{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T12:44:15Z","timestamp":1753274655639},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2013,10,16]],"date-time":"2013-10-16T00:00:00Z","timestamp":1381881600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Curr Oncol Rep"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1007\/s11912-013-0349-x","type":"journal-article","created":{"date-parts":[[2013,10,14]],"date-time":"2013-10-14T22:41:36Z","timestamp":1381790496000},"page":"573-580","source":"Crossref","is-referenced-by-count":6,"title":["\u201cUnresectable\u201d Vulval Cancers: Is Neoadjuvant Chemotherapy the Way Forward?"],"prefix":"10.1007","volume":"15","author":[{"given":"Kathryn","family":"Graham","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Burton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,10,16]]},"reference":[{"key":"349_CR1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-59745-416-2_1","volume":"471","author":"A Jemal","year":"2009","unstructured":"Jemal A, Center MM, Ward E, et al. Cancer occurrence. Methods Mol Biol. 2009;471:3\u201329.","journal-title":"Methods Mol Biol"},{"key":"349_CR2","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/his.12034","volume":"62","author":"M Pino Del","year":"2013","unstructured":"Del Pino M, Rodriguez-Carunchio L, Ordi J. Pathways of vulvar intraepithelial neoplasia and squamous cell carcinoma. Histopathology. 2013;62:161\u201375.","journal-title":"Histopathology"},{"key":"349_CR3","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/S0002-9378(15)30802-4","volume":"40","author":"FJ Taussig","year":"1940","unstructured":"Taussig FJ. Cancer of the vulva: an analysis of 155 cases. Am J Obstet Gynecol. 1940;40:764\u20139.","journal-title":"Am J Obstet Gynecol"},{"key":"349_CR4","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/0002-9378(60)90626-8","volume":"79","author":"S Way","year":"1960","unstructured":"Way S. Carcinoma of the vulva. Am J Obstet Gynecol. 1960;79:692\u20137.","journal-title":"Am J Obstet Gynecol"},{"key":"349_CR5","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1002\/cncr.10969","volume":"95","author":"JA Hullu De","year":"2002","unstructured":"De Hullu JA, Hollema H, Lolkema S, et al. Vulvar carcinoma. The price of less radical surgery. Cancer. 2002;95:2331\u20138.","journal-title":"Cancer"},{"key":"349_CR6","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0090-8258(90)90064-R","volume":"38","author":"JM Heaps","year":"1990","unstructured":"Heaps JM, Fu YS, Montz FJ, et al. Surgical-pathologic variables predictive of local recurrence in squamous cell carcinoma of the vulva. Gynecol Oncol. 1990;38:309\u201314.","journal-title":"Gynecol Oncol"},{"key":"349_CR7","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1006\/gyno.1995.1151","volume":"57","author":"MP Burger","year":"1995","unstructured":"Burger MP, Hollema H, Emanuels AG, et al. The importance of the groin node status for the survival of T1 and T2 vulval carcinoma patients. Gynecol Oncol. 1995;57:327\u201334.","journal-title":"Gynecol Oncol"},{"key":"349_CR8","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1006\/gyno.1995.1128","volume":"57","author":"TW Burke","year":"1995","unstructured":"Burke TW, Levenback C, Coleman RL, et al. Surgical therapy of T1 and T2 vulvar carcinoma: further experience with radical wide excision and selective inguinal lymphadenectomy. Gynecol Oncol. 1995;57:215\u201320.","journal-title":"Gynecol Oncol"},{"key":"349_CR9","first-page":"733","volume":"68","author":"HD Homesley","year":"1986","unstructured":"Homesley HD, Bundy BN, Sedlis A, et al. Radiation therapy versus pelvic node resection for carcinoma of the vulva with positive groin nodes. Obstet Gynecol. 1986;68:733\u201340.","journal-title":"Obstet Gynecol"},{"key":"349_CR10","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1006\/gyno.1993.1127","volume":"49","author":"HD Homesley","year":"1993","unstructured":"Homesley HD, Bundy BN, Sedlis A, et al. Prognostic factors for groin node metastasis in squamous cell carcinoma of the vulva (a Gynecologic Oncology Group study). Gynecol Oncol. 1993;49:279\u201383.","journal-title":"Gynecol Oncol"},{"key":"349_CR11","first-page":"81","volume":"140","author":"SC Ballon","year":"1975","unstructured":"Ballon SC, Lamb EJ. Separate inguinal incisions in the treatment of carcinoma of the vulva. Surg Gynecol Obstet. 1975;140:81\u20134.","journal-title":"Surg Gynecol Obstet"},{"key":"349_CR12","first-page":"401","volume":"114","author":"SC Byron","year":"1962","unstructured":"Byron SC, Lamb EJ, Yonemoto RH, Kase S. Radical inguinal node dissection in the treatment of cancer. Surg Gynecol Obstet. 1962;114:401\u20138.","journal-title":"Surg Gynecol Obstet"},{"key":"349_CR13","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.ygyno.2012.12.042","volume":"128","author":"DH Moore","year":"2013","unstructured":"Moore DH. Reflections on vulvar tumors, lymphatic drainage, and sentinel lymph node biopsy. Gynecol Oncol. 2013;128:153\u20134.","journal-title":"Gynecol Oncol"},{"key":"349_CR14","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0360-3016(98)00193-X","volume":"42","author":"DH Moore","year":"1998","unstructured":"Moore DH, Thomas GM, Montana GS, et al. Preoperative chemoradiation for advanced vulvar cancer: a phase II study of the Gynecologic Oncology Group. Int J Radiat Oncol Biol Phys. 1998;42:79\u201385.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"349_CR15","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ygyno.2009.03.029","volume":"114","author":"A Maggioni","year":"2009","unstructured":"Maggioni A, Roviglione G, Landoni F, et al. Pelvic exenteration: ten-year experience at the European Institute of Oncology in Milan. Gynecol Oncol. 2009;114:64\u20138.","journal-title":"Gynecol Oncol"},{"key":"349_CR16","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ygyno.2011.09.014","volume":"124","author":"DM Forner","year":"2012","unstructured":"Forner DM, Lampe B. Exenteration in the treatment of stage III\/IV vulvar cancer. Gynecol Oncol. 2012;124:87\u201391.","journal-title":"Gynecol Oncol"},{"key":"349_CR17","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.ejso.2012.07.002","volume":"38","author":"G Baiocchi","year":"2012","unstructured":"Baiocchi G, Guimaraes GC, Rosa Oliveira RA, et al. Prognostic factors in pelvic exenteration for gynecological malignancies. Eur J Surg Oncol. 2012;38:948\u201354.","journal-title":"Eur J Surg Oncol"},{"key":"349_CR18","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.critrevonc.2011.09.003","volume":"83","author":"A Gadducci","year":"2012","unstructured":"Gadducci A, Tana R, Barsotti C, et al. Clinico-pathological and biological prognostic variables in squamous cell carcinoma of the vulva. Crit Rev Oncol Hematol. 2012;83:71\u201383.","journal-title":"Crit Rev Oncol Hematol"},{"key":"349_CR19","first-page":"640","volume":"33","author":"A Gadducci","year":"2012","unstructured":"Gadducci A, Ferrero A, Tana R, et al. Prognostic value of lymph node status and number of removed nodes in patients with squamous cell carcinoma of the vulva treated with modified radical vulvectomy and inguinal-femoral lymphadenectomy. Eur J Gynaecol Oncol. 2012;33:640\u20133.","journal-title":"Eur J Gynaecol Oncol"},{"key":"349_CR20","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/00000421-198704000-00055","volume":"10","author":"RC Boronow","year":"1987","unstructured":"Boronow RC, Hickman BT, Reagan MT, et al. Combined therapy as an alternative to exenteration for locally advanced vulvovaginal cancer. II. Results, complications, and dosimetric and surgical considerations. Am J Clin Oncol. 1987;10:171\u201381.","journal-title":"Am J Clin Oncol"},{"key":"349_CR21","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1006\/gyno.1996.0150","volume":"61","author":"F Landoni","year":"1996","unstructured":"Landoni F, Maneo A, Zanetta G, et al. Concurrent preoperative chemotherapy with 5-fluorouracil and mitomycin C and radiotherapy (FUMIR) followed by limited surgery in locally advanced and recurrent vulvar carcinoma. Gynecol Oncol. 1996;61:321\u20137.","journal-title":"Gynecol Oncol"},{"key":"349_CR22","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1006\/gyno.1995.1267","volume":"59","author":"PJ Eifel","year":"1995","unstructured":"Eifel PJ, Morris M, Burke TW, et al. Prolonged continuous infusion cisplatin and 5-fluorouracil with radiation for locally advanced carcinoma of the vulva. Gynecol Oncol. 1995;59:51\u20136.","journal-title":"Gynecol Oncol"},{"key":"349_CR23","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/S0360-3016(00)00762-8","volume":"48","author":"GS Montana","year":"2000","unstructured":"Montana GS, Thomas GM, Moore DH, et al. Preoperative chemo-radiation for carcinoma of the vulva with N2\/N3 nodes: a Gynecologic Oncology Group study. Int J Radiat Oncol Biol Phys. 2000;48:1007\u201313.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"349_CR24","doi-asserted-by":"crossref","first-page":"657","DOI":"10.3109\/02841869309092448","volume":"32","author":"M Scheistroen","year":"1993","unstructured":"Scheistroen M, Trope C. Combined bleomycin and irradiation in preoperative treatment of advanced squamous cell carcinoma of the vulva. Acta Oncol. 1993;32:657\u201361.","journal-title":"Acta Oncol"},{"key":"349_CR25","volume":"3","author":"HC Doorn van","year":"2006","unstructured":"van Doorn HC, Ansink A, Verhaar-Langereis M, et al. Neoadjuvant chemoradiation for advanced primary vulvar cancer. Cochrane Database Syst Rev. 2006;3, CD003752.","journal-title":"Cochrane Database Syst Rev"},{"key":"349_CR26","doi-asserted-by":"crossref","unstructured":"\u2022 Shylasree TS, Bryant A, Howells RE. Chemoradiation for advanced primary vulval cancer. Cochrane Database Syst Rev. 2011;(4):CD003752. This updated review of neoadjuvant chemoradiotherapy suggests no improvement in survival compared with surgery alone.","DOI":"10.1002\/14651858.CD003752.pub3"},{"key":"349_CR27","doi-asserted-by":"crossref","unstructured":"Maneo A, Landoni, F, Colombo, A, et al. Randomised study between neoadjuvant chemoradiotherapy and primary surgery for the treatment of advanced vulval cancer. Int J Gyn Cancer. 2003;13 (Suppl 1):abstr PL39.","DOI":"10.1136\/ijgc-00009577-200303001-00019"},{"key":"349_CR28","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0090-8258(91)90223-R","volume":"42","author":"GM Thomas","year":"1991","unstructured":"Thomas GM, Dembo AJ, Bryson SC, et al. Changing concepts in the management of vulvar cancer. Gynecol Oncol. 1991;42:9\u201321.","journal-title":"Gynecol Oncol"},{"key":"349_CR29","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1097\/COC.0b013e3181cae6a1","volume":"34","author":"L Tans","year":"2011","unstructured":"\u2022 Tans L, Ansink AC, van Rooij PH, et al. The role of chemo-radiotherapy in the management of locally advanced carcinoma of the vulva: single institutional experience and review of literature. Am J Clin Oncol. 2011;34:22\u20136. This is a recent review of primary chemoradiotherapy in locally advanced vulval cancer.","journal-title":"Am J Clin Oncol"},{"key":"349_CR30","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.ygyno.2004.03.019","volume":"93","author":"N Mulayim","year":"2004","unstructured":"Mulayim N, Foster Silver D, Schwartz PE, et al. Chemoradiation with 5-fluorouracil and mitomycin C in the treatment of vulvar squamous cell carcinoma. Gynecol Oncol. 2004;93:659\u201366.","journal-title":"Gynecol Oncol"},{"key":"349_CR31","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.ygyno.2007.11.010","volume":"108","author":"LM Landrum","year":"2008","unstructured":"Landrum LM, Skaggs V, Gould N, et al. Comparison of outcome measures in patients with advanced squamous cell carcinoma of the vulva treated with surgery or primary chemoradiation. Gynecol Oncol. 2008;108:584\u201390.","journal-title":"Gynecol Oncol"},{"key":"349_CR32","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.meddos.2011.11.005","volume":"37","author":"MC Bloemers","year":"2012","unstructured":"Bloemers MC, Portelance L, Ruo R, et al. A dosimetric evaluation of dose escalation for the radical treatment of locally advanced vulvar cancer by intensity-modulated radiation therapy. Med Dosim. 2012;37:310\u20133.","journal-title":"Med Dosim"},{"key":"349_CR33","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1097\/00000421-198904000-00011","volume":"12","author":"HB Muss","year":"1989","unstructured":"Muss HB, Bundy BN, Christopherson WA. Mitoxantrone in the treatment of advanced vulvar and vaginal carcinoma. A Gynecologic Oncology Group study. Am J Clin Oncol. 1989;12:142\u20134.","journal-title":"Am J Clin Oncol"},{"key":"349_CR34","first-page":"869","volume":"71","author":"RE Slayton","year":"1987","unstructured":"Slayton RE, Blessing JA, Beecham J, et al. Phase II trial of etoposide in the management of advanced or recurrent squamous cell carcinoma of the vulva and carcinoma of the vagina: a Gynecologic Oncology Group study. Cancer Treat Rep. 1987;71:869\u201370.","journal-title":"Cancer Treat Rep"},{"key":"349_CR35","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.ygyno.2005.07.126","volume":"99","author":"K Gerszten","year":"2005","unstructured":"Gerszten K, Selvaraj RN, Kelley J, et al. Preoperative chemoradiation for locally advanced carcinoma of the vulva. Gynecol Oncol. 2005;99:640\u20134.","journal-title":"Gynecol Oncol"},{"key":"349_CR36","first-page":"13s","volume":"50","author":"G Deppe","year":"1977","unstructured":"Deppe G, Bruckner HW, Cohen CJ. Adriamycin treatment of advanced vulvar carcinoma. Obstet Gynecol. 1977;50:13s\u20134.","journal-title":"Obstet Gynecol"},{"key":"349_CR37","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0090-8258(79)90112-4","volume":"7","author":"G Deppe","year":"1979","unstructured":"Deppe G, Cohen CJ, Bruckner HW. Chemotherapy of squamous cell carcinoma of the vulva: a review. Gynecol Oncol. 1979;7:345\u20138.","journal-title":"Gynecol Oncol"},{"key":"349_CR38","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1093\/annonc\/mdp043","volume":"20","author":"PO Witteveen","year":"2009","unstructured":"Witteveen PO, van der Velden J, Vergote I, et al. Phase II study on paclitaxel in patients with recurrent, metastatic or locally advanced vulvar cancer not amenable to surgery or radiotherapy: a study of the EORTC-GCG (European Organisation for Research and Treatment of Cancer\u2013Gynaecological Cancer Group). Ann Oncol. 2009;20:1511\u20136.","journal-title":"Ann Oncol"},{"key":"349_CR39","first-page":"939","volume":"17","author":"M Jaakkola","year":"1997","unstructured":"Jaakkola M, Rantanen V, Grenman S, et al. Vulvar squamous cell carcinoma cell lines are sensitive to paclitaxel in vitro. Anticancer Res. 1997;17:939\u201343.","journal-title":"Anticancer Res"},{"key":"349_CR40","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1002\/1097-0142(197602)37:2<660::AID-CNCR2820370208>3.0.CO;2-V","volume":"37","author":"JF Conroy","year":"1976","unstructured":"Conroy JF, Lewis GC, Brady LW, et al. Low dose bleomycin and methotrexate in cervical cancer. Cancer. 1976;37:660\u20134.","journal-title":"Cancer"},{"key":"349_CR41","doi-asserted-by":"crossref","first-page":"4649","DOI":"10.1200\/JCO.2009.21.8909","volume":"27","author":"BJ Monk","year":"2009","unstructured":"Monk BJ, Sill MW, McMeekin DS, et al. Phase III trial of four cisplatin-containing doublet combinations in stage IVB, recurrent, or persistent cervical carcinoma: a Gynecologic Oncology Group study. J Clin Oncol. 2009;27:4649\u201355.","journal-title":"J Clin Oncol"},{"key":"349_CR42","doi-asserted-by":"crossref","first-page":"4626","DOI":"10.1200\/JCO.2005.10.021","volume":"23","author":"HJ Long 3rd","year":"2005","unstructured":"Long 3rd HJ, Bundy BN, Grendys Jr EC, et al. Randomized phase III trial of cisplatin with or without topotecan in carcinoma of the uterine cervix: a Gynecologic Oncology Group study. J Clin Oncol. 2005;23:4626\u201333.","journal-title":"J Clin Oncol"},{"key":"349_CR43","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1159\/000259259","volume":"77","author":"G Cormio","year":"2009","unstructured":"Cormio G, Loizzi V, Gissi F, et al. Cisplatin and vinorelbine chemotherapy in recurrent vulvar carcinoma. Oncology. 2009;77:281\u20134.","journal-title":"Oncology"},{"key":"349_CR44","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1111\/j.1447-0756.2011.01821.x","volume":"38","author":"C Achilli","year":"2012","unstructured":"Achilli C, Palaia I, Perniola G, et al. Complete remission after neoadjuvant chemotherapy of an advanced vulvar cancer patient: a case report. J Obstet Gynaecol Res. 2012;38:1036\u20139.","journal-title":"J Obstet Gynaecol Res"},{"key":"349_CR45","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1097\/AOG.0b013e318254fe64","volume":"120","author":"J Belotte","year":"2012","unstructured":"Belotte J, Awonuga AO, Bolinjkar R, et al. Platinum-based combination chemotherapy for the treatment of advanced-stage squamous cell carcinoma of the vulva. Obstet Gynecol. 2012;120:458\u201360.","journal-title":"Obstet Gynecol"},{"key":"349_CR46","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1097\/IGC.0b013e31824b4058","volume":"22","author":"SN Han","year":"2012","unstructured":"Han SN, Vergote I, Amant F. Weekly paclitaxel\/carboplatin in the treatment of locally advanced, recurrent, or metastatic vulvar cancer. Int J Gynecol Cancer. 2012;22:865\u20138.","journal-title":"Int J Gynecol Cancer"},{"key":"349_CR47","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/0090-8258(90)90156-F","volume":"36","author":"Y Shimizu","year":"1990","unstructured":"Shimizu Y, Hasumi K, Masubuchi K. Effective chemotherapy consisting of bleomycin, vincristine, mitomycin C, and cisplatin (BOMP) for a patient with inoperable vulvar cancer. Gynecol Oncol. 1990;36:423\u20137.","journal-title":"Gynecol Oncol"},{"key":"349_CR48","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/0090-8258(90)90367-T","volume":"37","author":"KR Durrant","year":"1990","unstructured":"Durrant KR, Mangioni C, Lacave AJ, et al. Bleomycin, methotrexate, and CCNU in advanced inoperable squamous cell carcinoma of the vulva: a phase II study of the EORTC Gynaecological Cancer Cooperative Group (GCCG). Gynecol Oncol. 1990;37:359\u201362.","journal-title":"Gynecol Oncol"},{"key":"349_CR49","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1006\/gyno.2001.6180","volume":"81","author":"HC Wagenaar","year":"2001","unstructured":"Wagenaar HC, Colombo N, Vergote I, et al. Bleomycin, methotrexate, and CCNU in locally advanced or recurrent, inoperable, squamous-cell carcinoma of the vulva: an EORTC Gynaecological Cancer Cooperative Group study. European Organization for Research and Treatment of Cancer. Gynecol Oncol. 2001;81:348\u201354.","journal-title":"Gynecol Oncol"},{"key":"349_CR50","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1006\/gyno.1993.1163","volume":"50","author":"P Benedetti-Panici","year":"1993","unstructured":"Benedetti-Panici P, Greggi S, Scambia G, et al. Cisplatin (P), bleomycin (B), and methotrexate (M) preoperative chemotherapy in locally advanced vulvar carcinoma. Gynecol Oncol. 1993;50:49\u201353.","journal-title":"Gynecol Oncol"},{"key":"349_CR51","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ygyno.2005.06.068","volume":"100","author":"JP Geisler","year":"2006","unstructured":"Geisler JP, Manahan KJ, Buller RE. Neoadjuvant chemotherapy in vulvar cancer: avoiding primary exenteration. Gynecol Oncol. 2006;100:53\u20137.","journal-title":"Gynecol Oncol"},{"key":"349_CR52","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/IGC.0b013e3181c93adc","volume":"20","author":"AP Domingues","year":"2010","unstructured":"Domingues AP, Mota F, Durao M, et al. Neoadjuvant chemotherapy in advanced vulvar cancer. Int J Gynecol Cancer. 2010;20:294\u20138.","journal-title":"Int J Gynecol Cancer"},{"key":"349_CR53","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1097\/IGC.0b013e318263ef55","volume":"22","author":"AM Aragona","year":"2012","unstructured":"\u2022\u2022 Aragona AM, Cuneo N, Soderini AH, et al. Tailoring the treatment of locally advanced squamous cell carcinoma of the vulva: neoadjuvant chemotherapy followed by radical surgery: results from a multicenter study. Int J Gynecol Cancer. 2012;22:1258\u201363. NACT produced a dramatic response rate of more than 80% and the 5-year survival rate following surgery was an impressive 92%.","journal-title":"Int J Gynecol Cancer"},{"key":"349_CR54","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.ygyno.2004.09.016","volume":"96","author":"F Bellati","year":"2005","unstructured":"Bellati F, Angioli R, Manci N, et al. Single agent cisplatin chemotherapy in surgically resected vulvar cancer patients with multiple inguinal lymph node metastases. Gynecol Oncol. 2005;96:227\u201331.","journal-title":"Gynecol Oncol"},{"key":"349_CR55","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.ygyno.2012.06.028","volume":"127","author":"NS Horowitz","year":"2012","unstructured":"Horowitz NS, Olawaiye AB, Borger DR, et al. Phase II trial of erlotinib in women with squamous cell carcinoma of the vulva. Gynecol Oncol. 2012;127:141\u20136.","journal-title":"Gynecol Oncol"},{"key":"349_CR56","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1111\/j.1525-1438.2007.01145.x","volume":"18","author":"SD Richard","year":"2008","unstructured":"Richard SD, Krivak TC, Beriwal S, et al. Recurrent metastatic vulvar carcinoma treated with cisplatin plus cetuximab. Int J Gynecol Cancer. 2008;18:1132\u20135.","journal-title":"Int J Gynecol Cancer"},{"key":"349_CR57","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s00066-011-4002-z","volume":"187","author":"CD Alt","year":"2011","unstructured":"Alt CD, Brocker KA, Eichbaum M, et al. Imaging of female pelvic malignancies regarding MRI, CT, and PET\/CT: part 2. Strahlenther Onkol. 2011;187:705\u201314.","journal-title":"Strahlenther Onkol"}],"container-title":["Current Oncology Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11912-013-0349-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11912-013-0349-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11912-013-0349-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T20:41:45Z","timestamp":1564519305000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11912-013-0349-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,16]]},"references-count":57,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["349"],"URL":"https:\/\/doi.org\/10.1007\/s11912-013-0349-x","relation":{},"ISSN":["1523-3790","1534-6269"],"issn-type":[{"value":"1523-3790","type":"print"},{"value":"1534-6269","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,16]]}}}