{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T09:12:08Z","timestamp":1791882728733,"version":"4.3.4"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T00:00:00Z","timestamp":1659052800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T00:00:00Z","timestamp":1659052800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Curr HIV\/AIDS Rep"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose of Review<\/jats:title>\n                    <jats:p>HIV self-testing (HIVST) has the potential to expand access to and uptake of HIV pre-exposure prophylaxis (PrEP) delivery. We conducted a systematic literature review to understand the evidence on HIVST use for PrEP delivery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Recent Findings<\/jats:title>\n                    <jats:p>After screening 1055 records, we included eight: three randomized trials and five values and preferences studies. None measured PrEP initiation. Most studies occurred in Sub-Saharan Africa (7\/8) and included different populations. One trial found that HIVST use between quarterly clinic visits as part of an adherence package with biofeedback slightly increased adherence; the other two trials found that HIVST use between or in lieu of quarterly clinic visits had no significant or non-inferior effects on adherence. HIVST to support PrEP delivery was acceptable, feasible, and preferred.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>HIVST use for PrEP continuation largely resulted in similar outcomes to standard-of-care delivery and was perceived acceptable and feasible. Further research is needed to optimize HIVST use within PrEP programming.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11904-022-00617-x","type":"journal-article","created":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T06:20:22Z","timestamp":1659075622000},"page":"394-408","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Examining the Use of HIV Self-Testing to Support PrEP Delivery: a Systematic Literature Review"],"prefix":"10.1007","volume":"19","author":[{"given":"Catherine","family":"Kiptinness","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra P.","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana M.","family":"Reedy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl C.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Ngure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjuli D.","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina F.","family":"Ortblad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,29]]},"reference":[{"key":"617_CR1","unstructured":"World Health Organization. Policy brief: pre-exposure prophylaxis (PrEP): WHO expands recommendation on oral pre-exposure prophylaxis of HIV infection (PrEP). 2015. https:\/\/apps.who.int\/iris\/handle\/10665\/197906. Accessed 1 Nov 2021."},{"issue":"5","key":"617_CR2","doi-asserted-by":"publisher","first-page":"1778","DOI":"10.1007\/s12325-020-01295-0","volume":"37","author":"KH Mayer","year":"2020","unstructured":"Mayer KH, Agwu A, Malebranche D. Barriers to the wider use of pre-exposure prophylaxis in the United States: a narrative review. Adv Ther. 2020;37(5):1778\u2013811.","journal-title":"Adv Ther"},{"issue":"4","key":"617_CR3","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1007\/s10508-020-01880-y","volume":"50","author":"R Muhumuza","year":"2021","unstructured":"Muhumuza R, Ssemata AS, Kakande A, Ahmed N, Atujuna M, Nomvuyo M, et al. Exploring perceived barriers and facilitators of PrEP uptake among young people in Uganda, Zimbabwe, and South Africa. Arch Sex Behav. 2021;50(4):1729\u201342.","journal-title":"Arch Sex Behav"},{"issue":"1","key":"617_CR4","doi-asserted-by":"publisher","first-page":"21134","DOI":"10.7448\/IAS.19.1.21134","volume":"19","author":"RC Patel","year":"2016","unstructured":"Patel RC, Stanford-Moore G, Odoyo J, Pyra M, Wakhungu I, Anand K, et al. \"Since both of us are using antiretrovirals, we have been supportive to each other\": facilitators and barriers of pre-exposure prophylaxis use in heterosexual HIV serodiscordant couples in Kisumu, Kenya. J Int AIDS Soc. 2016;19(1):21134.","journal-title":"J Int AIDS Soc"},{"key":"617_CR5","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1186\/1472-6963-14-231","volume":"14","author":"N Mack","year":"2014","unstructured":"Mack N, Odhiambo J, Wong CM, Agot K. Barriers and facilitators to pre-exposure prophylaxis (PrEP) eligibility screening and ongoing HIV testing among target populations in Bondo and Rarieda, Kenya: results of a consultation with community stakeholders. BMC Health Serv Res. 2014;14:231.","journal-title":"BMC Health Serv Res"},{"issue":"1","key":"617_CR6","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1186\/s12913-020-05898-9","volume":"20","author":"KF Ortblad","year":"2020","unstructured":"Ortblad KF, Mogere P, Roche S, Kamolloh K, Odoyo J, Irungu E, et al. Design of a care pathway for pharmacy-based PrEP delivery in Kenya: results from a collaborative stakeholder consultation. BMC Health Serv Res. 2020;20(1):1034. Accesed 1 Nov 2021.","journal-title":"BMC Health Serv Res"},{"key":"617_CR7","unstructured":"World Health Organization. Guidelines on HIV self-testing and partner notification: supplement to consolidated guidelines on HIV testing services. (2016). https:\/\/apps.who.int\/iris\/handle\/10665\/251655."},{"key":"617_CR8","unstructured":"World Health Organization. What\u2019s the 2+1+1? Event-driven oral pre-exposure prophylaxis to prevent HIV for men who have sex with men: update to WHO\u2019s recommendation on oral PrEP. Geneva; 2019 (WHO\/CDS\/HIV\/19.8). Licence: CC BY-NC-SA 3.0 IGO. Accessed 1 Nov 2021."},{"key":"617_CR9","unstructured":"World Health Organization. Coronavirus disease (COVID-19) technical guidance: maintaining essential health services and systems. https:\/\/www.who.int\/emergencies\/diseases\/novel-coronavirus-2019\/technical-guidance\/maintaining-essential-health-services-and-systems. Accessed 1 Nov 2021."},{"issue":"10","key":"617_CR10","doi-asserted-by":"publisher","first-page":"e25827","DOI":"10.1002\/jia2.25827","volume":"24","author":"JB Reed","year":"2021","unstructured":"Reed JB, Shrestha P, Were D, Chakare T, Mutegi J, Wakhutu B, et al. HIV PrEP is more than ART-lite: longitudinal study of real-world PrEP services data identifies missing measures meaningful to HIV prevention programming. J Int AIDS Soc. 2021;24(10):e25827.","journal-title":"J Int AIDS Soc"},{"key":"617_CR11","volume-title":"Consolidated guidelines on HIV prevention, testing, treatment, service delivery and monitoring: recommendations for a public health approach","author":"World Helath Organization","year":"2021","unstructured":"World Helath Organization. Consolidated guidelines on HIV prevention, testing, treatment, service delivery and monitoring: recommendations for a public health approach. Geneva: Licence: CC BY-NC-SA 3.0 IGO; 2021."},{"key":"617_CR12","unstructured":"Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al. Cochrane handbook for systematic reviews of interventions version 6.3 (updated 2022). Cochrane, 2022. 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Accessed 1 Feb 2022."},{"issue":"4","key":"617_CR17","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1097\/QAI.0000000000002895","volume":"89","author":"A Mujugira","year":"2022","unstructured":"Mujugira A, Nakyanzi A, Nabaggala MS, Muwonge TR, Ssebuliba T, Bagaya M, et al. Effect of HIV self-testing on PrEP adherence among gender-diverse sex workers in Uganda: a randomized trial. JAIDS J Acquir Immune Defic Syndr. 2022;89(4):381\u20139. One of the five identified studies assessing values and preferences related to HIVST-supported PrEP delivery.","journal-title":"JAIDS J Acquir Immune Defic Syndr"},{"key":"617_CR18","doi-asserted-by":"crossref","unstructured":"Ngure K, Ortblad KF, Mogere P, Thomas D, Mangale D, Kiptiness C, et al. Six-month PrEP dispensing with HIV self-testing to improve the efficiency of delivery in Kenya: a randomized non-inferiority implementation trial. Lancet HIV. 2022. One of the five identified studies assessing values and preferences related to HIVST-supported PrEP delivery.","DOI":"10.1016\/S2352-3018(22)00126-6"},{"issue":"2","key":"617_CR19","first-page":"ofab609","volume":"9","author":"DL Joseph Davey","year":"2022","unstructured":"Joseph Davey DL, Dovel K, Mvududu R, Nyemba D, Mashele N, Bekker LG, et al. Pre-exposure prophylaxis recent adherence with real-time adherence feedback and partner human immunodeficiency virus self-testing: a pilot trial among postpartum women. Open Forum. Infect Dis Ther. 2022;9(2):ofab609. One of the five identified studies assessing values and preferences related to HIVST-supported PrEP delivery.","journal-title":"Infect Dis Ther"},{"key":"617_CR20","unstructured":"Mugwanya K Streamlining the efficiency of PrEP implementation (Efficiency). NCT04424524. 2020. Accessed 1 Nov 2021."},{"key":"617_CR21","unstructured":"Mujugira A. Peer-Delivered HIV Self-testing, STI self-sampling and PrEP for transgender women in Uganda. NCT04328025. 2020. Accessed 1 Nov 2021."},{"key":"617_CR22","unstructured":"El-Sadr WM. IPrEP men\u2019s study: expanding the reach of prevention for men in Kisumu, Kenya. NCT04898699. 2022."},{"issue":"1","key":"617_CR23","doi-asserted-by":"publisher","first-page":"101037","DOI":"10.1016\/j.bjid.2020.11.002","volume":"25","author":"B Hoagland","year":"2021","unstructured":"Hoagland B, Torres TS, Bezerra DRB, Benedetti M, Pimenta C, Veloso VG, et al. High acceptability of PrEP teleconsultation and HIV self-testing among PrEP users during the COVID-19 pandemic in Brazil. Braz J Infect Dis. 2021;25(1):101037. 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Acceptability of HIV self-testing to support pre-exposure prophylaxis among female sex workers in Uganda and Zambia: results from two randomized controlled trials. BMC Infect Dis. 2018;18(1):503. One of the five identified studies assessing values and preferences related to HIVST-supported PrEP delivery.","journal-title":"BMC Infect Dis"},{"issue":"8","key":"617_CR26","doi-asserted-by":"publisher","first-page":"e25561","DOI":"10.1002\/jia2.25561","volume":"23","author":"V Wanga","year":"2020","unstructured":"Wanga V, Omollo V, Bukusi EA, Odoyo JB, Morton JF, Kidoguchi L, et al. Uptake and impact of facility-based HIV self-testing on PrEP delivery: a pilot study among young women in Kisumu, Kenya. J Int AIDS Soc. 2020;23(8):e25561. One of the five identified studies assessing values and preferences related to HIVST-supported PrEP delivery.","journal-title":"J Int AIDS Soc"},{"issue":"9","key":"617_CR27","doi-asserted-by":"publisher","first-page":"e25782","DOI":"10.1002\/jia2.25782","volume":"24","author":"A Mujugira","year":"2021","unstructured":"Mujugira A, Nakyanzi A, Kasiita V, Kamusiime B, Nalukwago GK, Nalumansi A, et al. HIV self-testing and oral pre-exposure prophylaxis are empowering for sex workers and their intimate partners: a qualitative study in Uganda. J Int AIDS Soc. 2021;24(9):e25782.","journal-title":"J Int AIDS Soc"},{"issue":"5","key":"617_CR28","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1007\/s10461-016-1458-y","volume":"21","author":"KR Amico","year":"2017","unstructured":"Amico KR, Wallace M, Bekker LG, Roux S, Atujuna M, Sebastian E, et al. Experiences with HPTN 067\/ADAPT study-provided open-label PrEP among women in Cape Town: facilitators and barriers within a mutuality framework. AIDS Behav. 2017;21(5):1361\u201375.","journal-title":"AIDS Behav"},{"issue":"Suppl 4","key":"617_CR29","doi-asserted-by":"crossref","first-page":"e25298","DOI":"10.1002\/jia2.25298","volume":"22","author":"CL Celum","year":"2019","unstructured":"Celum CL, Delany-Moretlwe S, Baeten JM, van der Straten A, Hosek S, Bukusi EA, et al. HIV pre-exposure prophylaxis for adolescent girls and young women in Africa: from efficacy trials to delivery. J Int AIDS Soc. 2019;22(Suppl 4):e25298.","journal-title":"J Int AIDS Soc"},{"issue":"4","key":"617_CR30","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1097\/QAI.0000000000000880","volume":"71","author":"A Corneli","year":"2016","unstructured":"Corneli A, Perry B, McKenna K, Agot K, Ahmed K, Taylor J, et al. Participants\u2019 explanations for nonadherence in the FEM-PrEP clinical trial. 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Aids. 2019;33(8):1369\u201378.","journal-title":"Aids."},{"issue":"6","key":"617_CR42","doi-asserted-by":"publisher","first-page":"e266","DOI":"10.1016\/S2352-3018(16)00041-2","volume":"3","author":"H Thirumurthy","year":"2016","unstructured":"Thirumurthy H, Masters SH, Mavedzenge SN, Maman S, Omanga E, Agot K. Promoting male partner HIV testing and safer sexual decision making through secondary distribution of self-tests by HIV-negative female sex workers and women receiving antenatal and post-partum care in Kenya: a cohort study. Lancet HIV. 2016;3(6):e266\u201374.","journal-title":"Lancet HIV"},{"key":"617_CR43","doi-asserted-by":"publisher","first-page":"100327","DOI":"10.1016\/j.eclinm.2020.100327","volume":"21","author":"A Pettifor","year":"2020","unstructured":"Pettifor A, Lippman SA, Kimaru L, Haber N, Mayakayaka Z, Selin A, et al. HIV self-testing among young women in rural South Africa: a randomized controlled trial comparing clinic-based HIV testing to the choice of either clinic testing or HIV self-testing with secondary distribution to peers and partners. EClinicalMedicine. 2020;21:100327.","journal-title":"EClinicalMedicine."},{"key":"617_CR44","unstructured":"National AIDS & STI Control Program(NASCOP). HIV self-testing: an operational manual for the delivery of HIV Self-Testing services in Kenya. Ministry of Health. 2017. Accessed 1 Feb 2022"},{"key":"617_CR45","unstructured":"Southern African HIV Clinicians Society. South African HIV self-testing policy and guidance considerations:\u00a0A supplement to the National HIV Testing Services Policy 2016. Johannesburg, South Africa: Southern African HIV Clinicians Society, 2017. Accessed February 1 2022."}],"container-title":["Current HIV\/AIDS Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11904-022-00617-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11904-022-00617-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11904-022-00617-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T22:34:26Z","timestamp":1700865266000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11904-022-00617-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,29]]},"references-count":45,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["617"],"URL":"https:\/\/doi.org\/10.1007\/s11904-022-00617-x","relation":{},"ISSN":["1548-3568","1548-3576"],"issn-type":[{"value":"1548-3568","type":"print"},{"value":"1548-3576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,29]]},"assertion":[{"value":"12 July 2022","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 July 2022","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable as this was a review of published literature.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the World Health Organization.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"This article does not contain any studies with human or animal subjects performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and Animal Rights and Informed Consent"}}]}}