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Key challenges include limited awareness, misinformation, provider-level stigma, structural discrimination, legal repression, prohibitive costs, and healthcare inaccessibility, burdens that fall disproportionately on priority populations in low- and middle-income countries. Conversely, evidence from sub-Saharan Africa, Asia, Europe, and the Americas demonstrates that community-led awareness campaigns, integration of PrEP into sexual and reproductive health services, long-acting injectable formulations, mobile clinics, peer support structures, and digital health and telemedicine tools meaningfully improve access and adherence, particularly among youth and rural populations. Policy-level interventions, including decriminalisation of sex work, same-sex relationships, and drug use, alongside subsidised access and inclusion in universal health coverage frameworks, are identified as critical enablers of equitable reach.<\/jats:p>\n                  <jats:p>Summary<\/jats:p>\n                  <jats:p>Achieving global HIV prevention targets requires more than biomedical innovation. This review underscores that rights-based, community-embedded, and culturally affirming strategies paired with structural reform and sustained investment are essential to expanding PrEP access and equity. PrEP must be positioned not merely as a clinical tool, but as a cornerstone of an equity-driven HIV prevention architecture.<\/jats:p>","DOI":"10.1007\/s11904-026-00783-2","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T08:01:04Z","timestamp":1774857664000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Barriers and Facilitators of Oral PrEP Uptake Against HIV Among Selected Priority Populations: A Global Perspective"],"prefix":"10.1007","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9371-0915","authenticated-orcid":false,"given":"Ifeanyi","family":"Ngwoke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9373-1600","authenticated-orcid":false,"given":"Adepeju Mary","family":"Adedire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1723-1350","authenticated-orcid":false,"given":"Nengak Precious","family":"Danladi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chinemerem Cynthia","family":"Eze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5575-1931","authenticated-orcid":false,"given":"Oluwasogo Kehinde","family":"Dada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3809-4271","authenticated-orcid":false,"given":"Olalekan John","family":"Okesanya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,30]]},"reference":[{"key":"783_CR1","doi-asserted-by":"publisher","unstructured":"Hillis A, Germain J, Hope V, McVeigh J, Van Hout MC. 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