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J Lab Clin Med 1955, 45:661\u2013664. This is a real classic in the physiology of high blood pressure and the role of careful clinical investigation as a clue to new diseases.","journal-title":"J Lab Clin Med"},{"key":"45_CR2","first-page":"768","volume-title":"Hypertension: Physiology and Treatment","author":"JW Conn","year":"1977","unstructured":"Conn JW: Primary aldosteronism. In Hypertension: Physiology and Treatment. Edited by Genest J, Koiw E, Kuchel O. New York: McGraw Hill; 1977:768\u2013780."},{"key":"45_CR3","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1001\/jama.1964.03070160046009","volume":"190","author":"JW Conn","year":"1994","unstructured":"Conn JW: Plasma renin activity in primary aldosteronism: importance in differential diagnosis and in research of essential hypertension. JAMA 1994, 190:222\u2013225.","journal-title":"JAMA"},{"key":"45_CR4","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1056\/NEJM196511182732106","volume":"273","author":"JW Conn","year":"1965","unstructured":"Conn JW: Hypertension, the potassium ion and impaired glucose tolerance. N Engl J Med 1965, 273:1135\u20131423.","journal-title":"N Engl J Med"},{"key":"45_CR5","first-page":"1109","volume":"95","author":"DJ Sutherland","year":"1966","unstructured":"Sutherland DJ, Ruse JL, Laidlaw JC: Hypertension, increased aldosterone secretion and low plasma renin activity relieved by dexamethasone. Can Med Assoc J 1966, 95:1109\u20131119.","journal-title":"Can Med Assoc J"},{"key":"45_CR6","first-page":"109","volume-title":"Hypertension in Childhood","author":"CE Grim","year":"1977","unstructured":"Grim CE, Weinberger MH, Anand S: Familial, dexamethasone suppressible, normokalemic hyperaldosteronism. In Hypertension in Childhood. Edited by New M. New York: Raven Press; 1977:109\u2013122."},{"key":"45_CR7","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/ng0992-66","volume":"2","author":"RP Lifton","year":"1992","unstructured":"Lifton RP, Dluhy RG, Powers M, et al.: Hereditary hypertension caused by a chimeric gene duplications and ectopic expression of aldosterone synthetase. Nat Genet 1992, 2:66\u201374.","journal-title":"Nat Genet"},{"key":"45_CR8","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1001\/archinte.1975.00330020151022","volume":"135","author":"CE Grim","year":"1975","unstructured":"Grim CE: Low renin \"essential\" hypertension: a variant of primary aldosteronism? Arch Intern Med 1975, 135:347\u2013350.","journal-title":"Arch Intern Med"},{"key":"45_CR9","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1210\/jc.2003-031337","volume":"89","author":"P Mulatero","year":"2004","unstructured":"Mulatero P, Stowasser M, Loh K, et al.: Increased diagnosis of primary aldosteronism, including surgically curable forms, in centers from five continents. J Clin Endo Metab 2004, 89:1045\u20131050.","journal-title":"J Clin Endo Metab"},{"key":"45_CR10","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1056\/NEJMoa033263","volume":"351","author":"RS Vasan","year":"2004","unstructured":"Vasan RS, Evans JC, Larson MG, et al.: Serum aldosterone and the incidence of hypertension in nonhypertensive person. N Engl J Med 2004, 351:33\u201341. This is the first report that relates circulating aldosterone to the rise in blood pressure with age in a prospective study.","journal-title":"N Engl J Med"},{"key":"45_CR11","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1056\/NEJMp048132","volume":"351","author":"RG Dluhy","year":"2004","unstructured":"Dluhy RG, Williams GH: Aldosterone: villain or bystander? N Engl J Med 2004, 351:8\u201310.","journal-title":"N Engl J Med"},{"key":"45_CR12","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1042\/cs0640273","volume":"64","author":"TW Meade","year":"1983","unstructured":"Meade TW, Imeson JD, Gordon D, Peart WS: The epidemiology of plasma renin. Clin Sci 1983, 64:273\u2013280.","journal-title":"Clin Sci"},{"key":"45_CR13","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1210\/jcem-40-4-652","volume":"40","author":"RE Shade","year":"1975","unstructured":"Shade RE, Grim CE: The response of the renin-angiotensinaldosterone system to small amounts of DOCA in normal man. J Clin Endo Metab 1975, 40:652\u2013658. Giving very low levels of DOCA results in rapid and complete suppression of renin and aldosterone production.","journal-title":"J Clin Endo Metab"},{"key":"45_CR14","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/0002-9343(72)90050-2","volume":"52","author":"AC Guyton","year":"1972","unstructured":"Guyton AC, Coleman TG, Cowley AW, et al.: Arterial pressure regulation: overriding dominance of the kidneys in longterm regulation and in hypertension. Am J Med 1972, 52:584\u2013594. 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This is the best-detailed review of the adrenal pathology seen in lowrenin hypertension.","journal-title":"Arch Path Lab Med"},{"key":"45_CR21","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1172\/JCI109101","volume":"62","author":"AA Taylor","year":"1978","unstructured":"Taylor AA, Mitchell JR, Bartter FC, et al.: Effect of aminoglutethiamide on blood pressure and steroid secretion in patients with low renin essential hypertension. J Clin Invest 1978, 62:162\u2013168. It is clear from this study that blocking adrenal steroid production lowers blood pressure in LREH.","journal-title":"J Clin Invest"},{"key":"45_CR22","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1524-6175.2004.03146.x","volume":"6","author":"T Saruta","year":"2004","unstructured":"Saruta T, Kageyama S, Ogihara T, et al.: Efficacy and safety of the selective aldosterone blocker eplerenone in Japanese patients with hypertension: a randomized, double-blind, placebo-controlled, dose-ranging study. J Clin Hypertens 2004, 6:175\u2013185.","journal-title":"J Clin Hypertens"},{"key":"45_CR23","first-page":"257","volume":"62","author":"JW Conn","year":"1966","unstructured":"Conn JW: The evolution of primary aldosteronism. 1954\u20131967. Harvey Lect 1966\u20137, 62:257\u2013291. Anyone who has an interest in high blood pressure should read this elegant summary of some of the best clinical research ever done in hypertension.","journal-title":"Harvey Lect"},{"key":"45_CR24","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1172\/JCI104269","volume":"40","author":"AV Chobanian","year":"1961","unstructured":"Chobanian AV, Burrows BA, Hollander W, Bikerman V: Body fluid and electrolyte composition in arterial hypertension. II. Studies in mineralocorticoid hypertension. J Clin Invest 1961, 40:416\u2013422.","journal-title":"J Clin Invest"},{"key":"45_CR25","first-page":"347","volume":"15","author":"A Abdo","year":"1999","unstructured":"Abdo A, Bebb RA, Wilkins GE: Ventricular fibrillation: an extreme presentation of primary hyperaldosteronism. 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