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DC receives research funding from the European Union, the Italian Ministry of Health, and the Italian Multiple Sclerosis Foundation. NWB is supported by a Canadian Institutes of Health Research Fellowship (FRN:489847) and the Health Data Research Network Canada Pragmatic Trials Training Program \u2013 Postdoctoral Fellowship Stream. NEF receives funding from NIH (R01; R21), National Multiple Sclerosis Society (NMSS), Consortium of MS Centers (CMSC), TEVA, and TG Therapeutics.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"32"}}