{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T11:04:53Z","timestamp":1648983893333},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Science Inc"],"published-print":{"date-parts":[[2006,5]]},"DOI":"10.1007\/s11906-006-0059-y","type":"journal-article","created":{"date-parts":[[2007,5,24]],"date-time":"2007-05-24T19:32:30Z","timestamp":1180035150000},"page":"255-261","source":"Crossref","is-referenced-by-count":5,"title":["Hypertension and the expanding role of aldosterone"],"prefix":"10.1007","volume":"8","author":[{"given":"Scott M.","family":"MacKenzie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M. C.","family":"Connell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"59_CR1","doi-asserted-by":"crossref","first-page":"20961","DOI":"10.1016\/S0021-9258(19)30030-4","volume":"264","author":"E Mornet","year":"1989","unstructured":"Mornet E, Dupont J, Vitek A, White PC: Characterization of two genes encoding human steroid 11beta-hydroxylase (P-450(11) beta). J Biol Chem 1989, 264:20961\u201320967.","journal-title":"J Biol Chem"},{"key":"59_CR2","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/0888-7543(91)90491-V","volume":"10","author":"M Wagner","year":"1991","unstructured":"Wagner M, Ge Y, Siciliano M, Wells E: A hybrid cell mapping panel for regional localisation of probes to human chromosome 8. Genomics 1991, 10:114\u2013125.","journal-title":"Genomics"},{"key":"59_CR3","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1074\/jbc.C100623200","volume":"277","author":"PM Snyder","year":"2002","unstructured":"Snyder PM, Olson DR, Thomas BC: Serum and glucocorticoid-regulated kinase modulate Nedd4-2 mediated inhibition of the epithelial Na+ channel. J Biol Chem 2002, 277:5\u20138.","journal-title":"J Biol Chem"},{"key":"59_CR4","first-page":"893","volume":"120","author":"CG Brilla","year":"1992","unstructured":"Brilla CG, Weber KT: Mineralocorticoid excess, dietary sodium, and myocardial flbrosis. J Lab Clin Med 1992, 120:893\u2013901.","journal-title":"J Lab Clin Med"},{"key":"59_CR5","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1006\/frne.1997.0157","volume":"18","author":"S\u00e1nchez EP G\u00f3mez","year":"1997","unstructured":"G\u00f3mez S\u00e1nchez EP: Central hypertensive effects of aldosterone. Front Neuroendocrinol 1997, 18:440\u2013462.","journal-title":"Front Neuroendocrinol"},{"key":"59_CR6","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.steroids.2005.02.004","volume":"70","author":"AS Mihailidou","year":"2005","unstructured":"Mihailidou AS, Funder JW: Nongenomic effects of mineralocorticoid receptor activation in the cardiovascular system. Steroids 2005, 70:347\u2013351.","journal-title":"Steroids"},{"key":"59_CR7","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1006\/bbrc.1999.1771","volume":"266","author":"K Haseroth","year":"1999","unstructured":"Haseroth K, Gerdes D, Berger S, et al.: Rapid nongenomic effects of aldosterone in mineralocorticoid-receptor-knockout mice. Biochem Biophys Res Comm 1999, 266:257\u2013261.","journal-title":"Biochem Biophys Res Comm"},{"key":"59_CR8","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0021-9150(02)00363-5","volume":"166","author":"P Romagni","year":"2003","unstructured":"Romagni P, Rossi F, Guerrini L, et al.: Aldosterone induces contraction of the resistance arteries in man. Atherosclerosis 2003, 166:345\u2013349.","journal-title":"Atherosclerosis"},{"key":"59_CR9","first-page":"3517","volume":"83","author":"M Wehling","year":"1998","unstructured":"Wehling M, Spes CH, Win N, et al.: Rapid cardiovascular action of aldosterone in man. J Clin Endocrinol Metab 1998, 83:3517\u20133522.","journal-title":"J Clin Endocrinol Metab"},{"key":"59_CR10","first-page":"3528","volume":"84","author":"BM Schmidt","year":"1999","unstructured":"Schmidt BM, Montealegre A, Janson CP, et al.: Short-term cardiovascular effects of aldosterone in healthy male volunteers. J Clin Endocrinol Metab 1999, 84:3528\u20133533.","journal-title":"J Clin Endocrinol Metab"},{"key":"59_CR11","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1016\/0024-3205(82)90441-6","volume":"30","author":"MA Weber","year":"1982","unstructured":"Weber MA, Purdy RE: Catecholamine-mediated constrictor effects of aldosterone on vascular smooth muscle. Life Sci 1982, 30:2009\u20132017.","journal-title":"Life Sci"},{"key":"59_CR12","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1042\/cs0950687","volume":"95","author":"KM Yee","year":"1998","unstructured":"Yee KM, Struthers AD: Aldosterone blunts the baroreflex response in man. Clin Sci 1998, 95:687\u2013692.","journal-title":"Clin Sci"},{"key":"59_CR13","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1046\/j.1440-1681.2003.03867.x","volume":"30","author":"E Davies","year":"2003","unstructured":"Davies E, MacKenzie SM: Extra-adrenal production of corticosteroids. Clin Exper Pharmacol Physiol 2003, 30:437\u2013445.","journal-title":"Clin Exper Pharmacol Physiol"},{"key":"59_CR14","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0169-328X(95)00140-N","volume":"34","author":"M Str\u00f6mstedt","year":"1995","unstructured":"Str\u00f6mstedt M, Waterman MR: Messenger RNAs encoding steroidogenic enzymes are expressed in rodent brain. Brain Res Mol Brain Res 1995, 34:75\u201388.","journal-title":"Brain Res Mol Brain Res"},{"key":"59_CR15","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1677\/jme.0.0240321","volume":"24","author":"SM MacKenzie","year":"2000","unstructured":"MacKenzie SM, Clark CJ, Fraser R, et al.: Expression of 11beta-hydroxylase and aldosterone synthase genes in the rat brain. J Mol Endocrinol 2000, 24:321\u2013328.","journal-title":"J Mol Endocrinol"},{"key":"59_CR16","doi-asserted-by":"crossref","first-page":"4883","DOI":"10.1074\/jbc.273.9.4883","volume":"273","author":"JS Silvestre","year":"1998","unstructured":"Silvestre JS, Robert V, Heymes C, et al.: Myocardial production of aldosterone and corticosterone in the rat. Physiological regulation. J Biol Chem 1998, 273:4883\u20134891.","journal-title":"J Biol Chem"},{"key":"59_CR17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/01.HYP.0000168924.37091.58","volume":"46","author":"C Xue","year":"2005","unstructured":"Xue C, Siragy HM: Local renal aldosterone system and its regulation by salt, diabetes and angiotensin II type 1 receptor. Hypertension 2005, 46:1\u20137.","journal-title":"Hypertension"},{"key":"59_CR18","doi-asserted-by":"crossref","first-page":"3321","DOI":"10.1210\/en.2003-0109","volume":"144","author":"P Ye","year":"2003","unstructured":"Ye P, Kenyon CJ, MacKenzie SM, et al.: Regulation of aldosterone synthase gene expression in the rat adrenal gland and central nervous system by sodium and angiotensin II. Endocrinology 2003, 144:3321\u20133328.","journal-title":"Endocrinology"},{"key":"59_CR19","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1159\/000126593","volume":"58","author":"MK Agarwal","year":"1993","unstructured":"Agarwal MK, Mirshahi F, Mirshahi M, Rostene W: Immunochemical detection of the mineralocorticoid receptor in rat brain. Neuroendocrinology 1993, 58:575\u2013580.","journal-title":"Neuroendocrinology"},{"key":"59_CR20","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1042\/cs1020381","volume":"102","author":"M Satoh","year":"2002","unstructured":"Satoh M, Nakamura M, Saitoh H, et al.: Aldosterone synthase (CYP11B2) expression and myocardial fibrosis in the failing human heart. Clin Sci 2002, 102:381\u2013386.","journal-title":"Clin Sci"},{"key":"59_CR21","first-page":"2519","volume":"85","author":"KM Kayes-Wandover","year":"2000","unstructured":"Kayes-Wandover KM, White PC: Steroidogenic enzyme gene expression in the human heart. J Clin Endocrinol Metab 2000, 85:2519\u20132525.","journal-title":"J Clin Endocrinol Metab"},{"key":"59_CR22","doi-asserted-by":"crossref","first-page":"5287","DOI":"10.1210\/en.2005-0370","volume":"146","author":"P Ye","year":"2005","unstructured":"Ye P, Kenyon CJ, MacKenzie SM, et al.: The aldosterone synthase (CYP11B2) and 11\u03b2-hydroxylase genes are not expressed in the rat heart. Endocrinology 2005, 146:5287\u20135293.","journal-title":"Endocrinology"},{"key":"59_CR23","doi-asserted-by":"crossref","first-page":"4796","DOI":"10.1210\/en.2004-0295","volume":"145","author":"S\u00e1nchez EP G\u00f2mez","year":"2004","unstructured":"G\u00f2mez S\u00e1nchez EP, Ahmad N, Romero DG, G\u00f2mez S\u00e1nchez CE: Origin of aldosterone in the rat heart. Endocrinology 2004, 145:4796\u20134802.","journal-title":"Endocrinology"},{"key":"59_CR24","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1056\/NEJMoa033263","volume":"351","author":"RS Vasan","year":"2004","unstructured":"Vasan RS, Evans JC, Larson MG, et al.: Serum aldosterone and the incidence of hypertension in nonhypertensive persons. N Engl J Med 2004, 351:33\u201341. Interindividual variations in serum aldosterone levels were found to predict the likelihood of nonhypertensive individuals becoming hypertensive. The authors suggest that increased physiologic levels of aldosterone predispose normotensive individuals to elevated blood pressure.","journal-title":"N Engl J Med"},{"key":"59_CR25","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1139\/y85-250","volume":"63","author":"EL Schiffrin","year":"1985","unstructured":"Schiffrin EL, Franks DJ, Gutkowska J: Effect of aldosterone on vascular angiotensin II receptors in the rat. Can J Physiol Pharmacol 1985, 63:1522\u20131527.","journal-title":"Can J Physiol Pharmacol"},{"key":"59_CR26","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1161\/01.HYP.21.6.929","volume":"21","author":"S Taddei","year":"1993","unstructured":"Taddei S, Virdis A, Mattei P, Salvetti A: Vasodilation to acetylcholine in primary and secondary forms of human hypertension. Hypertension 1993, 21:929\u2013933.","journal-title":"Hypertension"},{"key":"59_CR27","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1365-2265.1996.tb02059.x","volume":"45","author":"MB Vallotton","year":"1996","unstructured":"Vallotton MB: Primary aldosteronism. Part I. Diagnosis of primary hyperaldosteronism. Clin Endocrinol 1996, 45:47\u201352.","journal-title":"Clin Endocrinol"},{"key":"59_CR28","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/355262a0","volume":"355","author":"RP Lifton","year":"1992","unstructured":"Lifton RP, Dluhy RG, Powers M, et al.: A chimaeric 11\u03b2-hydroxylase\/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension. Nature 1992, 355:262\u2013265.","journal-title":"Nature"},{"key":"59_CR29","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0889-8529(18)30100-2","volume":"23","author":"PC White","year":"1994","unstructured":"White PC, Speiser PW: Steroid 11beta-hydroxylase deficiency and related disorder. Endocrinol Metabol Clin North Am 1994, 23:325\u2013339.","journal-title":"Endocrinol Metabol Clin North Am"},{"key":"59_CR30","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1161\/01.HYP.0000064344.00173.44","volume":"41","author":"JM Connell","year":"2003","unstructured":"Connell JM, Fraser R, MacKenzie SM, Davies E: Is altered adrenal steroid synthesis a key intermediate phenotype in hypertension? Hypertension 2003, 41:993\u2013999.","journal-title":"Hypertension"},{"key":"59_CR31","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.1440-1681.1994.tb02519.x","volume":"21","author":"RD Gordon","year":"1994","unstructured":"Gordon RD, Stowasser M, Tunny TJ, et al.: High incidence of primary aldosteronism in 199 patients referred with hypertension. Clin Exper Pharmacol Physiol 1994, 21:315\u2013318.","journal-title":"Clin Exper Pharmacol Physiol"},{"key":"59_CR32","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0140-6736(05)74868-6","volume":"353","author":"PO Lim","year":"1999","unstructured":"Lim PO, Rodgers P, Cardale K, et al.: Potentially high prevalence of primary aldosteronism in a primary-care population. Lancet 1999, 353:40.","journal-title":"Lancet"},{"key":"59_CR33","first-page":"1863","volume":"85","author":"CE Fardella","year":"2000","unstructured":"Fardella CE, Mosso L, G\u00f2mez S\u00e1nchez CE, et al.: Primary aldosteronism in essential hypertensives: prevalence, biochemical profile and molecular biology. J Clin Endocrinol Metab 2000, 85:1863\u20131867.","journal-title":"J Clin Endocrinol Metab"},{"key":"59_CR34","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/00019616-199707040-00003","volume":"7","author":"WF Young Jr","year":"1997","unstructured":"Young WF Jr: Primary aldosteronism: update on diagnosis and treatment. Endocrinologist 1997, 7:213\u2013221.","journal-title":"Endocrinologist"},{"key":"59_CR35","doi-asserted-by":"crossref","first-page":"4398","DOI":"10.1210\/jc.2001-012070","volume":"87","author":"PO Lim","year":"2002","unstructured":"Lim PO, MacDonald TM, Holloway CD, et al.: Variation at the aldosterone synthase (CYP11B2) locus contributes to hypertension in subjects with a raised aldosterone to renin ratio. J Clin Endocrinol Metab 2002, 87:4398\u20134402.","journal-title":"J Clin Endocrinol Metab"},{"key":"59_CR36","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1161\/01.HYP.33.2.703","volume":"33","author":"E Davies","year":"1999","unstructured":"Davies E, Holloway CD, Ingram MC, et al.: Aldosterone excretion rate and blood pressure in essential hypertension are related to polymorphic differences in the aldosterone synthase gene CYP11B2 Hypertension 1999, 33:703\u2013707.","journal-title":"Hypertension"},{"key":"59_CR37","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1161\/01.HYP.34.3.423","volume":"34","author":"F Paillard","year":"1999","unstructured":"Paillard F, Chansel D, Brand E, et al.: Genotype-phenotype relationships for the renin-angiotensin-aldosterone system in a normal population. Hypertension 1999, 34:423\u2013429.","journal-title":"Hypertension"},{"key":"59_CR38","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1161\/01.HYP.35.3.694","volume":"35","author":"P Mulatero","year":"2000","unstructured":"Mulatero P, Schiavone D, Fallo F, et al.: CYP11B2 gene polymorphisms in idiopathic hyperaldosteronism. Hypertension 2000, 35:694\u2013698.","journal-title":"Hypertension"},{"key":"59_CR39","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1677\/jme.0.0280125","volume":"28","author":"MH Bassett","year":"2002","unstructured":"Bassett MH, Zhang Y, Clyne C, et al.: Differential regulation of aldosterone synthase and 11\u03b2-hydroxylase transcription by steroidogenic factor-1. J Mol Endocrinol 2002, 28:125\u2013135.","journal-title":"J Mol Endocrinol"},{"key":"59_CR40","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1161\/01.HYP.7.2.204","volume":"7","author":"G Simone de","year":"1985","unstructured":"de Simone G, Tommaselli A, Rossi R, et al.: Partial deficiency of adrenal 11\u03b2-hydroxylase\u2014a possible cause of primary hypertension. Hypertension 1985, 7:204\u2013210.","journal-title":"Hypertension"},{"key":"59_CR41","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1080\/07435809609043764","volume":"22","author":"JM Connell","year":"1996","unstructured":"Connell JM, Jamieson A, Davies E, et al.: 11betahydroxylase activity in glucocorticoid suppressible hyperaldosteronism: Lessons for essential hypertension? Endocr Res 1996, 22:691\u2013700.","journal-title":"Endocr Res"},{"key":"59_CR42","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1046\/j.1365-2265.2001.01264.x","volume":"54","author":"E Davies","year":"2001","unstructured":"Davies E, Holloway CD, Ingram MC, et al.: An influence of variation in the aldosterone synthase gene (CYP11B2) on corticosteroid responses to ACTH in normal human subjects. Clin Endocrinol 2001, 54:813\u2013817.","journal-title":"Clin Endocrinol"},{"key":"59_CR43","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/j.1365-2265.2004.02073.x","volume":"61","author":"B Kennon","year":"2004","unstructured":"Kennon B, Ingram MC, Friel EC, et al.: Aldosterone synthase gene variation and adrenocortical response to sodium status, angiotensin II and ACTH in normal male subjects. Clin Endocrinol 2004, 61:174\u2013181.","journal-title":"Clin Endocrinol"},{"key":"59_CR44","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1365-2796.1997.tb00002.x","volume":"241","author":"A Hautanen","year":"1997","unstructured":"Hautanen A, Raikkonen K, Adlercreutz H: Associations between pituitary-adrenocortical function and abdominal obesity, hyperinsulinaemia and dyslipidaemia in normotensive males. J Intern Med 1997, 241:451\u2013461.","journal-title":"J Intern Med"},{"key":"59_CR45","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1161\/01.HYP.36.5.912","volume":"36","author":"JA Whitworth","year":"2000","unstructured":"Whitworth JA, Mangos GJ, Kelly JJ: Cushing, cortisol and cardiovascular disease. Hypertension 2000, 36:912\u2013916.","journal-title":"Hypertension"},{"key":"59_CR46","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1046\/j.1365-2265.2001.01287.x","volume":"54","author":"GC Inglis","year":"2001","unstructured":"Inglis GC, Plouin PF, Friel EC, et al.: Polymorphic differences from normal in the aldosterone synthase gene (CYP11B2) in patients with primary hyperaldosteronism and adrenal tumour (Conn\u2019s syndrome). Clin Endocrinol 2001, 54:725\u2013730.","journal-title":"Clin Endocrinol"},{"key":"59_CR47","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/j.jacc.2005.01.015","volume":"45","author":"P Milliez","year":"2005","unstructured":"Milliez P, Girerd X, Plouin PF, et al.: Evidence for an increased rate of cardiovascular events in patients with primary aldosteronism. J Am Coll Cardiol 2005, 45:1243\u20131248.","journal-title":"J Am Coll Cardiol"},{"key":"59_CR48","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1056\/NEJM199909023411001","volume":"341","author":"B Pitt","year":"1999","unstructured":"Pitt B, Zannad F, Remme WJ, et al.: The effect of spironolactone on morbidity and mortality in patients with severe heart failure. N Engl J Med 1999, 341:709\u2013717.","journal-title":"N Engl J Med"},{"key":"59_CR49","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1056\/NEJMoa030207","volume":"348","author":"B Pitt","year":"2003","unstructured":"Pitt B, Remme W, Zannad F, et al.: Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med 2003, 348:1309\u20131321.","journal-title":"N Engl J Med"},{"key":"59_CR50","doi-asserted-by":"crossref","first-page":"3153","DOI":"10.1210\/en.2004-0005","volume":"145","author":"M Young","year":"2004","unstructured":"Young M, Funder JW: Eplerenone, but not steroid withdrawal, reverses cardiac fibrosis in deoxycorticosterone\/ salt-treated rats. Endocrinology 2004, 145:3153\u20133157. The beneficial effects of eplerenone have been illustrated by several studies, but this paper further suggests that MR antagonism can lead to the reversal of mineralocorticoid-induced cardiac flbrosis.","journal-title":"Endocrinology"},{"key":"59_CR51","doi-asserted-by":"crossref","unstructured":"Komiya I, Yamada T, Takasu N, et al.: An abnormal sodium metabolism in Japanese patients with essential hypertension, judged by serum sodium distribution, renal function and the renin-aldosterone system. J Hypertens 15:65\u201372.","DOI":"10.1097\/00004872-199715010-00006"},{"key":"59_CR52","doi-asserted-by":"crossref","unstructured":"Lim PO, Dow E, Brennan G, et al.: High prevalence of primary aldosteronism in the Tayside hypertension clinic population. J Hum Hypertens 14:311\u2013315.","DOI":"10.1038\/sj.jhh.1001013"},{"key":"59_CR53","doi-asserted-by":"crossref","unstructured":"Loh K, Koay S, Khaw MC, et al.: Prevalence of primary aldosteronism among Asian hypertensive patients in Singapore. J Clin Endocrinol Metab 85:2854\u20132859.","DOI":"10.1210\/jc.85.8.2854"},{"key":"59_CR54","unstructured":"Rayner BL, Opie LH, Davidson JS: The aldosterone\/renin ratio as a screening test for primary aldosteronism. S Afr Med J 90:394\u2013400."},{"key":"59_CR55","doi-asserted-by":"crossref","unstructured":"Rossi E, Regolisti G, Negro A, et al.: High prevalence of primary aldosteronism using postcaptopril plasma aldosterone to renin ratio as a screening test among Italian hypertensives. Am J Hypertens 15:896\u2013902.","DOI":"10.1016\/S0895-7061(02)02969-2"}],"container-title":["Current Hypertension Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11906-006-0059-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11906-006-0059-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11906-006-0059-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,14]],"date-time":"2021-08-14T04:51:16Z","timestamp":1628916676000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11906-006-0059-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5]]},"references-count":55,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["59"],"URL":"https:\/\/doi.org\/10.1007\/s11906-006-0059-y","relation":{},"ISSN":["1522-6417","1534-3111"],"issn-type":[{"value":"1522-6417","type":"print"},{"value":"1534-3111","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5]]}}}