{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:22:59Z","timestamp":1790886179482,"version":"4.1.0"},"reference-count":105,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T00:00:00Z","timestamp":1709164800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T00:00:00Z","timestamp":1709164800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000069","name":"NIAMS","doi-asserted-by":"crossref","award":["ZIA AR041199"],"award-info":[{"award-number":["ZIA AR041199"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Curr Osteoporos Rep"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose of Review<\/jats:title>\n                <jats:p>In this review, we summarize the current evidence that suggests that neutrophils play a key role in facilitating damage to local bone structures.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Recent Findings<\/jats:title>\n                <jats:p>Neutrophil infiltration is a hallmark of inflammatory bone diseases such as rheumatoid arthritis (RA) and periodontitis disease (PD). Both of these human diseases are marked by an imbalance in bone homeostasis, favoring the degradation of local bone which ultimately leads to erosions. Osteoclasts, a multinucleated resident bone cell, are responsible for facilitating the turnover of bone and the bone damage observed in these diseases. The involvement of neutrophils and neutrophil extracellular trap formation have recently been implicated in exacerbating osteoclast function through direct and indirect mechanisms. We highlight a recent finding that NET proteins such as histones and elastase can generate non-canonical, inflammatory osteoclasts, and this process is mediated by post-translational modifications such as citrullination and carbamylation, both of which act as autoantigens in RA.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Summary<\/jats:title>\n                <jats:p>It appears that NETs, autoantibodies, modified proteins, cytokines, and osteoclasts all ultimately contribute to local and permanent bone damage in RA and PD. However, more studies are needed to fully understand the role of neutrophils in inflammatory bone diseases.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11914-024-00865-3","type":"journal-article","created":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T03:02:18Z","timestamp":1709175738000},"page":"280-289","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Neutrophils in Inflammatory Bone Diseases"],"prefix":"10.1007","volume":"22","author":[{"given":"Carmelo","family":"Carmona-Rivera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana J.","family":"Kaplan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liam J.","family":"O\u2019Neil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,29]]},"reference":[{"issue":"6","key":"865_CR1","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.jbspin.2010.04.015","volume":"77","author":"JM Berthelot","year":"2010","unstructured":"Berthelot JM, Le Goff B. Rheumatoid arthritis and periodontal disease. Joint Bone Spine. 2010;77(6):537\u201341.","journal-title":"Joint Bone Spine"},{"issue":"4","key":"865_CR2","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/nrrheum.2009.28","volume":"5","author":"P de Pablo","year":"2009","unstructured":"de Pablo P, Chapple IL, Buckley CD, Dietrich T. Periodontitis in systemic rheumatic diseases. Nat Rev Rheumatol. 2009;5(4):218\u201324.","journal-title":"Nat Rev Rheumatol"},{"issue":"6","key":"865_CR3","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/j.1600-051X.1996.tb01825.x","volume":"23","author":"E Firatli","year":"1996","unstructured":"Firatli E, Kantarci A, Cebeci I, Tanyeri H, Sonmez G, Carin M, Tuncer O. Association between HLA antigens and early onset periodontitis. J Clin Periodontol. 1996;23(6):563\u20136.","journal-title":"J Clin Periodontol"},{"issue":"3","key":"865_CR4","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1097\/BOR.0b013e32835fb8ec","volume":"25","author":"CO Bingham 3rd","year":"2013","unstructured":"Bingham CO 3rd, Moni M. Periodontal disease and rheumatoid arthritis: the evidence accumulates for complex pathobiologic interactions. Curr Opin Rheumatol. 2013;25(3):345\u201353.","journal-title":"Curr Opin Rheumatol"},{"issue":"3","key":"865_CR5","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/ng.1076","volume":"44","author":"S Raychaudhuri","year":"2012","unstructured":"Raychaudhuri S, Sandor C, Stahl EA, Freudenberg J, Lee HS, Jia X, et al. Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis. Nat Genet. 2012;44(3):291\u20136.","journal-title":"Nat Genet"},{"issue":"31","key":"865_CR6","first-page":"55","volume":"2003","author":"AJ Delima","year":"2000","unstructured":"Delima AJ, Van Dyke TE. Origin and function of the cellular components in gingival crevice fluid. Periodontol. 2000;2003(31):55\u201376.","journal-title":"Periodontol"},{"issue":"5663","key":"865_CR7","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1126\/science.1092385","volume":"303","author":"V Brinkmann","year":"2004","unstructured":"Brinkmann V, Reichard U, Goosmann C, Fauler B, Uhlemann Y, Weiss DS, et al. Neutrophil extracellular traps kill bacteria. Science. 2004;303(5663):1532\u20135.","journal-title":"Science"},{"issue":"5","key":"865_CR8","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/s41577-022-00787-0","volume":"23","author":"G Wigerblad","year":"2023","unstructured":"\u2022 Wigerblad G, Kaplan MJ. Neutrophil extracellular traps in systemic autoimmune and autoinflammatory diseases. Nat Rev Immunol. 2023;23(5):274\u201388.\u00a0Here, authors summarize the latest role of NETs in autoimmune and inflammatory conditions.","journal-title":"Nat Rev Immunol"},{"issue":"42","key":"865_CR9","doi-asserted-by":"crossref","first-page":"17372","DOI":"10.1073\/pnas.1114465108","volume":"108","author":"J Shi","year":"2011","unstructured":"Shi J, Knevel R, Suwannalai P, van der Linden MP, Janssen GM, van Veelen PA, et al. Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damage. Proc Natl Acad Sci U S A. 2011;108(42):17372\u20137.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"865_CR10","doi-asserted-by":"crossref","unstructured":"Carmona-Rivera C, Carlucci PM, Moore E, Lingampalli N, Uchtenhagen H, James E, et al. Synovial fibroblast-neutrophil interactions promote pathogenic adaptive immunity in rheumatoid arthritis. Sci Immunol. 2017;2(10):eaag3358.","DOI":"10.1126\/sciimmunol.aag3358"},{"key":"865_CR11","doi-asserted-by":"crossref","unstructured":"\u2022 O\u2019Neil LJ, Barrera-Vargas A, Sandoval-Heglund D, Merayo-Chalico J, Aguirre-Aguilar E, Aponte AM, et al. Neutrophil-mediated carbamylation promotes articular damage in rheumatoid arthritis. Sci Adv. 2020;6(44):eabd2688. This paper found novel antibodies against carbamylated proteins in RA patients that correlate with bone erosion and potentiate osteoclast formation.","DOI":"10.1126\/sciadv.abd2688"},{"key":"865_CR12","first-page":"55","volume":"69","author":"DL Scott","year":"2004","unstructured":"Scott DL. Radiological progression in established rheumatoid arthritis. J Rheumatol Suppl. 2004;69:55\u201365.","journal-title":"J Rheumatol Suppl"},{"issue":"4","key":"865_CR13","first-page":"943","volume":"152","author":"EM Gravallese","year":"1998","unstructured":"Gravallese EM, Harada Y, Wang JT, Gorn AH, Thornhill TS, Goldring SR. Identification of cell types responsible for bone resorption in rheumatoid arthritis and juvenile rheumatoid arthritis. Am J Pathol. 1998;152(4):943\u201351.","journal-title":"Am J Pathol"},{"key":"865_CR14","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/615486","volume":"2015","author":"SA Hienz","year":"2015","unstructured":"Hienz SA, Paliwal S, Ivanovski S. Mechanisms of bone resorption in periodontitis. J Immunol Res. 2015;2015: 615486.","journal-title":"J Immunol Res"},{"issue":"3","key":"865_CR15","first-page":"65","volume":"59","author":"NS Soysa","year":"2012","unstructured":"Soysa NS, Alles N, Aoki K, Ohya K. Osteoclast formation and differentiation: an overview. J Med Dent Sci. 2012;59(3):65\u201374.","journal-title":"J Med Dent Sci"},{"issue":"7","key":"865_CR16","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/s41577-022-00741-0","volume":"22","author":"V Malmstrom","year":"2022","unstructured":"Malmstrom V, Catrina AI, Klareskog L. Author correction: The immunopathogenesis of seropositive rheumatoid arthritis: from triggering to targeting. Nat Rev Immunol. 2022;22(7):459.","journal-title":"Nat Rev Immunol"},{"issue":"3","key":"865_CR17","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1186\/ar89","volume":"2","author":"L Fugger","year":"2000","unstructured":"Fugger L, Svejgaard A. Association of MHC and rheumatoid arthritis HLA-DR4 and rheumatoid arthritis: studies in mice and men. Arthritis Res. 2000;2(3):208\u201311.","journal-title":"Arthritis Res"},{"issue":"1","key":"865_CR18","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1600-0757.2012.00450.x","volume":"62","author":"PM Bartold","year":"2013","unstructured":"Bartold PM, Van Dyke TE. Periodontitis: a host-mediated disruption of microbial homeostasis. Unlearning learned concepts Periodontol 2000. 2013;62(1):203\u201317.","journal-title":"Unlearning learned concepts. Periodontol 2000"},{"issue":"5","key":"865_CR19","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1002\/art.38348","volume":"66","author":"TR Mikuls","year":"2014","unstructured":"Mikuls TR, Payne JB, Yu F, Thiele GM, Reynolds RJ, Cannon GW, et al. Periodontitis and Porphyromonas gingivalis in patients with rheumatoid arthritis. Arthritis Rheumatol. 2014;66(5):1090\u2013100.","journal-title":"Arthritis Rheumatol"},{"issue":"7","key":"865_CR20","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1136\/ard.2005.036913","volume":"65","author":"H Marotte","year":"2006","unstructured":"Marotte H, Farge P, Gaudin P, Alexandre C, Mougin B, Miossec P. The association between periodontal disease and joint destruction in rheumatoid arthritis extends the link between the HLA-DR shared epitope and severity of bone destruction. Ann Rheum Dis. 2006;65(7):905\u20139.","journal-title":"Ann Rheum Dis"},{"issue":"3","key":"865_CR21","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s00296-019-04460-z","volume":"40","author":"K Bialowas","year":"2020","unstructured":"Bialowas K, Radwan-Oczko M, Dus-Ilnicka I, Korman L, Swierkot J. Periodontal disease and influence of periodontal treatment on disease activity in patients with rheumatoid arthritis and spondyloarthritis. Rheumatol Int. 2020;40(3):455\u201363.","journal-title":"Rheumatol Int"},{"key":"865_CR22","doi-asserted-by":"crossref","unstructured":"Gomez-Banuelos E, Mukherjee A, Darrah E, Andrade F. Rheumatoid arthritis-associated mechanisms of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans. J Clin Med. 2019;8(9).","DOI":"10.3390\/jcm8091309"},{"issue":"9","key":"865_CR23","doi-asserted-by":"crossref","first-page":"2662","DOI":"10.1002\/art.27552","volume":"62","author":"N Wegner","year":"2010","unstructured":"Wegner N, Wait R, Sroka A, Eick S, Nguyen KA, Lundberg K, et al. Peptidylarginine deiminase from Porphyromonas gingivalis citrullinates human fibrinogen and alpha-enolase: implications for autoimmunity in rheumatoid arthritis. Arthritis Rheum. 2010;62(9):2662\u201372.","journal-title":"Arthritis Rheum"},{"issue":"3","key":"865_CR24","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.mehy.2009.04.008","volume":"73","author":"ED Rosenstein","year":"2009","unstructured":"Rosenstein ED, Weissmann G, Greenwald RA. Porphyromonas gingivalis, periodontitis and rheumatoid arthritis. Med Hypotheses. 2009;73(3):457\u20138.","journal-title":"Med Hypotheses"},{"issue":"1","key":"865_CR25","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.intimp.2008.09.008","volume":"9","author":"TR Mikuls","year":"2009","unstructured":"Mikuls TR, Payne JB, Reinhardt RA, Thiele GM, Maziarz E, Cannella AC, et al. Antibody responses to Porphyromonas gingivalis (P. gingivalis) in subjects with rheumatoid arthritis and periodontitis. Int Immunopharmacol. 2009;9(1):38\u201342.","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"865_CR26","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1186\/s13075-016-1100-4","volume":"18","author":"L Johansson","year":"2016","unstructured":"Johansson L, Sherina N, Kharlamova N, Potempa B, Larsson B, Israelsson L, et al. Concentration of antibodies against Porphyromonas gingivalis is increased before the onset of symptoms of rheumatoid arthritis. Arthritis Res Ther. 2016;18(1):201.","journal-title":"Arthritis Res Ther"},{"key":"865_CR27","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.804822","volume":"13","author":"N Sherina","year":"2022","unstructured":"Sherina N, de Vries C, Kharlamova N, Sippl N, Jiang X, Brynedal B, et al. Antibodies to a citrullinated Porphyromonas gingivalis epitope are increased in early rheumatoid arthritis, and can be produced by gingival tissue B Cells: Implications for a Bacterial Origin in RA Etiology. Front Immunol. 2022;13: 804822.","journal-title":"Front Immunol"},{"issue":"684","key":"865_CR28","doi-asserted-by":"crossref","first-page":"eabq8476","DOI":"10.1126\/scitranslmed.abq8476","volume":"15","author":"RC Brewer","year":"2023","unstructured":"Brewer RC, Lanz TV, Hale CR, Sepich-Poore GD, Martino C, Swafford AD, et al. Oral mucosal breaks trigger anti-citrullinated bacterial and human protein antibody responses in rheumatoid arthritis. Sci Transl Med. 2023;15(684):eabq8476.","journal-title":"Sci Transl Med"},{"key":"865_CR29","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/832127","volume":"2015","author":"DS Amarasekara","year":"2015","unstructured":"Amarasekara DS, Yu J, Rho J. Bone loss triggered by the cytokine network in inflammatory autoimmune diseases. J Immunol Res. 2015;2015: 832127.","journal-title":"J Immunol Res"},{"issue":"4","key":"865_CR30","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nm.1945","volume":"15","author":"NB Binder","year":"2009","unstructured":"Binder NB, Niederreiter B, Hoffmann O, Stange R, Pap T, Stulnig TM, et al. Estrogen-dependent and C-C chemokine receptor-2-dependent pathways determine osteoclast behavior in osteoporosis. Nat Med. 2009;15(4):417\u201324.","journal-title":"Nat Med"},{"key":"865_CR31","first-page":"52","volume":"2","author":"A Kennedy","year":"2011","unstructured":"Kennedy A, Fearon U, Veale DJ, Godson C. Macrophages in synovial inflammation Front Immunol. 2011;2:52.","journal-title":"Macrophages in synovial inflammation Front Immunol"},{"issue":"9","key":"865_CR32","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1902\/jop.2016.160081","volume":"87","author":"T Yu","year":"2016","unstructured":"Yu T, Zhao L, Huang X, Ma C, Wang Y, Zhang J, Xuan D. Enhanced activity of the macrophage M1\/M2 phenotypes and phenotypic switch to M1 in periodontal infection. J Periodontol. 2016;87(9):1092\u2013102.","journal-title":"J Periodontol"},{"issue":"3","key":"865_CR33","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.4049\/jimmunol.1202511","volume":"190","author":"G Papadopoulos","year":"2013","unstructured":"Papadopoulos G, Weinberg EO, Massari P, Gibson FC 3rd, Wetzler LM, Morgan EF, Genco CA. Macrophage-specific TLR2 signaling mediates pathogen-induced TNF-dependent inflammatory oral bone loss. J Immunol. 2013;190(3):1148\u201357.","journal-title":"J Immunol"},{"issue":"12","key":"865_CR34","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1172\/JCI11176","volume":"106","author":"J Lam","year":"2000","unstructured":"Lam J, Takeshita S, Barker JE, Kanagawa O, Ross FP, Teitelbaum SL. TNF-alpha induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand. J Clin Invest. 2000;106(12):1481\u20138.","journal-title":"J Clin Invest"},{"key":"865_CR35","doi-asserted-by":"crossref","first-page":"32001","DOI":"10.1038\/srep32001","volume":"6","author":"X Feng","year":"2016","unstructured":"Feng X, Shi Y, Xu L, Peng Q, Wang F, Wang X, et al. Modulation of IL-6 induced RANKL expression in arthritic synovium by a transcription factor SOX5. Sci Rep. 2016;6:32001.","journal-title":"Sci Rep"},{"issue":"4","key":"865_CR36","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1159\/000465455","volume":"41","author":"Q Wu","year":"2017","unstructured":"Wu Q, Zhou X, Huang D, Ji Y, Kang F. IL-6 enhances osteocyte-mediated osteoclastogenesis by promoting JAK2 and RANKL activity in vitro. Cell Physiol Biochem. 2017;41(4):1360\u20139.","journal-title":"Cell Physiol Biochem"},{"issue":"1","key":"865_CR37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jphs.2022.10.007","volume":"151","author":"Y Otsuka","year":"2023","unstructured":"Otsuka Y, Kondo T, Aoki H, Goto Y, Kawaguchi Y, Waguri-Nagaya Y, et al. IL-1beta promotes osteoclastogenesis by increasing the expression of IGF2 and chemokines in non-osteoclastic cells. J Pharmacol Sci. 2023;151(1):1\u20138.","journal-title":"J Pharmacol Sci"},{"issue":"1","key":"865_CR38","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/prd.12032","volume":"63","author":"C Sima","year":"2013","unstructured":"Sima C, Glogauer M. Macrophage subsets and osteoimmunology: tuning of the immunological recognition and effector systems that maintain alveolar bone. Periodontol 2000. 2013;63(1):80\u2013101.","journal-title":"Periodontol 2000"},{"issue":"2","key":"865_CR39","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1172\/JCI200523394","volume":"115","author":"S Wei","year":"2005","unstructured":"Wei S, Kitaura H, Zhou P, Ross FP, Teitelbaum SL. IL-1 mediates TNF-induced osteoclastogenesis. J Clin Invest. 2005;115(2):282\u201390.","journal-title":"J Clin Invest"},{"issue":"45","key":"865_CR40","doi-asserted-by":"crossref","first-page":"33098","DOI":"10.1074\/jbc.M611781200","volume":"282","author":"X Li","year":"2007","unstructured":"Li X, Qin L, Bergenstock M, Bevelock LM, Novack DV, Partridge NC. Parathyroid hormone stimulates osteoblastic expression of MCP-1 to recruit and increase the fusion of pre\/osteoclasts. J Biol Chem. 2007;282(45):33098\u2013106.","journal-title":"J Biol Chem"},{"issue":"11","key":"865_CR41","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1136\/ard.2003.018481","volume":"63","author":"SM Dai","year":"2004","unstructured":"Dai SM, Nishioka K, Yudoh K. Interleukin (IL) 18 stimulates osteoclast formation through synovial T cells in rheumatoid arthritis: comparison with IL1 beta and tumour necrosis factor alpha. Ann Rheum Dis. 2004;63(11):1379\u201386.","journal-title":"Ann Rheum Dis"},{"key":"865_CR42","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/782382","volume":"2015","author":"P Ruscitti","year":"2015","unstructured":"Ruscitti P, Cipriani P, Carubbi F, Liakouli V, Zazzeroni F, Di Benedetto P, et al. The role of IL-1beta in the bone loss during rheumatic diseases. Mediators Inflamm. 2015;2015: 782382.","journal-title":"Mediators Inflamm"},{"issue":"10","key":"865_CR43","doi-asserted-by":"crossref","first-page":"479","DOI":"10.5483\/BMBRep.2013.46.10.141","volume":"46","author":"Y Lee","year":"2013","unstructured":"Lee Y. The role of interleukin-17 in bone metabolism and inflammatory skeletal diseases. BMB Rep. 2013;46(10):479\u201383.","journal-title":"BMB Rep"},{"issue":"1","key":"865_CR44","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/prd.12083","volume":"69","author":"C Zenobia","year":"2015","unstructured":"Zenobia C, Hajishengallis G. Basic biology and role of interleukin-17 in immunity and inflammation. Periodontol 2000. 2015;69(1):142\u201359.","journal-title":"Periodontol 2000"},{"issue":"10","key":"865_CR45","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.4049\/jimmunol.2001432","volume":"206","author":"CMF Pacheco","year":"2021","unstructured":"Pacheco CMF, Maltos KLM, Shehabeldin MS, Thomas LL, Zhuang Z, Yoshizawa S, et al. Local sustained delivery of anti-IL-17A antibodies limits inflammatory bone loss in murine experimental periodontitis. J Immunol. 2021;206(10):2386\u201392.","journal-title":"J Immunol"},{"issue":"9","key":"865_CR46","doi-asserted-by":"crossref","first-page":"4783","DOI":"10.4049\/jimmunol.164.9.4783","volume":"164","author":"P Schwarzenberger","year":"2000","unstructured":"Schwarzenberger P, Huang W, Ye P, Oliver P, Manuel M, Zhang Z, et al. Requirement of endogenous stem cell factor and granulocyte-colony-stimulating factor for IL-17-mediated granulopoiesis. J Immunol. 2000;164(9):4783\u20139.","journal-title":"J Immunol"},{"issue":"9","key":"865_CR47","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1172\/JCI5703","volume":"103","author":"S Kotake","year":"1999","unstructured":"Kotake S, Udagawa N, Takahashi N, Matsuzaki K, Itoh K, Ishiyama S, et al. IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J Clin Invest. 1999;103(9):1345\u201352.","journal-title":"J Clin Invest"},{"issue":"12","key":"865_CR48","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1084\/jem.20061775","volume":"203","author":"K Sato","year":"2006","unstructured":"Sato K, Suematsu A, Okamoto K, Yamaguchi A, Morishita Y, Kadono Y, et al. Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. J Exp Med. 2006;203(12):2673\u201382.","journal-title":"J Exp Med"},{"issue":"1","key":"865_CR49","doi-asserted-by":"crossref","first-page":"5692","DOI":"10.1038\/s41598-020-62562-2","volume":"10","author":"JM Scheffler","year":"2020","unstructured":"Scheffler JM, Grahnemo L, Engdahl C, Drevinge C, Gustafsson KL, Corciulo C, et al. Interleukin 17A: a Janus-faced regulator of osteoporosis. Sci Rep. 2020;10(1):5692.","journal-title":"Sci Rep"},{"key":"865_CR50","doi-asserted-by":"crossref","unstructured":"Soe K. Osteoclast fusion: physiological regulation of multinucleation through heterogeneity-potential implications for drug sensitivity. Int J Mol Sci. 2020;21(20):7717.","DOI":"10.3390\/ijms21207717"},{"issue":"1","key":"865_CR51","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00774-020-01191-1","volume":"39","author":"H Takayanagi","year":"2021","unstructured":"Takayanagi H. RANKL as the master regulator of osteoclast differentiation. J Bone Miner Metab. 2021;39(1):13\u20138.","journal-title":"J Bone Miner Metab"},{"issue":"32","key":"865_CR52","doi-asserted-by":"crossref","first-page":"20551","DOI":"10.1074\/jbc.273.32.20551","volume":"273","author":"BG Darnay","year":"1998","unstructured":"Darnay BG, Haridas V, Ni J, Moore PA, Aggarwal BB. Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase. J Biol Chem. 1998;273(32):20551\u20135.","journal-title":"J Biol Chem"},{"issue":"3","key":"865_CR53","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0014-5793(98)01731-1","volume":"443","author":"HH Kim","year":"1999","unstructured":"Kim HH, Lee DE, Shin JN, Lee YS, Jeon YM, Chung CH, et al. Receptor activator of NF-kappaB recruits multiple TRAF family adaptors and activates c-Jun N-terminal kinase. FEBS Lett. 1999;443(3):297\u2013302.","journal-title":"FEBS Lett"},{"issue":"43","key":"865_CR54","doi-asserted-by":"crossref","first-page":"28355","DOI":"10.1074\/jbc.273.43.28355","volume":"273","author":"BR Wong","year":"1998","unstructured":"Wong BR, Josien R, Lee SY, Vologodskaia M, Steinman RM, Choi Y. The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor. J Biol Chem. 1998;273(43):28355\u20139.","journal-title":"J Biol Chem"},{"key":"865_CR55","doi-asserted-by":"crossref","unstructured":"Ethiraj LP, Fong ELS, Liu R, Chan M, Winkler C, Carney TJ. Colorimetric and fluorescent TRAP assays for visualising and quantifying fish osteoclast activity. Eur J Histochem. 2022;66(2):3369.","DOI":"10.4081\/ejh.2022.3369"},{"key":"865_CR56","doi-asserted-by":"crossref","unstructured":"Puchner A, Simader E, Saferding V, Hofmann M, Kieler M, Brunner J, et al. Bona fide dendritic cells are pivotal precursors for osteoclasts. Ann Rheum Dis. 2023:ard-2022-223817.","DOI":"10.1136\/ard-2022-223817"},{"issue":"4","key":"865_CR57","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.gendis.2020.03.009","volume":"8","author":"B Wang","year":"2021","unstructured":"Wang B, Dong Y, Tian Z, Chen Y, Dong S. The role of dendritic cells derived osteoclasts in bone destruction diseases. Genes Dis. 2021;8(4):401\u201311.","journal-title":"Genes Dis"},{"issue":"1","key":"865_CR58","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.bbrc.2011.12.149","volume":"418","author":"H Ahn","year":"2012","unstructured":"Ahn H, Kim JM, Lee K, Kim H, Jeong D. Extracellular acidosis accelerates bone resorption by enhancing osteoclast survival, adhesion, and migration. Biochem Biophys Res Commun. 2012;418(1):144\u20138.","journal-title":"Biochem Biophys Res Commun"},{"issue":"5","key":"865_CR59","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1016\/j.cell.2021.02.002","volume":"184","author":"MM McDonald","year":"2021","unstructured":"McDonald MM, Khoo WH, Ng PY, Xiao Y, Zamerli J, Thatcher P, et al. Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption. Cell. 2021;184(5):1330-47 e13.","journal-title":"Cell"},{"key":"865_CR60","volume":"11","author":"Q Jiang","year":"2021","unstructured":"Jiang Q, Zhao Y, Shui Y, Zhou X, Cheng L, Ren B, et al. Interactions between neutrophils and periodontal pathogens in late-onset periodontitis. Front Cell Infect Microbiol. 2021;11: 627328.","journal-title":"Front Cell Infect Microbiol"},{"issue":"10","key":"865_CR61","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/nrrheum.2014.80","volume":"10","author":"HL Wright","year":"2014","unstructured":"\u2022 Wright HL, Moots RJ, Edwards SW. The multifactorial role of neutrophils in rheumatoid arthritis. Nat Rev Rheumatol. 2014;10(10):593\u2013601.\u00a0Comprehensive review about neutrophils in rheumatoid arthritis.","journal-title":"Nat Rev Rheumatol"},{"issue":"5482","key":"865_CR62","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1126\/science.289.5482.1185","volume":"289","author":"A Belaaouaj","year":"2000","unstructured":"Belaaouaj A, Kim KS, Shapiro SD. Degradation of outer membrane protein A in Escherichia coli killing by neutrophil elastase. Science. 2000;289(5482):1185\u20138.","journal-title":"Science"},{"issue":"22","key":"865_CR63","doi-asserted-by":"crossref","first-page":"13875","DOI":"10.1074\/jbc.M115.642736","volume":"290","author":"P Zhao","year":"2015","unstructured":"Zhao P, Lieu T, Barlow N, Sostegni S, Haerteis S, Korbmacher C, et al. Neutrophil elastase activates protease-activated receptor-2 (PAR2) and transient receptor potential vanilloid 4 (TRPV4) to cause inflammation and pain. J Biol Chem. 2015;290(22):13875\u201387.","journal-title":"J Biol Chem"},{"key":"865_CR64","doi-asserted-by":"crossref","first-page":"9042851","DOI":"10.1155\/2017\/9042851","volume":"2017","author":"C Rosales","year":"2017","unstructured":"Rosales C, Uribe-Querol E. Phagocytosis: a fundamental process in immunity. Biomed Res Int. 2017;2017:9042851.","journal-title":"Biomed Res Int"},{"issue":"2","key":"865_CR65","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s00018-020-03591-y","volume":"78","author":"A Ulfig","year":"2021","unstructured":"Ulfig A, Leichert LI. The effects of neutrophil-generated hypochlorous acid and other hypohalous acids on host and pathogens. Cell Mol Life Sci. 2021;78(2):385\u2013414.","journal-title":"Cell Mol Life Sci"},{"key":"865_CR66","doi-asserted-by":"crossref","first-page":"373","DOI":"10.3389\/fcimb.2017.00373","volume":"7","author":"GT Nguyen","year":"2017","unstructured":"Nguyen GT, Green ER, Mecsas J. Neutrophils to the ROScue: mechanisms of NADPH oxidase activation and bacterial resistance. Front Cell Infect Microbiol. 2017;7:373.","journal-title":"Front Cell Infect Microbiol"},{"issue":"8","key":"865_CR67","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1136\/ard.2006.061507","volume":"66","author":"H Wittkowski","year":"2007","unstructured":"Wittkowski H, Foell D, af Klint E, De Rycke L, De Keyser F, Frosch M, et al. Effects of intra-articular corticosteroids and anti-TNF therapy on neutrophil activation in rheumatoid arthritis. Ann Rheum Dis. 2007;66(8):1020\u20135.","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"865_CR68","first-page":"228","volume":"35","author":"AF Mourao","year":"2010","unstructured":"Mourao AF, Canhao H, Sousa E, Cascao R, da Costa JB, de Almeida LS, et al. From a neutrophilic synovial tissue infiltrate to a challenging case of rheumatoid arthritis. Acta Reumatol Port. 2010;35(2):228\u201331.","journal-title":"Acta Reumatol Port"},{"key":"865_CR69","doi-asserted-by":"crossref","first-page":"635","DOI":"10.3389\/fimmu.2019.00635","volume":"10","author":"CGJ Moonen","year":"2019","unstructured":"Moonen CGJ, Hirschfeld J, Cheng L, Chapple ILC, Loos BG, Nicu EA. Oral neutrophils characterized: chemotactic, phagocytic, and neutrophil extracellular trap (NET) formation properties. Front Immunol. 2019;10:635.","journal-title":"Front Immunol"},{"issue":"3","key":"865_CR70","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.4049\/jimmunol.167.3.1601","volume":"167","author":"BT Wipke","year":"2001","unstructured":"Wipke BT, Allen PM. Essential role of neutrophils in the initiation and progression of a murine model of rheumatoid arthritis. J Immunol. 2001;167(3):1601\u20138.","journal-title":"J Immunol"},{"issue":"3","key":"865_CR71","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/jre.12211","volume":"50","author":"M Landzberg","year":"2015","unstructured":"Landzberg M, Doering H, Aboodi GM, Tenenbaum HC, Glogauer M. Quantifying oral inflammatory load: oral neutrophil counts in periodontal health and disease. J Periodontal Res. 2015;50(3):330\u20136.","journal-title":"J Periodontal Res"},{"key":"865_CR72","doi-asserted-by":"crossref","unstructured":"\u2022\u2022 Kim TS, Silva LM, Theofilou VI, Greenwell-Wild T, Li L, Williams DW, et al. Neutrophil extracellular traps and extracellular histones potentiate IL-17 inflammation in periodontitis. J Exp Med. 2023;220(9):e20221751. In this paper, authors describe the role of histones and NETs in Th17 polarization and bone erosion in periodontitis.","DOI":"10.1084\/jem.20221751"},{"issue":"178","key":"865_CR73","doi-asserted-by":"crossref","first-page":"178ra40","DOI":"10.1126\/scitranslmed.3005580","volume":"5","author":"R Khandpur","year":"2013","unstructured":"Khandpur R, Carmona-Rivera C, Vivekanandan-Giri A, Gizinski A, Yalavarthi S, Knight JS, et al. NETs are a source of citrullinated autoantigens and stimulate inflammatory responses in rheumatoid arthritis. Sci Transl Med. 2013;5(178):178ra40.","journal-title":"Sci Transl Med"},{"issue":"6575","key":"865_CR74","doi-asserted-by":"crossref","first-page":"eabl5450","DOI":"10.1126\/science.abl5450","volume":"374","author":"LM Silva","year":"2021","unstructured":"\u2022 Silva LM, Doyle AD, Greenwell-Wild T, Dutzan N, Tran CL, Abusleme L, et al. Fibrin is a critical regulator of neutrophil effector function at the oral mucosal barrier. Science. 2021;374(6575):eabl5450.\u00a0Interesting paper where authors demonstrate the role of neutrophils in periodontitis triggered by genetic alterations.","journal-title":"Science"},{"key":"865_CR75","doi-asserted-by":"crossref","unstructured":"Carmona-Rivera C, Carlucci PM, Goel RR, James E, Brooks SR, Rims C, et al. Neutrophil extracellular traps mediate articular cartilage damage and enhance cartilage component immunogenicity in rheumatoid arthritis. JCI Insight. 2020;5(13):e139388.","DOI":"10.1172\/jci.insight.139388"},{"key":"865_CR76","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2019.115216","volume":"132","author":"R Sugisaki","year":"2020","unstructured":"Sugisaki R, Miyamoto Y, Yoshimura K, Sasa K, Kaneko K, Tanaka M, et al. Possible involvement of elastase in enhanced osteoclast differentiation by neutrophils through degradation of osteoprotegerin. Bone. 2020;132: 115216.","journal-title":"Bone"},{"issue":"4","key":"865_CR77","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1111\/bph.13237","volume":"173","author":"MM Muley","year":"2016","unstructured":"Muley MM, Reid AR, Botz B, Bolcskei K, Helyes Z, McDougall JJ. Neutrophil elastase induces inflammation and pain in mouse knee joints via activation of proteinase-activated receptor-2. Br J Pharmacol. 2016;173(4):766\u201377.","journal-title":"Br J Pharmacol"},{"issue":"1","key":"865_CR78","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/s10266-012-0090-1","volume":"102","author":"H Ito","year":"2014","unstructured":"Ito H, Numabe Y, Sekino S, Murakashi E, Iguchi H, Hashimoto S, et al. Evaluation of bleeding on probing and gingival crevicular fluid enzyme activity for detection of periodontally active sites during supportive periodontal therapy. Odontology. 2014;102(1):50\u20136.","journal-title":"Odontology"},{"issue":"3","key":"865_CR79","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1083\/jcb.201006052","volume":"191","author":"V Papayannopoulos","year":"2010","unstructured":"Papayannopoulos V, Metzler KD, Hakkim A, Zychlinsky A. Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps. J Cell Biol. 2010;191(3):677\u201391.","journal-title":"J Cell Biol"},{"issue":"9","key":"865_CR80","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1073\/pnas.1414055112","volume":"112","author":"DN Douda","year":"2015","unstructured":"Douda DN, Khan MA, Grasemann H, Palaniyar N. SK3 channel and mitochondrial ROS mediate NADPH oxidase-independent NETosis induced by calcium influx. Proc Natl Acad Sci U S A. 2015;112(9):2817\u201322.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"865_CR81","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3389\/fimmu.2012.00307","volume":"3","author":"M Leshner","year":"2012","unstructured":"Leshner M, Wang S, Lewis C, Zheng H, Chen XA, Santy L, Wang Y. PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures. Front Immunol. 2012;3:307.","journal-title":"Front Immunol"},{"issue":"21","key":"865_CR82","doi-asserted-by":"crossref","first-page":"9813","DOI":"10.1073\/pnas.0909927107","volume":"107","author":"A Hakkim","year":"2010","unstructured":"Hakkim A, Furnrohr BG, Amann K, Laube B, Abed UA, Brinkmann V, et al. Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis. Proc Natl Acad Sci U S A. 2010;107(21):9813\u20138.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"865_CR83","doi-asserted-by":"crossref","unstructured":"Magan-Fernandez A, Rasheed Al-Bakri SM, O\u2019Valle F, Benavides-Reyes C, Abadia-Molina F, Mesa F. Neutrophil extracellular traps in periodontitis. Cells. 2020;9(6):1494.","DOI":"10.3390\/cells9061494"},{"issue":"5","key":"865_CR84","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/omi.12099","volume":"30","author":"K Jayaprakash","year":"2015","unstructured":"Jayaprakash K, Demirel I, Khalaf H, Bengtsson T. The role of phagocytosis, oxidative burst and neutrophil extracellular traps in the interaction between neutrophils and the periodontal pathogen Porphyromonas gingivalis. Mol Oral Microbiol. 2015;30(5):361\u201375.","journal-title":"Mol Oral Microbiol"},{"issue":"4","key":"865_CR85","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/omi.12171","volume":"32","author":"M Doke","year":"2017","unstructured":"Doke M, Fukamachi H, Morisaki H, Arimoto T, Kataoka H, Kuwata H. Nucleases from Prevotella intermedia can degrade neutrophil extracellular traps. Mol Oral Microbiol. 2017;32(4):288\u2013300.","journal-title":"Mol Oral Microbiol"},{"key":"865_CR86","doi-asserted-by":"crossref","first-page":"33070","DOI":"10.3402\/jom.v8.33070","volume":"8","author":"J Hirschfeld","year":"2016","unstructured":"Hirschfeld J, Roberts HM, Chapple IL, Parcina M, Jepsen S, Johansson A, Claesson R. Effects of Aggregatibacter actinomycetemcomitans leukotoxin on neutrophil migration and extracellular trap formation. J Oral Microbiol. 2016;8:33070.","journal-title":"J Oral Microbiol"},{"issue":"1","key":"865_CR87","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/art.41062","volume":"72","author":"M Bach","year":"2020","unstructured":"Bach M, Moon J, Moore R, Pan T, Nelson JL, Lood C. A Neutrophil activation biomarker panel in prognosis and monitoring of patients with rheumatoid arthritis. Arthritis Rheumatol. 2020;72(1):47\u201356.","journal-title":"Arthritis Rheumatol"},{"issue":"3","key":"865_CR88","volume":"35","author":"S Wu","year":"2021","unstructured":"Wu S, Peng W, Liang X, Wang W. Anti-citrullinated protein antibodies are associated with neutrophil extracellular trap formation in rheumatoid arthritis. J Clin Lab Anal. 2021;35(3): e23662.","journal-title":"J Clin Lab Anal"},{"issue":"1","key":"865_CR89","volume":"389","author":"Y Zou","year":"2020","unstructured":"Zou Y, Chen X, He B, Xiao J, Yu Q, Xie B, et al. Neutrophil extracellular traps induced by cigarette smoke contribute to airway inflammation in mice. Exp Cell Res. 2020;389(1): 111888.","journal-title":"Exp Cell Res"},{"issue":"2","key":"865_CR90","doi-asserted-by":"crossref","first-page":"R61","DOI":"10.1186\/ar4498","volume":"16","author":"D Di Giuseppe","year":"2014","unstructured":"Di Giuseppe D, Discacciati A, Orsini N, Wolk A. Cigarette smoking and risk of rheumatoid arthritis: a dose-response meta-analysis. Arthritis Res Ther. 2014;16(2):R61.","journal-title":"Arthritis Res Ther"},{"issue":"7","key":"865_CR91","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1136\/annrheumdis-2016-210059","volume":"76","author":"C Ospelt","year":"2017","unstructured":"Ospelt C, Bang H, Feist E, Camici G, Keller S, Detert J, et al. Carbamylation of vimentin is inducible by smoking and represents an independent autoantigen in rheumatoid arthritis. Ann Rheum Dis. 2017;76(7):1176\u201383.","journal-title":"Ann Rheum Dis"},{"issue":"5","key":"865_CR92","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1136\/ard-2022-223568","volume":"82","author":"LJ O\u2019Neil","year":"2023","unstructured":"O\u2019Neil LJ, Oliveira CB, Wang X, Navarrete M, Barrera-Vargas A, Merayo-Chalico J, et al. Neutrophil extracellular trap-associated carbamylation and histones trigger osteoclast formation in rheumatoid arthritis. Ann Rheum Dis. 2023;82(5):630\u20138.","journal-title":"Ann Rheum Dis"},{"key":"865_CR93","doi-asserted-by":"crossref","first-page":"192","DOI":"10.3389\/fimmu.2015.00192","volume":"6","author":"GJ Pruijn","year":"2015","unstructured":"Pruijn GJ. Citrullination and carbamylation in the pathophysiology of rheumatoid arthritis. Front Immunol. 2015;6:192.","journal-title":"Front Immunol"},{"issue":"3","key":"865_CR94","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1007\/s00784-020-03452-9","volume":"25","author":"YH Lee","year":"2021","unstructured":"Lee YH, Baharuddin NA, Chan SW, Rahman MT, Bartold PM, Sockalingam S, Vaithilingam RD. Localisation of citrullinated and carbamylated proteins in inflamed gingival tissues from rheumatoid arthritis patients. Clin Oral Investig. 2021;25(3):1441\u201350.","journal-title":"Clin Oral Investig"},{"issue":"1","key":"865_CR95","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.berh.2008.11.004","volume":"23","author":"H El-Gabalawy","year":"2009","unstructured":"El-Gabalawy H. The preclinical stages of RA: lessons from human studies and animal models. Best Pract Res Clin Rheumatol. 2009;23(1):49\u201358.","journal-title":"Best Pract Res Clin Rheumatol"},{"issue":"6","key":"865_CR96","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1136\/annrheumdis-2015-207326","volume":"75","author":"JH Humphreys","year":"2016","unstructured":"Humphreys JH, Verheul MK, Barton A, MacGregor AJ, Lunt M, Toes RE, et al. Anticarbamylated protein antibodies are associated with long-term disability and increased disease activity in patients with early inflammatory arthritis: results from the Norfolk Arthritis Register. Ann Rheum Dis. 2016;75(6):1139\u201344.","journal-title":"Ann Rheum Dis"},{"issue":"5","key":"865_CR97","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1172\/JCI60975","volume":"122","author":"U Harre","year":"2012","unstructured":"Harre U, Georgess D, Bang H, Bozec A, Axmann R, Ossipova E, et al. Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin. J Clin Invest. 2012;122(5):1791\u2013802.","journal-title":"J Clin Invest"},{"key":"865_CR98","volume":"12","author":"LJ O\u2019Neil","year":"2021","unstructured":"O\u2019Neil LJ, Oliveira CB, Sandoval-Heglund D, Barrera-Vargas A, Merayo-Chalico J, Aguirre-Aguilar E, et al. Anti-carbamylated LL37 antibodies promote pathogenic bone resorption in rheumatoid arthritis. Front Immunol. 2021;12: 715997.","journal-title":"Front Immunol"},{"issue":"5","key":"865_CR99","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1136\/annrheumdis-2012-202958","volume":"73","author":"A Kleyer","year":"2014","unstructured":"Kleyer A, Finzel S, Rech J, Manger B, Krieter M, Faustini F, et al. Bone loss before the clinical onset of rheumatoid arthritis in subjects with anticitrullinated protein antibodies. Ann Rheum Dis. 2014;73(5):854\u201360.","journal-title":"Ann Rheum Dis"},{"issue":"7","key":"865_CR100","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1136\/annrheumdis-2020-217215","volume":"79","author":"A Di Matteo","year":"2020","unstructured":"Di Matteo A, Mankia K, Duquenne L, Cipolletta E, Wakefield RJ, Garcia-Montoya L, et al. Ultrasound erosions in the feet best predict progression to inflammatory arthritis in anti-CCP positive at-risk individuals without clinical synovitis. Ann Rheum Dis. 2020;79(7):901\u20137.","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"865_CR101","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/art.42320","volume":"75","author":"A Krishnamurthy","year":"2023","unstructured":"Krishnamurthy A, Circiumaru A, Sun J, Kisten Y, Damberg P, Sakuraba K, et al. Combination of two monoclonal anti-citrullinated protein antibodies induced tenosynovitis, pain, and bone loss in mice in a peptidyl arginine deiminase-4-dependent manner. Arthritis Rheumatol. 2023;75(2):164\u201370.","journal-title":"Arthritis Rheumatol"},{"key":"865_CR102","doi-asserted-by":"crossref","first-page":"6651","DOI":"10.1038\/ncomms7651","volume":"6","author":"U Harre","year":"2015","unstructured":"Harre U, Lang SC, Pfeifle R, Rombouts Y, Fruhbeisser S, Amara K, et al. Glycosylation of immunoglobulin G determines osteoclast differentiation and bone loss. Nat Commun. 2015;6:6651.","journal-title":"Nat Commun"},{"issue":"8","key":"865_CR103","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1097\/j.pain.0000000000002543","volume":"163","author":"A Jurczak","year":"2022","unstructured":"Jurczak A, Delay L, Barbier J, Simon N, Krock E, Sandor K, et al. Antibody-induced pain-like behavior and bone erosion: links to subclinical inflammation, osteoclast activity, and acid-sensing ion channel 3-dependent sensitization. Pain. 2022;163(8):1542\u201359.","journal-title":"Pain"},{"issue":"26","key":"865_CR104","doi-asserted-by":"crossref","first-page":"10729","DOI":"10.1073\/pnas.1301001110","volume":"110","author":"M Seeling","year":"2013","unstructured":"Seeling M, Hillenhoff U, David JP, Schett G, Tuckermann J, Lux A, Nimmerjahn F. Inflammatory monocytes and Fcgamma receptor IV on osteoclasts are critical for bone destruction during inflammatory arthritis in mice. Proc Natl Acad Sci U S A. 2013;110(26):10729\u201334.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"865_CR105","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1002\/art.23284","volume":"58","author":"C Clavel","year":"2008","unstructured":"Clavel C, Nogueira L, Laurent L, Iobagiu C, Vincent C, Sebbag M, Serre G. Induction of macrophage secretion of tumor necrosis factor alpha through Fcgamma receptor IIa engagement by rheumatoid arthritis-specific autoantibodies to citrullinated proteins complexed with fibrinogen. Arthritis Rheum. 2008;58(3):678\u201388.","journal-title":"Arthritis Rheum"}],"container-title":["Current Osteoporosis Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11914-024-00865-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11914-024-00865-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11914-024-00865-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T11:22:40Z","timestamp":1722338560000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11914-024-00865-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,29]]},"references-count":105,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["865"],"URL":"https:\/\/doi.org\/10.1007\/s11914-024-00865-3","relation":{},"ISSN":["1544-1873","1544-2241"],"issn-type":[{"value":"1544-1873","type":"print"},{"value":"1544-2241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,29]]},"assertion":[{"value":"16 February 2024","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 February 2024","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}