{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:02:56Z","timestamp":1788368576169,"version":"build-2803163510"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T00:00:00Z","timestamp":1529625600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Curr Neurol Neurosci Rep"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1007\/s11910-018-0856-0","type":"journal-article","created":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T07:44:15Z","timestamp":1529653455000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Intractable Hiccups"],"prefix":"10.1007","volume":"18","author":[{"given":"Stasia","family":"Rouse","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Wodziak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,6,22]]},"reference":[{"key":"856_CR1","unstructured":"Singer C. A cure for hiccups? Retired farmer Charles Osborne isn\u2019t holding his breath\u2014he\u2019s had them for 60 years. People. 1982;"},{"key":"856_CR2","unstructured":"The Stanford Daily October 7, 1958 Vol 134 Number 8."},{"issue":"3","key":"856_CR3","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.jpainsymman.2008.10.008","volume":"38","author":"SK Wilcox","year":"2009","unstructured":"Wilcox SK, Garry A, Johnson MJ. Novel use of amantadine: to treat hiccups. J Pain Symptom Manag. 2009;38(3):460\u20135.","journal-title":"J Pain Symptom Manag"},{"key":"856_CR4","doi-asserted-by":"publisher","first-page":"123","DOI":"10.5056\/jnm.2012.18.2.123","volume":"18","author":"F Chang","year":"2012","unstructured":"Chang F, Lu C. Hiccup: mystery, nature and treatment. J Neurogastroenterol Motil. 2012;18:123\u201330. \n                      https:\/\/doi.org\/10.5056\/jnm.2012.18.2.123\n                      \n                    .","journal-title":"J Neurogastroenterol Motil"},{"key":"856_CR5","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1002\/bies.201100194","volume":"34","author":"D Howes","year":"2012","unstructured":"Howes D. Hiccups: a new explanation for the mysterious reflex. Bioessays. 2012;34:451\u20133.","journal-title":"Bioessays"},{"key":"856_CR6","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1111\/apt.13374","volume":"42","author":"M Steger","year":"2015","unstructured":"\u2022\u2022 Steger M, Schneemann M, Fox M. Systemic review: the pathogenesis and pharmacological treatment of hiccups. Aliment Pharmacol Ther. 2015;42:1037\u201350. \n                      https:\/\/doi.org\/10.1111\/apt.13374\n                      \n                    . Very good summaries and review of literature.","journal-title":"Aliment Pharmacol Ther"},{"issue":"1","key":"856_CR7","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1186\/s40064-016-3034-3","volume":"5","author":"F Nausheen","year":"2016","unstructured":"\u2022\u2022 Nausheen F, Mohsin H, Lakhan SE, et al. SpringerPlus. 2016;5(1):1357. Very good summaries and review of literature.","journal-title":"SpringerPlus"},{"issue":"6864","key":"856_CR8","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1136\/bmj.305.6864.1237","volume":"305","author":"RS Howard","year":"1992","unstructured":"Howard RS. Persistent hiccups. BMJ: Br Med J. 1992;305(6864):1237\u20138.","journal-title":"BMJ: Br Med J"},{"issue":"6","key":"856_CR9","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1179\/2045772313Y.0000000148","volume":"36","author":"XT Hao","year":"2013","unstructured":"Hao XT, Wang L, Yan B, Zhou HY. Intractable hiccup caused by spinal cord lesions in demyelination disease. J Spinal Cord Med. 2013;36(6):711\u20134.","journal-title":"J Spinal Cord Med"},{"issue":"4","key":"856_CR10","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/j.jemermed.2017.05.033","volume":"53","author":"NB Polito","year":"2017","unstructured":"Polito NB, Fellows SE. Pharmacologic interventions for intractable and persistent hiccups: a systematic review. J Emer Med. 2017;53(4):540\u20139. \n                      https:\/\/doi.org\/10.1016\/j.jemermed.2017.05.033\n                      \n                    .","journal-title":"J Emer Med"},{"issue":"6","key":"856_CR11","first-page":"480","volume":"94","author":"TC Cymet","year":"2002","unstructured":"Cymet TC. Retrospective analysis of hiccups in patients at a community hospital from 1995-2000. J Natl Med Assoc. 2002 Jun;94(6):480\u20133.","journal-title":"J Natl Med Assoc"},{"issue":"6","key":"856_CR12","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1097\/00002480-199911000-00003","volume":"45","author":"WH Dobelle","year":"1999","unstructured":"Dobelle WH. Use of breathing pacemakers to suppress intractable hiccups of up to thirteen years duration. ASAIO J. 1999;45(6):524\u20135.","journal-title":"ASAIO J"},{"issue":"9","key":"856_CR13","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1097\/01.meg.0000230081.53298.03","volume":"18","author":"E Rey","year":"2006","unstructured":"Rey E, Elola-Olaso CM, Rodr\u00edguez-Artalejo F, Locke GR, D\u00edaz-Rubio M. Prevalence of atypical symptoms and their association with typical symptoms of gastroesophageal reflux in Spain. Eur J Gastroenterol Hepatol. 2006;18(9):969\u201375.","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"3","key":"856_CR14","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1111\/j.1572-0241.2007.01612_4.x","volume":"103","author":"T Khorakiwala","year":"2008","unstructured":"Khorakiwala T, Arain R, Mulsow J, Walsh TN. Hiccups: an unrecognized symptom of esophageal cancer? Am J Gastroenterol. 2008;103(3):801.","journal-title":"Am J Gastroenterol"},{"key":"856_CR15","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1016\/j.genhosppsych.2008.09.014","volume":"31","author":"P Ray","year":"2009","unstructured":"Ray P, Zia Ul Haq M, Nizamie SH. Aripiprazole-induced hiccups: a case report. Gen Hosp Psychiatry. 2009;31:382\u20134.","journal-title":"Gen Hosp Psychiatry"},{"issue":"4","key":"856_CR16","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/S0168-0102(98)00011-X","volume":"30","author":"T Oshima","year":"1998","unstructured":"Oshima T, Sakamoto M, Tatsuta H, Arita H. GABAergic inhibition of hiccup-like reflex induced by electrical stimulation in medulla of cats. Neurosci Res. 1998;30(4):287\u201393.","journal-title":"Neurosci Res"},{"issue":"5","key":"856_CR17","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1016\/S0149-2918(97)80055-0","volume":"19","author":"G Petroianu","year":"1997","unstructured":"Petroianu G, Hein G, Petroianu A, Bergler W, Rufer R. Idiopathic chronic hiccup: combination therapy with cisapride, omeprazole, and baclofen. Clin Ther. 1997;19(5):1031\u20138.","journal-title":"Clin Ther"},{"issue":"4","key":"856_CR18","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1093\/brain\/93.4.851","volume":"93","author":"JN Davis","year":"1970","unstructured":"Davis JN. An experimental study of hiccup. Brain. 1970;93(4):851\u201372.","journal-title":"Brain"},{"key":"856_CR19","doi-asserted-by":"publisher","first-page":"397","DOI":"10.12659\/AJCR.908536","volume":"19","author":"AK Abubaker","year":"2018","unstructured":"Abubaker AK, Rabadi DK, Kassab M, Al-Qudah MA. Persistent hiccups after cervical epidural steroid injection. Am J Case Rep. 2018;19:397\u20139.","journal-title":"Am J Case Rep"},{"issue":"9","key":"856_CR20","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1016\/j.parkreldis.2015.07.010","volume":"21","author":"A Jochim","year":"2015","unstructured":"Jochim A, Castrop F, Gempt J, Haslinger B. Periodic hiccup in patients with subthalamic deep brain stimulation for Parkinson\u2019s disease. Parkinsonism Relat Disord. 2015;21(9):1117\u20138.","journal-title":"Parkinsonism Relat Disord"},{"issue":"1","key":"856_CR21","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1136\/jnnp.67.1.124","volume":"67","author":"RM Bie De","year":"1999","unstructured":"De Bie RM, Speelman JD, Schuurman PR, Bosch DA. Transient hiccups after posteroventral pallidotomy for Parkinson\u2019s disease. J Neurol Neurosurg Psychiatry. 1999;67(1):124\u20135.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"856_CR22","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.wneu.2018.01.139","volume":"112","author":"J Sweeney","year":"2018","unstructured":"Sweeney J, Bodman A, Hall WA. Brain abscess of basal ganglia presenting with persistent hiccups. World Neursurg. 2018;112:182\u20135.","journal-title":"World Neursurg"},{"key":"856_CR23","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.wneu.2017.12.118","volume":"111","author":"M Hashiguchi","year":"2018","unstructured":"Hashiguchi M, Fujita A, Ikeda M, Morikawa M, Kohmura E. Intractable hiccups after coil embolization of partially thrombosed posterior inferior cerebellar artery aneurysm. World Neurosurg. 2018;111:251\u20134.","journal-title":"World Neurosurg"},{"key":"856_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.inat.2015.10.004","volume":"3","author":"Y Takemoto","year":"2016","unstructured":"Takemoto Y, Hashiguchi A, Moroki K, Tokuda H, Kuratsu J. Chronic subdural hematoma with persistent hiccups: a case report. Interdiscip Neurosurg. 2016;3:1\u20132.","journal-title":"Interdiscip Neurosurg"},{"issue":"2","key":"856_CR25","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1097\/WNF.0000000000000129","volume":"39","author":"M Caloro","year":"2016","unstructured":"Caloro M, Pucci D, Calabro G, de Pisa E, Mancinelli I, Rosini E, et al. Development of hiccup in male patients hospitalized in a psychiatric ward: is it specifically related to the aripiprazole-benzodiazepine combination? Clin Neuropharmacol. 2016;39(2):67\u201372.","journal-title":"Clin Neuropharmacol"},{"key":"856_CR26","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1007\/s00228-017-2275-6","volume":"73","author":"U Lertxundi","year":"2017","unstructured":"Lertxundi U, Marquinez AC, Domingo-Echaburu S, Solinis MA, Calvo B, Del Pozo-Rodriguez A, et al. Hiccups in Parkinson\u2019s disease: an analysis of cases reported in the European pharmacovigilance database and a review of the literature. Eur J Clin Pharmacol. 2017;73:1159\u201364.","journal-title":"Eur J Clin Pharmacol"},{"issue":"4","key":"856_CR27","doi-asserted-by":"publisher","first-page":"A115","DOI":"10.1016\/j.chest.2017.08.146","volume":"152","author":"KP Nguyen","year":"2017","unstructured":"Nguyen KP, Pai V. Sternoclavicular joint (SCJ) septic arthritis presenting as excruciating cervical and chest pain with intractable hiccups. Chest. 2017;152(4):A115.","journal-title":"Chest"},{"key":"856_CR28","doi-asserted-by":"crossref","unstructured":"Munveer T, Cohen DA, Pulmonary embolism presenting as persistent hiccups, Am J Med 2018; 131(2).","DOI":"10.1016\/j.amjmed.2017.08.030"},{"key":"856_CR29","doi-asserted-by":"crossref","unstructured":"McGrane IR, Shuman MD, McDonald RW Donepezil-related intractable hiccups: a case report. Pharmacotherapy 2015;35(3)e1\u20135.","DOI":"10.1002\/phar.1551"},{"key":"856_CR30","doi-asserted-by":"crossref","unstructured":"Panchal R, Bhutt V, Anovadiya A, Purohut B, Dekhaiya F, Goswami N. Tramadol-induced hiccups: a report of two cases Druf Saf- Case Rep 2018; 5(3).","DOI":"10.1007\/s40800-017-0066-8"},{"issue":"6085","key":"856_CR31","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1136\/bmj.2.6085.501","volume":"2","author":"BW Williamson","year":"1977","unstructured":"Williamson BW, MacIntyre IM. Management of intractable hiccup. Br Med J. 1977;2(6085):501\u20133.","journal-title":"Br Med J"},{"key":"856_CR32","doi-asserted-by":"crossref","unstructured":"Kako J, Kobayashi M, Kanno Y, Tagami K. Intranasal vinegar as an effective treatment for persistent hiccups in a patient with advanced cancer undergoing palliative care. J Pain Symptom Manag 2017;54(2).","DOI":"10.1016\/j.jpainsymman.2017.02.011"},{"key":"856_CR33","unstructured":"Peleg R, Peleg A, Case report: sexual intercourse as potential treatment for intractable hiccups Can Fam Physician 2000;46:1631\u20131632."},{"issue":"2","key":"856_CR34","doi-asserted-by":"publisher","first-page":"e55","DOI":"10.1016\/j.jemermed.2016.07.116","volume":"52","author":"C Lee","year":"2017","unstructured":"Lee C, Tong LP. Termination of persistent hiccups by digital rectal massage. J Emerg Med. 2017;52(2):e55.","journal-title":"J Emerg Med"},{"key":"856_CR35","doi-asserted-by":"publisher","unstructured":"Moretto EN, Wee B, Wiffen PJ, Murchison AG. Interventions for treating persistent and intractable hiccups in adults. Cochrane Database Syst Rev 2013, Issue 1. Art. No.: CD008768. DOI: \n                      https:\/\/doi.org\/10.1002\/14651858.CD008768.pub2\n                      \n                    .","DOI":"10.1002\/14651858.CD008768.pub2"},{"key":"856_CR36","doi-asserted-by":"crossref","unstructured":"Grononger H, Cheng M A Case of persistent hiccups successfully managed with pregabalin. Progress in Palliative Care 2015; 23(4).","DOI":"10.1179\/1743291X14Y.0000000117"},{"issue":"1","key":"856_CR37","doi-asserted-by":"publisher","first-page":"42","DOI":"10.3344\/kjp.2010.23.1.42","volume":"23","author":"JH Lee","year":"2010","unstructured":"Lee JH, Kim TY, Lee HW, Choi YS, Moon SY, Cheong YK. Treatment of intractable hiccups with an oral agent monotherapy of baclofen. Korean J Pain. 2010;23(1):42\u20135.","journal-title":"Korean J Pain"},{"issue":"6","key":"856_CR38","doi-asserted-by":"publisher","first-page":"e9444","DOI":"10.1097\/MD.0000000000009444","volume":"97","author":"JE Kim","year":"2018","unstructured":"Kim JE, Lee MK, Lee DH, Choi SS, Park JS. Continuous cervical epidural block: treatment for intractable hiccups. Medicine (Baltimore). 2018;97(6):e9444.","journal-title":"Medicine (Baltimore)"},{"key":"856_CR39","doi-asserted-by":"crossref","unstructured":"Pittman T, DiStephano A, Chow R, Samet R Ultrasound-guided phrenic nerve block for intractable hiccups in patients with metastatic colon cancer: a case report J Palliat Care Med 2017; 7(3).","DOI":"10.4172\/2165-7386.1000302"}],"container-title":["Current Neurology and Neuroscience Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11910-018-0856-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11910-018-0856-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11910-018-0856-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T23:20:03Z","timestamp":1561159203000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11910-018-0856-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,22]]},"references-count":39,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["856"],"URL":"https:\/\/doi.org\/10.1007\/s11910-018-0856-0","relation":{},"ISSN":["1528-4042","1534-6293"],"issn-type":[{"value":"1528-4042","type":"print"},{"value":"1534-6293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,22]]},"assertion":[{"value":"22 June 2018","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"Stasia Rouse declares no potential conflicts of interest.Matthew Wodziak reports personal fees from Medtronic for consultancy.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"This article does not contain any studies with human or animal subjects performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and Animal Rights and Informed Consent"}}],"article-number":"51"}}