{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T08:09:57Z","timestamp":1768550997429,"version":"3.49.0"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Science Inc"],"published-print":{"date-parts":[[2007,12]]},"DOI":"10.1007\/s11906-007-0084-5","type":"journal-article","created":{"date-parts":[[2008,2,15]],"date-time":"2008-02-15T15:44:49Z","timestamp":1203090289000},"page":"455-461","source":"Crossref","is-referenced-by-count":25,"title":["Lipid-induced cell dysfunction and cell death: Lessons from yeast"],"prefix":"10.1007","volume":"9","author":[{"given":"Sepp D.","family":"Kohlwein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Petschnigg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2008,2,16]]},"reference":[{"key":"84_CR1","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0092-8674(03)01081-X","volume":"116","author":"J.S. Flier","year":"2004","unstructured":"Flier JS: Obesity wars: molecular progress confronts an expanding epidemic. Cell 2004, 116:337\u2013350.","journal-title":"Cell"},{"key":"84_CR2","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1126\/science.1079856","volume":"299","author":"J.M. Friedman","year":"2003","unstructured":"Friedman JM: A war on obesity, not the obese. Science 2003, 299:856\u2013858.","journal-title":"Science"},{"key":"84_CR3","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/nm0604-563","volume":"10","author":"J.M. Friedman","year":"2004","unstructured":"Friedman JM: Modern science versus the stigma of obesity. Nat Med 2004, 10:563\u2013569.","journal-title":"Nat Med"},{"key":"84_CR4","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0092-8674(01)00240-9","volume":"104","author":"B.M. Spiegelman","year":"2001","unstructured":"Spiegelman BM, Flier JS: Obesity and the regulation of energy balance. Cell 2001, 104:531\u2013543.","journal-title":"Cell"},{"key":"84_CR5","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.tips.2005.03.004","volume":"26","author":"W.H. Mager","year":"2005","unstructured":"Mager WH, Winderickx J: Yeast as a model for medical and medicinal research. Trends Pharmacol Sci 2005, 26:265\u2013273.","journal-title":"Trends Pharmacol Sci"},{"key":"84_CR6","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/S0140-6736(01)06382-6","volume":"358","author":"H. Frankish","year":"2001","unstructured":"Frankish H: Nobel prize awarded to US and UK cancer researchers. Lancet 2001, 358:1243.","journal-title":"Lancet"},{"key":"84_CR7","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1385\/JMN:28:2:161","volume":"28","author":"N. Sharma","year":"2006","unstructured":"Sharma N, Brandis KA, Herrera SK, et al.: Alpha-synuclein budding yeast model: toxicity enhanced by impaired proteasome and oxidative stress. J Mol Neurosci 2006, 28:161\u2013178.","journal-title":"J Mol Neurosci"},{"key":"84_CR8","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1007\/s00294-002-0310-2","volume":"41","author":"F. Madeo","year":"2002","unstructured":"Madeo F, Engelhardt S, Herker E, et al.: Apoptosis in yeast: a new model system with applications in cell biology and medicine. Curr Genet 2002, 41:208\u2013216.","journal-title":"Curr Genet"},{"key":"84_CR9","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1146\/annurev.med.56.082103.104617","volume":"56","author":"J. Vijg","year":"2005","unstructured":"Vijg J, Suh Y: Genetics of longevity and aging. Annu Rev Med 2005, 56:193\u2013212.","journal-title":"Annu Rev Med"},{"key":"84_CR10","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/ng1951","volume":"39","author":"J. Fischer","year":"2007","unstructured":"Fischer J, Lefevre C, Morava E, et al.: The gene encoding adipose triglyceride lipase (PNPLA2) is mutated in neutral lipid storage disease with myopathy. Nat Genet 2007, 39:28\u201330.","journal-title":"Nat Genet"},{"key":"84_CR11","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1126\/science.1100747","volume":"306","author":"R. Zimmermann","year":"2004","unstructured":"Zimmermann R, Strauss JG, Haemmerle G, et al.: Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase. Science 2004, 306:1383\u20131386.","journal-title":"Science"},{"key":"84_CR12","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1126\/science.1123965","volume":"312","author":"G. Haemmerle","year":"2006","unstructured":"Haemmerle G, Lass A, Zimmermann R, et al.: Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase. Science 2006, 312:734\u2013737.","journal-title":"Science"},{"key":"84_CR13","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1097\/01.mol.0000169354.20395.1c","volume":"16","author":"R. Zechner","year":"2005","unstructured":"Zechner R, Strauss JG, Haemmerle G, et al.: Lipolysis: pathway under construction. Curr Opin Lipidol 2005, 16:333\u2013340.","journal-title":"Curr Opin Lipidol"},{"key":"84_CR14","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.bbalip.2006.04.004","volume":"1771","author":"J.P. Fernandez-Murray","year":"2007","unstructured":"Fernandez-Murray JP, McMaster CR: Phosphatidylcholine synthesis and its catabolism by yeast neuropathy target esterase 1. Biochim Biophys Acta 2007, 1771:331\u2013336.","journal-title":"Biochim Biophys Acta"},{"key":"84_CR15","doi-asserted-by":"crossref","first-page":"8544","DOI":"10.1074\/jbc.M413999200","volume":"280","author":"J.P. Murray","year":"2005","unstructured":"Murray JP, McMaster CR: Nte1p-mediated deacylation of phosphatidylcholine functionally interacts with Sec14p. J Biol Chem 2005, 280:8544\u20138552.","journal-title":"J Biol Chem"},{"key":"84_CR16","doi-asserted-by":"crossref","first-page":"23317","DOI":"10.1074\/jbc.M302577200","volume":"278","author":"K. Athenstaedt","year":"2003","unstructured":"Athenstaedt K, Daum G: YMR313c\/TGL3 encodes a novel triacylglycerol lipase located in lipid particles of Saccharomyces cerevisiae. J Biol Chem 2003, 278:23317\u201323323.","journal-title":"J Biol Chem"},{"key":"84_CR17","doi-asserted-by":"crossref","first-page":"37301","DOI":"10.1074\/jbc.M507261200","volume":"280","author":"K. Athenstaedt","year":"2005","unstructured":"Athenstaedt K, Daum G: Tgl4p and Tgl5p, two triacylglycerol lipases of the yeast Saccharomyces cerevisiae are localized to lipid particles. J Biol Chem 2005, 280:37301\u201337309.","journal-title":"J Biol Chem"},{"key":"84_CR18","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1074\/jbc.M508414200","volume":"281","author":"C.F. Kurat","year":"2006","unstructured":"Kurat CF, Natter K, Petschnigg J, et al.: Obese yeast: triglyceride lipolysis is functionally conserved from mammals to yeast. J Biol Chem 2006, 281:491\u2013500.","journal-title":"J Biol Chem"},{"key":"84_CR19","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.cmet.2006.03.005","volume":"3","author":"A. Lass","year":"2006","unstructured":"Lass A, Zimmermann R, Haemmerle G, et al.: Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman syndrome. Cell Metab 2006, 3:309\u2013319.","journal-title":"Cell Metab"},{"key":"84_CR20","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1038\/sj.jid.5700332","volume":"126","author":"M. Demerjian","year":"2006","unstructured":"Demerjian M, Crumrine DA, Milstone LM, et al.: Barrier dysfunction and pathogenesis of neutral lipid storage disease with ichthyosis (Chanarin-Dorfman syndrome). J Invest Dermatol 2006, 126:2032\u20132038.","journal-title":"J Invest Dermatol"},{"key":"84_CR21","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1073\/pnas.022634399","volume":"99","author":"T.A. Huffman","year":"2002","unstructured":"Huffman TA, Mothe-Satney I, Lawrence JC Jr.: Insulin-stimulated phosphorylation of lipin mediated by the mammalian target of rapamycin. Proc Natl Acad Sci U S A 2002, 99:1047\u20131052.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"84_CR22","doi-asserted-by":"crossref","first-page":"34537","DOI":"10.1074\/jbc.M606654200","volume":"281","author":"L. O\u2019Hara","year":"2006","unstructured":"O\u2019Hara L, Han GS, Peak-Chew S, et al.: Control of phospholipid synthesis by phosphorylation of the yeast lipin Pah1p\/Smp2p Mg2+-dependent phosphatidate phosphatase. J Biol Chem 2006, 281:34537\u201334548.","journal-title":"J Biol Chem"},{"key":"84_CR23","doi-asserted-by":"crossref","first-page":"9210","DOI":"10.1074\/jbc.M600425200","volume":"281","author":"G.S. Han","year":"2006","unstructured":"Han GS, Wu WI, Carman GM: The Sacharomyces cerevisiae lipin homolog is a Mg2+-dependent phosphatidate phosphatase enzyme. J Biol Chem 2006, 281:9210\u20139218.","journal-title":"J Biol Chem"},{"key":"84_CR24","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.tibs.2006.10.003","volume":"31","author":"G.M. Carman","year":"2006","unstructured":"Carman GM, Han GS: Roles of phosphatidate phosphatase enzymes in lipid metabolism. Trends Biochem Sci 2006, 31:694\u2013699.","journal-title":"Trends Biochem Sci"},{"key":"84_CR25","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.bbalip.2006.05.017","volume":"1771","author":"M. Chen","year":"2007","unstructured":"Chen M, Hancock LC, Lopes JM: Transcriptional regulation of yeast phospholipid biosynthetic genes. Biochim Biophys Acta 2007, 1771:310\u2013321.","journal-title":"Biochim Biophys Acta"},{"key":"84_CR26","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1126\/science.1096083","volume":"304","author":"C.J. Loewen","year":"2004","unstructured":"Loewen CJ, Gaspar ML, Jesch SA, et al.: Phospholipid metabolism regulated by a transcription factor sensing phosphatidic acid. Science 2004, 304:1644\u20131647.","journal-title":"Science"},{"key":"84_CR27","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.bbalip.2006.07.004","volume":"1771","author":"O. Tehlivets","year":"2007","unstructured":"Tehlivets O, Scheuringer K, Kohlwein SD: Fatty acid synthesis and elongation in yeast. Biochim Biophys Acta 2007, 1771:255\u2013270.","journal-title":"Biochim Biophys Acta"},{"key":"84_CR28","doi-asserted-by":"crossref","unstructured":"Hardie DG: AMP-activated\/SNF1 protein kinases: conserved guardians of cellular energy. Nat Rev Mol Cell Biol 2007, Epub ahead of print.","DOI":"10.1038\/nrm2249"},{"key":"84_CR29","doi-asserted-by":"crossref","first-page":"5710","DOI":"10.1128\/MCB.21.17.5710-5722.2001","volume":"21","author":"M.K. Shirra","year":"2001","unstructured":"Shirra MK, Patton-Vogt J, Ulrich A, et al.: Inhibition of acetyl coenzyme A carboxylase activity restores expression of the INO1 gene in a snf1 mutant strain of Saccharomyces cerevisiae. Mol Cell Biol 2001, 21:5710\u20135722.","journal-title":"Mol Cell Biol"},{"key":"84_CR30","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1534\/genetics.104.032961","volume":"168","author":"H.J. Chang","year":"2004","unstructured":"Chang HJ, Jesch SA, Gaspar ML, Henry SA: Role of the unfolded protein response pathway in secretory stress and regulation of INO1 expression in Saccharomyces cerevisiae. Genetics 2004, 168:1899\u20131913.","journal-title":"Genetics"},{"key":"84_CR31","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1146\/annurev.cellbio.21.122303.120200","volume":"22","author":"S. Bernales","year":"2006","unstructured":"Bernales S, Papa FR, Walter P: Intracellular signaling by the unfolded protein response. Annu Rev Cell Dev Biol 2006, 22:487\u2013508.","journal-title":"Annu Rev Cell Dev Biol"},{"key":"84_CR32","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1146\/annurev.cellbio.21.012704.133250","volume":"21","author":"K. Romisch","year":"2005","unstructured":"Romisch K: Endoplasmic reticulum-associated degradation. Annu Rev Cell Dev Biol 2005, 21:435\u2013456.","journal-title":"Annu Rev Cell Dev Biol"},{"key":"84_CR33","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/0092-8674(93)90648-A","volume":"73","author":"J.S. Cox","year":"1993","unstructured":"Cox JS, Shamu CE, Walter P: Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase. Cell 1993, 73:1197\u20131206.","journal-title":"Cell"},{"key":"84_CR34","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/0092-8674(93)90521-Q","volume":"74","author":"K. Mori","year":"1993","unstructured":"Mori K, Ma W, Gething MJ, Sambrook J: A transmembrane protein with a cdc2+\/CDC28-related kinase activity is required for signaling from the ER to the nucleus. Cell 1993, 74:743\u2013756.","journal-title":"Cell"},{"key":"84_CR35","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1046\/j.1365-2443.1996.d01-274.x","volume":"1","author":"K. Mori","year":"1996","unstructured":"Mori K, Kawahara T, Yoshida H, et al.: Signalling from endoplasmic reticulum to nucleus: transcription factor with a basic-leucine zipper motif is required for the unfolded protein-reponse pathway. Genes Cells 1996, 1:803\u2013817.","journal-title":"Genes Cells"},{"key":"84_CR36","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0092-8674(00)81360-4","volume":"87","author":"J.S. Cox","year":"1996","unstructured":"Cox JS, Walter P: A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response. Cell 1996, 87:391\u2013404.","journal-title":"Cell"},{"key":"84_CR37","doi-asserted-by":"crossref","first-page":"7024","DOI":"10.1074\/jbc.M609490200","volume":"282","author":"R. Sriburi","year":"2007","unstructured":"Sriburi R, Bommiasamy H, Buldak GL, et al.: Coordinate regulation of phospholipid biosynthesis and secretory pathway gene expression in XBP-1(S)-induced endoplasmic reticulum biogenesis. J Biol Chem 2007, 282:7024\u20137034.","journal-title":"J Biol Chem"},{"key":"84_CR38","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1097\/00041433-200306000-00008","volume":"14","author":"J.E. Schaffer","year":"2003","unstructured":"Schaffer JE: Lipotoxicity: when tissues overeat. Curr Opin Lipidol 2003, 14:281\u2013287.","journal-title":"Curr Opin Lipidol"},{"key":"84_CR39","doi-asserted-by":"crossref","first-page":"726","DOI":"10.2337\/diabetes.52.3.726","volume":"52","author":"K. Maedler","year":"2003","unstructured":"Maedler K, Oberholzer J, Bucher P, et al.: Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function. Diabetes 2003, 52:726\u2013733.","journal-title":"Diabetes"},{"key":"84_CR40","doi-asserted-by":"crossref","first-page":"69","DOI":"10.2337\/diabetes.50.1.69","volume":"50","author":"K. Maedler","year":"2001","unstructured":"Maedler K, Spinas GA, Dyntar D, et al.: Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function. Diabetes 2001, 50:69\u201376.","journal-title":"Diabetes"},{"key":"84_CR41","doi-asserted-by":"crossref","first-page":"3398","DOI":"10.1210\/en.2005-1494","volume":"147","author":"E. Karaskov","year":"2006","unstructured":"Karaskov E, Scott C, Zhang L, et al.: Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis. Endocrinology 2006, 147:3398\u20133407.","journal-title":"Endocrinology"},{"key":"84_CR42","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1194\/jlr.M600299-JLR200","volume":"47","author":"N.M. Borradaile","year":"2006","unstructured":"Borradaile NM, Han X, Harp JD, et al.: Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death. J Lipid Res 2006, 47:2726\u20132737.","journal-title":"J Lipid Res"},{"key":"84_CR43","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/0003-9861(92)90600-2","volume":"296","author":"G.A. Keesler","year":"1992","unstructured":"Keesler GA, Casey WM, Parks LW: Stimulation by heme of steryl ester synthase and aerobic sterol exclusion in the yeast Saccharomyces cerevisiae. Arch Biochem Biophys 1992, 296:474\u2013481.","journal-title":"Arch Biochem Biophys"},{"key":"84_CR44","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1467-789X.2005.00177.x","volume":"6","author":"A. Dobrzyn","year":"2005","unstructured":"Dobrzyn A, Ntambi JM: Steroyl-CoA desaturase as a new drug target for obesity treatment. Obes Rev 2005, 6:169\u2013174.","journal-title":"Obes Rev"},{"key":"84_CR45","doi-asserted-by":"crossref","first-page":"6786","DOI":"10.1128\/MCB.00077-06","volume":"26","author":"K. Chu","year":"2006","unstructured":"Chu K, Miyazaki M, Man WC, Ntambi JM: Stearoylcoenzyme A desaturase 1 deficiency protects against hypertriglyceridemia and increases plasma high-density lipoprotein cholesterol induced by liver X receptor activation. Mol Cell Biol 2006, 26:6786\u20136798.","journal-title":"Mol Cell Biol"},{"key":"84_CR46","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.2337\/db06-1142","volume":"56","author":"J.B. Flowers","year":"2007","unstructured":"Flowers JB, Rabaglia ME, Schueler KL, et al.: Loss of stearoyl-CoA desaturase-1 improves insulin sensitivity in lean mice but worsens diabetes in leptin-deficient obese mice. Diabetes 2007, 56:1228\u20131239.","journal-title":"Diabetes"},{"key":"84_CR47","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.bbalip.2006.06.010","volume":"1771","author":"C.E. Martin","year":"2007","unstructured":"Martin CE, Oh CS, Jiang Y: Regulation of long chain unsaturated fatty acid synthesis in yeast. Biochim Biophys Acta 2007, 1771:271\u2013285.","journal-title":"Biochim Biophys Acta"},{"key":"84_CR48","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/S0092-8674(01)00595-5","volume":"107","author":"M. Rape","year":"2001","unstructured":"Rape M, Hoppe T, Gorr I, et al.: Mobilization of processed, membrane-tethered SPT23 transcription factor by CDC48(UFD1\/NPL4), a ubiquitin-selective chaperone. Cell 2001, 107:667\u2013677.","journal-title":"Cell"},{"key":"84_CR49","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1083\/jcb.139.3.729","volume":"139","author":"F. Madeo","year":"1997","unstructured":"Madeo F, Frohlich E, Frohlich KU: A yeast mutant showing diagnostic markers of early and late apoptosis. J Cell Biol 1997, 139:729\u2013734.","journal-title":"J Cell Biol"},{"key":"84_CR50","doi-asserted-by":"crossref","unstructured":"Espenshade PJ, Hughes AL: Regulation of sterol synthesis in eukaryotes. Annu Rev Genet 2007, Epub ahead of print. PMID: 17666007.","DOI":"10.1146\/annurev.genet.41.110306.130315"},{"key":"84_CR51","doi-asserted-by":"crossref","first-page":"4429","DOI":"10.1091\/mbc.e02-04-0196","volume":"13","author":"V. Tatzer","year":"2002","unstructured":"Tatzer V, Zellnig G, Kohlwein SD, Schneiter R: Lipid-dependent subcellular relocalization of the acyl chain desaturase in yeast. Mol Biol Cell 2002, 13:4429\u20134442.","journal-title":"Mol Biol Cell"},{"key":"84_CR52","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1083\/jcb.115.5.1249","volume":"115","author":"L.C. Stewart","year":"1991","unstructured":"Stewart LC, Yaffe MP: A role for unsaturated fatty acids in mitochondrial movement and inheritance. J Cell Biol 1991, 115:1249\u20131257.","journal-title":"J Cell Biol"},{"key":"84_CR53","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1534\/genetics.106.064428","volume":"175","author":"D. Lockshon","year":"2007","unstructured":"Lockshon D, Surface LE, Kerr EO, et al.: The sensitivity of yeast mutants to oleic acid implicates the peroxisome and other processes in membrane function. Genetics 2007, 175:77\u201391.","journal-title":"Genetics"},{"key":"84_CR54","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nature00935","volume":"418","author":"G. Giaever","year":"2002","unstructured":"Giaever G, Chu AM, Ni L, et al.: Functional profiling of the Saccharomyces cerevisiae genome. Nature 2002, 418:387\u2013391.","journal-title":"Nature"},{"key":"84_CR55","doi-asserted-by":"crossref","first-page":"14890","DOI":"10.1074\/jbc.M010286200","volume":"276","author":"L.L. Listenberger","year":"2001","unstructured":"Listenberger LL, Ory DS, Schaffer JE: Palmitate-induced apoptosis can occur through a ceramide-independent pathway. J Biol Chem 2001, 276:14890\u201314895.","journal-title":"J Biol Chem"},{"key":"84_CR56","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S1050-1738(02)00152-4","volume":"12","author":"L.L. Listenberger","year":"2002","unstructured":"Listenberger LL, Schaffer JE: Mechanisms of lipoapoptosis: implications for human heart disease. Trends Cardiovasc Med 2002, 12:134\u2013138.","journal-title":"Trends Cardiovasc Med"},{"key":"84_CR57","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.2337\/diabetes.51.5.1437","volume":"51","author":"R. Lupi","year":"2002","unstructured":"Lupi R, Dotta F, Marselli L, et al.: Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated. Diabetes 2002, 51:1437\u20131442.","journal-title":"Diabetes"},{"key":"84_CR58","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1073\/pnas.0630588100","volume":"100","author":"L.L. Listenberger","year":"2003","unstructured":"Listenberger LL, Han X, Lewis SE, et al.: Triglyceride accumulation protects against fatty acid-induced lipotoxicity. Proc Natl Acad Sci U S A 2003, 100:3077\u20133082.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"84_CR59","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.femsyr.2005.07.004","volume":"5","author":"C.P. Low","year":"2005","unstructured":"Low CP, Liew LP, Pervaiz S, Yang H: Apoptosis and lipoapoptosis in the fission yeast Schizosaccharomyces pombe. FEMS Yeast Res 2005, 5:1199\u20131206.","journal-title":"FEMS Yeast Res"},{"key":"84_CR60","doi-asserted-by":"crossref","first-page":"47145","DOI":"10.1074\/jbc.M306998200","volume":"278","author":"Q. Zhang","year":"2003","unstructured":"Zhang Q, Chieu HK, Low CP, et al.: Schizosaccharomyces pombe cells deficient in triacylglycerols synthesis undergo apoptosis upon entry into the stationary phase. J Biol Chem 2003, 278:47145\u201347155.","journal-title":"J Biol Chem"},{"key":"84_CR61","doi-asserted-by":"crossref","first-page":"6478","DOI":"10.1074\/jbc.M109109200","volume":"277","author":"L. Sandager","year":"2002","unstructured":"Sandager L, Gustavsson MH, Stahl U, et al.: Storage lipid synthesis is non-essential in yeast. J Biol Chem 2002, 277:6478\u20136482.","journal-title":"J Biol Chem"}],"container-title":["Current Hypertension Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11906-007-0084-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11906-007-0084-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11906-007-0084-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T00:14:19Z","timestamp":1559434459000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11906-007-0084-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":61,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["84"],"URL":"https:\/\/doi.org\/10.1007\/s11906-007-0084-5","relation":{},"ISSN":["1522-6417","1534-3111"],"issn-type":[{"value":"1522-6417","type":"print"},{"value":"1534-3111","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12]]}}}