{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:12:28Z","timestamp":1792660348612,"version":"4.5.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Curr Gastroenterol Rep"],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.1007\/s11894-010-0108-1","type":"journal-article","created":{"date-parts":[[2010,4,27]],"date-time":"2010-04-27T02:35:51Z","timestamp":1272335751000},"page":"215-222","source":"Crossref","is-referenced-by-count":92,"title":["Etiology of Esophageal Atresia and Tracheoesophageal Fistula: \u201cMind the Gap\u201d"],"prefix":"10.1007","volume":"12","author":[{"given":"Elisabeth M.","family":"de Jong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janine F.","family":"Felix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annelies","family":"de Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dick","family":"Tibboel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,4,28]]},"reference":[{"key":"108_CR1","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/tera.1420520408","volume":"52","author":"CP Torfs","year":"1995","unstructured":"Torfs CP, Curry CJ, Bateson TF: Population-based study of tracheoesophageal fistula and esophageal atresia. Teratology 1995, 52:220\u2013232.","journal-title":"Teratology"},{"key":"108_CR2","first-page":"76","volume-title":"Surgery of Infancy and Childhood","author":"RE Gross","year":"1953","unstructured":"Gross RE: Surgery of Infancy and Childhood. Philadelphia: WB Saunders; 1953:76."},{"key":"108_CR3","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1750-1172-2-24","volume":"2","author":"L Spitz","year":"2007","unstructured":"\u2022 Spitz L: Oesophageal atresia. Orphanet J Rare Dis 2007, 2:24. This article provides an overview of the history, epidemiology, classification, and clinical description of esophageal atresia. In addition, it discusses etiologic and pathophysiologic aspects and the developments in management.","journal-title":"Orphanet J Rare Dis"},{"key":"108_CR4","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/(SICI)1096-8628(19960628)63:4<525::AID-AJMG3>3.0.CO;2-N","volume":"63","author":"KP McMullen","year":"1996","unstructured":"McMullen KP, Karnes PS, Moir CR, Michels VV: Familial recurrence of tracheoesophageal fistula and associated malformations. Am J Med Genet 1996, 63:525\u2013528.","journal-title":"Am J Med Genet"},{"key":"108_CR5","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1111\/j.1399-0004.2007.00798.x","volume":"71","author":"D Genevieve","year":"2007","unstructured":"Genevieve D, de Pontual L, Amiel J, et al.: An overview of isolated and syndromic oesophageal atresia. Clin Genet 2007, 71:392\u2013399.","journal-title":"Clin Genet"},{"key":"108_CR6","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1002\/tera.1072","volume":"64","author":"E Gianantonio Di","year":"2001","unstructured":"Di Gianantonio E, Schaefer C, Mastroiacovo PP, et al.: Adverse effects of prenatal methimazole exposure. Teratology 2001, 64:262\u2013266.","journal-title":"Teratology"},{"key":"108_CR7","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0140-6736(76)91455-0","volume":"1","author":"JJ Nora","year":"1976","unstructured":"Nora JJ, Nora AH, Perinchief AG, et al.: Congenital abnormalities and first-trimester exposure to progestagen\/oestrogen [letter]. Lancet 1976, 1:313\u2013314.","journal-title":"Lancet"},{"key":"108_CR8","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1002\/bdra.20529","volume":"82","author":"DL Wong-Gibbons","year":"2008","unstructured":"Wong-Gibbons DL, Romitti PA, Sun L, et al.: Maternal periconceptional exposure to cigarette smoking and alcohol and esophageal atresia +\/\u2212\u2009tracheo-esophageal fistula. Birth Defects Res A Clin Mol Teratol 2008, 82:776\u2013784.","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"108_CR9","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1136\/jech.42.3.257","volume":"42","author":"P Kyyronen","year":"1988","unstructured":"Kyyronen P, Hemminki K: Gastro-intestinal atresias in Finland in 1970\u201379, indicating time-place clustering. J Epidemiol Community Health 1988, 42:257\u2013265.","journal-title":"J Epidemiol Community Health"},{"key":"108_CR10","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1002\/bdra.20423","volume":"82","author":"JF Felix","year":"2008","unstructured":"Felix JF, van Dooren MF, Klaassens M, et al.: Environmental factors in the etiology of esophageal atresia and congenital diaphragmatic hernia: results of a case-control study. Birth Defects Res A Clin Mol Teratol 2008, 82:98\u2013105.","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"108_CR11","doi-asserted-by":"crossref","unstructured":"Felix JF, Steegers-Theunissen RP, de Walle HE, et al.: Esophageal atresia and tracheoesophageal fistula in children of women exposed to diethylstilbestrol in utero. Am J Obstet Gynecol 2007, 197:38 e31\u2013e35.","DOI":"10.1016\/j.ajog.2007.02.036"},{"key":"108_CR12","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/bdra.20432","volume":"82","author":"M Castori","year":"2008","unstructured":"Castori M, Rinaldi R, Capocaccia P, et al.: VACTERL association and maternal diabetes: a possible causal relationship? Birth Defects Res A Clin Mol Teratol 2008, 82:169\u2013172.","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"108_CR13","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1111\/j.1471-0528.2009.02227.x","volume":"116","author":"M Loane","year":"2009","unstructured":"\u2022 Loane M, Dolk H, Morris JK: Maternal age-specific risk of non-chromosomal anomalies. Bjog 2009, 116:1111\u20131119.This population-based prevalence study found that older mothers were at a significantly greater risk of having a child with esophageal atresia. The authors used data from EUROCAT congenital anomaly registers in 23 regions of Europe, describing more than 1.75 million births from 2000 to 2004.","journal-title":"Bjog"},{"key":"108_CR14","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/S0022-3468(96)90482-0","volume":"31","author":"JA Diez-Pardo","year":"1996","unstructured":"Diez-Pardo JA, Baoquan Q, Navarro C, Tovar JA: A new rodent experimental model of esophageal atresia and tracheoesophageal fistula: preliminary report. J Pediatr Surg 1996, 31:498\u2013502.","journal-title":"J Pediatr Surg"},{"key":"108_CR15","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1093\/annonc\/mdh009","volume":"15","author":"N Germann","year":"2004","unstructured":"Germann N, Goffinet F, Goldwasser F: Anthracyclines during pregnancy: embryo-fetal outcome in 160 patients. Ann Oncol 2004, 15:146\u2013150.","journal-title":"Ann Oncol"},{"key":"108_CR16","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/aja.1000920202","volume":"92","author":"JG Wilson","year":"1953","unstructured":"Wilson JG, Roth CB, Warkany J: An analysis of the syndrome of malformations induced by maternal vitamin A deficiency. Effects of restoration of vitamin A at various times during gestation. Am J Anat 1953, 92:189\u2013217.","journal-title":"Am J Anat"},{"key":"108_CR17","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1101\/gad.479408","volume":"22","author":"D Szumska","year":"2008","unstructured":"Szumska D, Pieles G, Essalmani R, et al.: VACTERL\/caudal regression\/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5. Genes Dev 2008, 22:1465\u20131477.","journal-title":"Genes Dev"},{"key":"108_CR18","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ejmg.2009.04.004","volume":"52","author":"C Stoll","year":"2009","unstructured":"Stoll C, Alembik Y, Dott B, Roth MP: Associated malformations in patients with esophageal atresia. Eur J Med Genet 2009, 52:287\u2013290.","journal-title":"Eur J Med Genet"},{"key":"108_CR19","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/bdra.20437","volume":"82","author":"EM Jong de","year":"2008","unstructured":"de Jong EM, Felix JF, Deurloo JA, et al.: Non-VACTERL-type anomalies are frequent in patients with esophageal atresia\/tracheo-esophageal fistula and full or partial VACTERL association. Birth Defects Res A Clin Mol Teratol 2008, 82:92\u201397.","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"108_CR20","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1136\/jmg.2005.038158","volume":"43","author":"C Shaw-Smith","year":"2006","unstructured":"Shaw-Smith C: Oesophageal atresia, tracheo-oesophageal fistula, the VACTERL association: review of genetics and epidemiology. J Med Genet 2006, 43:545\u2013554.","journal-title":"J Med Genet"},{"key":"108_CR21","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1136\/jmg.22.2.149","volume":"22","author":"A Mendelberg","year":"1985","unstructured":"Mendelberg A, Ariel I, Mogle P, Arad I: Tracheo-oesophageal anomalies in the Goldenhar anomalad. J Med Genet 1985, 22:149\u2013150.","journal-title":"J Med Genet"},{"key":"108_CR22","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1136\/jmg.2006.041673","volume":"43","author":"ST Holden","year":"2006","unstructured":"Holden ST, Cox JJ, Kesterton I, et al.: Fanconi anaemia complementation group B presenting as X linked VACTERL with hydrocephalus syndrome. J Med Genet 2006, 43:750\u2013754.","journal-title":"J Med Genet"},{"key":"108_CR23","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1136\/jmg.38.12.820","volume":"38","author":"W Reardon","year":"2001","unstructured":"Reardon W, Zhou XP, Eng C: A novel germline mutation of the PTEN gene in a patient with macrocephaly, ventricular dilatation, and features of VATER association. J Med Genet 2001, 38:820\u2013823.","journal-title":"J Med Genet"},{"key":"108_CR24","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.ajhg.2009.05.005","volume":"84","author":"P Stankiewicz","year":"2009","unstructured":"\u2022\u2022 Stankiewicz P, Sen P, Bhatt SS, et al.: Genomic and genic deletions of the FOX gene cluster on 16q24.1 and inactivating mutations of FOXF1 cause alveolar capillary dysplasia and other malformations. Am J Hum Genet 2009, 84:780\u2013791. This study describes patients with alveolar capillary dysplasia and VACTERL-associated anomalies, including EA\/TEF and a microdeletion on chromosome 16q24. The deleted region includes the genes FOXF1, FOXC2, and FOXL1. Because haploinsufficiency of Foxf1 in mice causes EA\/TEF and other malformations, a genetic link between human and animal studies was established.","journal-title":"Am J Hum Genet"},{"key":"108_CR25","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/ng1546","volume":"37","author":"H Bokhoven van","year":"2005","unstructured":"van Bokhoven H, Celli J, van Reeuwijk J, et al.: MYCN haploinsufficiency is associated with reduced brain size and intestinal atresias in Feingold syndrome. Nat Genet 2005, 37:465\u2013467.","journal-title":"Nat Genet"},{"key":"108_CR26","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1002\/humu.20750","volume":"29","author":"CL Marcelis","year":"2008","unstructured":"\u2022\u2022 Marcelis CL, Hol FA, Graham GE, et al.: Genotype-phenotype correlations in MYCN-related Feingold syndrome. Hum Mutat 2008, 29:1125\u20131132. The authors correlated genotype to phenotype in patients with MYCN-related Feingold syndrome that causes dominantly inherited esophageal atresia, microcephaly, and toes syndactyly in humans","journal-title":"Hum Mutat"},{"key":"108_CR27","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1038\/ng1407","volume":"36","author":"LE Vissers","year":"2004","unstructured":"Vissers LE, van Ravenswaaij CM, Admiraal R, et al.: Mutations in a new member of the chromodomain gene family cause CHARGE syndrome. Nat Genet 2004, 36:955\u2013957.","journal-title":"Nat Genet"},{"key":"108_CR28","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1093\/hmg\/ddl064","volume":"15","author":"KA Williamson","year":"2006","unstructured":"Williamson KA, Hever AM, Rainger J, et al.: Mutations in SOX2 cause anophthalmia-esophageal-genital (AEG) syndrome. Hum Mol Genet 2006, 15:1413\u20131422.","journal-title":"Hum Mol Genet"},{"key":"108_CR29","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1242\/dev.003855","volume":"134","author":"J Que","year":"2007","unstructured":"\u2022\u2022 Que J, Okubo T, Goldenring JR, et al.: Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm. Development 2007, 134:2521\u20132531. This study investigated the importance of Sox2 in differentiation of the foregut into esophagus. In humans, heterozygosity for SOX2 is associated with AEG syndrome. This study provides evidence for a relation between murine models and the human phenotype of syndromic EA\/TEF. Downregulation of Sox2 plays a role in the etiology of EA\/TEF and of columnar mucous cell metaplasia in the esophagus.","journal-title":"Development"},{"key":"108_CR30","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1111\/j.1432-0436.2006.00096.x","volume":"74","author":"J Que","year":"2006","unstructured":"Que J, Choi M, Ziel JW, et al.: Morphogenesis of the trachea and esophagus: current players and new roles for noggin and Bmps. Differentiation 2006, 74:422\u2013437.","journal-title":"Differentiation"},{"key":"108_CR31","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1086\/429346","volume":"76","author":"JJ Johnston","year":"2005","unstructured":"Johnston JJ, Olivos-Glander I, Killoran C, et al.: Molecular and clinical analyses of Greig cephalopolysyndactyly and Pallister-Hall syndromes: robust phenotype prediction from the type and position of GLI3 mutations. Am J Hum Genet 2005, 76:609\u2013622.","journal-title":"Am J Hum Genet"},{"key":"108_CR32","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/1711","volume":"20","author":"J Motoyama","year":"1998","unstructured":"Motoyama J, Liu J, Mo R, et al.: Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus. Nat Genet 1998, 20:54\u201357.","journal-title":"Nat Genet"},{"key":"108_CR33","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/ajmg.a.10265","volume":"120","author":"F Falco De","year":"2003","unstructured":"De Falco F, Cainarca S, Andolfi G, et al.: X-linked Opitz syndrome: novel mutations in the MID1 gene and redefinition of the clinical spectrum. Am J Med Genet A 2003, 120:222\u2013228.","journal-title":"Am J Med Genet A"},{"key":"108_CR34","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/ng1295-459","volume":"11","author":"NH Robin","year":"1995","unstructured":"Robin NH, Feldman GJ, Aronson AL, et al.: Opitz syndrome is genetically heterogeneous, with one locus on Xp22, and a second locus on 22q11.2. Nat Genet 1995, 11:459\u2013461.","journal-title":"Nat Genet"},{"key":"108_CR35","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.mrfmmm.2009.01.013","volume":"668","author":"AD Auerbach","year":"2009","unstructured":"Auerbach AD: Fanconi anemia and its diagnosis. Mutat Res 2009, 668:4\u201310.","journal-title":"Mutat Res"},{"key":"108_CR36","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/ajmg.a.30853","volume":"137","author":"L Faivre","year":"2005","unstructured":"Faivre L, Portnoi MF, Pals G, et al.: Should chromosome breakage studies be performed in patients with VACTERL association? Am J Med Genet A 2005, 137:55\u201358.","journal-title":"Am J Med Genet A"},{"key":"108_CR37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/jmg.2006.043257","volume":"44","author":"BP Alter","year":"2007","unstructured":"Alter BP, Rosenberg PS, Brody LC: Clinical and molecular features associated with biallelic mutations in FANCD1\/BRCA2. J Med Genet 2007, 44:1\u20139.","journal-title":"J Med Genet"},{"key":"108_CR38","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/ng1624","volume":"37","author":"O Levran","year":"2005","unstructured":"Levran O, Attwooll C, Henry RT, et al.: The BRCA1-interacting helicase BRIP1 is deficient in Fanconi anemia. Nat Genet 2005, 37:931\u2013933.","journal-title":"Nat Genet"},{"key":"108_CR39","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s100380050203","volume":"45","author":"T Yamada","year":"2000","unstructured":"Yamada T, Tachibana A, Shimizu T, et al.: Novel mutations of the FANCG gene causing alternative splicing in Japanese Fanconi anemia. J Hum Genet 2000, 45:159\u2013166.","journal-title":"J Hum Genet"},{"key":"108_CR40","first-page":"137","volume":"36","author":"MC Digilio","year":"1999","unstructured":"Digilio MC, Marino B, Bagolan P, et al.: Microdeletion 22q11 and oesophageal atresia. J Med Genet 1999, 36:137\u2013139.","journal-title":"J Med Genet"},{"key":"108_CR41","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/1096-8628(20010115)98:2<137::AID-AJMG1022>3.0.CO;2-5","volume":"98","author":"LE Walsh","year":"2001","unstructured":"Walsh LE, Vance GH, Weaver DD: Distal 13q Deletion Syndrome and the VACTERL association: case report, literature review, and possible implications. Am J Med Genet 2001, 98:137\u2013144.","journal-title":"Am J Med Genet"},{"key":"108_CR42","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ejmg.2006.12.004","volume":"50","author":"JF Felix","year":"2007","unstructured":"Felix JF, Tibboel D, de Klein A: Chromosomal anomalies in the aetiology of oesophageal atresia and tracheo-oesophageal fistula. Eur J Med Genet 2007, 50:163\u2013175.","journal-title":"Eur J Med Genet"},{"key":"108_CR43","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ejmg.2008.09.006","volume":"52","author":"H Puusepp","year":"2009","unstructured":"Puusepp H, Zilina O, Teek R, et al.: 5.9\u00a0Mb microdeletion in chromosome band 17q22-q23.2 associated with tracheo-esophageal fistula and conductive hearing loss. Eur J Med Genet 2009, 52:71\u201374.","journal-title":"Eur J Med Genet"},{"key":"108_CR44","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1007\/s00383-004-1287-3","volume":"20","author":"JF Felix","year":"2004","unstructured":"Felix JF, Keijzer R, van Dooren MF, et al.: Genetics and developmental biology of oesophageal atresia and tracheo-oesophageal fistula: lessons from mice relevant for paediatric surgeons. Pediatr Surg Int 2004, 20:731\u2013736.","journal-title":"Pediatr Surg Int"},{"key":"108_CR45","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1242\/dev.128.12.2397","volume":"128","author":"M Mahlapuu","year":"2001","unstructured":"Mahlapuu M, Enerback S, Carlsson P: Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations. Development 2001, 128:2397\u20132406.","journal-title":"Development"},{"key":"108_CR46","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ejmg.2009.10.001","volume":"53","author":"C Shaw-Smith","year":"2010","unstructured":"\u2022 Shaw-Smith C: Genetic factors in esophageal atresia, tracheo-esophageal fistula and the VACTERL association: roles for FOXF1 and the 16q24.1 FOX transcription factor gene cluster, and review of the literature. Eur J Med Genet 2010, 53:6\u201313. This article reviews the recent findings in patients with alveolar capillary dysplasia combined with VACTERL associated anomalies, including EA\/TEF, and a microdeletion of the FOX gene cluster on chromosome 16q24. Attention is paid to the relevant mouse models, especially those for genes in the Sonic Hedgehog pathway, in relation to this microdeletion and the etiology of VACTERL-associated anomalies and EA\/TEF","journal-title":"Eur J Med Genet"},{"key":"108_CR47","doi-asserted-by":"crossref","unstructured":"Martinez CA, Northrup H, Lin JI, et al.: Genetic association study of putative functional single nucleotide polymorphisms of genes in folate metabolism and spina bifida. Am J Obstet Gynecol 2009, 201:394 e391\u2013e311.","DOI":"10.1016\/j.ajog.2009.06.042"},{"key":"108_CR48","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1136\/jmg.2009.066027","volume":"46","author":"D Furniss","year":"2009","unstructured":"Furniss D, Kan SH, Taylor IB, et al.: Genetic screening of 202 individuals with congenital limb malformations and requiring reconstructive surgery. J Med Genet 2009, 46:730\u2013735.","journal-title":"J Med Genet"},{"key":"108_CR49","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1101\/gr.092981.109","volume":"19","author":"S Yoon","year":"2009","unstructured":"Yoon S, Xuan Z, Makarov V, et al.: Sensitive and accurate detection of copy number variants using read depth of coverage. Genome Res 2009, 19:1586\u20131592.","journal-title":"Genome Res"},{"key":"108_CR50","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1101\/gr.086983.108","volume":"19","author":"MP Schnetz","year":"2009","unstructured":"Schnetz MP, Bartels CF, Shastri K, et al.: Genomic distribution of CHD7 on chromatin tracks H3K4 methylation patterns. Genome Res 2009, 19:590\u2013601.","journal-title":"Genome Res"}],"container-title":["Current Gastroenterology Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11894-010-0108-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T15:34:49Z","timestamp":1635262489000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11894-010-0108-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4,28]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["108"],"URL":"https:\/\/doi.org\/10.1007\/s11894-010-0108-1","relation":{},"ISSN":["1522-8037","1534-312X"],"issn-type":[{"value":"1522-8037","type":"print"},{"value":"1534-312X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,4,28]]}}}