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Moreover, excessive or insufficient sleep, reductions in slow-wave and REM sleep, and fragmented rest-activity rhythms have been linked to early alterations in amyloid-\u03b2 and tau biomarkers, even in cognitively unimpaired individuals. Various sleep disorders have also been identified as independent contributors to AD risk, particularly among genetically susceptible populations.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Summary<\/jats:title>\n            <jats:p>Sleep and circadian disturbances, as well as changes in sleep architecture, represent easily detectable and modifiable risk factors for Alzheimer\u2019s disease. Integrating sleep and sleep-based metrics into preventive strategies may enhance early identification and offer novel avenues for intervention, modulating the risk of Alzheimer\u2019s disease.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s11910-025-01451-5","type":"journal-article","created":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T07:42:27Z","timestamp":1760341347000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Sleep Abnormalities and Risk of Alzheimer\u2019s Disease"],"prefix":"10.1007","volume":"25","author":[{"given":"Merve","family":"Aktan S\u00fczg\u00fcn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambra","family":"Stefani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,13]]},"reference":[{"key":"1451_CR1","doi-asserted-by":"crossref","unstructured":"Shi L, Chen SJ, Ma MY, Bao YP, Han Y, Wang YM, et al. 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