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This review highlights three new biologic therapies approved by the FDA in 2017 to treat AML.","DOI":"10.1136\/jim-2018-000807"},{"issue":"5","key":"919_CR71","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1056\/NEJMoa1614359","volume":"377","author":"RM Stone","year":"2017","unstructured":"\u2022 Stone RM, et al. Midostaurin plus chemotherapy for acute myeloid leukemia with a FLT3 mutation. New England Journal of Medicine. 2017;377(5):454\u201364. This is a randomized, double-blinded, placebo controlled phase III study, the CALGB 10603\/RATIFY trial,evaluating the efficacy of midostaurin in combination with 7+3 chemotherapy compared to 7+3 chemotherapy with placebo for treatment of newly diagnosed FLT3-mutated AML. 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The overall response rate in patients with relapsed or refractory IDH2 mutant AML was 40.3% with a median response duration of 5.8 months, and median overall survival was 19.7 months."},{"issue":"2","key":"919_CR74","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1056\/NEJMoa1601202","volume":"375","author":"MS Davids","year":"2016","unstructured":"\u2022 Davids MS, et al. Ipilimumab for patients with relapse after allogeneic transplantation. New England Journal of Medicine. 2016;375(2):143\u201353. This study is a phase 1\/1b multicenter assessing the safety and efficiacy of ipilimumab in 28 patients with relapsed hematologic cancers after allogeneic HSCT and of the 22 patients who received the 10mg\/kg dose, 23% had a complete response, including 3 patients with LC and 1 with MS, 9% had a partial response, and 27% had decreased tumor burden. 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