Keren DF, Weisburger WR, Yardley JH, et al.: Whipple's disease: demonstration by immunofluorescence of similar bacterial antigens in macrophages from three cases. Johns Hopkins Med J 1976, 139:51\u201359.","journal-title":"Johns Hopkins Med J"},{"key":"22_CR14","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1093\/qjmed\/90.12.765","volume":"90","author":"SA Misbah","year":"1997","unstructured":"Misbah SA, Ozols B, Franks A, et al.: Whipple's disease without malabsorption: new atypical features. Q J Med 1997, 90:765\u2013772. Important therapeutic implications arose from this reported study and that of Marth et al. [15].","journal-title":"Q J Med"},{"key":"22_CR15","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1053\/gast.1997.v113.pm9247462","volume":"113","author":"T Marth","year":"1997","unstructured":"Marth T, Nuerath M, Cuccherini B, et al.: Defects of monocyte interleukin-12 production and humoral immunity in Whipple's disease. Gastroenterology 1997, 113:442. See previous annotation.","journal-title":"Gastroenterology"},{"key":"22_CR16","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0049-0172(86)90013-2","volume":"15","author":"SR Weiner","year":"1986","unstructured":"Weiner SR, Utsinger P: Whipple's disease. Semin Arthritis Rheum 1986, 15:155\u2013167.","journal-title":"Semin Arthritis Rheum"},{"key":"22_CR17","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1136\/pgmj.73.862.509","volume":"73","author":"P McGettigan","year":"1997","unstructured":"McGettigan P, Mooney EE, Sinnott M, et al.: Sudden death in Whipple's disease. Postgrad Med J 1997, 73:509\u2013511.","journal-title":"Postgrad Med J"},{"key":"22_CR18","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S0025-6196(12)64884-8","volume":"63","author":"JL Flemming","year":"1988","unstructured":"Flemming JL, Wiesner RH, Shorter RG: Whipple's disease: clinical, biochemical and histopathologic features and assessment of treatment in 29 patients. Mayo Clin Proc 1988, 63:539\u2013551.","journal-title":"Mayo Clin Proc"},{"key":"22_CR19","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/00005792-197005000-00001","volume":"49","author":"H Maizel","year":"1970","unstructured":"Maizel H, Ruffin JM, Dobbins WO III: Whipple's disease: a review of 19 patients from one hospital and a review of the literature since 1950. Medicine 1970, 49:175\u2013205.","journal-title":"Medicine"},{"key":"22_CR20","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1055\/s-0028-1098273","volume":"10","author":"JH Riehman","year":"1978","unstructured":"Riehman JH, Rosch W: Synopsis of endoscopic and related morphological findings in Whipple's disease. Endoscopy 1978, 10:98.","journal-title":"Endoscopy"},{"key":"22_CR21","doi-asserted-by":"crossref","first-page":"268","DOI":"10.2214\/ajr.123.2.268","volume":"124","author":"RL Phillips","year":"1975","unstructured":"Phillips RL, Carlson HC: The roentgenographic and clinical findings in Whipple's disease. Am J Roentgenol 1975, 124:268.","journal-title":"Am J Roentgenol"},{"key":"22_CR22","first-page":"107","volume":"78","author":"GM Comer","year":"1983","unstructured":"Comer GM, Brandt LJ, Abissi CJ: Whipple's disease: a review. Am J Gastroenterol 1983, 78:107\u2013114.","journal-title":"Am J Gastroenterol"},{"key":"22_CR23","volume-title":"Fleisenger and Fordran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, and Management","author":"JS Trier","year":"1997","unstructured":"Trier JS: Whipple's disease. In Fleisenger and Fordran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, and Management, edn 6. Edited by Feldman M, Scharschmidt BF, Sleisenger M, Zorab R. Philadelphia: WB Saunders; 1997.","edition":"edn 6"},{"key":"22_CR24","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1056\/NEJM198311243092113","volume":"309","author":"RI Roth","year":"1983","unstructured":"Roth RI, Own RL, Keren DF: AIDS with Mycobacterium avium: intracellular lesions resembling those of Whipple's disease. N Engl J Med 1983, 309:1323.","journal-title":"N Engl J Med"},{"key":"22_CR25","first-page":"1472","volume-title":"Textbook of Gastroenterology","author":"WO Dobbins III","year":"1991","unstructured":"Dobbins WO III, Klipstein FA: Chronic infections of the small intestine. In Textbook of Gastroenterology. Edited by Yamada T. Philadelphia: Lippincott; 1991:1472\u20131484."},{"key":"22_CR26","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1093\/ajcp\/74.4.486","volume":"74","author":"L Johnson","year":"1979","unstructured":"Johnson L, Diamond I: Cerebral Whipple's disease: diagnosis by brain biopsy. Am J Clin Pathol 1979, 74:486.","journal-title":"Am J Clin Pathol"},{"key":"22_CR27","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1136\/gut.40.3.425","volume":"40","author":"C Muller","year":"1997","unstructured":"Muller C, Petermann D, Stain C, et al.: Whipple's disease: comparison of histology with diagnosis based on polymerase chain reaction in four consecutive cases. Gut 1997, 40:425\u2013427.","journal-title":"Gut"},{"key":"22_CR28","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1056\/NEJM199502093320604","volume":"332","author":"LS Rickman","year":"1995","unstructured":"Rickman LS, Freeman WR, Green WR, et al.: Uveitis caused by Tropheryma whippelii. N Engl J Med 1995, 332:363\u2013366.","journal-title":"N Engl J Med"},{"key":"22_CR29","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/(SICI)1096-9896(199907)188:3<318::AID-PATH352>3.0.CO;2-E","volume":"188","author":"E Gras","year":"1999","unstructured":"Gras E, Xavier MG, Arnold G, et al.: PCR analysis in the pathological diagnosis of Whipple's disease: emphasis on extraintestinal involvement or atypical morphological features. J Pathol 1999, 188:318\u2013321.","journal-title":"J Pathol"},{"key":"22_CR30","first-page":"820","volume":"19","author":"A Rubino","year":"1976","unstructured":"Rubino A, Canoso JJ, Goldenberg DL, Cohen AS: Synovial fluid and synovial membrane pathology in Whipple's disease [abstract]. Arthritis Rheum 1976, 19:820.","journal-title":"Arthritis Rheum"},{"key":"22_CR31","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1093\/clinids\/20.3.501","volume":"20","author":"M Celard","year":"1995","unstructured":"Celard M, Gevigney N, Mosnier S, et al.: Polymerase chain reaction analysis for diagnosis of Tropheryema whippelii infective endocarditis in two patients with no previous evidence of Whipple's disease. Clin Infect Dis 1995, 20:501\u2013516.","journal-title":"Clin Infect Dis"},{"key":"22_CR32","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1016\/S0140-6736(99)01776-6","volume":"353","author":"HA Ehrbar","year":"1999","unstructured":"Ehrbar HA, Bauerfeind P, Dutly F, et al.: PCR-positive tests for Tropheryema whippelii in patients without Whipple's disease. Lancet 1999, 353:2214. Report of high specificity for duodenal biopsy specimens through PCR analysis.","journal-title":"Lancet"},{"key":"22_CR33","doi-asserted-by":"crossref","first-page":"520","DOI":"10.7326\/0003-4819-126-7-199704010-00004","volume":"126","author":"NN Ramzan","year":"1997","unstructured":"Ramzan NN, Loftus E, Burgart LJ, et al.: Diagnosis and monitoring of Whipple's disease by polymerase chain reaction. Ann Intern Med 1997, 126:520\u2013527.","journal-title":"Ann Intern Med"},{"key":"22_CR34","first-page":"1085","volume":"112","author":"T Schneider","year":"1997","unstructured":"Schneider T, Stallmack A, vonHerbay G, et al.: Successful treatment of refractory Whipple's disease with adjunctive interferon gamma therapy [abstract]. Gastroenterology 1997, 112:1085. Important report of symptoms found in patients with cerebral involvement treated with trimethoprim-sulfamethoxazole.","journal-title":"Gastroenterology"}],"container-title":["Current Gastroenterology Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11894-000-0022-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11894-000-0022-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11894-000-0022-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,22]],"date-time":"2020-04-22T05:32:48Z","timestamp":1587533568000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11894-000-0022-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,7]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2000,7]]}},"alternative-id":["22"],"URL":"https:\/\/doi.org\/10.1007\/s11894-000-0022-z","relation":{},"ISSN":["1522-8037","1534-312X"],"issn-type":[{"value":"1522-8037","type":"print"},{"value":"1534-312X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,7]]}}}