{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T11:34:42Z","timestamp":1789904082322,"version":"4.0.1"},"reference-count":85,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2010,8,18]],"date-time":"2010-08-18T00:00:00Z","timestamp":1282089600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Curr Neurol Neurosci Rep"],"published-print":{"date-parts":[[2010,11]]},"DOI":"10.1007\/s11910-010-0145-z","type":"journal-article","created":{"date-parts":[[2010,8,17]],"date-time":"2010-08-17T05:39:30Z","timestamp":1282023570000},"page":"504-511","source":"Crossref","is-referenced-by-count":16,"title":["Frontotemporal Dementia and Primary Progressive Aphasia: An Update"],"prefix":"10.1007","volume":"10","author":[{"given":"Howard S.","family":"Kirshner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,8,18]]},"reference":[{"key":"145_CR1","unstructured":"Pick A: On the relationship between aphasia and senile atrophy of the brain. In Neurological Classics in Modern Translation. Edited by Rottenberg DA, Hochberg FH. Hafner Press; 1977:35\u201340."},{"key":"145_CR2","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1002\/ana.410110607","volume":"11","author":"MM Mesulam","year":"1982","unstructured":"Mesulam MM: Slowly progressive aphasia without generalized dementia. Ann Neurol 1982, 11:592\u2013598.","journal-title":"Ann Neurol"},{"key":"145_CR3","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1001\/archneur.1990.00530120075013","volume":"47","author":"S Weintraub","year":"1990","unstructured":"Weintraub S, Rubin NP, Mesulam MM: Primary progressive aphasia. Longitudinal course, neuropsychological profile, and language features. Arch Neurol 1990, 47:1329\u20131335.","journal-title":"Arch Neurol"},{"key":"145_CR4","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/ana.91","volume":"49","author":"MM Mesulam","year":"2001","unstructured":"Mesulam MM: Primary progressive aphasia. Ann Neurol 2001, 49:425\u2013432.","journal-title":"Ann Neurol"},{"key":"145_CR5","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1056\/NEJMra022435","volume":"349","author":"MM Mesulam","year":"2003","unstructured":"Mesulam MM: Primary progressive aphasia\u2014a language-based dementia. N Engl J Med 2003, 349:1535\u20131542.","journal-title":"N Engl J Med"},{"key":"145_CR6","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/ana.10390","volume":"53","author":"SP Sonty","year":"2003","unstructured":"Sonty SP, Mesulam MM, Thompson CK, et al.: Primary progressive aphasia: PPA and the language network. Ann Neurol 2003, 53:35\u201349.","journal-title":"Ann Neurol"},{"key":"145_CR7","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1001\/archneur.1984.04050170037012","volume":"41","author":"HS Kirshner","year":"1984","unstructured":"Kirshner HS, Webb WG, Kelly MP, et al.: Language disturbance. An initial symptom of cortical degenerations and dementia. Arch Neurol 1984, 41:491\u2013496.","journal-title":"Arch Neurol"},{"key":"145_CR8","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1212\/WNL.40.3_Part_1.423","volume":"40","author":"J Green","year":"1990","unstructured":"Green J, Morris JC, Sandson J, et al.: Progressive aphasia: a precursor of global dementia? Neurology 1990, 40:423\u2013429.","journal-title":"Neurology"},{"key":"145_CR9","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1093\/brain\/120.6.1027","volume":"120","author":"T Edwards-Lee","year":"1997","unstructured":"Edwards-Lee T, Miller BL, Benson DF, et al.: The temporal variant of frontotemporal dementia. Brain 1997, 120:1027\u20131040.","journal-title":"Brain"},{"key":"145_CR10","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1212\/WNL.0b013e3181bf9945","volume":"73","author":"KA Josephs","year":"2009","unstructured":"Josephs KA, Whitwell JL, Knopman DS, et al.: Two distinct subtypes of right temporal variant frontotemporal dementia. Neurology 2009, 73:1443\u20131450.","journal-title":"Neurology"},{"key":"145_CR11","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1006\/brcg.1996.0041","volume":"31","author":"D Neary","year":"1996","unstructured":"Neary D, Snowden J: Fronto-temporal dementia: nosology, neuropsychology, and neuropathology. Brain Cogn 1996, 31:176\u2013187.","journal-title":"Brain Cogn"},{"key":"145_CR12","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1212\/WNL.51.6.1546","volume":"51","author":"D Neary","year":"1998","unstructured":"Neary D, Snowden JS, Gustafson L, et al.: Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria. Neurology 1998, 51:1546\u20131554.","journal-title":"Neurology"},{"key":"145_CR13","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s00401-007-0236-3","volume":"114","author":"J Snowden","year":"2007","unstructured":"Snowden J, Neary D, Mann D: Frontotemporal lobar degeneration: clinical and pathological relationships. Acta Neuropathol 2007, 114:31\u201338.","journal-title":"Acta Neuropathol"},{"key":"145_CR14","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1136\/jnnp.53.1.23","volume":"53","author":"D Neary","year":"1990","unstructured":"Neary D, Snowden JS, Mann DM, et al.: Frontal lobe dementia and motor neuron disease. J Neurol Neurosurg Psychiatry 1990, 53:23\u201332.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"145_CR15","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/ng1332","volume":"36","author":"GD Watts","year":"2004","unstructured":"Watts GD, Wymer J, Kovach MJ, et al.: Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein. Nat Genet 2004, 36:377\u2013381.","journal-title":"Nat Genet"},{"key":"145_CR16","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1212\/WNL.51.4.978","volume":"51","author":"BL Miller","year":"1998","unstructured":"Miller BL, Cummings J, Mishkin F, et al.: Emergence of artistic talent in frontotemporal dementia. Neurology 1998, 51:978\u2013982.","journal-title":"Neurology"},{"key":"145_CR17","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1001\/archneur.61.6.842","volume":"61","author":"BL Miller","year":"2004","unstructured":"Miller BL, Hou CE: Portraits of artists: emergence of visual creativity in dementia. Arch Neurol 2004, 61:842\u2013844.","journal-title":"Arch Neurol"},{"key":"145_CR18","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1155\/1989\/124043","volume":"2","author":"JS Snowden","year":"1989","unstructured":"Snowden JS, Goulding PS, Neary D: Semantic dementia: a form of circumscribed cerebral atrophy. Behav Neurol 1989, 2:167\u2013182.","journal-title":"Behav Neurol"},{"key":"145_CR19","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1093\/brain\/115.6.1783","volume":"115","author":"JR Hodges","year":"1992","unstructured":"Hodges JR, Patterson K, Oxbury S, et al.: Semantic dementia. Progressive fluent aphasia with temporal lobe atrophy. Brain 1992, 115:1783\u20131806.","journal-title":"Brain"},{"key":"145_CR20","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/S1474-4422(07)70266-1","volume":"6","author":"JR Hodges","year":"2007","unstructured":"Hodges JR, Patterson K: Semantic dementia: a unique clinicopathological syndrome. Lancet Neurol 2007, 6:1004\u20131014.","journal-title":"Lancet Neurol"},{"key":"145_CR21","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1093\/brain\/awh582","volume":"128","author":"RR Davies","year":"2005","unstructured":"Davies RR, Hodges JR, Kril JJ, et al.: The pathological basis of semantic dementia. Brain 2005, 128:1984\u20131995.","journal-title":"Brain"},{"key":"145_CR22","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1212\/01.wnl.0000320506.79811.da","volume":"71","author":"ML Gorno-Tempini","year":"2008","unstructured":"Gorno-Tempini ML, Brambati SM, Ginex V, et al.: The logopenic\/phonological variant of primary progressive aphasia. Neurology 2008, 71:1227\u20131234.","journal-title":"Neurology"},{"key":"145_CR23","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/ana.10825","volume":"55","author":"ML Gorno-Tempini","year":"2004","unstructured":"Gorno-Tempini ML, Dronkers NF, Rankin KP, et al.: Cognition and anatomy in three variants of primary progressive aphasia. Ann Neurol 2004, 55:335\u2013346.","journal-title":"Ann Neurol"},{"key":"145_CR24","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1006\/brln.1997.1840","volume":"60","author":"C Westbury","year":"1997","unstructured":"Westbury C, Bub D: Primary progressive aphasia: a review of 112 cases. Brain Lang 1997, 60:381\u2013406.","journal-title":"Brain Lang"},{"key":"145_CR25","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1212\/01.WNL.0000081230.09863.ED","volume":"61","author":"NL Graham","year":"2003","unstructured":"Graham NL, Bak T, Patterson K, et al.: Language function and dysfunction in corticobasal degeneration. Neurology 2003, 61:493\u2013499.","journal-title":"Neurology"},{"key":"145_CR26","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1159\/000117229","volume":"36","author":"Y Sakurai","year":"1996","unstructured":"Sakurai Y, Hashida H, Uesugi H, et al.: A clinical profile of corticobasal degeneration presenting as primary progressive aphasia. Eur Neurol 1996, 36:134\u2013137.","journal-title":"Eur Neurol"},{"key":"145_CR27","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1212\/01.wnl.0000191307.69661.c3","volume":"66","author":"KA Josephs","year":"2006","unstructured":"Josephs KA, Petersen RC, Knopman DS, et al.: Clinicopathologic analysis of frontotemporal and corticobasal degenerations and PSP. Neurology 2006, 66:41\u201348.","journal-title":"Neurology"},{"key":"145_CR28","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1162\/jocn.1996.8.2.135","volume":"8","author":"M Grossman","year":"1996","unstructured":"Grossman M, Mickanin J, Onishi K: Progressive nonfluent aphasia: language, cognitive, and PET measures contrasted with probable Alzheimer\u2019s disease. J Cogn Neurosci 1996, 8:135\u2013154.","journal-title":"J Cogn Neurosci"},{"key":"145_CR29","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1093\/brain\/awm213","volume":"130","author":"S Alladi","year":"2007","unstructured":"Alladi S, Xuereb J, Bak T, et al.: Focal cortical presentations of Alzheimer\u2019s disease. Brain 2007, 130:2636\u20132645.","journal-title":"Brain"},{"key":"145_CR30","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1006\/brcg.1996.0042","volume":"31","author":"SE Black","year":"1996","unstructured":"Black SE: Focal cortical atrophy syndromes. Brain Cogn 1996, 31:188\u2013229.","journal-title":"Brain Cogn"},{"issue":"Suppl 1","key":"145_CR31","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1097\/01.wad.0000183086.99691.91","volume":"19","author":"AL Boxer","year":"2005","unstructured":"Boxer AL, Miller BL: Clinical features of frontotemporal dementia. Alzheimer Dis Assoc Disord 2005, 19(Suppl 1):S3\u2013S6.","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"145_CR32","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nrneurol.2009.216","volume":"6","author":"M Grossman","year":"2010","unstructured":"Grossman M: Primary progressive aphasia: clinicopathological correlations. Nat Rev Neurol 2010, 6:88\u201397.","journal-title":"Nat Rev Neurol"},{"key":"145_CR33","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1136\/jnnp.57.4.416","volume":"57","author":"Clinical and neuropathological criteria for frontotemporal dementia","year":"1994","unstructured":"Clinical and neuropathological criteria for frontotemporal dementia. The Lund and Manchester Groups [no authors listed]. J Neurol Neurosurg Psychiatry 1994, 57:416\u2013418.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"145_CR34","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1212\/WNL.50.6.1541","volume":"50","author":"M Stevens","year":"1998","unstructured":"Stevens M, van Duijn CM, Kamphorst W, et al.: Familial aggregation in frontotemporal dementia. Neurology 1998, 50:1541\u20131545.","journal-title":"Neurology"},{"key":"145_CR35","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1212\/01.wnl.0000319702.37497.72","volume":"71","author":"H Seelaar","year":"2008","unstructured":"Seelaar H, Kamphorst W, Rosso SM, et al.: Distinct genetic forms of frontotemporal dementia. Neurology 2008, 71:1220\u20131226.","journal-title":"Neurology"},{"key":"145_CR36","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1007\/s002340050466","volume":"39","author":"K Abe","year":"1997","unstructured":"Abe K, Ukita H, Yanagihara T: Imaging in primary progressive aphasia. Neuroradiology 1997, 39:556\u2013559.","journal-title":"Neuroradiology"},{"key":"145_CR37","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1007\/BF00596535","volume":"38","author":"R Sinnatamby","year":"1996","unstructured":"Sinnatamby R, Antoun NA, Freer CE, et al.: Neuroradiological findings in primary progressive aphasia: CT, MRI and cerebral perfusion SPECT. Neuroradiology 1996, 38:232\u2013238.","journal-title":"Neuroradiology"},{"key":"145_CR38","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1212\/01.wnl.0000191395.69438.12","volume":"66","author":"JL Whitwell","year":"2006","unstructured":"Whitwell JL, Jack CR Jr, Senjem ML, et al.: Patterns of atrophy in pathologically confirmed FTLD with and without motor neuron degeneration. Neurology 2006, 66:102\u2013104.","journal-title":"Neurology"},{"key":"145_CR39","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1002\/ana.410190112","volume":"19","author":"JB Chawluk","year":"1986","unstructured":"Chawluk JB, Mesulam MM, Hurtig H, et al.: Slowly progressive aphasia without generalized dementia: studies with positron emission tomography. Ann Neurol 1986, 19:68\u201374.","journal-title":"Ann Neurol"},{"key":"145_CR40","first-page":"1321","volume":"113","author":"PJ Tyrrell","year":"1990","unstructured":"Tyrrell PJ, Warrington EK, Frackowiak RS, et al.: Heterogeneity in progressive aphasia due to focal cortical atrophy. A clinical and PET study. Brain 1990, 113:1321\u20131336.","journal-title":"A clinical and PET study. Brain"},{"key":"145_CR41","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.neurobiolaging.2003.10.007","volume":"25","author":"J Diehl","year":"2004","unstructured":"Diehl J, Grimmer T, Drzezga A, et al.: Cerebral metabolic patterns at early stages of frontotemporal dementia and semantic dementia. A PET study. Neurobiol Aging 2004, 25:1051\u20131056.","journal-title":"Neurobiol Aging"},{"key":"145_CR42","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/0093-934X(85)90096-3","volume":"24","author":"AL Holland","year":"1985","unstructured":"Holland AL, McBurney DH, Moossy J, et al.: The dissolution of language in Pick\u2019s disease with neurofibrillary tangles: a case study. Brain Lang 1985, 24:36\u201358.","journal-title":"Brain Lang"},{"key":"145_CR43","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1001\/archneur.1982.00510170029008","volume":"39","author":"AF Wechsler","year":"1982","unstructured":"Wechsler AF, Verity MA, Rosenschein S, et al.: Pick\u2019s disease. A clinical, computed tomographic, and histologic study with golgi impregnation observations. Arch Neurol 1982, 39:287\u2013290.","journal-title":"Arch Neurol"},{"key":"145_CR44","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1212\/WNL.40.4.620","volume":"40","author":"NR Graff-Radford","year":"1990","unstructured":"Graff-Radford NR, Damasio AR, Hyman BT, et al.: Progressive aphasia in a patient with Pick\u2019s disease: a neuropsychological, radiologic, and anatomic study. Neurology 1990, 40:620\u2013626.","journal-title":"Neurology"},{"key":"145_CR45","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1002\/ana.410220413","volume":"22","author":"HS Kirshner","year":"1987","unstructured":"Kirshner HS, Tanridag O, Thurman L, et al.: Progressive aphasia without dementia: two cases with focal spongiform degeneration. Ann Neurol 1987, 22:527\u2013532.","journal-title":"Ann Neurol"},{"key":"145_CR46","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1212\/WNL.40.2.251","volume":"40","author":"DS Knopman","year":"1990","unstructured":"Knopman DS, Mastri AR, Frey WH 2nd, et al.: Dementia lacking distinctive histologic features: a common non-Alzheimer degenerative dementia. Neurology 1990, 40:251\u2013256.","journal-title":"Neurology"},{"key":"145_CR47","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1212\/WNL.41.6.882","volume":"41","author":"CF Lippa","year":"1991","unstructured":"Lippa CF, Cohen R, Smith TW, et al.: Primary progressive aphasia with focal neuronal achromasia. Neurology 1991, 41:882\u2013886.","journal-title":"Neurology"},{"key":"145_CR48","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1212\/WNL.44.11.2065","volume":"44","author":"A Kertesz","year":"1994","unstructured":"Kertesz A, Hudson L, Mackenzie IR, et al.: The pathology and nosology of primary progressive aphasia. Neurology 1994, 44:2065\u20132072.","journal-title":"Neurology"},{"key":"145_CR49","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1212\/WNL.55.9.1368","volume":"55","author":"A Kertesz","year":"2000","unstructured":"Kertesz A, Martinez-Lage P, Davidson W, et al.: The corticobasal degeneration syndrome overlaps progressive aphasia and frontotemporal dementia. Neurology 2000, 55:1368\u20131375.","journal-title":"Neurology"},{"key":"145_CR50","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1093\/brain\/awh598","volume":"128","author":"A Kertesz","year":"2005","unstructured":"Kertesz A, McMonagle P, Blair M, et al.: The evolution and pathology of frontotemporal dementia. Brain 2005, 128:1996\u20132005.","journal-title":"Brain"},{"key":"145_CR51","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/ana.410410205","volume":"41","author":"P Heutink","year":"1997","unstructured":"Heutink P, Stevens M, Rizzu P, et al.: Hereditary frontotemporal dementia is linked to chromosome 17q21-q22: a genetic and clinicopathological study of three Dutch families. Ann Neurol 1997, 41:150\u2013159.","journal-title":"Ann Neurol"},{"key":"145_CR52","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/31508","volume":"393","author":"M Hutton","year":"1998","unstructured":"Hutton M, Lendon CL, Rizzu P, et al.: Association of missense and 5\u2032-splice-site mutations in tau with the inherited dementia FTDP-17. Nature 1998, 393:702\u2013705.","journal-title":"Nature"},{"key":"145_CR53","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1002\/ana.410430617","volume":"43","author":"P Poorkaj","year":"1998","unstructured":"Poorkaj P, Bird TD, Wijsman E, et al.: Tau is a candidate gene for chromosome 17 frontotemporal dementia. Ann Neurol 1998, 43:815\u2013825.","journal-title":"Ann Neurol"},{"key":"145_CR54","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/ana.410410202","volume":"41","author":"KC Wilhelmsen","year":"1997","unstructured":"Wilhelmsen KC: Frontotemporal dementia is on the MAPtau. Ann Neurol 1997, 41:139\u2013140.","journal-title":"Ann Neurol"},{"key":"145_CR55","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/ana.410160407","volume":"16","author":"JC Morris","year":"1984","unstructured":"Morris JC, Cole M, Banker BQ, et al.: Hereditary dysphasic dementia and the Pick-Alzheimer spectrum. Ann Neurol 1984, 16:455\u2013466.","journal-title":"Ann Neurol"},{"key":"145_CR56","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1212\/WNL.50.6.1546","volume":"50","author":"CL Lendon","year":"1998","unstructured":"Lendon CL, Lynch T, Norton J, et al.: Hereditary dysphasic disinhibition dementia. A frontotemporal dementia linked to 17q21-22. Neurology 1998, 50:1546\u20131555.","journal-title":"Neurology"},{"key":"145_CR57","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1002\/ana.20873","volume":"59","author":"MS Forman","year":"2006","unstructured":"Forman MS, Farmer J, Johnson JK, et al.: Frontotemporal dementia: clinicopathological correlations. Ann Neurol 2006, 59:952\u2013962.","journal-title":"Ann Neurol"},{"key":"145_CR58","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1097\/00005072-200606000-00005","volume":"65","author":"MS Forman","year":"2006","unstructured":"Forman MS, Mackenzie IR, Cairns NJ, et al.: Novel ubiquitin neuropathology in frontotemporal dementia with valosin-containing protein gene mutations. J Neuropathol Exp Neurol 2006, 65:571\u2013581.","journal-title":"J Neuropathol Exp Neurol"},{"key":"145_CR59","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1038\/nature05016","volume":"442","author":"M Baker","year":"2006","unstructured":"Baker M, Mackenzie IR, Pickering-Brown SM, et al.: Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17. Nature 2006, 442:916\u2013919.","journal-title":"Nature"},{"key":"145_CR60","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1038\/nature05017","volume":"442","author":"M Cruts","year":"2006","unstructured":"Cruts M, Gijselinck I, van den Zee J, et al.: Null mutations in progranulin cause ubiquitin positive frontotemporal dementia linked to chromosome 17q21. Nature 2006, 442:920\u2013924.","journal-title":"Nature"},{"key":"145_CR61","first-page":"161","volume":"67","author":"CE Yu","year":"2010","unstructured":"Yu CE, Bird TD, Bekris LM, et al.: The spectrum of mutations in progranulin: a collaborative study screening 545 cases of neurodegeneration. Arch Neurol 2010, 67:161\u2013170.","journal-title":"Arch Neurol"},{"key":"145_CR62","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1097\/NEN.0b013e31817d751c","volume":"67","author":"EH Bigio","year":"2008","unstructured":"\u2022\u2022 Bigio EH: Update on recent molecular and genetic advances in frontotemporal lobar degeneration. J Neuropathol Exp Neurol 2008, 67:635\u2013648. This paper summarizes the recent neurochemical, neuropathologic, and molecular genetic findings in FTD.","journal-title":"J Neuropathol Exp Neurol"},{"key":"145_CR63","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/ana.21426","volume":"64","author":"KA Josephs","year":"2008","unstructured":"\u2022 Josephs KA: Frontotemporal dementia and related disorders: deciphering the enigma. Ann Neurol 2008, 64:4\u201314. This paper is another excellent overview of recent advances in the FTD family of disorders.","journal-title":"Ann Neurol"},{"key":"145_CR64","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1001\/jama.284.13.1664","volume":"284","author":"BA Hosler","year":"2000","unstructured":"Hosler BA, Siddique T, Sapp PC, et al.: Linkage of familial amyotrophic lateral sclerosis with frontotemporal dementia to chromosome 9q21-q22. JAMA 2000, 284:1664\u20131669.","journal-title":"JAMA"},{"key":"145_CR65","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/ng1609","volume":"37","author":"G Skibinski","year":"2005","unstructured":"Skibinski G, Parkinson NJ, Brown JM, et al.: Mutations in the endosomal ESCRTIII-complex subunit CHMP2B in frontotemporal dementia. Nat Genet 2005, 37:806\u2013808.","journal-title":"Nat Genet"},{"key":"145_CR66","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1136\/jnnp.2006.109553","volume":"78","author":"JC Schymick","year":"2007","unstructured":"Schymick JC, Yang Y, Andersen PM, et al.: Progranulin mutations and amyotrophic lateral sclerosis or amyotrophic lateral sclerosis-frontotemporal dementia phenotypes. J Neurol Neurosurg Psychiatry 2007, 78:754\u2013756.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"145_CR67","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/ana.20203","volume":"56","author":"JR Hodges","year":"2004","unstructured":"Hodges JR, Davies RR, Xuereb JH, et al.: Clinicopathological correlates in frontotemporal dementia. Ann Neurol 2004, 56:399\u2013406.","journal-title":"Ann Neurol"},{"key":"145_CR68","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1212\/01.wnl.0000287073.12737.35","volume":"70","author":"KA Josephs","year":"2008","unstructured":"Josephs KA, Whitwell JL, Duffy JR, et al.: Progressive aphasia secondary to Alzheimer disease vs FTLD pathology. Neurology 2008, 70:25\u201334.","journal-title":"Neurology"},{"key":"145_CR69","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1212\/WNL.49.1.51","volume":"49","author":"MM Mesulam","year":"1997","unstructured":"Mesulam MM, Johnson N, Grujic Z, et al.: Apolipoprotein E genotypes in primary progressive aphasia. Neurology 1997, 49:51\u201355.","journal-title":"Neurology"},{"key":"145_CR70","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1002\/ana.410440122","volume":"44","author":"D Geschwind","year":"1998","unstructured":"Geschwind D, Karrim J, Nelson SF, et al.: The apolipoprotein E epsilon4 allele is not a significant risk factor for frontotemporal dementia. Ann Neurol 1998, 44:134\u2013138.","journal-title":"Ann Neurol"},{"key":"145_CR71","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1006\/exnr.2000.7387","volume":"163","author":"SM Pickering-Brown","year":"2000","unstructured":"Pickering-Brown SM, Owen F, Isaacs A, et al.: Apolipoprotein E epsilon4 allele has no effect on age at onset or duration of disease in cases of frontotemporal dementia with pick- or microvacuolar-type histology. Exp Neurol 2000, 163:452\u2013456.","journal-title":"Exp Neurol"},{"key":"145_CR72","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1159\/000106637","volume":"8","author":"L Gustafson","year":"1997","unstructured":"Gustafson L, Abrahamson M, Grubb A, et al.: Apolipoprotein-E genotyping in Alzheimer\u2019s disease and frontotemporal dementia. Dement Geriatr Cogn Disord 1997, 8:240\u2013243.","journal-title":"Dement Geriatr Cogn Disord"},{"key":"145_CR73","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1136\/jnnp.69.3.404","volume":"69","author":"DJ Lehmann","year":"2000","unstructured":"Lehmann DJ, Smith AD, Combrinck M, et al.: Apolipoprotein E epsilon2 may be a risk factor for sporadic frontotemporal dementia. J Neurol Neurosurg Psychiatry 2000, 69:404\u2013405.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"145_CR74","doi-asserted-by":"crossref","unstructured":"Rohrer JD, Ridgway GR, Modat M, et al.: Distinct profiles of brain atrophy in frontotemporal lobar degeneration caused by progranulin and tau mutations. Neuroimage 2010 Jan 4 [Epub ahead of print].","DOI":"10.1016\/j.neuroimage.2009.12.088"},{"key":"145_CR75","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1212\/01.wnl.0000191304.55196.4d","volume":"66","author":"ED Huey","year":"2006","unstructured":"Huey ED, Putnam KT, Grafman J: A systematic review of neurotransmitter deficits and treatments in frontotemporal dementia. Neurology 2006, 66:17\u201322.","journal-title":"Neurology"},{"key":"145_CR76","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1212\/WNL.38.6.877","volume":"38","author":"ML Albert","year":"1988","unstructured":"Albert ML, Bachman DL, Morgan A, Helm-Estabrooks N: Pharmacotherapy for aphasia. Neurology 1988, 38:877\u2013879.","journal-title":"Neurology"},{"key":"145_CR77","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1212\/WNL.45.12.2170","volume":"45","author":"SR Gupta","year":"1995","unstructured":"Gupta SR, Mlcoch AG, Scolaro C, Moritz T: Bromocriptine treatment of nonfluent aphasia. Neurology 1995, 45:2170\u20132173.","journal-title":"Neurology"},{"key":"145_CR78","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1212\/WNL.45.12.2272","volume":"45","author":"L Sabe","year":"1995","unstructured":"Sabe L, Salvarezza F, Garcia Cuerva A, et al.: A randomized, double-blind, placebo-controlled study of bromocriptine in nonfluent aphasia. Neurology 1995, 45:2272\u20132274.","journal-title":"Neurology"},{"key":"145_CR79","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1212\/01.wnl.0000203119.91762.0c","volume":"66","author":"F Ashtary","year":"2006","unstructured":"Ashtary F, Janghorbani M, Chitsaz A, et al.: A randomized, double-blind trial of bromocriptine efficacy in nonfluent aphasia after stroke. Neurology 2006, 66:914\u2013916.","journal-title":"Neurology"},{"key":"145_CR80","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1002\/ana.20301","volume":"56","author":"DA Reed","year":"2004","unstructured":"Reed DA, Johnson NA, Thompson C, et al.: A clinical trial of bromocriptine for treatment of primary progressive aphasia. Ann Neurol 2004, 56:750.","journal-title":"Ann Neurol"},{"key":"145_CR81","doi-asserted-by":"crossref","first-page":"212","DOI":"10.4088\/JCP.v58n0506","volume":"58","author":"JB Swartz","year":"1997","unstructured":"Swartz JB, Miller BL, Lesser IM, Darby AL: Frontotemporal dementia: treatment response to serotonin selective reuptake inhibitors. J Clin Psychiatry 1997, 58:212\u2013216.","journal-title":"J Clin Psychiatry"},{"key":"145_CR82","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1159\/000067021","volume":"49","author":"R Moretti","year":"2003","unstructured":"Moretti R, Torre P, Antonello RM, et al.: Frontotemporal dementia: paroxetine as a possible treatment of behavior symptoms. A randomized, controlled, open 14-month study. Eur Neurol 2003, 49:13\u201319.","journal-title":"Eur Neurol"},{"key":"145_CR83","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1007\/s00213-003-1686-5","volume":"172","author":"JB Deakin","year":"2004","unstructured":"Deakin JB, Rahman S, Nestor PJ, et al.: Paroxetine does not improve symptoms and impairs cognition in frontotemporal dementia: a double-blind randomized controlled trial. Psychopharmacology (Berl) 2004, 172:400\u2013408.","journal-title":"Psychopharmacology (Berl)"},{"key":"145_CR84","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1159\/000077171","volume":"17","author":"F Lebert","year":"2004","unstructured":"Lebert F, Stekke W, Hasenbroekx C, Pasquier F: Frontotemporal dementia: a randomised, controlled trial with trazodone. Dement Geriatr Cogn Disord 2004, 17:355\u2013359.","journal-title":"Dement Geriatr Cogn Disord"},{"key":"145_CR85","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1176\/appi.neuropsych.22.1.19","volume":"22","author":"ED Kaye","year":"2010","unstructured":"Kaye ED, Petrovic-Poljak A, Verheoff NP, Freedman M: Frontotemporal dementia and pharmacologic interventions. J Neuropsychiatry Clin Neurosci 2010, 22:19\u201329.","journal-title":"J Neuropsychiatry Clin Neurosci"}],"container-title":["Current Neurology and Neuroscience Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11910-010-0145-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11910-010-0145-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11910-010-0145-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,6]],"date-time":"2021-11-06T05:07:33Z","timestamp":1636175253000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11910-010-0145-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8,18]]},"references-count":85,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["145"],"URL":"https:\/\/doi.org\/10.1007\/s11910-010-0145-z","relation":{},"ISSN":["1528-4042","1534-6293"],"issn-type":[{"value":"1528-4042","type":"print"},{"value":"1534-6293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8,18]]}}}