{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T06:20:03Z","timestamp":1776493203896,"version":"3.51.2"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Science Inc"],"published-print":{"date-parts":[[2006,7]]},"DOI":"10.1007\/s11906-006-0075-y","type":"journal-article","created":{"date-parts":[[2007,5,24]],"date-time":"2007-05-24T20:11:57Z","timestamp":1180037517000},"page":"345-351","source":"Crossref","is-referenced-by-count":23,"title":["Phosphodiesterase-5 inhibitors and their hemodynamic effects"],"prefix":"10.1007","volume":"8","author":[{"given":"L. Michael","family":"Prisant","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"issue":"Suppl 5","key":"75_CR1","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1038\/sj.ijir.3901071","volume":"15","author":"DS Solursh","year":"2003","unstructured":"Solursh DS, Ernst JL, Lewis RW, et al.: The human sexuality education of physicians in North American medical schools. Int J Impot Res 2003, 15(Suppl 5):S41-S45.","journal-title":"Int J Impot Res"},{"key":"75_CR2","first-page":"470","volume-title":"Hypertension Primer","author":"LM Prisant","year":"2003","unstructured":"Prisant LM: Sexual dysfunction and hypertension. In Hypertension Primer, 3rd edn. Edited by Izzo JL, Black HR. Philadelphia, PA: Lippincott Williams & Wilkins; 2003:470\u2013472.","edition":"3rd edn"},{"issue":"5 Suppl","key":"75_CR3","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1016\/j.amjhyper.2004.03.036","volume":"17","author":"D Loebl","year":"2004","unstructured":"Loebl D, Fain H, Prisant LM: Relationship of arterial elasticity and erectile dysfunction in hypertensive men. Am J Hypertens 2004, 17(5 Suppl):S16.","journal-title":"Am J Hypertens"},{"key":"75_CR4","first-page":"22","volume":"1","author":"LM Prisant","year":"1999","unstructured":"Prisant LM, Weir MR, Frishman WH, et al.: Self reported sexual dysfunction in men and women treated with bisoprolol, hydrochlorothiazide, enalapril, amlodipine, placebo, or bisoprolol\/hydrochlorothiazide. J Clin Hypertens (Greenwich) 1999, 1:22\u2013126.","journal-title":"J Clin Hypertens (Greenwich)"},{"key":"75_CR5","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1001\/archinte.1994.00420070034004","volume":"154","author":"LM Prisant","year":"1994","unstructured":"Prisant LM, Carr AA, Bottini PB, et al.: Sexual dysfunction with antihypertensive drugs. Arch Intern Med 1994, 154:730\u2013736.","journal-title":"Arch Intern Med"},{"key":"75_CR6","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1161\/01.HYP.29.1.8","volume":"29","author":"RH Grimm Jr","year":"1997","unstructured":"Grimm RH Jr, Grandits GA, Prineas RJ, et al.: Long-term effects on sexual function of five antihypertensive drugs and nutritional hygienic treatment in hypertensive men and women. Treatment of Mild Hypertension Study (TOMHS). Hypertension 1997, 29(1 Pt 1):8\u201314. This is a prospective, double-blind, placebo-controlled study comparing the rate of sexual dysfunction in men and women with various classes of antihypertensive drugs.","journal-title":"Hypertension"},{"key":"75_CR7","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1001\/jama.294.23.2996","volume":"294","author":"IM Thompson","year":"2005","unstructured":"Thompson IM, Tangen CM, Goodman PJ, et al.: Erectile dysfunction and subsequent cardiovascular disease. JAMA 2005, 294:2996\u20133002.","journal-title":"JAMA"},{"key":"75_CR8","volume-title":"Viagra (sildenafil citrate): The Remarkable Story of the Discovery and Launch","author":"L Katzenstein","year":"2001","unstructured":"Katzenstein L: Viagra (sildenafil citrate): The Remarkable Story of the Discovery and Launch. New York, NY: Medical Information Press; 2001."},{"key":"75_CR9","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1056\/NEJM199201093260203","volume":"326","author":"J Rajfer","year":"1992","unstructured":"Rajfer J, Aronson WJ, Bush PA, et al.: Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. N Engl J Med 1992, 326:90\u201394.","journal-title":"N Engl J Med"},{"key":"75_CR10","first-page":"47","volume":"8","author":"M Boolell","year":"1996","unstructured":"Boolell M, Allen MJ, Ballard SA, et al.: Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction. Int J Impot Res 1996, 8:47\u201352.","journal-title":"Int J Impot Res"},{"key":"75_CR11","doi-asserted-by":"crossref","first-page":"3C","DOI":"10.1016\/S0002-9149(99)00042-9","volume":"83","author":"RM Wallis","year":"1999","unstructured":"Wallis RM, Corbin JD, Francis SH, et al.: Tissue distribution of phosphodiesterase families and the effects of sildenafil on tissue cyclic nucleotides, platelet function, and the contractile responses of trabeculae carneae and aortic rings in vitro. Am J Cardiol 1999, 83:3C-12C.","journal-title":"Am J Cardiol"},{"key":"75_CR12","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1056\/NEJM199805143382001","volume":"338","author":"I Goldstein","year":"1998","unstructured":"Goldstein I, Lue TF, Padma-Nathan H, et al.: Oral sildenafil in the treatment of erectile dysfunction. Sildenafil Study Group. N Engl J Med 1998, 338:1397\u20131404.","journal-title":"N Engl J Med"},{"key":"75_CR13","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/j.1743-6109.2005.20359.x","volume":"2","author":"G Jackson","year":"2005","unstructured":"Jackson G, Keltai M, Csanady M, et al.: Hemodynamic effects of sildenafil citrate and isosorbide mononitrate in men with coronary artery disease and erectile dysfunction. J Sex Med 2005, 2:407\u2013414.","journal-title":"J Sex Med"},{"key":"75_CR14","doi-asserted-by":"crossref","first-page":"21C","DOI":"10.1016\/S0002-9149(99)00044-2","volume":"83","author":"DJ Webb","year":"1999","unstructured":"Webb DJ, Freestone S, Allen MJ, et al.: Sildenafil citrate and blood-pressure-lowering drugs: results of drug interaction studies with an organic nitrate and a calcium antagonist. Am J Cardiol 1999, 83:21C-28C.","journal-title":"Am J Cardiol"},{"key":"75_CR15","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0735-1097(00)00705-1","volume":"36","author":"DJ Webb","year":"2000","unstructured":"Webb DJ, Muirhead GJ, Wulff M, et al.: Sildenafil citrate potentiates the hypotensive effects of nitric oxide donor drugs in male patients with stable angina. J Am Coll Cardiol 2000, 36:25\u201331.","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"75_CR16","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0735-1097(98)00656-1","volume":"33","author":"MD Cheitlin","year":"1999","unstructured":"Cheitlin MD, Hutter AM, Jr., Brindis RG, et al.: ACC\/AHA expert consensus document. Use of sildenafil (Viagra) in patients with cardiovascular disease. American College of Cardiology\/American Heart Association. J Am Coll Cardiol 1999, 33(1):273\u2013282.","journal-title":"J Am Coll Cardiol"},{"key":"75_CR17","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1097\/00004872-200018120-00022","volume":"18","author":"RM Zusman","year":"2000","unstructured":"Zusman RM, Prisant LM, Brown MJ: Effect of sildenafil citrate on blood pressure and heart rate in men with erectile dysfunction taking concomitant antihypertensive medication. Sildenafil Study Group. J Hypertens 2000, 18:1865\u20131869.","journal-title":"J Hypertens"},{"key":"75_CR18","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/S0895-7061(00)01177-8","volume":"14","author":"RA Kloner","year":"2001","unstructured":"Kloner RA, Brown M, Prisant LM, et al.: Effect of sildenafil in patients with erectile dysfunction taking antihypertensive therapy. Sildenafil Study Group. Am J Hypertens 2001, 14:70\u201373.","journal-title":"Am J Hypertens"},{"key":"75_CR19","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.amjhyper.2004.07.004","volume":"17","author":"TG Pickering","year":"2004","unstructured":"Pickering TG, Shepherd AM, Puddey I, et al.: Sildenafil citrate for erectile dysfunction in men receiving multiple antihypertensive agents: a randomized controlled trial. Am J Hypertens 2004, 17(12 Pt 1):1135\u20131142.","journal-title":"Am J Hypertens"},{"key":"75_CR20","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S0090-4295(02)01510-8","volume":"59","author":"Y Vardi","year":"2002","unstructured":"Vardi Y, Klein L, Nassar S, et al.: Effects of sildenafil citrate (Viagra) on blood pressure in normotensive and hypertensive men. Urology 2002, 59:747\u2013752.","journal-title":"Urology"},{"key":"75_CR21","unstructured":"Prescribing information for Viagra (sildenafil citrate) tablets. http:\/\/www.fda.gov\/cder\/foi\/label\/2005\/ 020895s021lbl.pdf. Accessed February 5, 2006."},{"key":"75_CR22","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/sj.jhh.1001244","volume":"15","author":"A Mahmud","year":"2001","unstructured":"Mahmud A, Hennessy M, Feely J: Effect of sildenafil on blood pressure and arterial wave reflection in treated hypertensive men. J Hum Hypertens 2001, 15:707\u2013713.","journal-title":"J Hum Hypertens"},{"key":"75_CR23","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1191\/1358863x03vm509ra","volume":"8","author":"C Vlachopoulos","year":"2003","unstructured":"Vlachopoulos C, Hirata K, O\u2019Rourke MF: Effect of sildenafil on arterial stiffness and wave reflection. Vasc Med 2003, 8:243\u2013248.","journal-title":"Vasc Med"},{"key":"75_CR24","first-page":"1488","volume":"44","author":"HA Ghofrani","year":"2004","unstructured":"Ghofrani HA, Voswinckel R, Reichenberger F, et al.: Differences in hemodynamic and oxygenation responses to three different phosphodiesterase-5 inhibitors in patients with pulmonary arterial hypertension: a randomized prospective study. J Am Coll Cardiol 2004, 44:1488\u20131496.","journal-title":"J Am Coll Cardiol"},{"key":"75_CR25","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1016\/S0735-1097(02)02563-9","volume":"40","author":"U Thadani","year":"2002","unstructured":"Thadani U, Smith W, Nash S, et al.: The effect of vardenafil, a potent and highly selective phosphodiesterase-5 inhibitor for the treatment of erectile dysfunction, on the cardiovascular response to exercise in patients with coronary artery disease. J Am Coll Cardiol 2002, 40:2006\u20132012.","journal-title":"J Am Coll Cardiol"},{"key":"75_CR26","unstructured":"Prescribing information for Levitra (vardenafil HCl) tablets. http:\/\/www.fda.gov\/cder\/foi\/label\/2005\/021400s004lbl.pdf. Accessed February 5, 2006."},{"key":"75_CR27","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1002\/j.1939-4640.2002.tb02332.x","volume":"23","author":"WJG Hellstrom","year":"2002","unstructured":"Hellstrom WJG, Gittelman M, Karlin G, et al.: Vardenafil for treatment of men with erectile dysfunction: efficacy and safety in a randomized, double-blind, placebo-controlled trial. J Androl 2002, 23:763\u2013771.","journal-title":"J Androl"},{"key":"75_CR28","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1002\/j.1939-4640.2004.tb02833.x","volume":"25","author":"G Pomara","year":"2004","unstructured":"Pomara G, Morelli G, Pomara S, et al.: Cardiovascular parameter changes in patients with erectile dysfunction using PDE-5 inhibitors: a study with sildenafil and vardenafil. J Androl 2004, 25:625\u2013629.","journal-title":"J Androl"},{"key":"75_CR29","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1111\/j.1743-6109.2005.00150.x","volume":"2","author":"H Ahlen van","year":"2005","unstructured":"van Ahlen H, Wahle K, Kupper W, et al.: Safety and efficacy of vardenafil, a selective phosphodiesterase 5 inhibitor, in patients with erectile dysfunction and arterial hypertension treated with multiple antihypertensives. J Sex Med 2005, 2:856\u2013864.","journal-title":"J Sex Med"},{"key":"75_CR30","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.urology.2004.07.038","volume":"64","author":"SM Auerbach","year":"2004","unstructured":"Auerbach SM, Gittelman M, Mazzu A, et al.: Simultaneous administration of vardenafil and tamsulosin does not induce clinically significant hypotension in patients with benign prostatic hyperplasia. Urology 2004, 64:998\u20131003; discussion 1003\u20131004.","journal-title":"Urology"},{"issue":"Suppl H","key":"75_CR31","doi-asserted-by":"crossref","first-page":"H32","DOI":"10.1016\/S1520-765X(02)90050-7","volume":"4","author":"JT Emmick","year":"2002","unstructured":"Emmick JT, Stuewe SR, Mitchell M: Overview of the cardiovascular effects of tadalafil. Eur Heart J 2002, 4(Suppl H):H32-H47.","journal-title":"Eur Heart J"},{"key":"75_CR32","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1016\/j.jacc.2003.09.023","volume":"42","author":"RA Kloner","year":"2003","unstructured":"Kloner RA, Hutter AM, Emmick JT, et al.: Time course of the interaction between tadalafil and nitrates. J Am Coll Cardiol 2003, 42:1855\u20131860.","journal-title":"J Am Coll Cardiol"},{"key":"75_CR33","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/sj.ijir.3901360","volume":"17","author":"RA Kloner","year":"2005","unstructured":"Kloner RA, Sadovsky R, Johnson EG, et al.: Efficacy of tadalafil in the treatment of erectile dysfunction in hypertensive men on concomitant thiazide diuretic therapy. Int J Impot Res 2005, 17:450\u2013454.","journal-title":"Int J Impot Res"},{"key":"75_CR34","doi-asserted-by":"crossref","first-page":"47M","DOI":"10.1016\/S0002-9149(03)00075-4","volume":"92","author":"RA Kloner","year":"2003","unstructured":"Kloner RA, Mitchell M, Emmick JT: Cardiovascular effects of tadalafil in patients on common antihypertensive therapies. Am J Cardiol 2003, 92:47M-57M.","journal-title":"Am J Cardiol"},{"key":"75_CR35","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1097\/01.ju.0000142687.75577.e4","volume":"172","author":"RA Kloner","year":"2004","unstructured":"Kloner RA, Jackson G, Emmick JT, et al.: Interaction between the phosphodiesterase 5 inhibitor, tadalafil and 2 alpha-blockers, doxazosin and tamsulosin in healthy normotensive men. J Urol 2004, 172:1935\u20131940.","journal-title":"J Urol"},{"key":"75_CR36","unstructured":"Prescribing information for Cialis (tadalafil) tablets. http:\/\/www.fda.gov\/cder\/foi\/label\/2005\/021368s006lbl.pdf. Accessed February 5, 2006."},{"key":"75_CR37","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1161\/01.CIR.0000146906.42375.D3","volume":"110","author":"RA Kloner","year":"2004","unstructured":"Kloner RA: Cardiovascular effects of the 3 phosphodiesterase-5 inhibitors approved for the treatment of erectile dysfunction. Circulation 2004, 110:3149\u20133155. This is a comprehensive review on the hemodynamics of phosphodiesterase-5 inhibitors.","journal-title":"Circulation"},{"key":"75_CR38","doi-asserted-by":"crossref","first-page":"42M","DOI":"10.1016\/j.amjcard.2005.07.011","volume":"96","author":"RA Kloner","year":"2005","unstructured":"Kloner RA: Pharmacology and drug interaction effects of the phosphodiesterase 5 inhibitors: focus on alpha-blocker interactions. Am J Cardiol 2005, 96:42M-46M.","journal-title":"Am J Cardiol"},{"key":"75_CR39","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.amjcard.2005.03.065","volume":"96","author":"JB Kostis","year":"2005","unstructured":"Kostis JB, Jackson G, Rosen R, et al.: Sexual dysfunction and cardiac risk (the Second Princeton Consensus Conference). Am J Cardiol 2005, 96:313\u2013321. These guidelines provide information on how to evaluate patients with cardiovascular disease that have erectile dysfunction.","journal-title":"Am J Cardiol"}],"container-title":["Current Hypertension Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11906-006-0075-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11906-006-0075-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11906-006-0075-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T14:08:26Z","timestamp":1707919706000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11906-006-0075-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["75"],"URL":"https:\/\/doi.org\/10.1007\/s11906-006-0075-y","relation":{},"ISSN":["1522-6417","1534-3111"],"issn-type":[{"value":"1522-6417","type":"print"},{"value":"1534-3111","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7]]}}}