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In addition, Dr. Stevanin has been issued a patent on Inhibitors of glucosylceramide synthase for the treatment of motor neuron diseases. Maxime Boutry reports personal fees from French Ministry of Research (Doctoral School ED3C), during the conduct of the study. In addition, Dr. Boutry has been issued a patent on Inhibitors of glucosylceramide synthase for the treatment of motor neuron diseases. Sara Morais reports personal fees from FCT (Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia), Portugal, during the conduct of the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"This article is a review and reports only studies approved by editorial boards based on peer reviews. When we cited our own work, all the procedures performed in the studies involving human materials or animals were conducted in accordance with the ethical standards of our institution, with informed consent obtained from patients and approval from ethics committees.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and Animal Rights and Informed Consent"}}],"article-number":"18"}}