{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T23:20:16Z","timestamp":1770074416006,"version":"3.49.0"},"reference-count":67,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2009,11,29]],"date-time":"2009-11-29T00:00:00Z","timestamp":1259452800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Science Inc"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1007\/s11906-009-0069-7","type":"journal-article","created":{"date-parts":[[2009,11,28]],"date-time":"2009-11-28T06:04:06Z","timestamp":1259388246000},"page":"396-405","source":"Crossref","is-referenced-by-count":16,"title":["Seek and destroy: The ubiquitin-proteasome system in cardiac disease"],"prefix":"10.1007","volume":"11","author":[{"given":"Jessica E.","family":"Rodr\u00edoguez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan C.","family":"Schisler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cam","family":"Patterson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monte S.","family":"Willis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,11,29]]},"reference":[{"key":"69_CR1","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1096\/fasebj.11.14.9409543","volume":"11","author":"K.D. Wilkinson","year":"1997","unstructured":"Wilkinson KD: Regulation of ubiquitin-dependent processes by deubiquitinating enzymes. FASEB J 1997, 11:1245\u20131256.","journal-title":"FASEB J"},{"key":"69_CR2","doi-asserted-by":"crossref","first-page":"17375","DOI":"10.1074\/jbc.M609659200","volume":"282","author":"H.T. Kim","year":"2007","unstructured":"Kim HT, Kim KP, Lledias F, et al.: Certain pairs of ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) synthesize nondegradable forked ubiquitin chains containing all possible isopeptide linkages. J Biol Chem 2007, 282:17375\u201317386.","journal-title":"J Biol Chem"},{"key":"69_CR3","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1038\/emboj.2009.115","volume":"28","author":"H.T. Kim","year":"2009","unstructured":"Kim HT, Kim KP, Uchiki T, et al.: S5a promotes protein degradation by blocking synthesis of nondegradable forked ubiquitin chains. EMBO J 2009, 28:1867\u20131877.","journal-title":"EMBO J"},{"key":"69_CR4","doi-asserted-by":"crossref","first-page":"50089","DOI":"10.1074\/jbc.M402006200","volume":"279","author":"E. Leithe","year":"2004","unstructured":"Leithe E, Rivedal E: Ubiquitination and down-regulation of gap junction protein connexin-43 in response to 12-O-tetradecanoylphorbol 13-acetate treatment. J Biol Chem 2004, 279:50089\u201350096.","journal-title":"J Biol Chem"},{"key":"69_CR5","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1242\/jcs.00951","volume":"117","author":"E. Leithe","year":"2004","unstructured":"Leithe E, Rivedal E: Epidermal growth factor regulates ubiquitination, internalization and proteasome-dependent degradation of connexin43. J Cell Sci 2004, 117:1211\u20131220.","journal-title":"J Cell Sci"},{"key":"69_CR6","doi-asserted-by":"crossref","first-page":"26661","DOI":"10.1016\/S0021-9258(19)61427-4","volume":"275","author":"H. Huang","year":"2000","unstructured":"Huang H, Joazeiro CA, Bonfoco E, et al.: The inhibitor of apoptosis, cIAP2, functions as a ubiquitin-protein ligase and promotes in vitro monoubiquitination of caspases 3 and 7. J Biol Chem 2000, 275:26661\u201326664.","journal-title":"J Biol Chem"},{"key":"69_CR7","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1515\/bchm3.1988.369.2.1325","volume":"369","author":"H.P. Jennissen","year":"1988","unstructured":"Jennissen HP, Laub M: Ubiquitin-calmodulin conjugating activity from cardiac muscle. Biol Chem Hoppe Seyler 1988, 369:1325\u20131330.","journal-title":"Biol Chem Hoppe Seyler"},{"key":"69_CR8","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/nbt849","volume":"21","author":"J. Peng","year":"2003","unstructured":"Peng J, Schwartz D, Elias JE, et al.: A proteomics approach to understanding protein ubiquitination. Nat Biotechnol 2003, 21:921\u2013926.","journal-title":"Nat Biotechnol"},{"key":"69_CR9","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1016\/j.bbapap.2006.09.004","volume":"1764","author":"P. Xu","year":"2006","unstructured":"Xu P, Peng J: Dissecting the ubiquitin pathway by mass spectrometry. Biochim Biophys Acta 2006, 1764:1940\u20131947.","journal-title":"Biochim Biophys Acta"},{"key":"69_CR10","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1111\/j.1365-2443.2004.00780.x","volume":"9","author":"T. Tenno","year":"2004","unstructured":"Tenno T, Fujiwara K, Tochio H, et al.: Structural basis for distinct roles of Lys63- and Lys48-linked polyubiquitin chains. Genes Cells 2004, 9:865\u2013875.","journal-title":"Genes Cells"},{"key":"69_CR11","doi-asserted-by":"crossref","first-page":"7055","DOI":"10.1074\/jbc.M309184200","volume":"279","author":"R. Varadan","year":"2004","unstructured":"Varadan R, Assfalg M, Haririnia A, et al.: Solution conformation of Lys63-linked di-ubiquitin chain provides clues to functional diversity of polyubiquitin signaling. J Biol Chem 2004, 279:7055\u20137063.","journal-title":"J Biol Chem"},{"key":"69_CR12","doi-asserted-by":"crossref","first-page":"3211","DOI":"10.1172\/JCI31757","volume":"117","author":"H.H. Li","year":"2007","unstructured":"Li HH, Willis MS, Lockyer P, et al.: Atrogin-1 inhibits Akt-dependent cardiac hypertrophy in mice via ubiquitin-dependent coactivation of forkhead proteins. J Clin Invest 2007, 117:3211\u20133223.","journal-title":"J Clin Invest"},{"key":"69_CR13","doi-asserted-by":"crossref","first-page":"5488","DOI":"10.1074\/jbc.M806487200","volume":"284","author":"P. Xie","year":"2009","unstructured":"Xie P, Guo S, Fan Y, et al.: Atrogin-1\/MAFbx enhances simulated ischemia\/reperfusion-induced apoptosis in cardiomyocytes through degradation of MAPK phosphatase-1 and sustained JNK activation. J Biol Chem 2009, 284:5488\u20135496.","journal-title":"J Biol Chem"},{"key":"69_CR14","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2217\/14796678.4.1.65","volume":"4","author":"M.S. Willis","year":"2008","unstructured":"Willis MS, Schisler JC, Patterson C: Appetite for destruction: E3 ubiquitin-ligase protection in cardiac disease. Future Cardiol 2008, 4:65\u201375.","journal-title":"Future Cardiol"},{"key":"69_CR15","doi-asserted-by":"crossref","first-page":"H2836","DOI":"10.1152\/ajpheart.01122.2004","volume":"288","author":"C. Zhang","year":"2005","unstructured":"Zhang C, Xu Z, He XR, et al.: CHIP, a cochaperone\/ubiquitin ligase that regulates protein quality control, is required for maximal cardioprotection after myocardial infarction in mice. Am J Physiol Heart Circ Physiol 2005, 288:H2836\u2013H2842.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"69_CR16","doi-asserted-by":"crossref","first-page":"4377","DOI":"10.1073\/pnas.0611726104","volume":"104","author":"J. Fielitz","year":"2007","unstructured":"Fielitz J, van Rooij E, Spencer JA, et al.: Loss of muscle-specific RING-finger 3 predisposes the heart to cardiac rupture after myocardial infarction. Proc Natl Acad Sci U S A 2007, 104:4377\u20134382.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"69_CR17","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1172\/JCI32827","volume":"117","author":"J. Fielitz","year":"2007","unstructured":"Fielitz J, Kim MS, Shelton JM, et al.: Myosin accumulation and striated muscle myopathy result from the loss of muscle RING finger 1 and 3. J Clin Invest 2007, 117:2486\u20132495.","journal-title":"J Clin Invest"},{"key":"69_CR18","doi-asserted-by":"crossref","first-page":"4018","DOI":"10.1128\/MCB.00296-08","volume":"28","author":"J.N. Min","year":"2008","unstructured":"Min JN, Whaley RA, Sharpless NE, et al.: CHIP deficiency decreases longevity, with accelerated aging phenotypes accompanied by altered protein quality control. Mol Cell Biol 2008, 28:4018\u20134025.","journal-title":"Mol Cell Biol"},{"key":"69_CR19","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1093\/cvr\/cvn289","volume":"81","author":"M.S. Willis","year":"2009","unstructured":"Willis MS, Schisler JC, Portbury AL, Patterson C: Build it up-Tear it down: protein quality control in the cardiac sarcomere. Cardiovasc Res 2009, 81:439\u2013448.","journal-title":"Cardiovasc Res"},{"key":"69_CR20","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1083\/jcb.200402033","volume":"167","author":"R. Arya","year":"2004","unstructured":"Arya R, Kedar V, Hwang JR, et al.: Muscle ring finger protein- 1 inhibits PKC{epsilon} activation and prevents cardiomyocyte hypertrophy. J Cell Biol 2004, 167:1147\u20131159.","journal-title":"J Cell Biol"},{"key":"69_CR21","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1161\/01.RES.0000259559.48597.32","volume":"100","author":"M.S. Willis","year":"2007","unstructured":"Willis MS, Ike C, Li L, et al.: Muscle ring finger 1, but not muscle ring finger 2, regulates cardiac hypertrophy in vivo. Circ Res 2007, 100:456\u2013459.","journal-title":"Circ Res"},{"key":"69_CR22","doi-asserted-by":"crossref","first-page":"H997","DOI":"10.1152\/ajpheart.00660.2008","volume":"296","author":"M.S. Willis","year":"2009","unstructured":"Willis MS, Rojas M, Li L, et al.: Muscle ring finger 1 mediates cardiac atrophy in vivo. Am J Physiol Heart Circ Physiol 2009, 296:H997\u2013H1006.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"69_CR23","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1161\/CIRCRESAHA.109.194928","volume":"105","author":"M.S. Willis","year":"2009","unstructured":"Willis MS, Schisler JC, Li L, et al.: Cardiac muscle ring finger-1 increases susceptibility to heart failure in vivo. Circ Res 2009, 105:80\u201388.","journal-title":"Circ Res"},{"key":"69_CR24","doi-asserted-by":"crossref","first-page":"12022","DOI":"10.1074\/jbc.M610363200","volume":"282","author":"T.J. Zhao","year":"2007","unstructured":"Zhao TJ, Yan YB, Liu Y, Zhou HM: The generation of the oxidized form of creatine kinase is a negative regulation on muscle creatine kinase. J Biol Chem 2007, 282:12022\u201312029.","journal-title":"J Biol Chem"},{"key":"69_CR25","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1016\/j.jmb.2007.11.049","volume":"376","author":"S. Koyama","year":"2008","unstructured":"Koyama S, Hata S, Witt CC, et al.: Muscle RING-finger protein-1 (MuRF1) as a connector of muscle energy metabolism and protein synthesis. J Mol Biol 2008, 376:1224\u20131236.","journal-title":"J Mol Biol"},{"key":"69_CR26","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.jmb.2005.05.021","volume":"350","author":"S.H. Witt","year":"2005","unstructured":"Witt SH, Granzier H, Witt CC, Labeit S: MURF-1 and MURF-2 target a specific subset of myofibrillar proteins redundantly: towards understanding MURF-dependent muscle ubiquitination. J Mol Biol 2005, 350:713\u2013722.","journal-title":"J Mol Biol"},{"key":"69_CR27","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1006\/jmbi.2001.4448","volume":"306","author":"T. Centner","year":"2001","unstructured":"Centner T, Yano J, Kimura E, et al.: Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain. J Mol Biol 2001, 306:717\u2013726.","journal-title":"J Mol Biol"},{"key":"69_CR28","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/sj.emboj.7601952","volume":"27","author":"C.C. Witt","year":"2008","unstructured":"Witt CC, Witt SH, Lerche S, et al.: Cooperative control of striated muscle mass and metabolism by MuRF1 and MuRF2. EMBO J 2008, 27:350\u2013360.","journal-title":"EMBO J"},{"key":"69_CR29","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/0022-2828(92)91862-Y","volume":"24","author":"H.D. Kim","year":"1992","unstructured":"Kim HD, Kim DJ, Lee IJ, et al.: Human fetal heart development after mid-term: morphometry and ultrastructural study. J Mol Cell Cardiol 1992, 24:949\u2013965.","journal-title":"J Mol Cell Cardiol"},{"key":"69_CR30","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1006\/jmcc.1996.0163","volume":"28","author":"F. Li","year":"1996","unstructured":"Li F, Wang X, Capasso JM, Gerdes AM: Rapid transition of cardiac myocytes from hyperplasia to hypertrophy during postnatal development. J Mol Cell Cardiol 1996, 28:1737\u20131746.","journal-title":"J Mol Cell Cardiol"},{"key":"69_CR31","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/S0960-9822(00)80027-5","volume":"9","author":"S.M. Kolodziejczyk","year":"1999","unstructured":"Kolodziejczyk SM, Wang L, Balazsi K, et al.: MEF2 is upregulated during cardiac hypertrophy and is required for normal post-natal growth of the myocardium. Curr Biol 1999, 9:1203\u20131206.","journal-title":"Curr Biol"},{"key":"69_CR32","doi-asserted-by":"crossref","first-page":"440","DOI":"10.4161\/cc.7.4.5451","volume":"7","author":"J.C. Schisler","year":"2008","unstructured":"Schisler JC, Willis MS, Patterson C: You spin me round: MaFBx\/atrogin-1 feeds forward on FOXO transcription factors (like a record). Cell Cycle 2008, 7:440\u2013443.","journal-title":"Cell Cycle"},{"key":"69_CR33","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.bbadis.2008.06.009","volume":"1782","author":"G. Mearini","year":"2008","unstructured":"Mearini G, Schlossarek S, Willis MS, Carrier L: The ubiquitin-proteasome system in cardiac dysfunction. Biochim Biophys Acta 2008, 1782:749\u2013763.","journal-title":"Biochim Biophys Acta"},{"issue":"4","key":"69_CR34","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.yjmcc.2006.04.022","volume":"41","author":"S. Balasubramanian","year":"2006","unstructured":"Balasubramanian S, Mani S, Shiraishi H, et al.: Enhanced ubiquitination of cytoskeletal proteins in pressure overloaded myocardium is accompanied by changes in specific E3 ligases. J Mol Cell Cardiol 2006, 41(4):669\u2013679.","journal-title":"J Mol Cell Cardiol"},{"key":"69_CR35","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.bbrc.2006.01.163","volume":"342","author":"P. Razeghi","year":"2006","unstructured":"Razeghi P, Baskin KK, Sharma S, et al.: Atrophy, hypertrophy, and hypoxemia induce transcriptional regulators of the ubiquitin proteasome system in the rat heart. Biochem Biophys Res Commun 2006, 342:361\u2013364.","journal-title":"Biochem Biophys Res Commun"},{"key":"69_CR36","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1161\/01.CIR.0000096481.45105.13","volume":"108","author":"P. Razeghi","year":"2003","unstructured":"Razeghi P, Sharma S, Ying J, et al.: Atrophic remodeling of the heart in vivo simultaneously activates pathways of protein synthesis and degradation. Circulation 2003, 108:2536\u20132541.","journal-title":"Circulation"},{"key":"69_CR37","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1159\/000090550","volume":"105","author":"S. Sharma","year":"2006","unstructured":"Sharma S, Ying J, Razeghi P, et al.: Atrophic remodeling of the transplanted rat heart. Cardiology 2006, 105:128\u2013136.","journal-title":"Cardiology"},{"key":"69_CR38","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1126\/science.1065874","volume":"294","author":"S.C. Bodine","year":"2001","unstructured":"Bodine SC, Latres E, Baumhueter S, et al.: Identification of ubiquitin ligases required for skeletal muscle atrophy. Science 2001, 294:1704\u20131708.","journal-title":"Science"},{"key":"69_CR39","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/0002-9149(72)90595-4","volume":"30","author":"S. Rubler","year":"1972","unstructured":"Rubler S, Dlugash J, Yuceoglu YZ, et al.: New type of cardiomyopathy associated with diabetic glomerulosclerosis. Am J Cardiol 1972, 30:595\u2013602.","journal-title":"Am J Cardiol"},{"key":"69_CR40","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1002\/clc.4960211205","volume":"21","author":"K.S. Spector","year":"1998","unstructured":"Spector KS: Diabetic cardiomyopathy. Clin Cardiol 1998, 21:885\u2013887.","journal-title":"Clin Cardiol"},{"key":"69_CR41","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s11892-008-0042-x","volume":"8","author":"R. Harmancey","year":"2008","unstructured":"Harmancey R, Taegtmeyer H: The complexities of diabetic cardiomyopathy: lessons from patients and animal models. Curr Diab Rep 2008, 8:243\u2013248.","journal-title":"Curr Diab Rep"},{"key":"69_CR42","doi-asserted-by":"crossref","first-page":"21945","DOI":"10.1074\/jbc.M703048200","volume":"282","author":"S. Kobayashi","year":"2007","unstructured":"Kobayashi S, Mao K, Zheng H, et al.: Diminished GATA4 protein levels contribute to hyperglycemia-induced cardiomyocyte injury. J Biol Chem 2007, 282:21945\u201321952.","journal-title":"J Biol Chem"},{"key":"69_CR43","doi-asserted-by":"crossref","first-page":"4160","DOI":"10.1210\/en.2006-0251","volume":"147","author":"X. Wang","year":"2006","unstructured":"Wang X, Hu Z, Hu J, et al.: Insulin resistance accelerates muscle protein degradation: activation of the ubiquitin-proteasome pathway by defects in muscle cell signaling. Endocrinology 2006, 147:4160\u20134168.","journal-title":"Endocrinology"},{"key":"69_CR44","doi-asserted-by":"crossref","first-page":"5384","DOI":"10.1210\/en.2008-0132","volume":"149","author":"J. Hu","year":"2008","unstructured":"Hu J, Klein JD, Du J, Wang XH: Cardiac muscle protein catabolism in diabetes mellitus: activation of the ubiquitin-proteasome system by insulin deficiency. Endocrinology 2008, 149:5384\u20135390.","journal-title":"Endocrinology"},{"key":"69_CR45","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.yjmcc.2007.12.009","volume":"44","author":"S.R. Powell","year":"2008","unstructured":"Powell SR, Samuel SM, Wang P, et al.: Upregulation of myocardial 11S-activated proteasome in experimental hyperglycemia. J Mol Cell Cardiol 2008, 44:618\u2013621.","journal-title":"J Mol Cell Cardiol"},{"key":"69_CR46","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/35040607","volume":"408","author":"F.G. Whitby","year":"2000","unstructured":"Whitby FG, Masters EI, Kramer L, et al.: Structural basis for the activation of 20S proteasomes by 11S regulators. Nature 2000, 408:115\u2013120.","journal-title":"Nature"},{"key":"69_CR47","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1161\/CIRCULATIONAHA.106.637827","volume":"114","author":"C. Depre","year":"2006","unstructured":"Depre C, Wang Q, Yan L, et al.: Activation of the cardiac proteasome during pressure overload promotes ventricular hypertrophy. Circulation 2006, 114:1821\u20131828.","journal-title":"Circulation"},{"key":"69_CR48","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/S1357-2725(02)00381-3","volume":"35","author":"S. Merforth","year":"2003","unstructured":"Merforth S, Kuehn L, Osmers A, Dahlmann B: Alteration of 20S proteasome-subtypes and proteasome activator PA28 in skeletal muscle of rat after induction of diabetes mellitus. Int J Biochem Cell Biol 2003, 35:740\u2013748.","journal-title":"Int J Biochem Cell Biol"},{"key":"69_CR49","doi-asserted-by":"crossref","unstructured":"Marfella R, Filippo CD, Portoghese M, et al.: The ubiquitin-proteasome system contributes to the inflammatory injury in ischemic diabetic myocardium: the role of glycemic control. Cardiovasc Pathol 2009 Jan 12 (Epub ahead of print).","DOI":"10.1016\/j.carpath.2008.09.008"},{"key":"69_CR50","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/77053","volume":"25","author":"K. Avela","year":"2000","unstructured":"Avela K, Lipsanen-Nyman M, Idanheimo N, et al.: Gene encoding a new RING-B-box-Coiled-coil protein is mutated in mulibrey nanism. Nat Genet 2000, 25:298\u2013301.","journal-title":"Nat Genet"},{"key":"69_CR51","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.1161\/01.CIR.0000070949.76608.E2","volume":"107","author":"M. Lipsanen-Nyman","year":"2003","unstructured":"Lipsanen-Nyman M, Perheentupa J, Rapola J, et al.: Mulibrey heart disease: clinical manifestations, long-term course, and results of pericardiectomy in a series of 49 patients born before 1985. Circulation 2003, 107:2810\u20132815.","journal-title":"Circulation"},{"key":"69_CR52","doi-asserted-by":"crossref","first-page":"3577","DOI":"10.2337\/diabetes.54.12.3577","volume":"54","author":"N. Karlberg","year":"2005","unstructured":"Karlberg N, Jalanko H, Kallijarvi J, et al.: Insulin resistance syndrome in subjects with mutated RING finger protein TRIM37. Diabetes 2005, 54:3577\u20133581.","journal-title":"Diabetes"},{"key":"69_CR53","doi-asserted-by":"crossref","first-page":"18135","DOI":"10.1073\/pnas.0404341102","volume":"101","author":"V. Kedar","year":"2004","unstructured":"Kedar V, McDonough H, Arya R, et al.: Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I. Proc Natl Acad Sci U S A 2004, 101:18135\u201318140.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"69_CR54","doi-asserted-by":"crossref","first-page":"751.11","DOI":"10.1096\/fasebj.22.1_supplement.751.11","volume":"22","author":"M.S. Willis","year":"2008","unstructured":"Willis MS, Li HH, Rodriguez JE, et al.: MuRF1 inhibits JNK signaling in cardiac ischemia reperfusion injury by degrading phosphorylated cJun [abstract]. FASEB J 2008, 22:751.11.","journal-title":"FASEB J"},{"key":"69_CR55","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1126\/science.1110463","volume":"308","author":"S. Lange","year":"2005","unstructured":"Lange S, Xiang F, Yakovenko A, et al.: The kinase domain of titin controls muscle gene expression and protein turnover. Science 2005, 308:1599\u20131603.","journal-title":"Science"},{"key":"69_CR56","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1172\/JCI200422220","volume":"114","author":"H.H. Li","year":"2004","unstructured":"Li HH, Kedar V, Zhang C, et al.: Atrogin-1\/muscle atrophy F-box inhibits calcineurin-dependent cardiac hypertrophy by participating in an SCF ubiquitin ligase complex. J Clin Invest 2004, 114:1058\u20131071.","journal-title":"J Clin Invest"},{"key":"69_CR57","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1379\/1466-1268(2003)008<0303:CALBTC>2.0.CO;2","volume":"8","author":"H. McDonough","year":"2003","unstructured":"McDonough H, Patterson C: CHIP: a link between the chaperone and proteasome systems. Cell Stress Chaperones 2003, 8:303\u2013308.","journal-title":"Cell Stress Chaperones"},{"key":"69_CR58","doi-asserted-by":"crossref","unstructured":"Patterson C, Schisler JC (eds): STIP1 homology and U box-containing protein 1 \u2014 [Isoform 1]. Targeted Protein Database 2008, DOI 10.2970\/tpdb.2008.130.","DOI":"10.2970\/tpdb.2008.130"},{"key":"69_CR59","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1128\/MCB.01737-08","volume":"29","author":"P. Xie","year":"2009","unstructured":"Xie P, Fan Y, Zhang H, et al.: CHIP represses myocardin-induced smooth muscle cell differentiation via ubiquitin-mediated proteasomal degradation. Mol Cell Biol 2009, 29:2398\u20132408.","journal-title":"Mol Cell Biol"},{"key":"69_CR60","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/0092-8674(92)90644-R","volume":"69","author":"J. Momand","year":"1992","unstructured":"Momand J, Zambetti GP, Olson DC, et al.: The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 1992, 69:1237\u20131245.","journal-title":"Cell"},{"key":"69_CR61","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1128\/MCB.26.1.192-198.2006","volume":"26","author":"J.D. Grier","year":"2006","unstructured":"Grier JD, Xiong S, Elizondo-Fraire AC, et al.: Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4. Mol Cell Biol 2006, 26:192\u2013198.","journal-title":"Mol Cell Biol"},{"key":"69_CR62","doi-asserted-by":"crossref","first-page":"3679","DOI":"10.1074\/jbc.M509630200","volume":"281","author":"A. Toth","year":"2006","unstructured":"Toth A, Nickson P, Qin LL, Erhardt P: Differential regulation of cardiomyocyte survival and hypertrophy by MDM2, an E3 ubiquitin ligase. J Biol Chem 2006, 281:3679\u20133689.","journal-title":"J Biol Chem"},{"key":"69_CR63","doi-asserted-by":"crossref","first-page":"5529","DOI":"10.1074\/jbc.M609046200","volume":"282","author":"R.S. Foo","year":"2007","unstructured":"Foo RS, Chan LK, Kitsis RN, Bennett MR: Ubiquitination and degradation of the anti-apoptotic protein ARC by MDM2. J Biol Chem 2007, 282:5529\u20135535.","journal-title":"J Biol Chem"},{"key":"69_CR64","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1096\/fj.03-1095fje","volume":"18","author":"N. Rosenblatt-Velin","year":"2004","unstructured":"Rosenblatt-Velin N, Lerch R, Papageorgiou I, Montessuit C: Insulin resistance in adult cardiomyocytes undergoing dedifferentiation: role of GLUT4 expression and translocation. FASEB J 2004, 18:872\u2013874.","journal-title":"FASEB J"},{"key":"69_CR65","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/sj.cr.7290268","volume":"15","author":"C. Rubin","year":"2005","unstructured":"Rubin C, Gur G, Yarden Y: Negative regulation of receptor tyrosine kinases: unexpected links to c-Cbl and receptor ubiquitylation. Cell Res 2005, 15:66\u201371.","journal-title":"Cell Res"},{"key":"69_CR66","doi-asserted-by":"crossref","first-page":"36259","DOI":"10.1074\/jbc.M402469200","volume":"279","author":"K. Kaabeche","year":"2004","unstructured":"Kaabeche K, Lemonnier J, Le Mee S, et al.: Cbl-mediated degradation of Lyn and Fyn induced by constitutive fibroblast growth factor receptor-2 activation supports osteoblast differentiation. J Biol Chem 2004, 279:36259\u201336267.","journal-title":"J Biol Chem"},{"key":"69_CR67","doi-asserted-by":"crossref","first-page":"9557","DOI":"10.1073\/pnas.96.17.9557","volume":"96","author":"H. Oda","year":"1999","unstructured":"Oda H, Kumar S, Howley PM: Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination. Proc Natl Acad Sci U S A 1999, 96:9557\u20139562.","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Current Hypertension Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11906-009-0069-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11906-009-0069-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11906-009-0069-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T00:27:13Z","timestamp":1634257633000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11906-009-0069-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11,29]]},"references-count":67,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["69"],"URL":"https:\/\/doi.org\/10.1007\/s11906-009-0069-7","relation":{},"ISSN":["1522-6417","1534-3111"],"issn-type":[{"value":"1522-6417","type":"print"},{"value":"1534-3111","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11,29]]}}}