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R-methadone AUC decreased only slightly (19%), and no opioid withdrawal or excess was observed.","journal-title":"Addict Biol"},{"key":"48_CR36","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1592\/phco.28.7.863","volume":"28","author":"YJ Cao","year":"2008","unstructured":"\u2022 Cao YJ, Smith PF, Wire MB, et al.: Pharmacokinetics and pharmacodynamics of methadone enantiomers after coadministration with fosamprenavir-ritonavir in opioid-dependent subjects. Pharmacotherapy 2008, 28:863\u2013874. Twenty-six HIV-negative methadone maintenance patients received fosamprenavir-ritonavir for 14 days. 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