{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T13:33:20Z","timestamp":1782135200233,"version":"3.54.5"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Curr Gastroenterol Rep"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1007\/s11894-017-0545-1","type":"journal-article","created":{"date-parts":[[2017,2,2]],"date-time":"2017-02-02T07:30:03Z","timestamp":1486020603000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["The Association Between Helicobacter pylori Infection and Nonalcoholic Fatty Liver Disease"],"prefix":"10.1007","volume":"19","author":[{"given":"Derek M.","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,2,2]]},"reference":[{"issue":"9","key":"545_CR1","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1111\/j.1572-0241.1999.01360.x","volume":"94","author":"GD Eslick","year":"1999","unstructured":"Eslick GD et al. Association of Helicobacter pylori infection with gastric carcinoma: a meta-analysis. Am J Gastroenterol. 1999;94(9):2373\u20139.","journal-title":"Am J Gastroenterol"},{"key":"545_CR2","doi-asserted-by":"crossref","unstructured":"NIH Consensus Conference. Helicobacter pylori in peptic ulcer disease. NIH Consensus Development Panel on Helicobacter pylori in Peptic Ulcer Disease. JAMA 1994; 272(1):65-9","DOI":"10.1001\/jama.272.1.65"},{"issue":"11","key":"545_CR3","first-page":"1592","volume":"86","author":"GA Rocha","year":"1991","unstructured":"Rocha GA et al. Helicobacter pylori acute gastritis: histological, endoscopical, clinical, and therapeutic features. Am J Gastroenterol. 1991;86(11):1592\u20135.","journal-title":"Am J Gastroenterol"},{"issue":"8390","key":"545_CR4","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/S0140-6736(84)91816-6","volume":"1","author":"BJ Marshall","year":"1984","unstructured":"Marshall BJ, Warren JR. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet. 1984;1(8390):1311\u20135.","journal-title":"Lancet"},{"key":"545_CR5","unstructured":"Schistosomes, liver flukes and Helicobacter pylori. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Lyon, 7-14 June 1994. IARC Monogr Eval Carcinog Risks Hum 1994; 61:1-241."},{"issue":"6","key":"545_CR6","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/S0016-5085(98)70422-6","volume":"114","author":"JQ Huang","year":"1998","unstructured":"Huang JQ et al. Meta-analysis of the relationship between Helicobacter pylori seropositivity and gastric cancer. Gastroenterology. 1998;114(6):1169\u201379.","journal-title":"Gastroenterology"},{"issue":"4","key":"545_CR7","first-page":"236","volume":"91","author":"J Fashner","year":"2015","unstructured":"Fashner J, Gitu AC. Diagnosis and treatment of peptic ulcer disease and H. pylori infection. Am Fam Physician. 2015;91(4):236\u201342.","journal-title":"Am Fam Physician"},{"issue":"8","key":"545_CR8","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1111\/j.1572-0241.2007.01393.x","volume":"102","author":"WD Chey","year":"2007","unstructured":"Chey WD, Wong BC, Practice Parameters Committee of the American College of Gastroenterology. American College of Gastroenterology guideline on the management of Helicobacter pylori infection. Am J Gastroenterol. 2007;102(8):1808\u201325.","journal-title":"Am J Gastroenterol"},{"issue":"3","key":"545_CR9","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1053\/j.gastro.2014.11.039","volume":"148","author":"RJ Wong","year":"2015","unstructured":"Wong RJ et al. Nonalcoholic steatohepatitis is the second leading etiology of liver disease among adults awaiting liver transplantation in the United States. Gastroenterology. 2015;148(3):547\u201355.","journal-title":"Gastroenterology"},{"issue":"7","key":"545_CR10","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1053\/j.gastro.2012.04.001","volume":"142","author":"N Chalasani","year":"2012","unstructured":"Chalasani N et al. The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology. Gastroenterology. 2012;142(7):1592\u2013609.","journal-title":"Gastroenterology"},{"issue":"6","key":"545_CR11","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1002\/hep.20251","volume":"39","author":"JB Dixon","year":"2004","unstructured":"Dixon JB et al. Nonalcoholic fatty liver disease: improvement in liver histological analysis with weight loss. Hepatology. 2004;39(6):1647\u201354.","journal-title":"Hepatology"},{"issue":"1","key":"545_CR12","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/hep.23276","volume":"51","author":"K Promrat","year":"2010","unstructured":"Promrat K et al. Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis. Hepatology. 2010;51(1):121\u20139.","journal-title":"Hepatology"},{"issue":"1","key":"545_CR13","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jhep.2012.02.023","volume":"57","author":"SE Keating","year":"2012","unstructured":"Keating SE et al. Exercise and non-alcoholic fatty liver disease: a systematic review and meta-analysis. J Hepatol. 2012;57(1):157\u201366.","journal-title":"J Hepatol"},{"issue":"2","key":"545_CR14","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/ajg.2012.407","volume":"108","author":"A Sonnenberg","year":"2013","unstructured":"Sonnenberg A, Genta RM. Helicobacter pylori is a risk factor for colonic neoplasms. Am J Gastroenterol. 2013;108(2):208\u201315.","journal-title":"Am J Gastroenterol"},{"issue":"9","key":"545_CR15","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/s00384-008-0479-z","volume":"23","author":"YS Zhao","year":"2008","unstructured":"Zhao YS et al. Meta-analysis of different test indicators: Helicobacter pylori infection and the risk of colorectal cancer. Int J Colorectal Dis. 2008;23(9):875\u201382.","journal-title":"Int J Colorectal Dis"},{"issue":"2","key":"545_CR16","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1523-5378.2006.00381.x","volume":"11","author":"N Zumkeller","year":"2006","unstructured":"Zumkeller N et al. Helicobacter pylori infection and colorectal cancer risk: a meta-analysis. Helicobacter. 2006;11(2):75\u201380.","journal-title":"Helicobacter"},{"issue":"4","key":"545_CR17","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/nrgastro.2013.243","volume":"11","author":"F Franceschi","year":"2014","unstructured":"Franceschi F et al. Clinical effects of Helicobacter pylori outside the stomach. Nat Rev Gastroenterol Hepatol. 2014;11(4):234\u201342.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"6","key":"545_CR18","doi-asserted-by":"crossref","first-page":"850","DOI":"10.3324\/haematol.2008.005348","volume":"94","author":"DM Arnold","year":"2009","unstructured":"Arnold DM et al. Platelet count response to H. pylori treatment in patients with immune thrombocytopenic purpura with and without H. pylori infection: a systematic review. Haematologica. 2009;94(6):850\u20136.","journal-title":"Haematologica"},{"issue":"9","key":"545_CR19","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1001\/archinte.160.9.1349","volume":"160","author":"K Kaptan","year":"2000","unstructured":"Kaptan K et al. Helicobacter pylori\u2014is it a novel causative agent in vitamin B12 deficiency? Arch Intern Med. 2000;160(9):1349\u201353.","journal-title":"Arch Intern Med"},{"issue":"7","key":"545_CR20","first-page":"886","volume":"16","author":"XH Qu","year":"2010","unstructured":"Qu XH et al. Does Helicobacter pylori infection play a role in iron deficiency anemia? A meta-analysis. World J Gastroenterol. 2010;16(7):886\u201396.","journal-title":"World J Gastroenterol"},{"issue":"1","key":"545_CR21","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1097\/MEG.0b013e3282efa4f2","volume":"20","author":"M Cindoruk","year":"2008","unstructured":"Cindoruk M et al. Identification of Helicobacter species by 16S rDNA PCR and sequence analysis in human liver samples from patients with various etiologies of benign liver diseases. Eur J Gastroenterol Hepatol. 2008;20(1):33\u20136.","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"7","key":"545_CR22","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1007\/s10620-008-0522-5","volume":"54","author":"T Pirouz","year":"2009","unstructured":"Pirouz T et al. Detection of Helicobacter pylori in paraffin-embedded specimens from patients with chronic liver diseases, using the amplification method. Dig Dis Sci. 2009;54(7):1456\u20139.","journal-title":"Dig Dis Sci"},{"key":"545_CR23","doi-asserted-by":"crossref","unstructured":"\u2022 Polyzos SA et al. Helicobacter pylori infection in patients with nonalcoholic fatty liver disease. Metabolism. 2013;62(1):121\u20136. Higher rates of anti-HP IgG are present in patients with NAFLD, HP infection is an independent predictor of NALFD. and HP-positive patients have lower adiponectin rates.","DOI":"10.1016\/j.metabol.2012.06.007"},{"issue":"11","key":"545_CR24","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1038\/labinvest.2009.90","volume":"89","author":"MJ Goo","year":"2009","unstructured":"Goo MJ et al. Helicobacter pylori promotes hepatic fibrosis in the animal model. Lab Invest. 2009;89(11):1291\u2013303.","journal-title":"Lab Invest"},{"issue":"1","key":"545_CR25","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1097\/MEG.0b013e3283590c10","volume":"25","author":"Z Dogan","year":"2013","unstructured":"Dogan Z et al. Association between Helicobacter pylori and liver-to-spleen ratio: a randomized-controlled single-blind study. Eur J Gastroenterol Hepatol. 2013;25(1):107\u201310.","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"545_CR26","doi-asserted-by":"crossref","unstructured":"\u2022 Sumida Y et al. Helicobacter pylori infection might have a potential role in hepatocyte ballooning in nonalcoholic fatty liver disease. J Gastroenterol. 2015;50:996\u20131004. HP infection is an independent predictor of NASH; HP-positive patients also have a higher grade of hepatocyte ballooning.","DOI":"10.1007\/s00535-015-1039-2"},{"key":"545_CR27","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s12876-015-0247-9","volume":"15","author":"K Okushin","year":"2015","unstructured":"Okushin K et al. Helicobacter pylori infection is not associated with fatty liver disease including non-alcoholic fatty liver disease: a large-scale cross-sectional study in Japan. BMC Gastroenterol. 2015;15:25.","journal-title":"BMC Gastroenterol"},{"issue":"8","key":"545_CR28","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.3748\/wjg.v22.i8.2592","volume":"22","author":"MK Baeg","year":"2016","unstructured":"Baeg MK et al. Helicobacter pylori infection is not associated with nonalcoholic fatty liver disease. World J Gastroenterol. 2016;22(8):2592\u2013600.","journal-title":"World J Gastroenterol"},{"key":"545_CR29","doi-asserted-by":"crossref","unstructured":"\u2022 Polyzos SA et al. Effect of Helicobacter pylori eradication on hepatic steatosis, NAFLD fibrosis score and HSENSI in patients with nonalcoholic steatohepatitis: a MR imaging-based pilot open-label study. Arq Gastroenterol. 2014;51(3):261\u20138. HP eradication leads to improvement in markers of NAFLD activity and NAFLD fibrosis score.","DOI":"10.1590\/S0004-28032014000300017"},{"key":"545_CR30","doi-asserted-by":"crossref","unstructured":"\u2022 Jamali R et al. The effect of helicobacter pylori eradication on liver fat content in subjects with non-alcoholic fatty liver disease: a randomized open-label clinical trial. Hepat Mon. 2013;13(12):e14679. HP eradication leads to a substantial decrease in mean liver fat content, though this was not evaluated statistically.","DOI":"10.5812\/hepatmon.14679"},{"issue":"41","key":"545_CR31","doi-asserted-by":"crossref","first-page":"7024","DOI":"10.3748\/wjg.v19.i41.7024","volume":"19","author":"M Li","year":"2013","unstructured":"Li M, Shen Z, Li YM. Potential role of Helicobacter pylori infection in nonalcoholic fatty liver disease. World J Gastroenterol. 2013;19(41):7024\u201331.","journal-title":"World J Gastroenterol"},{"issue":"10","key":"545_CR32","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.5551\/jat.5157","volume":"17","author":"H Satoh","year":"2010","unstructured":"Satoh H et al. Helicobacter pylori infection is a significant risk for modified lipid profile in Japanese male subjects. J Atheroscler Thromb. 2010;17(10):1041\u20138.","journal-title":"J Atheroscler Thromb"},{"issue":"1","key":"545_CR33","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/nrc703","volume":"2","author":"RM Peek Jr","year":"2002","unstructured":"Peek Jr RM, Blaser MJ. Helicobacter pylori and gastrointestinal tract adenocarcinomas. Nat Rev Cancer. 2002;2(1):28\u201337.","journal-title":"Nat Rev Cancer"},{"issue":"Suppl 1","key":"545_CR34","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1523-5378.2010.00781.x","volume":"15","author":"D Basso","year":"2010","unstructured":"Basso D, Plebani M, Kusters JG. Pathogenesis of Helicobacter pylori infection. Helicobacter. 2010;15 Suppl 1:14\u201320.","journal-title":"Helicobacter"},{"issue":"1","key":"545_CR35","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/hep.20280","volume":"40","author":"JM Hui","year":"2004","unstructured":"Hui JM et al. Beyond insulin resistance in NASH: TNF-alpha or adiponectin? Hepatology. 2004;40(1):46\u201354.","journal-title":"Hepatology"},{"issue":"35","key":"545_CR36","doi-asserted-by":"crossref","first-page":"26055","DOI":"10.1016\/S0021-9258(19)74276-8","volume":"268","author":"R Feinstein","year":"1993","unstructured":"Feinstein R et al. Tumor necrosis factor-alpha suppresses insulin-induced tyrosine phosphorylation of insulin receptor and its substrates. J Biol Chem. 1993;268(35):26055\u20138.","journal-title":"J Biol Chem"},{"issue":"5091","key":"545_CR37","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1126\/science.7678183","volume":"259","author":"GS Hotamisligil","year":"1993","unstructured":"Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science. 1993;259(5091):87\u201391.","journal-title":"Science"},{"issue":"1","key":"545_CR38","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.freeradbiomed.2011.10.003","volume":"52","author":"AP Rolo","year":"2012","unstructured":"Rolo AP, Teodoro JS, Palmeira CM. Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis. Free Radic Biol Med. 2012;52(1):59\u201369.","journal-title":"Free Radic Biol Med"},{"issue":"2","key":"545_CR39","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1097\/MPG.0b013e31822578db","volume":"53","author":"SH Ibrahim","year":"2011","unstructured":"Ibrahim SH, Kohli R, Gores GJ. Mechanisms of lipotoxicity in NAFLD and clinical implications. J Pediatr Gastroenterol Nutr. 2011;53(2):131\u201340.","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"23","key":"545_CR40","first-page":"2801","volume":"17","author":"C Buechler","year":"2011","unstructured":"Buechler C, Wanninger J, Neumeier M. Adiponectin, a key adipokine in obesity related liver diseases. World J Gastroenterol. 2011;17(23):2801\u201311.","journal-title":"World J Gastroenterol"},{"issue":"8","key":"545_CR41","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1097\/MCG.0b013e31819e9048","volume":"43","author":"S Savvidou","year":"2009","unstructured":"Savvidou S et al. Low serum adiponectin levels are predictive of advanced hepatic fibrosis in patients with NAFLD. J Clin Gastroenterol. 2009;43(8):765\u201372.","journal-title":"J Clin Gastroenterol"},{"key":"545_CR42","doi-asserted-by":"crossref","unstructured":"\u2022 Ando T et al. Impact of Helicobacter pylori eradication on circulating adiponectin in humans. Helicobacter. 2013;18(2):158\u201364. HP eradication leads to increase in adiponectin levels.","DOI":"10.1111\/hel.12028"},{"issue":"5","key":"545_CR43","doi-asserted-by":"crossref","first-page":"826","DOI":"10.5114\/aoms.2012.31616","volume":"8","author":"NA Ismail","year":"2012","unstructured":"Ismail NA et al. Fetuin-A levels in obesity: differences in relation to metabolic syndrome and correlation with clinical and laboratory variables. Arch Med Sci. 2012;8(5):826\u201333.","journal-title":"Arch Med Sci"},{"issue":"17","key":"545_CR44","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.2174\/138161210791208938","volume":"16","author":"A Tonjes","year":"2010","unstructured":"Tonjes A, Bluher M, Stumvoll M. Retinol-binding protein 4 and new adipocytokines in nonalcoholic fatty liver disease. Curr Pharm Des. 2010;16(17):1921\u20138.","journal-title":"Curr Pharm Des"},{"key":"545_CR45","doi-asserted-by":"crossref","unstructured":"\u2022 Manolakis AC et al. Increased fetuin A levels in Helicobacter pylori infection: a missing link between H. pylori and insulin resistance? Diabetologia. 2011;54(2):472\u20134. Fetuin-A levels are significantly higher in HP-positive patients.","DOI":"10.1007\/s00125-010-1995-2"},{"issue":"8","key":"545_CR46","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1590\/S1807-59322010000800010","volume":"65","author":"L Kebapcilar","year":"2010","unstructured":"Kebapcilar L et al. The effect of Helicobacter pylori eradication on macrophage migration inhibitory factor, C-reactive protein and fetuin-a levels. Clinics (Sao Paulo). 2010;65(8):799\u2013802.","journal-title":"Clinics (Sao Paulo)"}],"container-title":["Current Gastroenterology Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11894-017-0545-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11894-017-0545-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11894-017-0545-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T06:45:01Z","timestamp":1658558701000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11894-017-0545-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["545"],"URL":"https:\/\/doi.org\/10.1007\/s11894-017-0545-1","relation":{},"ISSN":["1522-8037","1534-312X"],"issn-type":[{"value":"1522-8037","type":"print"},{"value":"1534-312X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2]]},"article-number":"5"}}