{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:45:55Z","timestamp":1791931555831,"version":"4.3.4"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"ERA4Health","award":["HFpEF-DIVA"],"award-info":[{"award-number":["HFpEF-DIVA"]}]},{"name":"ERA4Health","award":["ID-PRESERVED"],"award-info":[{"award-number":["ID-PRESERVED"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Curr Heart Fail Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose of Review<\/jats:title>\n                    <jats:p>This review aims to examine the role of clonal hematopoiesis of indeterminate potential (CHIP) in the pathophysiology of heart failure with preserved ejection fraction (HFpEF), focusing on its contribution to inflammation, disease development, and clinical implications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Recent Findings<\/jats:title>\n                    <jats:p>Recent studies demonstrate that CHIP is enriched in HFpEF populations and is associated with increased disease risk and worse clinical outcomes. Mechanistically, CHIP promotes inflammatory signaling through activation of pathways such as the NLRP3 inflammasome and IL-1\u03b2\/IL-6 axis. TET2 mutations, in particular, have been consistently linked to diastolic dysfunction and adverse remodeling, especially in patients with high inflammatory burden and cardiometabolic comorbidities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>CHIP represents a novel link between ageing, inflammation, and HFpEF, contributing to disease heterogeneity and progression. It may serve as a biomarker for early detection, risk stratification, and patient phenotyping, while also offering potential therapeutic targets. Future research should focus on validating these findings and integrating CHIP into precision medicine approaches for HFpEF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11897-026-00779-4","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:39:15Z","timestamp":1791920355000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clonal Hematopoiesis and Inflammatory Pathways in Heart Failure with Preserved Ejection Fraction"],"prefix":"10.1007","volume":"23","author":[{"given":"Eline","family":"Verghote","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa P. M.","family":"van Empel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5549-1298","authenticated-orcid":false,"given":"Job A. J.","family":"Verdonschot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"issue":"2","key":"779_CR1","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1056\/NEJMcp2305181","volume":"392","author":"A Cannata","year":"2025","unstructured":"Cannata A, McDonagh TA. Heart Failure with Preserved Ejection Fraction. N Engl J Med. 2025;392(2):173\u201384. https:\/\/doi.org\/10.1056\/NEJMcp2305181.","journal-title":"N Engl J Med"},{"key":"779_CR2","doi-asserted-by":"publisher","first-page":"947147","DOI":"10.3389\/fimmu.2022.947147","volume":"13","author":"C Li","year":"2022","unstructured":"Li C, Qin D, Hu J, Yang Y, Hu D, Yu B. Inflamed adipose tissue: A culprit underlying obesity and heart failure with preserved ejection fraction. Front Immunol. 2022;13:947147. https:\/\/doi.org\/10.3389\/fimmu.2022.947147.","journal-title":"Front Immunol"},{"issue":"1","key":"779_CR3","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1161\/circulationaha.116.021884","volume":"134","author":"SJ Shah","year":"2016","unstructured":"Shah SJ, Kitzman DW, Borlaug BA, van Heerebeek L, Zile MR, Kass DA, Paulus WJ. Phenotype-Specific Treatment of Heart Failure With Preserved Ejection Fraction: A Multiorgan Roadmap. Circulation. 2016;134(1):73\u201390. https:\/\/doi.org\/10.1161\/circulationaha.116.021884.","journal-title":"Circulation"},{"key":"779_CR4","doi-asserted-by":"publisher","DOI":"10.1007\/s11897-026-00745-0","author":"E Cami","year":"2026","unstructured":"Cami E, Verghote E, Pecetto E, Gonz\u00e1lez A, Brakenhielm E, Van Jones EA. Comorbidity-Driven Inflammation in HFpEF: Immune Profiling and Therapeutic Targets. Curr Heart Fail Rep. 2026. https:\/\/doi.org\/10.1007\/s11897-026-00745-0.","journal-title":"Curr Heart Fail Rep"},{"issue":"4","key":"779_CR5","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.jacc.2013.02.092","volume":"62","author":"WJ Paulus","year":"2013","unstructured":"Paulus WJ, Tsch\u00f6pe C. A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation. J Am Coll Cardiol. 2013;62(4):263\u201371. https:\/\/doi.org\/10.1016\/j.jacc.2013.02.092.","journal-title":"J Am Coll Cardiol"},{"issue":"10","key":"779_CR6","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1161\/circresaha.121.318159","volume":"128","author":"WJ Paulus","year":"2021","unstructured":"Paulus WJ, Zile MR. From Systemic Inflammation to Myocardial Fibrosis: The Heart Failure With Preserved Ejection Fraction Paradigm Revisited. Circul Res. 2021;128(10):1451\u201367. https:\/\/doi.org\/10.1161\/circresaha.121.318159.","journal-title":"Circul Res"},{"issue":"15","key":"779_CR7","doi-asserted-by":"publisher","first-page":"e030603","DOI":"10.1161\/jaha.123.030603","volume":"12","author":"MA Sikking","year":"2023","unstructured":"Sikking MA, Stroeks S, Waring OJ, Henkens M, Riksen NP, Hoischen A, et al. Clonal Hematopoiesis of Indeterminate Potential From a Heart Failure Specialist\u2019s Point of View. J Am Heart Association. 2023;12(15):e030603. https:\/\/doi.org\/10.1161\/jaha.123.030603.","journal-title":"J Am Heart Association"},{"issue":"2","key":"779_CR8","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1056\/NEJMoa1701719","volume":"377","author":"S Jaiswal","year":"2017","unstructured":"Jaiswal S, Natarajan P, Silver AJ, Gibson CJ, Bick AG, Shvartz E, et al. Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease. N Engl J Med. 2017;377(2):111\u201321. https:\/\/doi.org\/10.1056\/NEJMoa1701719.","journal-title":"N Engl J Med"},{"issue":"1","key":"779_CR9","doi-asserted-by":"publisher","first-page":"e70094","DOI":"10.1111\/imr.70094","volume":"337","author":"MA Evans","year":"2026","unstructured":"Evans MA, Walsh K. The Immunological Consequences of Clonal Hematopoiesis in Heart Failure. Immunol Rev. 2026;337(1):e70094. https:\/\/doi.org\/10.1111\/imr.70094.","journal-title":"Immunol Rev"},{"key":"779_CR10","doi-asserted-by":"publisher","first-page":"132580","DOI":"10.1016\/j.ijcard.2024.132580","volume":"417","author":"GHD Voordes","year":"2024","unstructured":"Voordes GHD, Voors AA, Hoegl A, Madsen CT, van Essen BJ, Ouwerkerk W, et al. Clinical and proteomic profiles of chronic kidney disease in heart failure with reduced and preserved ejection fraction. Int J Cardiol. 2024;417:132580. https:\/\/doi.org\/10.1016\/j.ijcard.2024.132580.","journal-title":"Int J Cardiol"},{"issue":"11","key":"779_CR11","doi-asserted-by":"publisher","first-page":"e010618","DOI":"10.1161\/circheartfailure.123.010618","volume":"16","author":"MF Ramirez","year":"2023","unstructured":"Ramirez MF, Lau ES, Parekh JK, Pan AS, Owunna N, Wang D, et al. Obesity-Related Biomarkers Are Associated With Exercise Intolerance and HFpEF. Circ Heart Fail. 2023;16(11):e010618. https:\/\/doi.org\/10.1161\/circheartfailure.123.010618.","journal-title":"Circ Heart Fail"},{"key":"779_CR12","doi-asserted-by":"publisher","unstructured":"Simmonds SJ, Cuijpers I, Heymans S, Jones EAV. Cellular and Molecular Differences between HFpEF and HFrEF: A Step Ahead in an Improved Pathological Understanding. Cells. 2020;9(1). https:\/\/doi.org\/10.3390\/cells9010242.","DOI":"10.3390\/cells9010242"},{"issue":"7","key":"779_CR13","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1161\/circulationaha.111.076075","volume":"126","author":"L van Heerebeek","year":"2012","unstructured":"van Heerebeek L, Hamdani N, Falc\u00e3o-Pires I, Leite-Moreira AF, Begieneman MP, Bronzwaer JG, et al. Low myocardial protein kinase G activity in heart failure with preserved ejection fraction. Circulation. 2012;126(7):830\u20139. https:\/\/doi.org\/10.1161\/circulationaha.111.076075.","journal-title":"Circulation"},{"issue":"14","key":"779_CR14","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1161\/circulationaha.114.013215","volume":"131","author":"MR Zile","year":"2015","unstructured":"Zile MR, Baicu CF, Ikonomidis JS, Stroud RE, Nietert PJ, Bradshaw AD, et al. Myocardial stiffness in patients with heart failure and a preserved ejection fraction: contributions of collagen and titin. Circulation. 2015;131(14):1247\u201359. https:\/\/doi.org\/10.1161\/circulationaha.114.013215.","journal-title":"Circulation"},{"issue":"11","key":"779_CR15","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1016\/j.jchf.2023.06.031","volume":"11","author":"A Alogna","year":"2023","unstructured":"Alogna A, Koepp KE, Sabbah M, Espindola Netto JM, Jensen MD, Kirkland JL, et al. Interleukin-6 in Patients With Heart Failure and Preserved Ejection Fraction. JACC Heart Fail. 2023;11(11):1549\u201361. https:\/\/doi.org\/10.1016\/j.jchf.2023.06.031.","journal-title":"JACC Heart Fail"},{"issue":"1","key":"779_CR16","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1186\/s12933-025-02734-4","volume":"24","author":"S Delalat","year":"2025","unstructured":"Delalat S, Sultana I, Osman H, Sieme M, Zhazykbayeva S, Herwig M, et al. Dysregulated inflammation, oxidative stress, and protein quality control in diabetic HFpEF: unraveling mechanisms and therapeutic targets. Cardiovasc Diabetol. 2025;24(1):211. https:\/\/doi.org\/10.1186\/s12933-025-02734-4.","journal-title":"Cardiovasc Diabetol"},{"issue":"6","key":"779_CR17","doi-asserted-by":"publisher","first-page":"3607","DOI":"10.1002\/ehf2.14959","volume":"11","author":"M Berger","year":"2024","unstructured":"Berger M, M\u00e4rz W, Niessner A, Delgado G, Kleber M, Scharnagl H, et al. IL-6 and hsCRP predict cardiovascular mortality in patients with heart failure with preserved ejection fraction. ESC Heart Fail. 2024;11(6):3607\u201315. https:\/\/doi.org\/10.1002\/ehf2.14959.","journal-title":"ESC Heart Fail"},{"issue":"11","key":"779_CR18","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1016\/j.jacc.2019.12.069","volume":"75","author":"JA Chirinos","year":"2020","unstructured":"Chirinos JA, Orlenko A, Zhao L, Basso MD, Cvijic ME, Li Z, et al. Multiple Plasma Biomarkers for Risk Stratification in Patients With Heart Failure and Preserved Ejection Fraction. J Am Coll Cardiol. 2020;75(11):1281\u201395. https:\/\/doi.org\/10.1016\/j.jacc.2019.12.069.","journal-title":"J Am Coll Cardiol"},{"key":"779_CR19","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.molimm.2022.04.003","volume":"146","author":"DN Ngwa","year":"2022","unstructured":"Ngwa DN, Pathak A, Agrawal A. IL-6 regulates induction of C-reactive protein gene expression by activating STAT3 isoforms. Mol Immunol. 2022;146:50\u20136. https:\/\/doi.org\/10.1016\/j.molimm.2022.04.003.","journal-title":"Mol Immunol"},{"issue":"8","key":"779_CR20","doi-asserted-by":"publisher","first-page":"e0201836","DOI":"10.1371\/journal.pone.0201836","volume":"13","author":"HM DuBrock","year":"2018","unstructured":"DuBrock HM, AbouEzzeddine OF, Redfield MM. High-sensitivity C-reactive protein in heart failure with preserved ejection fraction. PLoS ONE. 2018;13(8):e0201836. https:\/\/doi.org\/10.1371\/journal.pone.0201836.","journal-title":"PLoS ONE"},{"key":"779_CR21","doi-asserted-by":"publisher","first-page":"3003","DOI":"10.2147\/jir.S459989","volume":"17","author":"Z Zhao","year":"2024","unstructured":"Zhao Z, Qi D, Zhang Z, Du X, Zhang F, Ma R, et al. Prognostic Value of Inflammatory Cytokines in Predicting Hospital Readmissions in Heart Failure with Preserved Ejection Fraction. J Inflamm Res. 2024;17:3003\u201312. https:\/\/doi.org\/10.2147\/jir.S459989.","journal-title":"J Inflamm Res"},{"issue":"11","key":"779_CR22","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1161\/circresaha.123.323119","volume":"133","author":"V Agrawal","year":"2023","unstructured":"Agrawal V, Kropski JA, Gokey JJ, Kobeck E, Murphy MB, Murray KT, et al. Myeloid Cell Derived IL1\u03b2 Contributes to Pulmonary Hypertension in HFpEF. Circul Res. 2023;133(11):885\u201398. https:\/\/doi.org\/10.1161\/circresaha.123.323119.","journal-title":"Circul Res"},{"issue":"1","key":"779_CR23","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1186\/s12933-025-02772-y","volume":"24","author":"E Gorica","year":"2025","unstructured":"Gorica E, Spezzini J, Papadopoulou I, Telesca M, Masciovecchio V, Moahmmed SA, et al. Single nuclei RNA-sequencing unveils alveolar macrophages as drivers of endothelial damage in obese HFpEF-related pulmonary hypertension. Cardiovasc Diabetol. 2025;24(1):268. https:\/\/doi.org\/10.1186\/s12933-025-02772-y.","journal-title":"Cardiovasc Diabetol"},{"issue":"6","key":"779_CR24","doi-asserted-by":"publisher","first-page":"e99495","DOI":"10.1371\/journal.pone.0099495","volume":"9","author":"BN Putko","year":"2014","unstructured":"Putko BN, Wang Z, Lo J, Anderson T, Becher H, Dyck JR, et al. Circulating levels of tumor necrosis factor-alpha receptor 2 are increased in heart failure with preserved ejection fraction relative to heart failure with reduced ejection fraction: evidence for a divergence in pathophysiology. PLoS ONE. 2014;9(6):e99495. https:\/\/doi.org\/10.1371\/journal.pone.0099495.","journal-title":"PLoS ONE"},{"issue":"6","key":"779_CR25","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1007\/s10557-020-07071-0","volume":"34","author":"A Hanna","year":"2020","unstructured":"Hanna A, Frangogiannis NG. Inflammatory Cytokines and Chemokines as Therapeutic Targets in Heart Failure. Cardiovasc Drugs Ther. 2020;34(6):849\u201363. https:\/\/doi.org\/10.1007\/s10557-020-07071-0.","journal-title":"Cardiovasc Drugs Ther"},{"issue":"5","key":"779_CR26","doi-asserted-by":"publisher","first-page":"0","DOI":"10.1152\/physiol.00004.2023","volume":"38","author":"D Daou","year":"2023","unstructured":"Daou D, Gillette TG, Hill JA. Inflammatory Mechanisms in Heart Failure with Preserved Ejection Fraction. Physiol (Bethesda). 2023;38(5):0. https:\/\/doi.org\/10.1152\/physiol.00004.2023.","journal-title":"Physiol (Bethesda)"},{"issue":"6","key":"779_CR27","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1038\/s41569-023-00964-1","volume":"21","author":"TJ Guzik","year":"2024","unstructured":"Guzik TJ, Nosalski R, Maffia P, Drummond GR. Immune and inflammatory mechanisms in hypertension. Nat reviews Cardiol. 2024;21(6):396\u2013416. https:\/\/doi.org\/10.1038\/s41569-023-00964-1.","journal-title":"Nat reviews Cardiol"},{"key":"779_CR28","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.amjcard.2022.05.026","volume":"178","author":"D Chaar","year":"2022","unstructured":"Chaar D, Dumont BL, Vulesevic B, Neagoe PE, R\u00e4kel A, White M, Sirois MG. Neutrophils and Circulating Inflammatory Biomarkers in Diabetes Mellitus and Heart Failure With Preserved Ejection Fraction. Am J Cardiol. 2022;178:80\u20138. https:\/\/doi.org\/10.1016\/j.amjcard.2022.05.026.","journal-title":"Am J Cardiol"},{"issue":"9","key":"779_CR29","doi-asserted-by":"publisher","first-page":"e13453","DOI":"10.1111\/acel.13453","volume":"20","author":"T Mesquita","year":"2021","unstructured":"Mesquita T, Lin YN, Ibrahim A. Chronic low-grade inflammation in heart failure with preserved ejection fraction. Aging Cell. 2021;20(9):e13453. https:\/\/doi.org\/10.1111\/acel.13453.","journal-title":"Aging Cell"},{"issue":"15","key":"779_CR30","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1016\/j.jacc.2025.07.058","volume":"86","author":"D Ezzat","year":"2025","unstructured":"Ezzat D, Uddin MM, Xue L, Pershad Y, Zhang S, Collins JM, et al. Clonal Hematopoiesis and Cardiovascular Outcomes in Older Women. J Am Coll Cardiol. 2025;86(15):1093\u2013106. https:\/\/doi.org\/10.1016\/j.jacc.2025.07.058.","journal-title":"J Am Coll Cardiol"},{"issue":"11","key":"779_CR31","doi-asserted-by":"publisher","first-page":"e940","DOI":"10.1161\/cir.0000000000001404","volume":"153","author":"JW Rhee","year":"2026","unstructured":"Rhee JW, Bolton KL, Gupta D, Weeks LD, Bick AG, Tall AR, et al. Clonal Hematopoiesis and Its Cardiovascular Implications: A Scientific Statement From the American Heart Association. Circulation. 2026;153(11):e940\u201352. https:\/\/doi.org\/10.1161\/cir.0000000000001404.","journal-title":"Circulation"},{"key":"779_CR32","doi-asserted-by":"publisher","unstructured":"Liu W, Hardaway BD, Kim E, Pauli J, Wettich JL, Yalcinkaya M, et al. Inflammatory crosstalk impairs phagocytic receptors and aggravates atherosclerosis in clonal hematopoiesis in mice. J Clin Investig. 2024;135(1). https:\/\/doi.org\/10.1172\/jci182939.","DOI":"10.1172\/jci182939"},{"issue":"7853","key":"779_CR33","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1038\/s41586-021-03341-5","volume":"592","author":"TP Fidler","year":"2021","unstructured":"Fidler TP, Xue C, Yalcinkaya M, Hardaway B, Abramowicz S, Xiao T, et al. The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis. Nature. 2021;592(7853):296\u2013301. https:\/\/doi.org\/10.1038\/s41586-021-03341-5.","journal-title":"Nature"},{"issue":"6327","key":"779_CR34","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1126\/science.aag1381","volume":"355","author":"JJ Fuster","year":"2017","unstructured":"Fuster JJ, MacLauchlan S, Zuriaga MA, Polackal MN, Ostriker AC, Chakraborty R, et al. Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice. Sci (New York NY). 2017;355(6327):842\u20137. https:\/\/doi.org\/10.1126\/science.aag1381.","journal-title":"Sci (New York NY)"},{"issue":"8","key":"779_CR35","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1016\/j.jacc.2017.12.037","volume":"71","author":"S Sano","year":"2018","unstructured":"Sano S, Oshima K, Wang Y, MacLauchlan S, Katanasaka Y, Sano M, et al. Tet2-Mediated Clonal Hematopoiesis Accelerates Heart Failure Through a Mechanism Involving the IL-1\u03b2\/NLRP3 Inflammasome. J Am Coll Cardiol. 2018;71(8):875\u201386. https:\/\/doi.org\/10.1016\/j.jacc.2017.12.037.","journal-title":"J Am Coll Cardiol"},{"issue":"22","key":"779_CR36","doi-asserted-by":"publisher","first-page":"1622","DOI":"10.1161\/circulationaha.124.072909","volume":"151","author":"A Pandey","year":"2025","unstructured":"Pandey A, Thomas T, Ji Y, Kroger B, Carlsgaard P, Irion CI, et al. TET2-Mutant Clonal Hematopoiesis Promotes Heart Failure With Preserved Ejection Fraction. Circulation. 2025;151(22):1622\u20135. https:\/\/doi.org\/10.1161\/circulationaha.124.072909.","journal-title":"Circulation"},{"issue":"5","key":"779_CR37","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1001\/jamacardio.2022.0386","volume":"7","author":"EC Svensson","year":"2022","unstructured":"Svensson EC, Madar A, Campbell CD, He Y, Sultan M, Healey ML, et al. TET2-Driven Clonal Hematopoiesis and Response to Canakinumab: An Exploratory Analysis of the CANTOS Randomized Clinical Trial. JAMA Cardiol. 2022;7(5):521\u20138. https:\/\/doi.org\/10.1001\/jamacardio.2022.0386.","journal-title":"JAMA Cardiol"},{"issue":"43","key":"779_CR38","doi-asserted-by":"publisher","first-page":"4601","DOI":"10.1093\/eurheartj\/ehae546","volume":"45","author":"MA Zuriaga","year":"2024","unstructured":"Zuriaga MA, Yu Z, Matesanz N, Truong B, Ramos-Neble BL, Asensio-L\u00f3pez MC, et al. Colchicine prevents accelerated atherosclerosis in TET2-mutant clonal haematopoiesis. Eur Heart J. 2024;45(43):4601\u201315. https:\/\/doi.org\/10.1093\/eurheartj\/ehae546.","journal-title":"Eur Heart J"},{"issue":"26","key":"779_CR39","doi-asserted-by":"publisher","first-page":"2488","DOI":"10.1056\/NEJMoa1408617","volume":"371","author":"S Jaiswal","year":"2014","unstructured":"Jaiswal S, Fontanillas P, Flannick J, Manning A, Grauman PV, Mar BG, et al. Age-related clonal hematopoiesis associated with adverse outcomes. N Engl J Med. 2014;371(26):2488\u201398. https:\/\/doi.org\/10.1056\/NEJMoa1408617.","journal-title":"N Engl J Med"},{"issue":"45","key":"779_CR40","doi-asserted-by":"publisher","first-page":"4797","DOI":"10.1093\/eurheartj\/ehae682","volume":"45","author":"JAJ Verdonschot","year":"2024","unstructured":"Verdonschot JAJ, Fuster JJ, Walsh K, Heymans SRB. The emerging role of clonal haematopoiesis in the pathogenesis of dilated cardiomyopathy. Eur Heart J. 2024;45(45):4797\u2013807. https:\/\/doi.org\/10.1093\/eurheartj\/ehae682.","journal-title":"Eur Heart J"},{"key":"779_CR41","doi-asserted-by":"publisher","DOI":"10.1101\/2023.06.07.23291038","author":"AP Reiner","year":"2023","unstructured":"Reiner AP, Roberts MB, Honigberg MC, Kooperberg C, Desai P, Bick AG, et al. Association of Clonal Hematopoiesis of Indeterminate Potential with Incident Heart Failure with Preserved Ejection Fraction. medRxiv: preprint Serv health Sci. 2023. https:\/\/doi.org\/10.1101\/2023.06.07.23291038.","journal-title":"medRxiv: preprint Serv health Sci"},{"issue":"43","key":"779_CR42","doi-asserted-by":"publisher","first-page":"4420","DOI":"10.1093\/eurheartj\/ehab389","volume":"42","author":"C Withaar","year":"2021","unstructured":"Withaar C, Lam CSP, Schiattarella GG, de Boer RA, Meems LMG. Heart failure with preserved ejection fraction in humans and mice: embracing clinical complexity in mouse models. Eur Heart J. 2021;42(43):4420\u201330. https:\/\/doi.org\/10.1093\/eurheartj\/ehab389.","journal-title":"Eur Heart J"},{"issue":"15","key":"779_CR43","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1161\/circulationaha.123.064170","volume":"148","author":"JD Cochran","year":"2023","unstructured":"Cochran JD, Yura Y, Thel MC, Doviak H, Polizio AH, Arai Y, et al. Clonal Hematopoiesis in Clinical and Experimental Heart Failure With Preserved Ejection Fraction. Circulation. 2023;148(15):1165\u201378. https:\/\/doi.org\/10.1161\/circulationaha.123.064170.","journal-title":"Circulation"},{"issue":"1","key":"779_CR44","doi-asserted-by":"publisher","first-page":"e2353244","DOI":"10.1001\/jamanetworkopen.2023.53244","volume":"7","author":"A Schuermans","year":"2024","unstructured":"Schuermans A, Honigberg MC, Raffield LM, Yu B, Roberts MB, Kooperberg C, et al. Clonal Hematopoiesis and Incident Heart Failure With Preserved Ejection Fraction. JAMA Netw open. 2024;7(1):e2353244. https:\/\/doi.org\/10.1001\/jamanetworkopen.2023.53244.","journal-title":"JAMA Netw open"},{"issue":"1","key":"779_CR45","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1002\/ejhf.2715","volume":"25","author":"C Shi","year":"2023","unstructured":"Shi C, Aboumsallem JP, Suthahar N, de Graaf AO, Jansen JH, van Zeventer IA, et al. Clonal haematopoiesis of indeterminate potential: associations with heart failure incidence, clinical parameters and biomarkers. Eur J Heart Fail. 2023;25(1):4\u201313. https:\/\/doi.org\/10.1002\/ejhf.2715.","journal-title":"Eur J Heart Fail"},{"issue":"7","key":"779_CR46","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1042\/cs20200306","volume":"135","author":"L Mooney","year":"2021","unstructured":"Mooney L, Goodyear CS, Chandra T, Kirschner K, Copland M, Petrie MC, Lang NN. Clonal haematopoiesis of indeterminate potential: intersections between inflammation, vascular disease and heart failure. Clin Sci (Lond). 2021;135(7):991\u20131007. https:\/\/doi.org\/10.1042\/cs20200306.","journal-title":"Clin Sci (Lond)"},{"key":"779_CR47","doi-asserted-by":"publisher","first-page":"104621","DOI":"10.1016\/j.ebiom.2023.104621","volume":"92","author":"JC Andersson-Assarsson","year":"2023","unstructured":"Andersson-Assarsson JC, van Deuren RC, Kristensson FM, Steehouwer M, Sj\u00f6holm K, Svensson PA, et al. Evolution of age-related mutation-driven clonal haematopoiesis over 20 years is associated with metabolic dysfunction in obesity. EBioMedicine. 2023;92:104621. https:\/\/doi.org\/10.1016\/j.ebiom.2023.104621.","journal-title":"EBioMedicine"},{"issue":"4","key":"779_CR48","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1097\/moh.0000000000000819","volume":"31","author":"SK Pasupuleti","year":"2024","unstructured":"Pasupuleti SK, Kapur R. The impact of obesity-induced inflammation on clonal hematopoiesis. Curr Opin Hematol. 2024;31(4):193\u20138. https:\/\/doi.org\/10.1097\/moh.0000000000000819.","journal-title":"Curr Opin Hematol"},{"key":"779_CR49","doi-asserted-by":"publisher","unstructured":"Pasupuleti SK, Ramdas B, Burns SS, Palam LR, Kanumuri R, Kumar R, et al. Obesity-induced inflammation exacerbates clonal hematopoiesis. J Clin Investig. 2023;133(11). https:\/\/doi.org\/10.1172\/jci163968.","DOI":"10.1172\/jci163968"},{"issue":"3","key":"779_CR50","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1161\/circulationaha.114.010637","volume":"131","author":"SJ Shah","year":"2015","unstructured":"Shah SJ, Katz DH, Selvaraj S, Burke MA, Yancy CW, Gheorghiade M, et al. Phenomapping for novel classification of heart failure with preserved ejection fraction. Circulation. 2015;131(3):269\u201379. https:\/\/doi.org\/10.1161\/circulationaha.114.010637.","journal-title":"Circulation"},{"issue":"2","key":"779_CR51","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1161\/circulationaha.119.044362","volume":"141","author":"AG Bick","year":"2020","unstructured":"Bick AG, Pirruccello JP, Griffin GK, Gupta N, Gabriel S, Saleheen D, et al. Genetic Interleukin 6 Signaling Deficiency Attenuates Cardiovascular Risk in Clonal Hematopoiesis. Circulation. 2020;141(2):124\u201331. https:\/\/doi.org\/10.1161\/circulationaha.119.044362.","journal-title":"Circulation"},{"issue":"4","key":"779_CR52","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1161\/circulationaha.122.062126","volume":"147","author":"C Vlasschaert","year":"2023","unstructured":"Vlasschaert C, Heimlich JB, Rauh MJ, Natarajan P, Bick AG. Interleukin-6 Receptor Polymorphism Attenuates Clonal Hematopoiesis-Mediated Coronary Artery Disease Risk Among 451 180 Individuals in the UK Biobank. Circulation. 2023;147(4):358\u201360. https:\/\/doi.org\/10.1161\/circulationaha.122.062126.","journal-title":"Circulation"},{"issue":"21","key":"779_CR53","doi-asserted-by":"publisher","first-page":"1983","DOI":"10.1016\/j.jacc.2025.08.025","volume":"86","author":"N Mohammadnia","year":"2025","unstructured":"Mohammadnia N, Xue L, Vestjens LTW, Uddin MM, Niroula A, de Kleijn DPV, et al. Colchicine and Longitudinal Dynamics of Clonal Hematopoiesis: An Exploratory Substudy of the LoDoCo2 Trial. J Am Coll Cardiol. 2025;86(21):1983\u201396. https:\/\/doi.org\/10.1016\/j.jacc.2025.08.025.","journal-title":"J Am Coll Cardiol"},{"key":"779_CR54","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2025.287443","author":"M Hosseini","year":"2025","unstructured":"Hosseini M, Chan SM. Novel and emerging therapeutic strategies for clonal haematopoiesis. Haematologica. 2025. https:\/\/doi.org\/10.3324\/haematol.2025.287443.","journal-title":"Haematologica"},{"issue":"8067","key":"779_CR55","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/s41586-025-08871-w","volume":"642","author":"M Hosseini","year":"2025","unstructured":"Hosseini M, Voisin V, Chegini A, Varesi A, Cathelin S, Ayyathan DM, et al. Metformin reduces the competitive advantage of Dnmt3a(R878H) HSPCs. Nature. 2025;642(8067):421\u201330. https:\/\/doi.org\/10.1038\/s41586-025-08871-w.","journal-title":"Nature"},{"key":"779_CR56","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2026.3593","author":"N Chiu","year":"2026","unstructured":"Chiu N, Oren O, Small AM, Weeks LD, Marston NA, Honigberg MC, Libby P. Designing Cardiovascular Outcomes Trials in Clonal Hematopoiesis of Indeterminate Potential. JAMA Cardiol. 2026. https:\/\/doi.org\/10.1001\/jamacardio.2026.3593.","journal-title":"JAMA Cardiol"}],"container-title":["Current Heart Failure Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11897-026-00779-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11897-026-00779-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11897-026-00779-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:02:07Z","timestamp":1791928927000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11897-026-00779-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,13]]},"references-count":56,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["779"],"URL":"https:\/\/doi.org\/10.1007\/s11897-026-00779-4","relation":{},"ISSN":["1546-9549"],"issn-type":[{"value":"1546-9549","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,13]]},"assertion":[{"value":"8 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing Interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None of the authors declare a conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"47"}}