{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T02:53:10Z","timestamp":1774234390471,"version":"3.50.1"},"reference-count":71,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Curr Oncol Rep"],"DOI":"10.1007\/s11912-026-01760-z","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:44:58Z","timestamp":1774226698000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Closing the Gap: HPV Vaccination and Head and Neck Cancer Prevention"],"prefix":"10.1007","volume":"28","author":[{"given":"Alicia","family":"Tosoni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Bibb\u00f2","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Di Nunno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Galvani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lidia","family":"Gatto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Bartolini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Aprile","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliana","family":"Gabrielli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Venturoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Querzoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Pandolfi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Pia","family":"Foschini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Franceschi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"issue":"4","key":"1760_CR1","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1136\/jcp.55.4.244","volume":"55","author":"FX Bosch","year":"2002","unstructured":"Bosch FX, Lorincz A, Mu\u00f1oz N, Meijer CJ, Shah KV. The causal relation between human papillomavirus and cervical cancer. J Clin Pathol. 2002;55(4):244\u201365.","journal-title":"J Clin Pathol"},{"issue":"suppl 5","key":"1760_CR2","doi-asserted-by":"publisher","first-page":"F55","DOI":"10.1016\/j.vaccine.2012.06.083","volume":"30","author":"J Doorbar","year":"2012","unstructured":"Doorbar J, Quint W, Banks L, Bravo IG, Stoler M, Broker TR, Stanley M. The biology and life-cycle of human papillomaviruses. Vaccine. 2012;30(suppl 5):F55\u201370.","journal-title":"Vaccine"},{"issue":"1","key":"1760_CR3","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.2337","volume":"33","author":"M Wierzbicka","year":"2023","unstructured":"Wierzbicka M, San Giorgi MRM, Dikkers FG. Transmission and clearance of human papillomavirus infection in the oral cavity and its role in oropharyngeal carcinoma - a review. Rev Med Virol. 2023;33(1):e2337.","journal-title":"Rev Med Virol"},{"issue":"4","key":"1760_CR4","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1200\/JCO.2007.14.1713","volume":"26","author":"AK Chaturvedi","year":"2008","unstructured":"Chaturvedi AK, Engels EA, Anderson WF, Gillison ML. Incidence trends for human papillomavirus-related and -unrelated oral squamous cell carcinomas in the United States. J Clin Oncol. 2008;26(4):612\u20139.","journal-title":"J Clin Oncol"},{"issue":"3","key":"1760_CR5","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1590\/1414-431X20132703","volume":"46","author":"J Betiol","year":"2013","unstructured":"Betiol J, Villa LL, Sichero L. Impact of HPV infection on the development of head and neck cancer. Braz J Med Biol Res. 2013;46(3):217\u201326.","journal-title":"Braz J Med Biol Res"},{"issue":"3","key":"1760_CR6","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1038\/s41416-019-0602-7","volume":"122","author":"ME Sabatini","year":"2020","unstructured":"Sabatini ME, Chiocca S. Human papillomavirus as a driver of head and neck cancers. Br J Cancer. 2020;122(3):306\u201314.","journal-title":"Br J Cancer"},{"issue":"9895","key":"1760_CR7","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1016\/S0140-6736(13)60809-0","volume":"382","author":"AR Kreimer","year":"2013","unstructured":"Kreimer AR, Pierce Campbell CM, Lin HY, Fulp W, Papenfuss MR, Abrahamsen M, Hildesheim A, Villa LL, Salmer\u00f3n JJ, Lazcano-Ponce E, Giuliano AR. Incidence and clearance of oral human papillomavirus infection in men: the HIM cohort study. Lancet. 2013;382(9895):877\u201387.","journal-title":"Lancet"},{"issue":"5","key":"1760_CR8","doi-asserted-by":"publisher","first-page":"pkaa047","DOI":"10.1093\/jncics\/pkaa047","volume":"4","author":"G D\u2019Souza","year":"2020","unstructured":"D\u2019Souza G, Clemens G, Strickler HD, Wiley DJ, Troy T, Struijk L, Gillison M, Fakhry C. Long-term persistence of oral HPV over 7 years of follow-up. JNCI Cancer Spectr. 2020;4(5):pkaa047.","journal-title":"JNCI Cancer Spectr"},{"issue":"18","key":"1760_CR9","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.21037\/atm-20-3346","volume":"8","author":"NC Schmitt","year":"2020","unstructured":"Schmitt NC. HPV in non-oropharyngeal head and neck cancer: does it matter? Ann Transl Med. 2020;8(18):1120.","journal-title":"Ann Transl Med"},{"issue":"5","key":"1760_CR10","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/j.oraloncology.2013.11.004","volume":"50","author":"JD Combes","year":"2014","unstructured":"Combes JD, Franceschi S. Role of human papillomavirus in non-oropharyngeal head and neck cancers. Oral Oncol. 2014;50(5):370\u20139.","journal-title":"Oral Oncol"},{"issue":"suppl 1","key":"1760_CR11","doi-asserted-by":"publisher","first-page":"S104","DOI":"10.1007\/s12105-012-0368-1","volume":"6","author":"T Isayeva","year":"2012","unstructured":"Isayeva T, Li Y, Maswahu D, Brandwein-Gensler M. Human papillomavirus in non-oropharyngeal head and neck cancers: a systematic literature review. Head Neck Pathol. 2012;6(suppl 1):S104\u201320.","journal-title":"Head Neck Pathol"},{"issue":"4","key":"1760_CR12","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1093\/jnci\/djn011","volume":"100","author":"C Fakhry","year":"2008","unstructured":"Fakhry C, Westra WH, Li S, Cmelak A, Ridge JA, Pinto H, Forastiere A, Gillison ML. Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial. J Natl Cancer Inst. 2008;100(4):261\u20139.","journal-title":"J Natl Cancer Inst"},{"issue":"9","key":"1760_CR13","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1093\/jnci\/92.9.709","volume":"92","author":"ML Gillison","year":"2000","unstructured":"Gillison ML, Koch WM, Capone RB, Spafford M, Westra WH, Wu L, Shah KV, Sidransky D. Evidence for a causal association between human papillomavirus and a subset of head and neck cancers. J Natl Cancer Inst. 2000;92(9):709\u201320.","journal-title":"J Natl Cancer Inst"},{"issue":"32","key":"1760_CR14","doi-asserted-by":"publisher","first-page":"4294","DOI":"10.1200\/JCO.2011.36.4596","volume":"29","author":"AK Chaturvedi","year":"2011","unstructured":"Chaturvedi AK, Engels EA, Pfeiffer RM, Hernandez BY, Xiao W, Kim E, Gillison ML. Human papillomavirus and rising oropharyngeal cancer incidence in the united States. J Clin Oncol. 2011;29(32):4294\u2013301.","journal-title":"J Clin Oncol"},{"issue":"1","key":"1760_CR15","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1056\/NEJMoa0912217","volume":"363","author":"KK Ang","year":"2010","unstructured":"Ang KK, Harris J, Wheeler R, Weber R, Rosenthal DI, Nguyen-T\u00e2n PF, Westra WH, Chung CH, Jordan RC, Lu C, Kim H, Axelrod R, Silverman CC, Redmond KP, Gillison ML. Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med. 2010;363(1):24\u201335.","journal-title":"N Engl J Med"},{"issue":"3","key":"1760_CR16","first-page":"209","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global cancer statistics 2020: GLOBOCAN estimates. CA Cancer J Clin. 2021;71(3):209\u201349.","journal-title":"CA Cancer J Clin"},{"issue":"11","key":"1760_CR17","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1016\/j.annonc.2020.07.011","volume":"31","author":"V Gregoire","year":"2020","unstructured":"Gregoire V, Lefebvre JL, Licitra L, Felip E, ESMO Guidelines Committee. Squamous cell carcinoma of the oral cavity, larynx, oropharynx and hypopharynx: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2020;31(11):1462\u201375.","journal-title":"Ann Oncol"},{"issue":"7","key":"1760_CR18","first-page":"1965","volume":"43","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Fakhry C, D\u2019Souza G. Human papillomavirus-related oropharyngeal cancer: epidemiology, diagnosis, and prevention. Head Neck. 2021;43(7):1965\u201374.","journal-title":"Head Neck"},{"key":"1760_CR19","volume":"106","author":"TA Day","year":"2020","unstructured":"Day TA, Fakhry C. Considerations in human papillomavirus vaccination and oropharyngeal cancer. Oral Oncol. 2020;106:104748.","journal-title":"Oral Oncol"},{"issue":"12","key":"1760_CR20","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.3390\/vaccines9121413","volume":"9","author":"S Kamolratanakul","year":"2021","unstructured":"Kamolratanakul S, Pitisuttithum P. Human papillomavirus vaccine efficacy and effectiveness against cancer. Vaccines (Basel). 2021;9(12):1413.","journal-title":"Vaccines (Basel)"},{"key":"1760_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2025.103290","volume":"84","author":"J Han","year":"2025","unstructured":"Han J, Zhang L, Chen Y, Zhang Y, Wang L, Cai R, et al. Global HPV vaccination programs and coverage rates: a systematic review. EClinicalMedicine. 2025;84:103290.","journal-title":"EClinicalMedicine"},{"issue":"11","key":"1760_CR22","volume":"2019","author":"H Bergman","year":"2019","unstructured":"Bergman H, Buckley BS, Villanueva G, Petkovic J, Garritty C, Lutje V, et al. Comparison of different human papillomavirus (HPV) vaccine types and dose schedules for prevention of HPV-related disease in females and males. Cochrane Database Syst Rev. 2019;2019(11):CD013479.","journal-title":"Cochrane Database Syst Rev"},{"issue":"10197","key":"1760_CR23","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/S0140-6736(19)30298-3","volume":"394","author":"M Drolet","year":"2019","unstructured":"Drolet M, B\u00e9nard \u00c9, P\u00e9rez N, Brisson M, HPV Vaccination Impact Study Group. Population-level impact and herd effects following the introduction of human papillomavirus vaccination programmes: updated systematic review and meta-analysis. Lancet. 2019;394(10197):497\u2013509.","journal-title":"Lancet"},{"issue":"10108","key":"1760_CR24","doi-asserted-by":"publisher","first-page":"2143","DOI":"10.1016\/S0140-6736(17)31821-4","volume":"390","author":"WK Huh","year":"2017","unstructured":"Huh WK, Joura EA, Giuliano AR, Iversen OE, de Andra RP, Ault KA, et al. Final efficacy, immunogenicity, and safety analyses of a nine-valent human papillomavirus vaccine in women aged 16\u201326 years: a randomised, double-blind trial. Lancet. 2017;390(10108):2143\u201359.","journal-title":"Lancet"},{"key":"1760_CR25","volume-title":"Primary End-points for Prophylactic HPV Vaccine Trials","author":"IARC HPV Working Group","year":"2014","unstructured":"IARC HPV Working Group. Primary End-points for Prophylactic HPV Vaccine Trials. Lyon (FR): International Agency for Research on Cancer; 2014."},{"issue":"5","key":"1760_CR26","doi-asserted-by":"publisher","first-page":"e226","DOI":"10.1016\/S1470-2045(15)70075-6","volume":"16","author":"DR Lowy","year":"2015","unstructured":"Lowy DR, Herrero R, Hildesheim A. Participants in the IARC\/NCI workshop on primary endpoints for prophylactic HPV vaccine Trials. primary endpoints for future prophylactic human papillomavirus vaccine trials: towards infection and Immunobridging. Lancet Oncol. 2015;16(5):e226\u201333.","journal-title":"Lancet Oncol"},{"issue":"21","key":"1760_CR27","doi-asserted-by":"publisher","first-page":"2708","DOI":"10.1200\/JCO.2012.47.2738","volume":"31","author":"AR Kreimer","year":"2013","unstructured":"Kreimer AR, Johansson M, Waterboer T, Kaaks R, Chang-Claude J, Drogen D, Tj\u00f8nneland A, Overvad K, Quir\u00f3s JR, Gonz\u00e1lez CA, S\u00e1nchez MJ, Larra\u00f1aga N, Navarro C, Barricarte A, Travis RC, Khaw KT, Wareham N, Trichopoulou A, Lagiou P, Trichopoulos D, Peeters PH, Panico S, Masala G, Grioni S, Tumino R, Vineis P, Bueno-de-Mesquita HB, Laurell G, Hallmans G, Manjer J, Ekstr\u00f6m J, Skeie G, Lund E, Weiderpass E, Ferrari P, Byrnes G, Romieu I, Riboli E, Hildesheim A, Boeing H, Pawlita M, Brennan P. Evaluation of human papillomavirus antibodies and risk of subsequent head and neck cancer. J Clin Oncol. 2013;31(21):2708\u201315.","journal-title":"J Clin Oncol"},{"issue":"31","key":"1760_CR28","doi-asserted-by":"publisher","first-page":"3613","DOI":"10.1200\/JCO.21.01785","volume":"40","author":"HA Robbins","year":"2022","unstructured":"Robbins HA, Ferreiro-Iglesias A, Waterboer T, Brenner N, Nygard M, Bender N, Schroeder L, Hildesheim A, Pawlita M, D\u2019Souza G, Visvanathan K, Langseth H, Schlecht NF, Tinker LF, Agalliu I, Wassertheil-Smoller S, Ness-Jensen E, Hveem K, Grioni S, Kaaks R, S\u00e1nchez MJ, Weiderpass E, Giles GG, Milne RL, Cai Q, Blot WJ, Zheng W, Weinstein SJ, Albanes D, Huang WY, Freedman ND, Kreimer AR, Johansson M, Brennan P. Absolute risk of oropharyngeal cancer after an HPV16-E6 serology test and potential implications for screening: results from the human papillomavirus cancer cohort consortium. J Clin Oncol. 2022;40(31):3613\u201322.","journal-title":"J Clin Oncol"},{"issue":"7","key":"1760_CR29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068329","volume":"8","author":"R Herrero","year":"2013","unstructured":"Herrero R, Quint W, Hildesheim A, Gonzalez P, Struijk L, Katki HA, et al. Reduced prevalence of oral HPV 4 years after bivalent vaccine in Costa Rica. PLoS ONE. 2013;8(7):e68329.","journal-title":"PLoS ONE"},{"issue":"1","key":"1760_CR30","doi-asserted-by":"publisher","first-page":"djv302","DOI":"10.1093\/jnci\/djv302","volume":"108","author":"DC Beachler","year":"2015","unstructured":"Beachler DC, Kreimer AR, Schiffman M, Herrero R, Wacholder S, Rodriguez AC, Lowy DR, Porras C, Schiller JT, Quint W, Jimenez S, Safaeian M, Struijk L, Schussler J, Hildesheim A, Gonzalez P. Costa Rica HPV vaccine trial (CVT) Group. Multisite HPV16\/18 vaccine efficacy against Cervical, Anal, and oral HPV infection. J Natl Cancer Inst. 2015;108(1):djv302.","journal-title":"J Natl Cancer Inst"},{"issue":"1","key":"1760_CR31","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1002\/ijc.32791","volume":"147","author":"M Lehtinen","year":"2020","unstructured":"Lehtinen M, Apter D, Eriksson T, Harjula K, Hokkanen M, Lehtinen T, et al. Effectiveness of the AS04-adjuvanted HPV-16\/18 vaccine in reducing oropharyngeal HPV infections in young females-results from a community-randomized trial. Int J Cancer. 2020;147(1):170\u20134.","journal-title":"Int J Cancer"},{"key":"1760_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2022.106244","volume":"136","author":"T Gheit","year":"2023","unstructured":"Gheit T, Muwonge R, Lucas E, Galati L, Anantharaman D, McKay-Chopin S, et al. Impact of HPV vaccination on HPV-related oral infections. Oral Oncol. 2023;136:106244.","journal-title":"Oral Oncol"},{"issue":"9","key":"1760_CR33","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1093\/cid\/ciy274","volume":"67","author":"TJ Wilkin","year":"2018","unstructured":"Wilkin TJ, Chen H, Cespedes MS, Leon-Cruz JT, Godfrey C, Chiao EY, et al. A randomized, placebo-controlled trial of the quadrivalent human papillomavirus vaccine in human immunodeficiency virus-infected adults aged 27 years or older: AIDS clinical trials group protocol A5298. Clin Infect Dis. 2018;67(9):1339\u201346.","journal-title":"Clin Infect Dis"},{"issue":"10","key":"1760_CR34","doi-asserted-by":"publisher","first-page":"714","DOI":"10.7326\/M17-1363","volume":"167","author":"K Sonawane","year":"2017","unstructured":"Sonawane K, Suk R, Chiao EY, Chhatwal J, Qiu P, Wilkin T, et al. Oral human papillomavirus infection: differences in prevalence between sexes and concordance with genital human papillomavirus infection, NHANES 2011 to 2014. Ann Intern Med. 2017;167(10):714\u201324.","journal-title":"Ann Intern Med"},{"key":"1760_CR35","unstructured":"Phase A. 3, International, Multi-center, Randomized, Double-blind, Placebo-controlled Clinical Trial to Study the Efficacy, Immunogenicity, and Safety of the 9vHPV Vaccine, a Multivalent L1 Virus-like Particle Vaccine, in the prevention of oral persistent infection with HPV Types 16, 18, 31, 33, 45, 52, or 58 in adult males, 20 to 45 years of age. European Clinical Trials Register. Accessed December 3, 2025."},{"key":"1760_CR36","unstructured":"Clinical Review - GARDASIL 9. US Food and Drug Administration. June 9, 2020. Accessed December 3, 2025."},{"issue":"10","key":"1760_CR37","doi-asserted-by":"publisher","first-page":"e212907","DOI":"10.1001\/jamaoncol.2021.2907","volume":"7","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Fakhry C, D\u2019Souza G. Projected association of human papillomavirus vaccination with oropharynx cancer incidence in the US, 2020\u20132045. JAMA Oncol. 2021;7(10):e212907.","journal-title":"JAMA Oncol"},{"key":"1760_CR38","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.926555","volume":"12","author":"F Guo","year":"2022","unstructured":"Guo F, Chang M, Scholl M, McKinnon B, Berenson AB. Trends in oropharyngeal cancer incidence among adult men and women in the United States from 2001 to 2018. Front Oncol. 2022;12:926555.","journal-title":"Front Oncol"},{"issue":"7","key":"1760_CR39","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1001\/jama.2012.101","volume":"307","author":"ML Gillison","year":"2012","unstructured":"Gillison ML, Broutian T, Pickard RK, Tong ZY, Xiao W, Kahle L, Graubard BI, Chaturvedi AK. Prevalence of oral HPV infection in the united States, 2009\u20132010. JAMA. 2012;307(7):693\u2013703.","journal-title":"JAMA"},{"key":"1760_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2024.103018","volume":"79","author":"L Alemany","year":"2025","unstructured":"Alemany L, Felsher M, Giuliano AR, Waterboer T, Mirghani H, Mehanna H, et al. Oral human papillomavirus (HPV) prevalence and genotyping among healthy adult populations in the United States and Europe: results from the PROGRESS (PRevalence of Oral hpv infection, a Global aSSessment) study. EClinicalMedicine. 2025;79:103018.","journal-title":"EClinicalMedicine"},{"issue":"50","key":"1760_CR41","first-page":"645","volume":"97","author":"Human papillomavirus vaccines","year":"2022","unstructured":"Human papillomavirus vaccines. WHO position paper, December 2022. Wkly Epidemiol Rec. 2022;97(50):645\u201372.","journal-title":"Wkly Epidemiol Rec"},{"key":"1760_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2020.106399","volume":"144","author":"L Bruni","year":"2021","unstructured":"Bruni L, Saura-L\u00e1zaro A, Montoliu A, Brotons M, Alemany L, Diallo MS, et al. HPV vaccination introduction worldwide and WHO and UNICEF estimates of national HPV immunization coverage 2010\u20132019. Prev Med. 2021;144:106399.","journal-title":"Prev Med"},{"issue":"11","key":"1760_CR43","first-page":"300","volume":"64","author":"Centers for Disease Control and Prevention (CDC)","year":"2015","unstructured":"Centers for Disease Control and Prevention (CDC). Use of 9-valent human papillomavirus (HPV) vaccine: updated HPV vaccination recommendations of the advisory committee on immunization practices. MMWR Morb Mortal Wkly Rep. 2015;64(11):300\u20134.","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"1760_CR44","unstructured":"Hung M-C, Srivastav A, Lu P-J, Black CL, Lindley MC, Singleton JA. Vaccination Coverage among Adults in the United States, National Health Interview Survey, 2022. Centers for Disease Control and Prevention. Accessed December 3, 2025."},{"key":"1760_CR45","unstructured":"Guidance on HPV vaccination. in EU countries: focus on boys, people living with HIV and 9-valent HPV vaccine introduction. European Centre for Disease Prevention and Control. Accessed December 3, 2025."},{"issue":"3","key":"1760_CR46","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/S1473-3099(21)00327-3","volume":"22","author":"SE Goldstone","year":"2022","unstructured":"Goldstone SE, Giuliano AR, Palefsky JM, Lazcano-Ponce E, Penny ME, Cabello RE, Moreira ED Jr, Baraldi E, Jessen H, Ferenczy A, Kurman R, Ronnett BM, Stoler MH, Bautista O, Das R, Luxembourg A, Zhou HJ, Saah A. Efficacy, immunogenicity, and safety of a quadrivalent HPV vaccine in men: results of an open-label, long-term extension of a randomised, placebo-controlled, phase 3 trial. Lancet Infect Dis. 2022;22(3):413\u201325.","journal-title":"Lancet Infect Dis"},{"key":"1760_CR47","doi-asserted-by":"crossref","unstructured":"Rosado C, Fernandes \u00c2R, Rodrigues AG, Lisboa C. Impact of Human Papillomavirus Vaccination on Male Disease: A Systematic Review. Vaccines (Basel). 2023;11(6):1083.","DOI":"10.3390\/vaccines11061083"},{"key":"1760_CR48","doi-asserted-by":"crossref","unstructured":"DeKloe J, et al. Effects of HPV vaccination on the development of HPV-related cancers: A retrospective analysis of a United States-based cohort. J Clin Oncol. 2024;42(16 suppl):10507-10507.","DOI":"10.1200\/JCO.2024.42.16_suppl.10507"},{"issue":"8","key":"1760_CR49","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.3390\/v13081644","volume":"13","author":"M Grandahl","year":"2021","unstructured":"Grandahl M, Nev\u00e9us T. Barriers towards HPV vaccinations for boys and young men: A narrative review. Viruses. 2021;13(8):1644.","journal-title":"Viruses"},{"issue":"10","key":"1760_CR50","first-page":"1786","volume":"121","author":"DM Graham","year":"2015","unstructured":"Graham DM, Isaranuwatchai W, Habbous S, de Oliveira C, Liu G, Siu LL. A cost-effectiveness analysis of human papillomavirus vaccination of boys for the prevention of oropharyngeal cancer. Cancer. 2015;121(10):1786\u201394.","journal-title":"Cancer"},{"key":"1760_CR51","doi-asserted-by":"publisher","first-page":"1584956","DOI":"10.3389\/fpubh.2025.1584956","volume":"13","author":"J Li","year":"2025","unstructured":"Li J, Li R, Qin R, Wang H, Wang D, Zhou L. Cost-effectiveness analysis of HPV vaccination for the prevention of oropharyngeal cancer in Chinese adolescent males. Front Public Health. 2025;13:1584956.","journal-title":"Front Public Health"},{"issue":"21","key":"1760_CR52","doi-asserted-by":"publisher","first-page":"3556","DOI":"10.3390\/cancers16213556","volume":"16","author":"A Tosoni","year":"2024","unstructured":"Tosoni A, Galvani L, Di Nunno V, Gatto L, Bartolini S, Aprile M, D\u2019Angelo E, Pasquini E, Baietti AM, Franceschi E. Awareness of the link between human papilloma virus infection and head and neck cancer among the general population and practitioners: A literature review. Cancers. 2024;16(21):3556.","journal-title":"Cancers"},{"issue":"2","key":"1760_CR53","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1002\/lary.26739","volume":"128","author":"MH Berger","year":"2018","unstructured":"Berger MH, Cohen ER, Shamrock AG, Chan B, Camp M, Lo K, Sargi ZB. Assessment of human papillomavirus awareness in association with head and neck cancer at a screening event. Laryngoscope. 2018;128(2):386\u201392.","journal-title":"Laryngoscope"},{"issue":"7","key":"1760_CR54","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1001\/jamaoto.2014.867","volume":"140","author":"AL Luryi","year":"2014","unstructured":"Luryi AL, Yarbrough WG, Niccolai LM, Roser S, Reed S. Public awareness of head and neck cancers: a cross-sectional survey. JAMA Otolaryngol Head Neck Surg. 2014;140(7):639\u201346.","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"issue":"10","key":"1760_CR55","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1159\/000525697","volume":"45","author":"SJ Sharma","year":"2022","unstructured":"Sharma SJ, Schartinger VH, Wuerdemann N, Langer C, M\u00f6llenhoff K, Collin L, Sutton L, Riedl D, Kreuter A, Lechner M, et al. Awareness of human papillomavirus (HPV) and HPV vaccination amongst the general population in germany: lack of awareness and need for action. Oncol Res Treat. 2022;45(10):561\u20137.","journal-title":"Oncol Res Treat"},{"issue":"6","key":"1760_CR56","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1007\/s00345-014-1379-1","volume":"33","author":"P Capogrosso","year":"2015","unstructured":"Capogrosso P, Ventimiglia E, Matloob R, Colicchia M, Serino A, Castagna G, Clementi MC, La Croce G, Capitanio U, Gandaglia G, et al. Awareness and knowledge of human papillomavirus-related diseases are still dramatically insufficient in the era of high-coverage vaccination programs. World J Urol. 2015;33(6):873\u201380.","journal-title":"World J Urol"},{"key":"1760_CR57","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2023.1195588","volume":"11","author":"G Paduano","year":"2023","unstructured":"Paduano G, Vaienna S, Maisto G, Di Giuseppe G, Pavia M. Investigating women\u2019s awareness and perceptions on human papillomavirus infection and oropharyngeal cancer in Italy. Front Public Health. 2023;11:1195588.","journal-title":"Front Public Health"},{"key":"1760_CR58","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2021.106660","volume":"150","author":"RH Dodd","year":"2021","unstructured":"Dodd RH, Freeman M, Dekaj F, Bamforth J, Miah A, Sasieni P, et al. Awareness of the link between human papillomavirus and oral cancer in UK university students. Prev Med. 2021;150:106660.","journal-title":"Prev Med"},{"issue":"11","key":"1760_CR59","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0141003","volume":"10","author":"J Jackowska","year":"2015","unstructured":"Jackowska J, Bartochowska A, Karlik M, Wichtowski M, Tokarski M, Wierzbicka M. The knowledge of the role of papillomavirus-related head and neck pathologies among general practitioners, otolaryngologists and trainees. A survey-based study. PLoS One. 2015;10(11):e0141003.","journal-title":"PLoS One"},{"issue":"2","key":"1760_CR60","first-page":"37","volume":"169","author":"V Mehta","year":"2017","unstructured":"Mehta V, Holmes S, Master A, Leblanc B, Caldito L. Knowledge of HPV-related oropharyngeal cancer and use of human papillomavirus vaccines by pediatricians in Louisiana. J La State Med Soc. 2017;169(2):37\u201342.","journal-title":"J La State Med Soc"},{"issue":"4","key":"1760_CR61","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1001\/jamaoto.2017.3089","volume":"144","author":"BM Laitman","year":"2018","unstructured":"Laitman BM, Oliver K, Genden E. Medical student knowledge of human Papillomavirus-positive head and neck cancer. JAMA Otolaryngol Head Neck Surg. 2018;144(4):380\u20132.","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"issue":"1","key":"1760_CR62","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-019-0864-8","volume":"19","author":"M Sallam","year":"2019","unstructured":"Sallam M, Al-Fraihat E, Dababseh D, Yaseen A, Taim D, Zabadi S, et al. Dental students\u2019 awareness and attitudes toward HPV-related oral cancer: a cross sectional study at the University of Jordan. BMC Oral Health. 2019;19(1):171.","journal-title":"BMC Oral Health"},{"issue":"4","key":"1760_CR63","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1007\/s13187-018-1373-1","volume":"34","author":"AI Lorenzo-Pouso","year":"2019","unstructured":"Lorenzo-Pouso AI, G\u00e1ndara-Vila P, Banga C, Gallas M, P\u00e9rez-Say\u00e1ns M, Garc\u00eda A, et al. Human papillomavirus-related oral cancer: knowledge and awareness among Spanish dental students. J Cancer Educ. 2019;34(4):782\u20138.","journal-title":"J Cancer Educ"},{"issue":"12","key":"1760_CR64","doi-asserted-by":"publisher","first-page":"3595","DOI":"10.31557\/APJCP.2020.21.12.3595","volume":"21","author":"NJ Farsi","year":"2020","unstructured":"Farsi NJ, Al Sharif S, Al Qathmi M, Merdad M, Marzouki H, Merdad L. Knowledge of human papillomavirus (HPV) and oropharyngeal cancer and acceptability of the HPV vaccine among dental students. Asian Pac J Cancer Prev. 2020;21(12):3595\u2013603.","journal-title":"Asian Pac J Cancer Prev"},{"issue":"6","key":"1760_CR65","doi-asserted-by":"publisher","first-page":"806","DOI":"10.3390\/medicina58060806","volume":"58","author":"A Murariu","year":"2022","unstructured":"Murariu A, Baciu E-R, Bobu L, Diaconu-Popa D, Zetu I, Gele\u021bu G, et al. Knowledge, practice, and awareness of oral cancer and HPV infection among dental students and residents: a cross-sectional study. Medicina. 2022;58(6):806.","journal-title":"Medicina"},{"issue":"2","key":"1760_CR66","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2021-004232","volume":"10","author":"LG Sousa","year":"2022","unstructured":"Sousa LG, Rajapakshe K, Rodriguez Canales J, Chin RL, Feng L, Wang Q, et al. ISA101 and nivolumab for HPV-16\u2009+\u2009cancer: updated clinical efficacy and immune correlates of response. J Immunother Cancer. 2022;10(2):e004232.","journal-title":"J Immunother Cancer"},{"issue":"5","key":"1760_CR67","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s00262-025-04009-z","volume":"74","author":"CS Floudas","year":"2025","unstructured":"Floudas CS, Goswami M, Donahue RN, Strauss J, Pastor DM, Redman JM, Brownell I, Turkbey EB, Steinberg SM, Cordes LM, Mart\u00e9 JL, Khan MH, McMahon S, Lamping E, Manu M, Manukyan M, Brough DE, Lankford A, Jochems C, Schlom J, Gulley JL. PRGN-2009 and bintrafusp Alfa for patients with advanced or metastatic human papillomavirus-associated cancer. Cancer Immunol Immunother. 2025;74(5):155.","journal-title":"Cancer Immunol Immunother"},{"key":"1760_CR68","doi-asserted-by":"publisher","DOI":"10.1177\/10732748241238629","volume":"31","author":"L Iqbal","year":"2024","unstructured":"Iqbal L, Jehan M, Azam S. Advancements in mRNA vaccines: a promising approach for combating human papillomavirus-related cancers. Cancer Control. 2024;31:10732748241238629.","journal-title":"Cancer Control"},{"issue":"6","key":"1760_CR69","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17060977","volume":"17","author":"FM Parisi","year":"2025","unstructured":"Parisi FM, Lentini M, Chiesa-Estomba CM, Mayo-Yanez M, Leichen JR, White M, et al. Liquid biopsy in HPV-associated head and neck cancer: a comprehensive review. Cancers (Basel). 2025;17(6):977.","journal-title":"Cancers (Basel)"},{"issue":"15","key":"1760_CR70","doi-asserted-by":"publisher","first-page":"3329","DOI":"10.1158\/1078-0432.CCR-24-0590","volume":"30","author":"GJ Hanna","year":"2024","unstructured":"Hanna GJ, Dennis MJ, Scarfo N, Mullin MS, Sethi RKV, Sehgal K, et al. Personalized ctDNA for monitoring disease status in head and neck squamous cell carcinoma. Clin Cancer Res. 2024;30(15):3329\u201336.","journal-title":"Clin Cancer Res"},{"issue":"8","key":"1760_CR71","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1038\/s41416-022-01716-7","volume":"126","author":"S Flach","year":"2022","unstructured":"Flach S, Howarth K, Hackinger S, Pipinikas C, Ellis P, McLay K, et al. Liquid biopsy for minimal residual disease detection in head and neck squamous cell carcinoma (LIONESS)-a personalised circulating tumour DNA analysis in head and neck squamous cell carcinoma. Br J Cancer. 2022;126(8):1186\u201395.","journal-title":"Br J Cancer"}],"container-title":["Current Oncology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11912-026-01760-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11912-026-01760-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11912-026-01760-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T02:02:11Z","timestamp":1774231331000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11912-026-01760-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,23]]},"references-count":71,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["1760"],"URL":"https:\/\/doi.org\/10.1007\/s11912-026-01760-z","relation":{},"ISSN":["1534-6269"],"issn-type":[{"value":"1534-6269","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,23]]},"assertion":[{"value":"12 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"26"}}