{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T03:02:08Z","timestamp":1774926128900,"version":"3.50.1"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Curr Oncol Rep"],"DOI":"10.1007\/s11912-026-01771-w","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T02:10:18Z","timestamp":1774923018000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Aspirin in Colorectal Cancer Care: Who to Treat, When, and Why"],"prefix":"10.1007","volume":"28","author":[{"given":"Dimitrios","family":"Stylianakis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilberto","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cinzia","family":"Solinas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleonora","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Pretta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Letizia","family":"Ledda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Pusceddu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Puzzoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pina","family":"Ziranu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serafina","family":"Martella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Tsavdaris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis","family":"Stylianakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Demurtas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo","family":"Giampieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Puleo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Willard-Gallo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Zorcolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Restivo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Scartozzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,31]]},"reference":[{"issue":"3","key":"1771_CR1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","volume":"74","author":"F Bray","year":"2024","unstructured":"Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74(3):229\u201363. https:\/\/doi.org\/10.3322\/caac.21834. PMID:38572751.","journal-title":"CA Cancer J Clin"},{"issue":"1","key":"1771_CR2","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/S1470-2045(24)00600-4","volume":"26","author":"H Sung","year":"2025","unstructured":"Sung H, Siegel RL, Laversanne M, et al. Colorectal cancer incidence trends in younger versus older adults: an analysis of population-based cancer registry data. Lancet Oncol. 2025;26(1):51\u201363. PMID:39674189.","journal-title":"Lancet Oncol"},{"issue":"8060","key":"1771_CR3","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1038\/s41586-025-08626-7","volume":"640","author":"J Yang","year":"2025","unstructured":"Yang J, Yamashita-Kanemaru Y, Morris BI, et al. Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity. Nature. 2025;640(8060):1052\u201361. https:\/\/doi.org\/10.1038\/s41586-025-08626-7. PMID:40044852.","journal-title":"Nature"},{"issue":"9826","key":"1771_CR4","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1016\/S0140-6736(12)60209-8","volume":"379","author":"PM Rothwell","year":"2012","unstructured":"Rothwell PM, Wilson M, Price JF, et al. Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials. Lancet. 2012;379(9826):1591\u2013601. https:\/\/doi.org\/10.1016\/S0140-6736(12)60209-8. PMID:22440947.","journal-title":"Lancet"},{"key":"1771_CR5","doi-asserted-by":"publisher","unstructured":"Chan AT, Ogino S, Fuchs CS. Aspirin use and survival after diagnosis of colorectal cancer. JAMA. 2009;302(6):649\u2013658. https:\/\/doi.org\/10.1001\/jama.2009.1112. PMID:19671906.","DOI":"10.1001\/jama.2009.1112"},{"issue":"17","key":"1771_CR6","doi-asserted-by":"publisher","first-page":"1596","DOI":"10.1056\/NEJMoa1207756","volume":"367","author":"X Liao","year":"2012","unstructured":"Liao X, Lochhead P, Nishihara R, et al. Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival. N Engl J Med. 2012;367(17):1596\u2013606. https:\/\/doi.org\/10.1056\/NEJMoa1207756. PMID:23094721.","journal-title":"N Engl J Med"},{"issue":"3","key":"1771_CR7","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/S2468-1253(24)00387-X","volume":"10","author":"JWK Chia","year":"2025","unstructured":"Chia JWK, Segelov E, Deng Y, et al. Aspirin after completion of standard adjuvant therapy for colorectal cancer (ASCOLT): an international, multicentre, phase 3, randomised, double-blind, placebo-controlled trial. Lancet Gastroenterol Hepatol. 2025;10(3):198\u2013209. https:\/\/doi.org\/10.1016\/S2468-1253(24)00387-X. PMID:39824200.","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"11","key":"1771_CR8","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1056\/NEJMoa2504650","volume":"393","author":"A Martling","year":"2025","unstructured":"Martling A, Hed Myrberg I, Nilbert M, ALASCCA Study Group, et al. Low-Dose Aspirin for PI3K-Altered Localized Colorectal Cancer. N Engl J Med. 2025;393(11):1051\u201364. https:\/\/doi.org\/10.1056\/NEJMoa2504650. PMID:40961426.","journal-title":"N Engl J Med"},{"issue":"15","key":"1771_CR9","doi-asserted-by":"publisher","first-page":"3142","DOI":"10.1158\/1078-0432.CCR-24-4048","volume":"31","author":"U G\u00fcller","year":"2025","unstructured":"G\u00fcller U, Hayoz S, Horber D, et al. Adjuvant Aspirin Treatment in PIK3CA-Mutated Colon Cancer Patients: The SAKK 41\/13 Prospective Randomized Placebo-Controlled Double-Blind Trial. Clin Cancer Res. 2025;31(15):3142\u20139. https:\/\/doi.org\/10.1158\/1078-0432.CCR-24-4048. PMID:40067142.","journal-title":"Clin Cancer Res"},{"issue":"10240","key":"1771_CR10","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.1016\/S0140-6736(20)30366-4","volume":"395","author":"J Burn","year":"2020","unstructured":"Burn J, Sheth H, Elliott F, et al. Cancer prevention with aspirin in hereditary colorectal cancer (Lynch syndrome), 10-year follow-up and registry-based 20-year data in the CAPP2 study: a double-blind, randomised, placebo-controlled trial. Lancet. 2020;395(10240):1855\u201363. https:\/\/doi.org\/10.1016\/S0140-6736(20)30366-4. PMID:32534647.","journal-title":"Lancet"},{"issue":"16","key":"1771_CR11","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1056\/NEJMoa1805819","volume":"379","author":"JJ McNeil","year":"2018","unstructured":"McNeil JJ, Wolfe R, Woods RL, et al. Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly. N Engl J Med. 2018;379(16):1509\u201318. https:\/\/doi.org\/10.1056\/NEJMoa1805819. PMID:30221597.","journal-title":"N Engl J Med"},{"key":"1771_CR12","doi-asserted-by":"publisher","unstructured":"US Preventive Services Task Force. Aspirin use to prevent Cardiovascular Disease: US Preventive Services Task Force recommendation statement. JAMA. 2022;327(16):1577\u20131584. https:\/\/doi.org\/10.1001\/jama.2022.4983. PMID:35471505.","DOI":"10.1001\/jama.2022.4983"},{"key":"1771_CR13","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s11888-016-0306-9","volume":"12","author":"C Coyle","year":"2016","unstructured":"Coyle C, Cafferty FH, Langley RE. Aspirin and Colorectal Cancer Prevention and Treatment: Is It for Everyone? Curr Colorectal Cancer Rep. 2016;12:27\u201334. https:\/\/doi.org\/10.1007\/s11888-016-0306-9. PMID:27069437.","journal-title":"Curr Colorectal Cancer Rep"},{"issue":"1","key":"1771_CR14","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.clcc.2016.07.011","volume":"16","author":"R Giampieri","year":"2017","unstructured":"Giampieri R, Restivo A, Pusceddu V, et al. The Role of Aspirin as Antitumoral Agent for Heavily Pretreated Patients With Metastatic Colorectal Cancer Receiving Capecitabine Monotherapy. Clin Colorectal Cancer. 2017;16(1):38\u201343. https:\/\/doi.org\/10.1016\/j.clcc.2016.07.011. PMID:27576095.","journal-title":"Clin Colorectal Cancer"},{"issue":"4","key":"1771_CR15","doi-asserted-by":"publisher","first-page":"e0152402","DOI":"10.1371\/journal.pone.0152402","volume":"11","author":"PC Elwood","year":"2016","unstructured":"Elwood PC, Morgan G, Pickering JE, et al. Aspirin in the Treatment of Cancer: Reductions in Metastatic Spread and in Mortality: A Systematic Review and Meta-Analyses of Published Studies. PLoS ONE. 2016;11(4):e0152402. https:\/\/doi.org\/10.1371\/journal.pone.0152402. PMID:27096951.","journal-title":"PLoS ONE"},{"key":"1771_CR16","doi-asserted-by":"publisher","unstructured":"Patrono C. Fifty years with aspirin and platelets. Br J Pharmacol. 2023;180(1):25\u201343. https:\/\/doi.org\/10.1111\/bph.15966. PMID:36189951.","DOI":"10.1111\/bph.15966"},{"issue":"25","key":"1771_CR17","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1038\/newbio231232a0","volume":"231","author":"JR Vane","year":"1971","unstructured":"Vane JR. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat New Biol. 1971;231(25):232\u20135. https:\/\/doi.org\/10.1038\/newbio231232a0. PMID:5284360.","journal-title":"Nat New Biol"},{"issue":"8","key":"1771_CR18","doi-asserted-by":"publisher","first-page":"3073","DOI":"10.1073\/pnas.72.8.3073","volume":"72","author":"GJ Roth","year":"1975","unstructured":"Roth GJ, Stanford N, Majerus PW. Acetylation of prostaglandin synthase by aspirin. Proc Natl Acad Sci U S A. 1975;72(8):3073\u20136. https:\/\/doi.org\/10.1073\/pnas.72.8.3073. PMID:810797.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"17","key":"1771_CR19","doi-asserted-by":"publisher","first-page":"12387","DOI":"10.1016\/S0021-9258(19)49852-9","volume":"267","author":"T Shimokawa","year":"1992","unstructured":"Shimokawa T, Smith WL. Prostaglandin endoperoxide synthase. The aspirin acetylation region. J Biol Chem. 1992;267(17):12387\u201392. PMID:1601897.","journal-title":"J Biol Chem"},{"issue":"16","key":"1771_CR20","first-page":"11235","volume":"269","author":"M Lecomte","year":"1994","unstructured":"Lecomte M, Laneuville O, Ji C, DeWitt DL, Smith WL. Acetylation of human prostaglandin endoperoxide synthase-2 (cyclooxygenase-2) by aspirin. J Biol Chem. 1994;269(16):11235\u201343. PMID:8175750.","journal-title":"J Biol Chem"},{"issue":"21","key":"1771_CR21","doi-asserted-by":"publisher","first-page":"9475","DOI":"10.1073\/pnas.92.21.9475","volume":"92","author":"J Cl\u00e0ria","year":"1995","unstructured":"Cl\u00e0ria J, Serhan CN. Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions. Proc Natl Acad Sci U S A. 1995;92(21):9475\u20139. https:\/\/doi.org\/10.1073\/pnas.92.21.9475. PMID:7568157.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"1771_CR22","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1038\/nrc2809","volume":"10","author":"D Wang","year":"2010","unstructured":"Wang D, Dubois RN. Eicosanoids and cancer. Nat Rev Cancer. 2010;10(3):181\u201393. https:\/\/doi.org\/10.1038\/nrc2809. PMID:20168319.","journal-title":"Nat Rev Cancer"},{"issue":"7","key":"1771_CR23","doi-asserted-by":"publisher","first-page":"1884","DOI":"10.1053\/j.gastro.2015.07.064","volume":"149","author":"D Wang","year":"2015","unstructured":"Wang D, Fu L, Sun H, Guo L, DuBois RN. Prostaglandin E2 Promotes Colorectal Cancer Stem Cell Expansion and Metastasis in Mice. Gastroenterology. 2015;149(7):1884\u2013e18954. https:\/\/doi.org\/10.1053\/j.gastro.2015.07.064. PMID:26261008.","journal-title":"Gastroenterology"},{"issue":"5","key":"1771_CR24","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/j.ccr.2011.09.009","volume":"20","author":"M Labelle","year":"2011","unstructured":"Labelle M, Begum S, Hynes RO. Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis. Cancer Cell. 2011;20(5):576\u201390. https:\/\/doi.org\/10.1016\/j.ccr.2011.09.009. PMID:22094253.","journal-title":"Cancer Cell"},{"issue":"30","key":"1771_CR25","doi-asserted-by":"publisher","first-page":"E3053","DOI":"10.1073\/pnas.1411082111","volume":"111","author":"M Labelle","year":"2014","unstructured":"Labelle M, Begum S, Hynes RO. Platelets guide the formation of early metastatic niches. Proc Natl Acad Sci U S A. 2014;111(30):E3053\u201361. https:\/\/doi.org\/10.1073\/pnas.1411082111. PMID:25024172.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"1771_CR26","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1016\/j.cell.2015.08.015","volume":"162","author":"S Zelenay","year":"2015","unstructured":"Zelenay S, van der Veen AG, B\u00f6ttcher JP, et al. Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity. Cell. 2015;162(6):1257\u201370. https:\/\/doi.org\/10.1016\/j.cell.2015.08.015. PMID:26343581.","journal-title":"Cell"},{"issue":"6706","key":"1771_CR27","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1038\/23948","volume":"396","author":"MJ Yin","year":"1998","unstructured":"Yin MJ, Yamamoto Y, Gaynor RB. The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta. Nature. 1998;396(6706):77\u201380. https:\/\/doi.org\/10.1038\/23948. PMID:9817203.","journal-title":"Nature"},{"issue":"1","key":"1771_CR28","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1053\/j.seminoncol.2015.09.010","volume":"43","author":"A Umar","year":"2016","unstructured":"Umar A, Steele VE, Menter DG, Hawk ET. Mechanisms of nonsteroidal anti-inflammatory drugs in cancer prevention. Semin Oncol. 2016;43(1):65\u201377. https:\/\/doi.org\/10.1053\/j.seminoncol.2015.09.010. PMID:26970125.","journal-title":"Semin Oncol"},{"issue":"9826","key":"1771_CR29","doi-asserted-by":"publisher","first-page":"1602","DOI":"10.1016\/S0140-6736(11)61720-0","volume":"379","author":"PM Rothwell","year":"2012","unstructured":"Rothwell PM, Price JF, Fowkes FGR, et al. Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: analysis of the time course of risks and benefits in 51 randomised controlled trials. Lancet. 2012;379(9826):1602\u201312. https:\/\/doi.org\/10.1016\/S0140-6736(11)61720-0. PMID:22440946.","journal-title":"Lancet"},{"issue":"2","key":"1771_CR30","doi-asserted-by":"publisher","first-page":"77","DOI":"10.7326\/0003-4819-159-2-201307160-00002","volume":"159","author":"NR Cook","year":"2013","unstructured":"Cook NR, Lee I-M, Zhang SM, Moorthy MV, Buring JE. Alternate-day, low-dose aspirin and cancer risk: long-term observational follow-up of a randomized trial. Ann Intern Med. 2013;159(2):77\u201385. https:\/\/doi.org\/10.7326\/0003-4819-159-2-201307160-00002. PMID:23856681.","journal-title":"Ann Intern Med"},{"issue":"9754","key":"1771_CR31","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1016\/S0140-6736(10)61543-7","volume":"376","author":"PM Rothwell","year":"2010","unstructured":"Rothwell PM, Wilson M, Elwin CE, et al. Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials. Lancet. 2010;376(9754):1741\u201350. https:\/\/doi.org\/10.1016\/S0140-6736(10)61543-7. PMID:20970847.","journal-title":"Lancet"},{"issue":"3","key":"1771_CR32","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1093\/jnci\/djaa114","volume":"113","author":"JJ McNeil","year":"2021","unstructured":"McNeil JJ, Gibbs P, Orchard SG, ASPREE Investigator Group, et al. Effect of Aspirin on Cancer Incidence and Mortality in Older Adults. J Natl Cancer Inst. 2021;113(3):258\u201365. https:\/\/doi.org\/10.1093\/jnci\/djaa114. PMID:32778876.","journal-title":"J Natl Cancer Inst"},{"issue":"10","key":"1771_CR33","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1056\/NEJMoa021633","volume":"348","author":"RS Sandler","year":"2003","unstructured":"Sandler RS, Halabi S, Baron JA, et al. A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer. N Engl J Med. 2003;348(10):883\u201390. https:\/\/doi.org\/10.1056\/NEJMoa021633. PMID:12621132.","journal-title":"N Engl J Med"},{"issue":"10","key":"1771_CR34","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1056\/NEJMoa021735","volume":"348","author":"JA Baron","year":"2003","unstructured":"Baron JA, Cole BF, Sandler RS, et al. A randomized trial of aspirin to prevent colorectal adenomas. N Engl J Med. 2003;348(10):891\u20139. https:\/\/doi.org\/10.1056\/NEJMoa021735. PMID:12621133.","journal-title":"N Engl J Med"},{"issue":"4","key":"1771_CR35","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1093\/jnci\/djn485","volume":"101","author":"BF Cole","year":"2009","unstructured":"Cole BF, Logan RF, Halabi S, et al. Aspirin for the chemoprevention of colorectal adenomas: meta-analysis of the randomized trials. J Natl Cancer Inst. 2009;101(4):256\u201366. https:\/\/doi.org\/10.1093\/jnci\/djn485. PMID:19211452.","journal-title":"J Natl Cancer Inst"},{"key":"1771_CR36","doi-asserted-by":"publisher","unstructured":"Guirguis-Blake JM, Evans CV, Senger CA et al. Aspirin use to prevent Cardiovascular Disease: updated evidence report and systematic review for the US Preventive Services Task Force. JAMA. 2022;327(16):1585\u20131597. https:\/\/doi.org\/10.1001\/jama.2022.3337. PMID:35471507.","DOI":"10.1001\/jama.2022.3337"},{"issue":"2","key":"1771_CR37","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1136\/gutjnl-2011-300113","volume":"61","author":"R Benamouzig","year":"2012","unstructured":"Benamouzig R, Uzzan B, Deyra J, Martin A, Girard B, Little J, Chaussade S. Association pour la Pr\u00e9vention par l\u2019Aspirine du Cancer Colorectal Study Group. Prevention by daily soluble aspirin of colorectal adenoma recurrence: four-year results of the APACC randomized trial. Gut. 2012;61(2):255\u201361. https:\/\/doi.org\/10.1136\/gutjnl-2011-300113. PMID:21890814.","journal-title":"Gut"},{"key":"1771_CR38","doi-asserted-by":"publisher","unstructured":"Logan RF, Grainge MJ, Shepherd VC, Armitage NC, Muir KR, UKCAP Trial Group. Aspirin and folic acid for the prevention of recurrent colorectal adenomas: a randomized factorial trial. Gastroenterology 2008, 134(1), 29\u201338. https:\/\/doi.org\/10.1053\/j.gastro.2007.10.014. PMID:18022173.","DOI":"10.1053\/j.gastro.2007.10.014"},{"issue":"10164","key":"1771_CR39","doi-asserted-by":"publisher","first-page":"2583","DOI":"10.1016\/S0140-6736(18)31775-6","volume":"392","author":"MA Hull","year":"2018","unstructured":"Hull MA, Sprange K, Hepburn T, et al. Eicosapentaenoic acid and aspirin, alone and in combination, for the prevention of colorectal adenomas (seAFOod Polyp Prevention trial): a multicentre, randomized, double-blind, placebo-controlled, 2\u00d72 factorial trial. Lancet. 2018;392(10164):2583\u201394. https:\/\/doi.org\/10.1016\/S0140-6736(18)31775-6. PMID:30466866.","journal-title":"Lancet"},{"key":"1771_CR40","doi-asserted-by":"publisher","unstructured":"Ishikawa H, Mutoh M, Suzuki S et al. The preventive effects of low-dose enteric-coated aspirin tablets on the development of colorectal tumours in Asian patients: a randomized trial. Gut 2014, 63(11), 1755\u20139. https:\/\/doi.org\/10.1136\/gutjnl-2013-305827. PMID:25214553.","DOI":"10.1136\/gutjnl-2013-305827"},{"issue":"1","key":"1771_CR41","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1053\/j.gastro.2015.09.010","volume":"150","author":"HC Pommergaard","year":"2016","unstructured":"Pommergaard HC, Burcharth J, Rosenberg J, Raskov H. Aspirin, calcitriol, and calcium do not prevent adenoma recurrence in a randomized controlled trial. Gastroenterology. 2016;150(1):114\u2013e1224. https:\/\/doi.org\/10.1053\/j.gastro.2015.09.010. PMID:26404953.","journal-title":"Gastroenterology"},{"issue":"5","key":"1771_CR42","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1016\/j.ejca.2012.10.024","volume":"49","author":"C McCowan","year":"2013","unstructured":"McCowan C, Munro AJ, Donnan PT, Steele RJ. Use of aspirin post-diagnosis in a cohort of patients with colorectal cancer and its association with all-cause and colorectal cancer specific mortality. Eur J Cancer. 2013;49(5):1049\u201357. https:\/\/doi.org\/10.1016\/j.ejca.2012.10.024.","journal-title":"Eur J Cancer"},{"key":"1771_CR43","doi-asserted-by":"publisher","unstructured":"Ng K, Meyerhardt JA, Chan AT et al. Aspirin and COX-2 inhibitor use in patients with stage III colon cancer. J Natl Cancer Inst. 2014;107(1):345. Published 2014 Nov 27. https:\/\/doi.org\/10.1093\/jnci\/dju345","DOI":"10.1093\/jnci\/dju345"},{"key":"1771_CR44","doi-asserted-by":"publisher","unstructured":"Davis JS, Chavez JC, Kok M et al. Association of Prediagnosis obesity and Postdiagnosis aspirin with survival from stage IV Colorectal Cancer. JAMA Netw Open. 2022;5(10):e2236357. https:\/\/doi.org\/10.1001\/jamanetworkopen.2022.36357. PMID:36239938.","DOI":"10.1001\/jamanetworkopen.2022.36357"},{"key":"1771_CR45","doi-asserted-by":"publisher","unstructured":"Rho S, Wang C, Hosseini Dehkordi SH, Sears JJ, Hu ZI. Bleeding and thrombotic events in bevacizumab-treated patients with colorectal cancer on novel oral anticoagulants and antiplatelet medications. Am Heart J Plus. 2023;27:100283. https:\/\/doi.org\/10.1016\/j.ahjo.2023.100283. PMID:38511095.","DOI":"10.1016\/j.ahjo.2023.100283"},{"issue":"3","key":"1771_CR46","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1001\/jama.2018.20578","volume":"321","author":"SL Zheng","year":"2019","unstructured":"Zheng SL, Alistair JR. Association of Aspirin Use for Primary Prevention With Cardiovascular Events and Bleeding Events: A Systematic Review and Meta-analysis. JAMA vol. 2019;321(3):277\u201387. https:\/\/doi.org\/10.1001\/jama.2018.20578.","journal-title":"JAMA vol"},{"key":"1771_CR47","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1056\/NEJMoa1709118","volume":"377","author":"JW Eikelboom","year":"2017","unstructured":"Eikelboom JW, et al. Rivaroxaban with or without Aspirin in Stable Cardiovascular Disease (COMPASS). N Engl J Med. 2017;377:1319\u201330. https:\/\/doi.org\/10.1056\/NEJMoa1709118. PMID:28844192.","journal-title":"N Engl J Med"},{"issue":"10363","key":"1771_CR48","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1016\/S0140-6736(22)01843-8","volume":"400","author":"C Hawkey","year":"2022","unstructured":"Hawkey C, et al. Helicobacter pylori eradication for primary prevention of peptic ulcer bleeding in older patients prescribed aspirin in primary care (HEAT): a randomised, double-blind, placebo-controlled trial. Lancet (London England) vol. 2022;400(10363):1597\u2013606. https:\/\/doi.org\/10.1016\/S0140-6736(22)01843-8.","journal-title":"Lancet (London England) vol"},{"issue":"3","key":"1771_CR49","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1056\/NEJMoa042087","volume":"352","author":"FKL Chan","year":"2005","unstructured":"Chan FKL, et al. Clopidogrel versus aspirin and esomeprazole to prevent recurrent ulcer bleeding. New Engl J Med vol. 2005;352(3):238\u201344. https:\/\/doi.org\/10.1056\/NEJMoa042087.","journal-title":"New Engl J Med vol"},{"key":"1771_CR50","doi-asserted-by":"publisher","unstructured":"Sung JJY, et al. Continuation of low-dose aspirin therapy in peptic ulcer bleeding: a randomized trial. Ann Intern Med. 2010;152(1). https:\/\/doi.org\/10.7326\/0003-4819-152-1-201001050-00179. PMID:19949136.","DOI":"10.7326\/0003-4819-152-1-201001050-00179"},{"issue":"7407","key":"1771_CR51","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1038\/nature11252","volume":"487","author":"The Cancer Genome Atlas Network","year":"2012","unstructured":"The Cancer Genome Atlas Network. Comprehensive molecular characterization of human colon and rectal cancer. Nature. 2012;487(7407):330\u20137. https:\/\/doi.org\/10.1038\/nature11252. PMID:22810696.","journal-title":"Nature"},{"issue":"21","key":"1771_CR52","doi-asserted-by":"publisher","first-page":"2189","DOI":"10.1056\/NEJMsr077003","volume":"357","author":"R Wang","year":"2007","unstructured":"Wang R, Lagakos SW, Ware JH, Hunter DJ, Drazen JM. Statistics in medicine\u2014reporting of subgroup analyses in clinical trials. N Engl J Med. 2007;357(21):2189\u201394. https:\/\/doi.org\/10.1056\/NEJMsr077003. PMID:18032770.","journal-title":"N Engl J Med"},{"key":"1771_CR53","doi-asserted-by":"publisher","first-page":"e1553","DOI":"10.1136\/bmj.e1553","volume":"344","author":"X Sun","year":"2012","unstructured":"Sun X, Briel M, Busse JW, et al. Credibility of claims of subgroup effects in randomised controlled trials: systematic review. BMJ. 2012;344:e1553. https:\/\/doi.org\/10.1136\/bmj.e1553. PMID:22422832.","journal-title":"BMJ"},{"issue":"10152","key":"1771_CR54","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1016\/S0140-6736(18)31924-X","volume":"392","author":"JM Gaziano","year":"2018","unstructured":"Gaziano JM, Brotons C, Coppolecchia R, et al. A randomized trial of aspirin in the primary prevention of cardiovascular disease in people at moderate risk. Lancet. 2018;392(10152):1036\u201346. https:\/\/doi.org\/10.1016\/S0140-6736(18)31924-X. PMID:30158069.","journal-title":"Lancet"},{"issue":"16","key":"1771_CR55","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1056\/NEJMoa1804988","volume":"379","author":"L Bowman","year":"2018","unstructured":"Bowman L, Mafham M, Wallendszus K, et al. Effects of aspirin for primary prevention in persons with diabetes mellitus. N Engl J Med. 2018;379(16):1529\u201339. https:\/\/doi.org\/10.1056\/NEJMoa1804988. PMID:30146931.","journal-title":"N Engl J Med"},{"key":"1771_CR56","doi-asserted-by":"publisher","unstructured":"Reinert T, Henriksen TV, Christensen E et al. Analysis of plasma cell-free DNA by ultradeep sequencing in patients with stages I to III colorectal cancer. JAMA Oncol. 2019, 5(8), 1124\u20131131. https:\/\/doi.org\/10.1001\/jamaoncol.2019.0528. PMID:31070691.","DOI":"10.1001\/jamaoncol.2019.0528"},{"issue":"24","key":"1771_CR57","doi-asserted-by":"publisher","first-page":"2261","DOI":"10.1056\/NEJMoa2200075","volume":"386","author":"J Tie","year":"2022","unstructured":"Tie J, Cohen JD, Wang Y, et al. Circulating Tumor DNA Analysis Guiding Adjuvant Therapy in Stage II Colon Cancer. N Engl J Med. 2022;386(24):2261\u201372. https:\/\/doi.org\/10.1056\/NEJMoa2200075. PMID:35657320.","journal-title":"N Engl J Med"},{"key":"1771_CR58","doi-asserted-by":"publisher","unstructured":"Ioannidis JPA. Why most published research findings are false. PLoS Med. 2005, 2(8), e124. https:\/\/doi.org\/10.1371\/journal.pmed.0020124. PMID:16060722.","DOI":"10.1371\/journal.pmed.0020124"},{"key":"1771_CR59","doi-asserted-by":"publisher","unstructured":"Ioannidis JPA. How to make more published research true. PLoS Med. 2014, 11(10), e1001747. https:\/\/doi.org\/10.1371\/journal.pmed.1001747. PMID:25334033.","DOI":"10.1371\/journal.pmed.1001747"},{"issue":"9683","key":"1771_CR60","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/S0140-6736(09)60329-9","volume":"374","author":"I Chalmers","year":"2009","unstructured":"Chalmers I, Glasziou P. Avoidable waste in the production and reporting of research evidence. Lancet. 2009;374(9683):86\u20139. https:\/\/doi.org\/10.1016\/S0140-6736(09)60329-9. PMID:19733780.","journal-title":"Lancet"},{"issue":"9759","key":"1771_CR61","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/S0140-6736(10)62110-1","volume":"377","author":"PM Rothwell","year":"2011","unstructured":"Rothwell PM, Fowkes FGR, Belch JF, Ogawa H, Warlow CP, Meade TW. Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials. Lancet. 2011;377(9759):31\u201341. https:\/\/doi.org\/10.1016\/S0140-6736(10)62110-1. PMID:21144578.","journal-title":"Lancet"},{"issue":"21","key":"1771_CR62","doi-asserted-by":"publisher","first-page":"2351","DOI":"10.1001\/jama.297.21.2351","volume":"297","author":"BF Cole","year":"2007","unstructured":"Cole BF, Baron JA, Sandler RS, et al. Folic acid for the prevention of colorectal adenomas: a randomized clinical trial. JAMA. 2007;297(21):2351\u20139. https:\/\/doi.org\/10.1001\/jama.297.21.2351. PMID:17551129.","journal-title":"JAMA"},{"key":"1771_CR63","doi-asserted-by":"publisher","unstructured":"Wu K, Platz EA, Willett WC et al. A randomized trial on folic acid supplementation and risk of recurrent colorectal adenoma. Am J Clin Nutr. 2009, 90(6), 1623\u201331. https:\/\/doi.org\/10.3945\/ajcn.2009.28319. PMID:19864409.","DOI":"10.3945\/ajcn.2009.28319"},{"issue":"13","key":"1771_CR64","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1056\/NEJMoa050613","volume":"352","author":"PM Ridker","year":"2005","unstructured":"Ridker PM, et al. A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women. New Engl J Med vol. 2005;352(13):1293\u2013304. https:\/\/doi.org\/10.1056\/NEJMoa050613.","journal-title":"New Engl J Med vol"}],"container-title":["Current Oncology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11912-026-01771-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11912-026-01771-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11912-026-01771-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T02:10:25Z","timestamp":1774923025000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11912-026-01771-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,31]]},"references-count":64,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["1771"],"URL":"https:\/\/doi.org\/10.1007\/s11912-026-01771-w","relation":{},"ISSN":["1534-6269"],"issn-type":[{"value":"1534-6269","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,31]]},"assertion":[{"value":"12 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This work did not require use of human subjects.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"No patients were used and thus no consent was required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The lead author (DS) affirms that this manuscript is an honest, accurate, and transparent account of the study being reported; that no important aspects of the study have been omitted; and that any discrepancies from the study as planned (and, if relevant, registered) have been explained.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Transparency Statement"}}],"article-number":"33"}}