{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T22:32:44Z","timestamp":1772749964696,"version":"3.50.1"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Curr Gastroenterol Rep"],"published-print":{"date-parts":[[2008,6]]},"DOI":"10.1007\/s11894-008-0043-6","type":"journal-article","created":{"date-parts":[[2008,10,12]],"date-time":"2008-10-12T03:19:01Z","timestamp":1223781541000},"page":"195-199","source":"Crossref","is-referenced-by-count":22,"title":["Otolaryngological perspective on patients with throat symptoms and laryngeal irritation"],"prefix":"10.1007","volume":"10","author":[{"given":"C.","family":"Gaelyn Garrett","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seth M.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2008,10,11]]},"reference":[{"key":"43_CR1","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1097\/MLG.0b013e318158f72d","volume":"117","author":"S.M. Cohen","year":"2008","unstructured":"Cohen SM, Garrett CG: Hoarseness: is it really laryngopharyngeal reflux? Laryngoscope 2008, 117:363\u2013366.","journal-title":"Laryngoscope"},{"key":"43_CR2","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1288\/00005537-196811000-00008","volume":"78","author":"J.E. Delahunty","year":"1968","unstructured":"Delahunty JE, Cherry J: Experimentally produced vocal cord granulomas. Laryngoscope 1968, 78:1941\u20131947.","journal-title":"Laryngoscope"},{"issue":"4Part2Suppl53","key":"43_CR3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/lary.1991.101.s53.1","volume":"101","author":"J.A. Koufman","year":"1991","unstructured":"Koufman JA: The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): a clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury. Laryngoscope 1991, 101(4 Part 2 Suppl 53):1\u201378.","journal-title":"Laryngoscope"},{"key":"43_CR4","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s11894-007-0018-z","volume":"9","author":"M.D. Long","year":"2007","unstructured":"Long MD, Shaheen NJ: Extra-esophageal GERD: clinical dilemma of epidemiology versus clinical practice. Curr Gastroenterol Rep 2007, 9:195\u2013202.","journal-title":"Curr Gastroenterol Rep"},{"key":"43_CR5","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/S0892-1997(02)00097-8","volume":"16","author":"P.C. Belafsky","year":"2002","unstructured":"Belafsky PC, Postma GN, Koufman JA: Validity and reliability of the reflux symptom index (RSI). J Voice 2002, 16:274\u2013277.","journal-title":"J Voice"},{"key":"43_CR6","unstructured":"Simberg S, Sala E, Tuomainen J, Ronnemaa AM: Vocal symptoms and allergy\u2014a pilot study. J Voice 2007 July 9 (Epub ahead of print)."},{"key":"43_CR7","doi-asserted-by":"crossref","unstructured":"Bhalla RK, Jones AS, Roland NJ: Prevalence of pharyngeal and laryngeal complications in adult asthmatics using inhaled corticosteroids. J Laryngol Otol 2008 Jan 18 (Epub ahead of print).","DOI":"10.1017\/S0022215107001272"},{"key":"43_CR8","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1067\/mhn.2000.109935","volume":"123","author":"J.A. Koufman","year":"2000","unstructured":"Koufman JA, Amin MR, Panetti M: Prevalence of reflux in 113 consecutive patients with laryngeal and voice disorders. Otolaryngol Head Neck Surg 2000, 123:385\u2013388.","journal-title":"Otolaryngol Head Neck Surg"},{"key":"43_CR9","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.jvoice.2004.03.007","volume":"19","author":"K.W. Altman","year":"2005","unstructured":"Altman KW, Atkinson C, Lazarus C: Current and emerging concepts in muscle tension dysphonia: a 30-month review. J Voice 2005, 19:261\u2013267.","journal-title":"J Voice"},{"key":"43_CR10","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1097\/01.mlg.0000184325.44968.b1","volume":"115","author":"C.F. Milstein","year":"2005","unstructured":"Milstein CF, Charbel S, Hicks DM, et al.: Prevalence of laryngeal irritation signs associated with reflux in asymptomatic volunteers: impact of endoscopic technique (rigid vs. flexible laryngoscope). Laryngoscope 2005, 115:2256\u20132261.","journal-title":"Laryngoscope"},{"key":"43_CR11","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1097\/00005537-200108000-00001","volume":"111","author":"P.C. Belafsky","year":"2001","unstructured":"Belafsky PC, Postma GN, Koufman JA: The validity and reliability of the reflux finding score (RFS). Laryngoscope 2001, 111:1313\u20131317.","journal-title":"Laryngoscope"},{"key":"43_CR12","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s00405-006-0222-8","volume":"264","author":"P.D. Karkos","year":"2007","unstructured":"Karkos PD, Benton J, Leong SC, et al.: Trends in laryngopharyngeal reflux: a British survey. Eur Arch Otorhinolaryngol 2007, 264:513\u2013517.","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"43_CR13","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1001\/jama.294.12.1534","volume":"294","author":"C.N. Ford","year":"2005","unstructured":"Ford CN: Evaluation and management of laryngopharyngeal reflux. JAMA 2005, 294:1534\u20131540.","journal-title":"JAMA"},{"key":"43_CR14","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1111\/j.1572-0241.2006.00502.x","volume":"101","author":"T.F. Ahmed","year":"2006","unstructured":"Ahmed TF, Khandwala F, Abelson TI, et al.: Chronic laryngitis associated with gastroesophageal reflux: prospective assessment of differences in practice patterns between gastroenterologists and ENT physicians. Am J Gastroenterol 2006, 101:470\u2013478.","journal-title":"Am J Gastroenterol"},{"key":"43_CR15","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.1111\/j.1572-0241.2006.00844.x","volume":"101","author":"M.A. Qadeer","year":"2006","unstructured":"Qadeer MA, Phillips CO, Lopez AR, et al.: Proton pump inhibitor therapy for suspected GERD-related chronic laryngitis: a meta-analysis of randomized controlled trials. Am J Gastroenterol 2006, 101:2646\u20132654.","journal-title":"Am J Gastroenterol"},{"key":"43_CR16","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1111\/j.1572-0241.2006.00693.x","volume":"101","author":"J.M. Wo","year":"2006","unstructured":"Wo JM, Koopman J, Harrell SP, et al.: Double-blind, placebo-controlled trial with single-dose pantoprazole for laryngopharyngeal reflux. Am J Gastroenterol 2006, 101:1972\u20131978.","journal-title":"Am J Gastroenterol"},{"key":"43_CR17","doi-asserted-by":"crossref","unstructured":"Oridate N, Takeda H, Asaka M, et al.: Acid-suppression therapy offers varied laryngopharyngeal and esophageal symptom relief in laryngopharyngeal reflux patients. Dig Dis Sci 2007 Dec 13 (Epub ahead of print).","DOI":"10.1007\/s10620-007-0114-9"},{"key":"43_CR18","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1097\/01.mlg.0000192173.00498.ba","volume":"116","author":"M.F. Vaezi","year":"2006","unstructured":"Vaezi MF, Richter JE, Stasney CR, et al.: Treatment of chronic posterior laryngitis with esomeprazole. Laryngoscope 2006, 116:254\u2013260.","journal-title":"Laryngoscope"},{"key":"43_CR19","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1097\/00005537-200112000-00013","volume":"111","author":"J.P. Noordzij","year":"2001","unstructured":"Noordzij JP, Khidr A, Evans BA, et al.: Evaluation of omeprazole in the treatment of reflux laryngitis: a prospective, placebo-controlled, randomized, double-blind study. Laryngoscope 2001, 111:2147\u20132151.","journal-title":"Laryngoscope"},{"key":"43_CR20","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.otohns.2004.03.037","volume":"131","author":"D.L. Steward","year":"2004","unstructured":"Steward DL, Wilson KM, Kelly DH, et al.: Proton pump inhibitor therapy for chronic laryngo-pharyngitis: a randomized, placebo-control trial. Otolaryngol Head Neck Surg 2004, 131:342\u2013350.","journal-title":"Otolaryngol Head Neck Surg"},{"key":"43_CR21","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/j.1572-0241.2006.00448_2.x","volume":"101","author":"P.C. Belafsky","year":"2006","unstructured":"Belafsky PC, Vaezi MF, DeVault K: Debate: treatment of chronic throat symptoms with PPIs should be preceded by pH monitoring. Am J Gastroenterol 2006, 101:6\u201311.","journal-title":"Am J Gastroenterol"},{"key":"43_CR22","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.otohns.2006.12.004","volume":"136","author":"S. Joniau","year":"2007","unstructured":"Joniau S, Bradshaw A, Esterman A, Carney AS: Reflux and laryngitis: a systematic review. Otolaryngol Head Neck Surg 2007, 136:686\u2013692.","journal-title":"Otolaryngol Head Neck Surg"},{"key":"43_CR23","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1097\/01.mlg.0000149445.07146.03","volume":"114","author":"N. Johnston","year":"2004","unstructured":"Johnston N, Knight J, Dettmar PW, et al.: Pepsin and carbonic anhydrase isoenzyme III as diagnostic markers for laryngopharyngeal reflux disease. Laryngoscope 2004, 114:2129\u20132134.","journal-title":"Laryngoscope"},{"key":"43_CR24","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1177\/000348940611500108","volume":"115","author":"N. Johnston","year":"2006","unstructured":"Johnston N, Dettmer PW, Lively MO, et al.: Effect of pepsin on laryngeal stress protein (Sep70, Sep53, and Hsp70) response: role in laryngopharyngeal reflux disease. Ann Otol Rhinol Laryngol 2006, 115:47\u201358.","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"43_CR25","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1097\/MLG.0b013e31804154c3","volume":"117","author":"N. Johnston","year":"2007","unstructured":"Johnston N, Dettmer PW, Bishwokarma B, et al.: Activity\/stability of human pepsin: implications for reflux attributed laryngeal disease. Laryngoscope 2007, 117:1036\u20131039.","journal-title":"Laryngoscope"},{"key":"43_CR26","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1177\/000348940711601211","volume":"116","author":"N. Johnston","year":"2007","unstructured":"Johnston N, Wells CW, Blumin JH, et al.: Receptor-mediated uptake of pepsin by laryngeal epithelial cells. Ann Otol Rhinol Laryngol 2007, 116:934\u2013938.","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"43_CR27","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1097\/MLG.0b013e318124a992","volume":"117","author":"S.L. Thibeault","year":"2007","unstructured":"Thibeault SL, Smith ME, Peterson K, Ylitalo-Moller R: Gene expression changes of inflammatory mediators in posterior laryngitis due to laryngopharyngeal reflux and evolution with PPI treatment: a preliminary study. Laryngoscope 2007, 117:2050\u20132056.","journal-title":"Laryngoscope"},{"key":"43_CR28","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.otohns.2007.09.006","volume":"138","author":"P.C. Belafsky","year":"2008","unstructured":"Belafsky PC, Rees CJ, Rodriguez K, et al.: Esophagopharyngeal reflux. Otolaryngol Head Neck Surg 2008, 138:57\u201361.","journal-title":"Otolaryngol Head Neck Surg"}],"container-title":["Current Gastroenterology Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11894-008-0043-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11894-008-0043-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11894-008-0043-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T00:04:02Z","timestamp":1559433842000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11894-008-0043-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["43"],"URL":"https:\/\/doi.org\/10.1007\/s11894-008-0043-6","relation":{},"ISSN":["1522-8037","1534-312X"],"issn-type":[{"value":"1522-8037","type":"print"},{"value":"1534-312X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6]]}}}