{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:55:26Z","timestamp":1786982126555,"version":"build-2736575974"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Curr Hypertens Rep"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1007\/s11906-011-0181-3","type":"journal-article","created":{"date-parts":[[2011,1,31]],"date-time":"2011-01-31T00:00:59Z","timestamp":1296432059000},"page":"103-108","source":"Crossref","is-referenced-by-count":18,"title":["Hypertension Due to Loss of Clock: Novel Insight From the Molecular Analysis of Cry1\/Cry2\u2013Deleted Mice"],"prefix":"10.1007","volume":"13","author":[{"given":"Hitoshi","family":"Okamura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Doi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Michel","family":"Fustin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,2,1]]},"reference":[{"issue":"17","key":"181_CR1","doi-asserted-by":"crossref","first-page":"R805","DOI":"10.1016\/j.cub.2008.07.021","volume":"18","author":"MH Hastings","year":"2008","unstructured":"Hastings MH, Maywood ES, O\u2019Neil JS: Cellular circadian pacemaking and the role of cytosolic rhythms. Curr Biol 2008, 18(17):R805-R815.","journal-title":"Curr Biol"},{"issue":"11","key":"181_CR2","doi-asserted-by":"crossref","first-page":"4453","DOI":"10.1073\/pnas.0808180106","volume":"106","author":"FA Scheer","year":"2009","unstructured":"\u2022 Scheer FA, Hilton MF, Mantzoros CS, et al.: Adverse metabolic and cardiovascular consequences of circadian misalignment. Proc Natl Acad Sci U S A 2009;106(11):4453-4458. Scheer et al. applied a forced desynchrony protocol in humans and examined how the internal desynchrony between the clock and the shifted behavior affects systems involved in cardiovascular and metabolic physiology. Core body temperature was recorded continuously for 10 days to assess circadian phase. Circadian misalignment, when subjects ate and slept approximately 12 hours out of phase from their habitual times, completely reversed the daily cortisol rhythm and increased mean arterial pressure. These findings demonstrate the adverse cardiac and metabolic implications of circadian misalignment, as occurs acutely with jet lag and chronically with shift work. This paper provides evidence to support the hypothesis that circadian systems are important to cardiovascular and metabolic risk not just in mice but also in humans.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"181_CR3","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1161\/HYPERTENSIONAHA.108.114553","volume":"52","author":"Y Suwazono","year":"2008","unstructured":"\u2022 Suwazono Y, Dochi M, Sakata K, et al.: Shift work is a risk factor for increased blood pressure in Japanese men: a 14-year historical cohort study. Hypertension 2008, 52(3):581-586. This is a 14-year historical cohort study on the effect of shift work on blood pressure in 3,963 day workers and 2,748 alternating-shift workers in a Japanese company. The authors reported that alternating shift work was a significant independent risk factor for an increase in blood pressure in male Japanese workers. Moreover, the effect of shift work on blood pressure was more pronounced than other well-established factors, such as age and body mass index.","journal-title":"Hypertension"},{"issue":"14","key":"181_CR4","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1161\/01.CIR.0000160923.04524.5B","volume":"111","author":"R Sega","year":"2005","unstructured":"Sega R, Facchetti R, Bombelli M, et al.: Prognostic values of ambulatory and home blood pressure compared with office blood pressure in the beneral population follow up results from the Pressioni Arteriose Monitorate e Loro Associazioni (PAMELA) study, Circulation 2005, 111(14):1777-1783.","journal-title":"Circulation"},{"issue":"9-10","key":"181_CR5","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.addr.2010.06.004","volume":"62","author":"H Okamura","year":"2010","unstructured":"Okamura H, Doi M, Fustin JM, et al.: Mammalian circadian clock system: molecular mechanisms for pharmaceutical and medical sciences. Adv Drug Deliv Rev. 2010, 62(9-10):876-884.","journal-title":"Adv Drug Deliv Rev"},{"issue":"5649","key":"181_CR6","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1126\/science.1089287","volume":"302","author":"S Yamaguchi","year":"2003","unstructured":"Yamaguchi S, Isejima H, Matsuo T, et al.: Synchronization of cellular clocks in the suprachiasmatic nucleus. Science 2003, 302(5649):255-259.","journal-title":"Science"},{"issue":"6728","key":"181_CR7","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/19323","volume":"398","author":"GT Horst van der","year":"1999","unstructured":"van der Horst GT, Muijtjens M, Kobayashi K et al.: Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms. Nature 1999, 398(6728):627-630.","journal-title":"Nature"},{"issue":"5449","key":"181_CR8","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1126\/science.286.5449.2531","volume":"286","author":"H Okamura","year":"1999","unstructured":"Okamura H, Miyake S, Sumi Y, et al.: Photic induction of mPer1 and mPer2 in Cry-deficient mice lacking a biological clock. Science 1999, 286(5449):2531-2534.","journal-title":"Science"},{"issue":"5515","key":"181_CR9","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1126\/science.1059542","volume":"292","author":"K Yagita","year":"2001","unstructured":"Yagita K, Tamanini F, van der Horst GTJ, et al.: Molecular mechanisms of the biological clock in cultured fibroblasts. Science 2001, 292(5515):278-292.","journal-title":"Science"},{"issue":"10","key":"181_CR10","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/nm1095-1009","volume":"1","author":"D Denton","year":"1995","unstructured":"Denton D, Weisinger R, Mundy NI, et al.: The effect of increased salt intake on blood pressure of chimpanzees. Nature Med, 1995, 1(10), 1009-1016.","journal-title":"Nature Med"},{"issue":"1","key":"181_CR11","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/nm.2061","volume":"16","author":"M Doi","year":"2010","unstructured":"\u2022\u2022 Doi M, Takahashi Y, Komatsu R, et al.: Salt-sensitive hypertension in circadian clock-deficient mice involves dysregulated adrenal Hsd3b6. Nat Med 2010, 16(1):67-74. Doi et al. show that mice lacking the core clock components Cry1 and Cry2 (Cry-null mice) show salt-sensitive hypertension owing to abnormally high synthesis of the mineralocorticoid aldosterone by the adrenal gland. An extensive search for the underlying cause led us to identify type VI 3\u03b2-hydroxyl-steroid dehydrogenase (Hsd3b6) as a new hypertension risk factor in mice. These data place Hsd3b6 in a pivotal position through which circadian clock malfunction is coupled with the development of hypertension. Translation of these findings to humans will require clinical examination of the human HSD3B1 gene, which we found to be functionally similar to mouse Hsd3b6.","journal-title":"Nat Med"},{"issue":"13","key":"181_CR12","doi-asserted-by":"crossref","first-page":"4773","DOI":"10.1128\/MCB.20.13.4773-4781.2000","volume":"20","author":"S Yamaguchi","year":"2000","unstructured":"Yamaguchi S, Mitsui S, Yan L, et al.: Role of DBP in the circadian oscillatory mechanism. Mol Cell Biol 2000, 20(13):4773-4781.","journal-title":"Mol Cell Biol"},{"issue":"6","key":"181_CR13","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1101\/gad.14.6.679","volume":"14","author":"JA Ripperger","year":"2000","unstructured":"Ripperger JA, Shearman LP, Reppert SM, et al.: CLOCK, an essential pacemaker component, controls expression of the circadian transcription factor DBP. Genes Dev 2000; 14(6):679-689.","journal-title":"Genes Dev"},{"issue":"8","key":"181_CR14","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1101\/gad.873501","volume":"15","author":"S Mitsui","year":"2001","unstructured":"Mitsui S, Yamaguchi S, Matsuo T, et al.: Antagonistic role of E4BP4 and PAR proteins in the circadian oscillatory mechanism. Genes Dev 2001, 15(8):995-1006.","journal-title":"Genes Dev"},{"issue":"1","key":"181_CR15","first-page":"3","volume":"45","author":"JW Conn","year":"1955","unstructured":"Conn JW: Presidential Addresses. Part I. Painting background. Part II. Primary aldosteronism, a new clinical syndrome. J Lab Clin Med 1955, 45(1):3-17.","journal-title":"J Lab Clin Med"},{"key":"181_CR16","first-page":"410","volume-title":"Kaplan\u2019s Clinical Hypertension","author":"NM Kaplan","year":"2006","unstructured":"Kaplan NM: Primary aldosteronism. In Kaplan\u2019s Clinical Hypertension. Edited by Kaplan NM and Flynn JT. Philadelphia: Lippincott William & Wilkins; 2006:410-433."},{"issue":"1","key":"181_CR17","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0006-291X(02)00234-6","volume":"293","author":"R Rosmond","year":"2002","unstructured":"Rosmond R, Chagnon M, Bouchard C, et al. Polymorphism in exon 4 of the human 3 beta-hydroxysteroid dehydrogenase type I gene (HSD3B1) and blood pressure. Biochem Biophys Res Commun 2002, 293(1):629-632.","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"181_CR18","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1530\/EJE-10-0428","volume":"163","author":"M Shimodaira","year":"2010","unstructured":"Shimodaira M, Nakayama T, Sato N, et al. Association of HSD3B1 and HSD3B2 gene polymorphisms with essential hypertension, aldosterone level, and left ventricular structure. Eur J Endocrinol 2010, 163(4):671-680.","journal-title":"Eur J Endocrinol"},{"issue":"3","key":"181_CR19","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.tem.2005.02.004","volume":"16","author":"RD Gordon","year":"2005","unstructured":"Gordon RD, Laragh JH, Funder JW: Low renin hypertensive states: perspectives, unsolved problems, future research. Trends Endocrinol Metab 2005, 16(3):108\u2013113.","journal-title":"Trends Endocrinol Metab"},{"issue":"11","key":"181_CR20","doi-asserted-by":"crossref","first-page":"5098","DOI":"10.1210\/en.2010-0465","volume":"151","author":"JW Funder","year":"2010","unstructured":"Funder JW: Aldosterone and Mineralocorticoid Receptors: Past, Present, and Future. Endocrinology, 2010, 151(11):5098-5102.","journal-title":"Endocrinology"},{"issue":"Pt 1","key":"181_CR21","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1113\/jphysiol.2005.086728","volume":"566","author":"S Masuki","year":"2005","unstructured":"Masuki S, Todo T, Nakano Y, et al.: Reduced alpha-adrenoceptor responsiveness and enhanced baroreflex sensitivity in Cry-deficient mice lacking biological clock. J Physiol 2005, 566(Pt 1):213-224.","journal-title":"J Physiol"}],"container-title":["Current Hypertension Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11906-011-0181-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11906-011-0181-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11906-011-0181-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T03:08:14Z","timestamp":1637204894000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11906-011-0181-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,1]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["181"],"URL":"https:\/\/doi.org\/10.1007\/s11906-011-0181-3","relation":{},"ISSN":["1522-6417","1534-3111"],"issn-type":[{"value":"1522-6417","type":"print"},{"value":"1534-3111","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,1]]}}}