{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:17:18Z","timestamp":1789726638610,"version":"4.0.1"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2013,7,27]],"date-time":"2013-07-27T00:00:00Z","timestamp":1374883200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Curr Hematol Malig Rep"],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1007\/s11899-013-0165-2","type":"journal-article","created":{"date-parts":[[2013,7,26]],"date-time":"2013-07-26T12:26:42Z","timestamp":1374841602000},"page":"163-172","source":"Crossref","is-referenced-by-count":28,"title":["T-Cell Receptor Signaling in Peripheral T-Cell Lymphoma \u2013 A Review of Patterns of Alterations in a Central Growth Regulatory Pathway"],"prefix":"10.1007","volume":"8","author":[{"given":"Kathrin","family":"Warner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Weit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliano","family":"Crispatzu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Admirand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Herling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,7,27]]},"reference":[{"key":"165_CR1","volume-title":"WHO classification of tumours of haematopoietic and lymphoid tissue","author":"SH Swerdlow","year":"2008","unstructured":"Swerdlow SH, Campo E, Harris NL, et al. WHO classification of tumours of haematopoietic and lymphoid tissue. Lyon: IARC; 2008."},{"issue":"25","key":"165_CR2","doi-asserted-by":"crossref","first-page":"4124","DOI":"10.1200\/JCO.2008.16.4558","volume":"26","author":"J Vose","year":"2008","unstructured":"Vose J, Armitage J, Weisenburger D. International peripheral T-cell and natural killer\/T-cell lymphoma study: pathology findings and clinical outcomes. J Clin Oncol. 2008;26(25):4124\u201330.","journal-title":"J Clin Oncol"},{"issue":"10","key":"165_CR3","doi-asserted-by":"crossref","first-page":"3448","DOI":"10.1172\/JCI61205","volume":"122","author":"SA Pileri","year":"2012","unstructured":"\u2022 Pileri SA, Piccaluga PP. New molecular insights into peripheral T cell lymphomas. J Clin Invest. 2012;122(10):3448\u201355. This is an up-to-date review by experts from the European T-Cell Lymphoma Study Group on our current concepts of the molecular pathogenesis and histogenesis of major subsets of nodal peripheral T-cell lymphomas.","journal-title":"J Clin Invest"},{"key":"165_CR4","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1146\/annurev.immunol.021908.132706","volume":"27","author":"J Smith-Garvin","year":"2009","unstructured":"Smith-Garvin J, Koretzky G, Jordan M. T cell activation. Annu Rev Immunol. 2009;27:591\u2013619.","journal-title":"Annu Rev Immunol."},{"issue":"9","key":"165_CR5","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/nri2397","volume":"8","author":"O Acuto","year":"2008","unstructured":"Acuto O, Di Bartolo V, Michel F. Tailoring T-cell receptor signals by proximal negative feedback mechanisms. Nat Rev Immunol. 2008;8(9):699\u2013712.","journal-title":"Nat Rev Immunol"},{"issue":"17","key":"165_CR6","doi-asserted-by":"crossref","first-page":"4644","DOI":"10.1093\/emboj\/19.17.4644","volume":"19","author":"M Baker","year":"2000","unstructured":"Baker M, Gamble J, Tooze R, et al. Development of T-leukaemias in CD45 tyrosine phosphatase-deficient mutant lck mice. EMBO J. 2000;19(17):4644\u201354.","journal-title":"EMBO J"},{"issue":"5","key":"165_CR7","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.smim.2010.04.010","volume":"22","author":"T Nakayama","year":"2010","unstructured":"Nakayama T, Yamashita M. The TCR-mediated signaling pathways that control the direction of helper T cell differentiation. Semin Immunol. 2010;22(5):303\u20139.","journal-title":"Semin Immunol"},{"issue":"2","key":"165_CR8","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1182\/blood.V96.2.685","volume":"96","author":"D Jones","year":"2000","unstructured":"Jones D, O\u2019Hara C, Kraus MD, et al. Expression pattern of T-cell-associated chemokine receptors and their chemokines correlates with specific subtypes of T-cell non-Hodgkin lymphoma. Blood. 2000;96(2):685\u201390.","journal-title":"Blood"},{"issue":"5","key":"165_CR9","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.immuni.2009.05.001","volume":"30","author":"L Zhou","year":"2009","unstructured":"Zhou L, Chong MMW, Littman DR. Plasticity of CD4+ T cell lineage differentiation. Immunity. 2009;30(5):646\u201355.","journal-title":"Immunity"},{"issue":"4","key":"165_CR10","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.jaci.2009.02.011","volume":"123","author":"S L\u00e9tourneau","year":"2009","unstructured":"L\u00e9tourneau S, Krieg C, Pantaleo G, Boyman O. IL-2- and CD25-dependent immunoregulatory mechanisms in the homeostasis of T-cell subsets. J Allergy Clin Immunol. 2009;123(4):758\u201362.","journal-title":"J Allergy Clin Immunol"},{"issue":"8","key":"165_CR11","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1002\/eji.200939444","volume":"39","author":"O Boyman","year":"2009","unstructured":"Boyman O, L\u00e9tourneau S, Krieg C, Sprent J. Homeostatic proliferation and survival of na\u00efve and memory T cells. Eur J Immunol. 2009;39(8):2088\u201394.","journal-title":"Eur J Immunol"},{"issue":"6","key":"165_CR12","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.immuni.2008.11.002","volume":"29","author":"CD Surh","year":"2008","unstructured":"Surh CD, Sprent J. Homeostasis of naive and memory T cells. Immunity. 2008;29(6):848\u201362.","journal-title":"Immunity"},{"issue":"7","key":"165_CR13","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/nri2115","volume":"7","author":"PH Krammer","year":"2007","unstructured":"Krammer PH, Arnold R, Lavrik IN. Life and death in peripheral T cells. Nat Rev Immunol. 2007;7(7):532\u201342.","journal-title":"Nat Rev Immunol"},{"issue":"2","key":"165_CR14","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1007\/s12185-010-0758-7","volume":"93","author":"J An","year":"2011","unstructured":"An J, Fujiwara H, Suemori K, et al. Activation of T-cell receptor signaling in peripheral T-cell lymphoma cells plays an important role in the development of lymphoma-associated hemophagocytosis. Int J Hematol. 2011;93(2):176\u201385.","journal-title":"Int J Hematol"},{"issue":"3","key":"165_CR15","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.autrev.2008.07.042","volume":"8","author":"JC Crisp\u00edn","year":"2009","unstructured":"Crisp\u00edn JC, Tsokos GC. Transcriptional regulation of IL-2 in health and autoimmunity. Autoimmun Rev. 2009;8(3):190\u20135.","journal-title":"Autoimmun Rev"},{"key":"165_CR16","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/978-3-642-59410-6_32","volume":"160","author":"G Burg","year":"2002","unstructured":"Burg G, Kempf W, Haeffner A, et al. From inflammation to neoplasia: new concepts in the pathogenesis of cutaneous lymphomas. Recent Results Cancer Res. 2002;160:271\u201380.","journal-title":"Recent Results Cancer Res."},{"issue":"3","key":"165_CR17","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/nri1310","volume":"4","author":"TS Kupper","year":"2004","unstructured":"Kupper TS, Fuhlbrigge RC. Immune surveillance in the skin: mechanisms and clinical consequences. Nat Rev Immunol. 2004;4(3):211\u201322.","journal-title":"Nat Rev Immunol"},{"issue":"8","key":"165_CR18","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1038\/sj.jid.5700304","volume":"126","author":"SM Morgan","year":"2006","unstructured":"Morgan SM, Hodges E, Mitchell TJ, et al. Molecular analysis of T-cell receptor \u03b2 genes in cutaneous T-cell lymphoma reveals J\u03b21 bias. J Invest Dermatol. 2006;126(8):1893\u20139.","journal-title":"J Invest Dermatol"},{"issue":"16","key":"165_CR19","doi-asserted-by":"crossref","first-page":"4812","DOI":"10.1158\/1078-0432.CCR-06-0532","volume":"12","author":"S Hahtola","year":"2006","unstructured":"Hahtola S, Tuomela S, Elo L, et al. Th1 response and cytotoxicity genes are down-regulated in cutaneous T-cell lymphoma. Clin Cancer Res. 2006;12(16):4812\u201321.","journal-title":"Clin Cancer Res"},{"issue":"5\u20136","key":"165_CR20","doi-asserted-by":"crossref","first-page":"515","DOI":"10.3109\/10428199809058359","volume":"28","author":"R Dummer","year":"1998","unstructured":"Dummer R, Geertsen R, Ludwig E, Niederer E, Burg G. S\u00e9zary syndrome, T-helper 2 cytokines and accessory factor-1 (AF-1). Leuk Lymphoma. 1998;28(5\u20136):515\u201322.","journal-title":"Leuk Lymphoma"},{"issue":"4","key":"165_CR21","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1046\/j.1365-2133.2003.05224.x","volume":"148","author":"E Papadavid","year":"2003","unstructured":"Papadavid E, Economidou J, Psarra A, et al. The relevance of peripheral blood T-helper 1 and 2 cytokine pattern in the evaluation of patients with mycosis fungoides and S\u00e9zary syndrome. Br J Dermatol. 2003;148(4):709\u201318.","journal-title":"Br J Dermatol"},{"key":"165_CR22","volume-title":"T-cell lymphomas","author":"F Abdulla","year":"2013","unstructured":"Abdulla F, Duvic M, Kim Y. T-cell lymphomas. Totowa, NJ: Humana Press; 2013."},{"issue":"12","key":"165_CR23","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1038\/sj.leu.2403960","volume":"19","author":"B Mart\u00ednez-Delgado","year":"2005","unstructured":"Mart\u00ednez-Delgado B, Cuadros M, Honrado E, et al. Differential expression of NF-\u03baB pathway genes among peripheral T-cell lymphomas. Leukemia. 2005;19(12):2254\u201363.","journal-title":"Leukemia"},{"issue":"8","key":"165_CR24","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1182\/blood-2004-10-4045","volume":"106","author":"MW Wlodarski","year":"2005","unstructured":"Wlodarski MW, O\u2019Keefe C, Howe EC, et al. Pathologic clonal cytotoxic T-cell responses: nonrandom nature of the T-cell-receptor restriction in large granular lymphocyte leukemia. Blood. 2005;106(8):2769\u201380.","journal-title":"Blood"},{"issue":"11","key":"165_CR25","doi-asserted-by":"crossref","first-page":"4890","DOI":"10.1182\/blood-2006-05-022277","volume":"109","author":"P Garrido","year":"2007","unstructured":"Garrido P, Ruiz-Cabello F, B\u00e1rcena P, et al. Monoclonal TCR-V\u03b213.1+\/CD4+\/NKa+\/CD8-\/+dim T-LGL lymphocytosis: evidence for an antigen-driven chronic T-cell stimulation origin. Blood. 2007;109(11):4890\u20138.","journal-title":"Blood"},{"issue":"5","key":"165_CR26","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1016\/S0002-9440(10)63032-5","volume":"159","author":"M Lima","year":"2001","unstructured":"Lima M, Almeida J, Santos AH, et al. Immunophenotypic analysis of the TCR-v\u03b2 repertoire in 98 persistent expansions of CD3+\/TCR-\u03b1\u03b2\u2009+\u2009large granular lymphocytes. Am J Pathol. 2001;159(5):1861\u20138.","journal-title":"Am J Pathol"},{"issue":"3","key":"165_CR27","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/sj.leu.2404112","volume":"20","author":"Y Sandberg","year":"2006","unstructured":"Sandberg Y, Almeida J, Gonzalez M, et al. TCR\u03b3\/\u03b4\u2009+\u2009large granular lymphocyte leukemias reflect the spectrum of normal antigen-selected TCR\u03b3\/\u03b4\u2009+\u2009T-cells. Leukemia. 2006;20(3):505\u201313.","journal-title":"Leukemia"},{"issue":"3","key":"165_CR28","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.4049\/jimmunol.172.3.1960","volume":"172","author":"CL O\u2019Keefe","year":"2004","unstructured":"O\u2019Keefe CL, Plasilova M, Wlodarski M, et al. Molecular analysis of TCR clonotypes in LGL: a clonal model for polyclonal responses. J Immunol. 2004;172(3):1960\u20139.","journal-title":"J Immunol"},{"key":"165_CR29","unstructured":"Sandberg Y. Basic and clinical aspects of the T-cell receptor in mature T-cell malignancies. Ph.D. Thesis. Erasmus University Rotterdam; 2007. p. 221."},{"issue":"16","key":"165_CR30","doi-asserted-by":"crossref","first-page":"4384","DOI":"10.1182\/blood-2011-02-338517","volume":"118","author":"MJ Clemente","year":"2011","unstructured":"\u2022\u2022 Clemente MJ, Wlodarski MW, Makishima H, et al. Clonal drift demonstrates unexpected dynamics of the T-cell repertoire in T-large granular lymphocyte leukemia. Blood. 2011;118(16):4384\u201393. This paper instructively shows for T-LGL what many researchers in the field of mature T-cell lymphomas have been observing, namely a marked clonal dynamics of retraction and expansion of various TCR-defined clones within one tumor. It also contributes particularly to our understanding of T-LGL representing a spectrum of gradual overlap between reactive lesions and overt malignant neoplasms.","journal-title":"Blood"},{"issue":"1","key":"165_CR31","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1182\/blood.V85.1.146.bloodjournal851146","volume":"85","author":"MP Davey","year":"1995","unstructured":"Davey MP, Starkebaum G, Loughran TP. CD3+ leukemic large granular lymphocytes utilize diverse T-cell receptor V\u03b2 genes. Blood. 1995;85(1):146\u201350.","journal-title":"Blood"},{"issue":"2","key":"165_CR32","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1046\/j.1365-2141.1998.00691.x","volume":"101","author":"TP Loughran","year":"1998","unstructured":"Loughran TP, Hadlock KG, Perzova R, et al. Epitope mapping of HTLV envelope seroreactivity in LGL leukaemia. Br J Haematol. 1998;101(2):318\u201324.","journal-title":"Br J Haematol"},{"issue":"12","key":"165_CR33","doi-asserted-by":"crossref","first-page":"4059","DOI":"10.1182\/blood-2003-04-1044","volume":"102","author":"N Yawalkar","year":"2003","unstructured":"Yawalkar N, Ferenczi K, Jones DA, et al. Profound loss of T-cell receptor repertoire complexity in cutaneous T-cell lymphoma. Blood. 2003;102(12):4059\u201366.","journal-title":"Blood"},{"issue":"1","key":"165_CR34","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1182\/blood.V89.1.32","volume":"89","author":"CM Jackow","year":"1997","unstructured":"Jackow CM, Cather JC, Hearne V, et al. Association of erythrodermic cutaneous T-cell lymphoma, superantigen-positive Staphylococcus aureus, and oligoclonal T-cell receptor V\u03b2 gene expansion. Blood. 1997;89(1):32\u201340.","journal-title":"Blood"},{"key":"165_CR35","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1749-6632.2001.tb03712.x","volume":"941","author":"JT Abrams","year":"2001","unstructured":"Abrams JT, Balin BJ, Vonderheid EC. Association between S\u00e9zary T cell-activating factor, Chlamydia pneumoniae, and cutaneous T cell lymphoma. Ann N Y Acad Sci. 2001;941:69\u201385.","journal-title":"Ann N Y Acad Sci."},{"issue":"6","key":"165_CR36","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1078\/0344-0338-00271","volume":"198","author":"F Tissier","year":"2002","unstructured":"Tissier F, Martinon F, Camilleri-Bro\u00ebt S, et al. T-cell receptor V\u03b2 repertoire in nodal non-anaplastic peripheral T-cell lymphomas. Pathol Res Pract. 2002;198(6):389\u201395.","journal-title":"Pathol Res Pract"},{"issue":"2","key":"165_CR37","first-page":"295","volume":"8","author":"E Hodges","year":"1994","unstructured":"Hodges E, Edwards SE, Howell WM, Smith JL. Polymerase chain reaction amplification analyses of clonality in T-cell malignancy including peripheral T-cell lymphoma. Leukemia. 1994;8(2):295\u20138.","journal-title":"Leukemia"},{"issue":"6","key":"165_CR38","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1309\/AJCPV2D1DDSGJDBW","volume":"135","author":"P Tembhare","year":"2011","unstructured":"Tembhare P, Yuan CM, Xi L, et al. Flow cytometric immunophenotypic assessment of T-cell clonality by V\u03b2 repertoire analysis. Am J Clin Pathol. 2011;135(6):890\u2013900.","journal-title":"Am J Clin Pathol"},{"issue":"12","key":"165_CR39","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1038\/leu.2012.142","volume":"26","author":"S Newrzela","year":"2012","unstructured":"\u2022\u2022 Newrzela S, Al-Ghaili N, Heinrich T, et al. T-cell receptor diversity prevents T-cell lymphoma development. Leukemia. 2012;26(12):2499\u2013507. Mature T cells have been considered to be largely resistant to (experimental) transformation by most known T-cell oncogenes. However, these researchers present data that indicate that in a background of clonal T-cell restriction, as for example observed during senescence or in lymphopenia, the outgrowth of mature T-cell lymphomas is facilitated. This supports a model in which homeostatic mechanisms that stabilize the diversity of the normal T-cell repertoire, e.g. clonal competition, also control the emergence of potentially malignant T-cell clones.","journal-title":"Leukemia"},{"issue":"10","key":"165_CR40","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.3324\/haematol.2009.021428","volume":"95","author":"E Geissinger","year":"2010","unstructured":"\u2022 Geissinger E, Sadler P, Roth S, et al. Disturbed expression of the T-cell receptor\/CD3 complex and associated signaling molecules in CD30+ T-cell lymphoproliferations. Haematologica. 2010;95(10):1697\u2013704. This study shows that severely altered expression of the TCR\/CD3 complex, of TCR-associated transcription factors, and of signal transduction molecules is common and a shared characteristic in CD30 + T-cell lymphomas. This distinguishes these tumors from other subsets, e.g. PTCL-nos, and supports the TCR-based concept of a functional categorization of mature T-cell tumors outlined here.","journal-title":"Haematologica"},{"key":"165_CR41","doi-asserted-by":"crossref","first-page":"220A","DOI":"10.1038\/sj.modpathol.3800915","volume":"18","author":"J Admirand","year":"2005","unstructured":"Admirand J, Herling M, Patel K, et al. T-cell receptor signaling and growth pathways in T-cell tumors. Mod Pathol. 2005;18:220A.","journal-title":"Mod Pathol."},{"issue":"1","key":"165_CR42","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1182\/blood-2007-07-101519","volume":"111","author":"M Herling","year":"2008","unstructured":"Herling M, Patel KA, Teitell MA, et al. High TCL1 expression and intact T-cell receptor signaling define a hyperproliferative subset of T-cell prolymphocytic leukemia. Blood. 2008;111(1):328\u201337.","journal-title":"Blood"},{"issue":"2","key":"165_CR43","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1182\/blood-2004-01-0002","volume":"104","author":"M Herling","year":"2004","unstructured":"Herling M, Khoury JD, Washington LT, et al. A systematic approach to diagnosis of mature T-cell leukemias reveals heterogeneity among WHO categories. Blood. 2004;104(2):328\u201335.","journal-title":"Blood"},{"issue":"2","key":"165_CR44","doi-asserted-by":"crossref","first-page":"864","DOI":"10.4049\/jimmunol.175.2.864","volume":"175","author":"KK Hoyer","year":"2005","unstructured":"Hoyer KK, Herling M, Bagrintseva K, et al. T cell leukemia-1 modulates TCR signal strength and IFN-\u03b3 levels through phosphatidylinositol 3-kinase and protein kinase c pathway activation. J Immunol. 2005;175(2):864\u201373.","journal-title":"J Immunol"},{"issue":"21","key":"165_CR45","doi-asserted-by":"crossref","first-page":"4675","DOI":"10.1182\/blood-2009-03-208256","volume":"114","author":"M Herling","year":"2009","unstructured":"Herling M, Patel KA, Weit N, et al. High TCL1 levels are a marker of B-cell receptor pathway responsiveness and adverse outcome in chronic lymphocytic leukemia. Blood. 2009;114(21):4675\u201386.","journal-title":"Blood"},{"issue":"2","key":"165_CR46","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/sj.leu.2404045","volume":"20","author":"B Streubel","year":"2006","unstructured":"Streubel B, Vinatzer U, Willheim M, Raderer M, Chott A. Novel t(5;9)(q33;q22) fuses ITK to SYK in unspecified peripheral T-cell lymphoma. Leukemia. 2006;20(2):313\u20138.","journal-title":"Leukemia"},{"issue":"6","key":"165_CR47","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1038\/leu.2008.77","volume":"22","author":"AL Feldman","year":"2008","unstructured":"Feldman AL, Sun DX, Law ME, et al. Overexpression of SYK tyrosine kinase in peripheral T-cell lymphomas. Leukemia. 2008;22(6):1139\u201343.","journal-title":"Leukemia"},{"issue":"24","key":"165_CR48","doi-asserted-by":"crossref","first-page":"5795","DOI":"10.1182\/blood-2011-12-396150","volume":"119","author":"M Travert","year":"2012","unstructured":"Travert M, Huang Y, De Leval L, et al. Molecular features of hepatosplenic T-cell lymphoma unravels potential novel therapeutic targets. Blood. 2012;119(24):5795\u2013806.","journal-title":"Blood"},{"issue":"12","key":"165_CR49","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1258\/ebm.2010.010056","volume":"235","author":"S Ortiz","year":"2010","unstructured":"Ortiz S, Lee W, Smith D, et al. Comparative analyses of differentially induced T-cell receptor-mediated phosphorylation pathways in T lymphoma cells. Exp Biol Med (Maywood). 2010;235(12):1450\u201363.","journal-title":"Exp Biol Med (Maywood)."},{"issue":"5","key":"165_CR50","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1084\/jem.20092042","volume":"207","author":"K Pechloff","year":"2010","unstructured":"\u2022 Pechloff K, Holch J, Ferch U, et al. The fusion kinase ITK-SYK mimics a T-cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T-cell lymphoma. J Exp Med. 2010;207(5):1031\u201344. In the context of the recurrence of the t(5;9)(q33;q22) in a subset of PTCL-nos and the frequently high levels of SYK across many mature T-cell tumors, these authors provide experimental evidence of the transforming capacity of the ITK-SYK fusion tyrosine kinase in peripheral T-cells. Their work supports our TCR-based model by showing that constitutive TCR signaling is a strong oncogenic force.","journal-title":"J Exp Med"},{"issue":"15","key":"165_CR51","doi-asserted-by":"crossref","first-page":"6193","DOI":"10.1158\/0008-5472.CAN-08-3719","volume":"70","author":"C Dierks","year":"2010","unstructured":"Dierks C, Adrian F, Fisch P, et al. The ITK-SYK fusion oncogene induces a T-cell lymphoproliferative disease in mice mimicking human disease. Cancer Res. 2010;70(15):6193\u2013204.","journal-title":"Cancer Res"},{"issue":"7","key":"165_CR52","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1182\/blood-2007-04-060715","volume":"110","author":"HM Amin","year":"2007","unstructured":"Amin HM, Lai R. Pathobiology of ALK\u2009+\u2009anaplastic large-cell lymphoma. Blood. 2007;110(7):2259\u201367.","journal-title":"Blood"},{"issue":"5","key":"165_CR53","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/ajh.23144","volume":"87","author":"JO Armitage","year":"2012","unstructured":"Armitage JO. The aggressive peripheral T-cell lymphomas: 2012 update on diagnosis, risk stratification, and management. Am J Hematol. 2012;87(5):511\u20139.","journal-title":"Am J Hematol"},{"issue":"51","key":"165_CR54","doi-asserted-by":"crossref","first-page":"53407","DOI":"10.1074\/jbc.M403775200","volume":"279","author":"M Hiromura","year":"2004","unstructured":"Hiromura M, Okada F, Obata T, et al. Inhibition of AKT kinase activity by a peptide spanning the \u03b2A strand of the proto-oncogene TCL1. J Biol Chem. 2004;279(51):53407\u201318.","journal-title":"J Biol Chem"},{"key":"165_CR55","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1749-6632.2001.tb03715.x","volume":"941","author":"CL Berger","year":"2001","unstructured":"Berger CL, Longley J, Hanlon D, Girardi M, Edelson R. The clonotypic T-cell receptor is a source of tumor-associated antigens in cutaneous T cell lymphoma. Ann N Y Acad Sci. 2001;941:106\u201322.","journal-title":"Ann N Y Acad Sci."}],"container-title":["Current Hematologic Malignancy Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11899-013-0165-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11899-013-0165-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11899-013-0165-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T20:01:12Z","timestamp":1596225672000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11899-013-0165-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,27]]},"references-count":55,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["165"],"URL":"https:\/\/doi.org\/10.1007\/s11899-013-0165-2","relation":{},"ISSN":["1558-8211","1558-822X"],"issn-type":[{"value":"1558-8211","type":"print"},{"value":"1558-822X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,27]]}}}