{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T22:14:00Z","timestamp":1781043240464,"version":"3.54.1"},"reference-count":95,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"This research was supported in part by the Intramural Research Program of the National Institutes of Health (NIH), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)."}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Curr Osteoporos Rep"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s11914-025-00939-w","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T06:37:55Z","timestamp":1761633475000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Inequities Across the Spectrum of Osteoporosis Care and Post-Fracture Management in Men"],"prefix":"10.1007","volume":"23","author":[{"given":"Reuben Joaquim Ricardo","family":"De Almeida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashna","family":"Grover","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubham","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruban","family":"Dhaliwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,28]]},"reference":[{"issue":"8","key":"939_CR1","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1002\/jbmr.4821","volume":"38","author":"CW Sing","year":"2023","unstructured":"Sing CW, Lin TC, Bartholomew S, Bell JS, Bennett C, Beyene K, et al. Global epidemiology of hip fractures: secular trends in incidence rate, post-fracture treatment, and all-cause mortality. J Bone Miner Res. 2023;38(8):1064\u201375.","journal-title":"J Bone Miner Res"},{"issue":"3","key":"939_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2022.101766","volume":"36","author":"S Bjornsdottir","year":"2022","unstructured":"Bjornsdottir S, Clarke BL, Mannstadt M, Langdahl BL. Male osteoporosis-what are the causes, diagnostic challenges, and management. Best Pract Res Clin Rheumatol. 2022;36(3):101766.","journal-title":"Best Pract Res Clin Rheumatol"},{"issue":"10","key":"939_CR3","doi-asserted-by":"publisher","first-page":"1810","DOI":"10.1002\/jbmr.2836","volume":"31","author":"JA Cauley","year":"2016","unstructured":"Cauley JA, Cawthon PM, Peters KE, Cummings SR, Ensrud KE, Bauer DC, et al. Risk factors for hip fracture in older men: the osteoporotic fractures in men study (MrOS). J Bone Miner Res. 2016;31(10):1810\u20139.","journal-title":"J Bone Miner Res"},{"issue":"9319","key":"939_CR4","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1016\/S0140-6736(02)08657-9","volume":"359","author":"SR Cummings","year":"2002","unstructured":"Cummings SR, Melton LJ. Epidemiology and outcomes of osteoporotic fractures. Lancet. 2002;359(9319):1761\u20137.","journal-title":"Lancet"},{"issue":"5","key":"939_CR5","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1007\/s00198-011-1601-6","volume":"22","author":"C Cooper","year":"2011","unstructured":"Cooper C, Cole ZA, Holroyd CR, Earl SC, Harvey NC, Dennison EM, et al. Secular trends in the incidence of hip and other osteoporotic fractures. Osteoporos Int. 2011;22(5):1277\u201388.","journal-title":"Osteoporos Int"},{"issue":"2","key":"939_CR6","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1097\/JS9.0000000000000883","volume":"110","author":"B Xu","year":"2024","unstructured":"Xu B, Radojcic MR, Anderson DB, Shi B, Yao L, Chen Y, et al. Trends in prevalence of fractures among adults in the United States, 1999\u20132020: a population-based study. Int J Surg. 2024;110(2):721\u201332.","journal-title":"Int J Surg"},{"issue":"6","key":"939_CR7","doi-asserted-by":"publisher","first-page":"4002","DOI":"10.1097\/JS9.0000000000000964","volume":"110","author":"X Zhang","year":"2024","unstructured":"Zhang X, Chen Y, Zhu W, Xu L. Reevaluating fracture prevalence trends in the U.S.: the importance of weighted analysis in NHANES data - letter to the editor regarding \u201ctrends in prevalence of fractures among adults in the United States, 1999\u20132020: a population-based study\u201d by Bin Xu et al. Int J Surg. 2024;110(6):4002\u20133.","journal-title":"Int J Surg"},{"issue":"6","key":"939_CR8","doi-asserted-by":"publisher","first-page":"1857","DOI":"10.1007\/s00198-017-3948-9","volume":"28","author":"F Cosman","year":"2017","unstructured":"Cosman F, Krege JH, Looker AC, Schousboe JT, Fan B, Sarafrazi Isfahani N, et al. Spine fracture prevalence in a nationally representative sample of US women and men aged >\/=40 years: results from the National Health and Nutrition Examination Survey (NHANES) 2013\u20132014. Osteoporos Int. 2017;28(6):1857\u201366.","journal-title":"Osteoporos Int"},{"issue":"8","key":"939_CR9","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1359\/jbmr.060513","volume":"21","author":"EJ Samelson","year":"2006","unstructured":"Samelson EJ, Hannan MT, Zhang Y, Genant HK, Felson DT, Kiel DP. Incidence and risk factors for vertebral fracture in women and men: 25-year follow-up results from the population-based Framingham study. J Bone Miner Res. 2006;21(8):1207\u201314.","journal-title":"J Bone Miner Res"},{"issue":"1","key":"939_CR10","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-94871-9","volume":"15","author":"HG Niu","year":"2025","unstructured":"Niu HG, Hu Y, Gong YK, Hu GK, Ye GQ, Gao WS. Trends in prevalence of spine fractures and risk factors in spine fractures among US adults, 1999\u20132018. Sci Rep. 2025;15(1):11696.","journal-title":"Sci Rep"},{"issue":"10","key":"939_CR11","doi-asserted-by":"publisher","first-page":"2725","DOI":"10.1007\/s00198-013-2375-9","volume":"24","author":"JA Stevens","year":"2013","unstructured":"Stevens JA, Rudd RA. The impact of decreasing U.S. hip fracture rates on future hip fracture estimates. Osteoporos Int. 2013;24(10):2725\u20138.","journal-title":"Osteoporos Int"},{"key":"939_CR12","doi-asserted-by":"publisher","first-page":"177","DOI":"10.2147\/CIA.S291071","volume":"16","author":"YW Zhang","year":"2021","unstructured":"Zhang YW, Lu PP, Li YJ, Dai GC, Chen MH, Zhao YK, et al. Prevalence, Characteristics, and Associated Risk Factors of the Elderly with Hip Fractures: A Cross-Sectional Analysis of NHANES 2005\u20132010. Clin Interv Aging. 2021;16:177\u201385.","journal-title":"Clin Interv Aging"},{"issue":"5","key":"939_CR13","doi-asserted-by":"publisher","first-page":"739","DOI":"10.20945\/2359-3997000000563","volume":"66","author":"L Bandeira","year":"2022","unstructured":"Bandeira L, Silva BC, Bilezikian JP. Male osteoporosis. Arch Endocrinol Metab. 2022;66(5):739\u201347.","journal-title":"Arch Endocrinol Metab"},{"issue":"12","key":"939_CR14","doi-asserted-by":"publisher","first-page":"2347","DOI":"10.1002\/jbmr.3228","volume":"32","author":"JN Farr","year":"2017","unstructured":"Farr JN, Melton LJ 3rd, Achenbach SJ, Atkinson EJ, Khosla S, Amin S. Fracture Incidence and Characteristics in Young Adults Aged 18 to 49 Years: A Population-Based Study. J Bone Miner Res. 2017;32(12):2347\u201354.","journal-title":"J Bone Miner Res"},{"issue":"3","key":"939_CR15","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1002\/jbmr.2072","volume":"29","author":"S Amin","year":"2014","unstructured":"Amin S, Achenbach SJ, Atkinson EJ, Khosla S, Melton LJ 3rd. Trends in fracture incidence: a population-based study over 20 years. J Bone Miner Res. 2014;29(3):581\u20139.","journal-title":"J Bone Miner Res"},{"issue":"4","key":"939_CR16","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1359\/JBMR.040109","volume":"19","author":"KP Chang","year":"2004","unstructured":"Chang KP, Center JR, Nguyen TV, Eisman JA. Incidence of hip and other osteoporotic fractures in elderly men and women: Dubbo Osteoporosis Epidemiology Study. J Bone Miner Res. 2004;19(4):532\u20136.","journal-title":"J Bone Miner Res"},{"issue":"6","key":"939_CR17","doi-asserted-by":"publisher","first-page":"380","DOI":"10.7326\/0003-4819-152-6-201003160-00008","volume":"152","author":"P Haentjens","year":"2010","unstructured":"Haentjens P, Magaziner J, Colon-Emeric CS, Vanderschueren D, Milisen K, Velkeniers B, et al. Meta-analysis: excess mortality after hip fracture among older women and men. Ann Intern Med. 2010;152(6):380\u201390.","journal-title":"Ann Intern Med"},{"issue":"5","key":"939_CR18","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1001\/jama.2009.50","volume":"301","author":"D Bliuc","year":"2009","unstructured":"Bliuc D, Nguyen ND, Milch VE, Nguyen TV, Eisman JA, Center JR. Mortality risk associated with low-trauma osteoporotic fracture and subsequent fracture in men and women. JAMA. 2009;301(5):513\u201321.","journal-title":"JAMA"},{"issue":"3","key":"939_CR19","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1359\/JBMR.041133","volume":"20","author":"HX Jiang","year":"2005","unstructured":"Jiang HX, Majumdar SR, Dick DA, Moreau M, Raso J, Otto DD, et al. Development and initial validation of a risk score for predicting in-hospital and 1-year mortality in patients with hip fractures. J Bone Miner Res. 2005;20(3):494\u2013500.","journal-title":"J Bone Miner Res"},{"issue":"12","key":"939_CR20","doi-asserted-by":"publisher","first-page":"2231","DOI":"10.1359\/jbmr.2003.18.12.2231","volume":"18","author":"LE Wehren","year":"2003","unstructured":"Wehren LE, Hawkes WG, Orwig DL, Hebel JR, Zimmerman SI, Magaziner J. Gender differences in mortality after hip fracture: the role of infection. J Bone Miner Res. 2003;18(12):2231\u20137.","journal-title":"J Bone Miner Res"},{"issue":"11","key":"939_CR21","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1007\/s00198-007-0429-6","volume":"18","author":"AN Tosteson","year":"2007","unstructured":"Tosteson AN, Gottlieb DJ, Radley DC, Fisher ES, Melton LJ 3rd. Excess mortality following hip fracture: the role of underlying health status. Osteoporos Int. 2007;18(11):1463\u201372.","journal-title":"Osteoporos Int"},{"key":"939_CR22","doi-asserted-by":"publisher","DOI":"10.1177\/21514593241294048","volume":"15","author":"SA Doxey","year":"2024","unstructured":"Doxey SA, Kibble K, Kleinsmith RM, Huyke-Hernandez FA, Switzer JA, Cunningham BP. Hip fracture patterns, hospital course, and mortality differ between males and females. Geriatr Orthop Surg Rehabil. 2024;15:21514593241294048.","journal-title":"Geriatr Orthop Surg Rehabil"},{"issue":"1","key":"939_CR23","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-79297-z","volume":"14","author":"CY Wu","year":"2024","unstructured":"Wu CY, Tsai CF, Hsu YH, Yang HY. Exploring mortality risk factors and specific causes of death within 30 days after hip fracture hospitalization. Sci Rep. 2024;14(1):27544.","journal-title":"Sci Rep"},{"issue":"8","key":"939_CR24","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.2105\/AJPH.84.8.1287","volume":"84","author":"GL Lu-Yao","year":"1994","unstructured":"Lu-Yao GL, Baron JA, Barrett JA, Fisher ES. Treatment and survival among elderly Americans with hip fractures: a population-based study. Am J Public Health. 1994;84(8):1287\u201391.","journal-title":"Am J Public Health"},{"issue":"1","key":"939_CR25","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-023-00306-4","volume":"12","author":"YY Zhang","year":"2024","unstructured":"Zhang YY, Xie N, Sun XD, Nice EC, Liou YC, Huang C, et al. Insights and implications of sexual dimorphism in osteoporosis. Bone Res. 2024;12(1):8.","journal-title":"Bone Res"},{"issue":"3","key":"939_CR26","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1111\/joim.12586","volume":"281","author":"M Katsoulis","year":"2017","unstructured":"Katsoulis M, Benetou V, Karapetyan T, Feskanich D, Grodstein F, Pettersson-Kymmer U, et al. Excess mortality after hip fracture in elderly persons from Europe and the USA: the CHANCES project. J Intern Med. 2017;281(3):300\u201310.","journal-title":"J Intern Med"},{"issue":"4","key":"939_CR27","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/S2213-8587(22)00012-2","volume":"10","author":"T Vilaca","year":"2022","unstructured":"Vilaca T, Eastell R, Schini M. Osteoporosis in men. Lancet Diabetes Endocrinol. 2022;10(4):273\u201383.","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"7","key":"939_CR28","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1177\/1060028020970518","volume":"55","author":"SA Williams","year":"2021","unstructured":"Williams SA, Daigle SG, Weiss R, Wang Y, Arora T, Curtis JR. Economic burden of osteoporosis-related fractures in the US Medicare population. Ann Pharmacother. 2021;55(7):821\u20139.","journal-title":"Ann Pharmacother"},{"issue":"4","key":"939_CR29","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1038\/s41584-024-01094-9","volume":"20","author":"NR Fuggle","year":"2024","unstructured":"Fuggle NR, Beaudart C, Bruyere O, Abrahamsen B, Al-Daghri N, Burlet N, et al. Evidence-based guideline for the management of osteoporosis in men. Nat Rev Rheumatol. 2024;20(4):241\u201351.","journal-title":"Nat Rev Rheumatol"},{"issue":"1","key":"939_CR30","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s40266-024-01163-4","volume":"42","author":"C Ruggiero","year":"2025","unstructured":"Ruggiero C, Caffarelli C, Calsolaro V, Tafaro L, Riuzzi F, Bubba V, et al. Osteoporosis in older men: informing patient management and improving health-related outcomes. Drugs Aging. 2025;42(1):21\u201338.","journal-title":"Drugs Aging"},{"key":"939_CR31","doi-asserted-by":"crossref","unstructured":"Rinonapoli G, Ruggiero C, Meccariello L, Bisaccia M, Ceccarini P, Caraffa A. Osteoporosis in men: a review of an underestimated bone condition. Int J Mol Sci. 2021.","DOI":"10.3390\/ijms22042105"},{"key":"939_CR32","doi-asserted-by":"crossref","unstructured":"Drake MT, Murad MH, Mauck KF, Lane MA, Undavalli C, Elraiyah T, et al. Clinical review. Risk factors for low bone mass-related fractures in men: a systematic review and meta-analysis. J Clin Endocrinol Metab. 2012;97(6):1861\u201370.","DOI":"10.1210\/jc.2011-3058"},{"issue":"4","key":"939_CR33","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1007\/s00198-008-0720-1","volume":"20","author":"A Papaioannou","year":"2009","unstructured":"Papaioannou A, Kennedy CC, Cranney A, Hawker G, Brown JP, Kaiser SM, et al. Risk factors for low BMD in healthy men age 50 years or older: a systematic review. Osteoporos Int. 2009;20(4):507\u201318.","journal-title":"Osteoporos Int"},{"issue":"9","key":"939_CR34","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.3899\/jrheum.080527","volume":"36","author":"M Thomas-John","year":"2009","unstructured":"Thomas-John M, Codd MB, Manne S, Watts NB, Mongey AB. Risk factors for the development of osteoporosis and osteoporotic fractures among older men. J Rheumatol. 2009;36(9):1947\u201352.","journal-title":"J Rheumatol"},{"issue":"11","key":"939_CR35","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1007\/s001980170023","volume":"12","author":"T Tanaka","year":"2001","unstructured":"Tanaka T, Latorre MR, Jaime PC, Florindo AA, Pippa MG, Zerbini CA. Risk factors for proximal femur osteoporosis in men aged 50 years or older. Osteoporos Int. 2001;12(11):942\u20139.","journal-title":"Osteoporos Int"},{"issue":"4","key":"939_CR36","doi-asserted-by":"publisher","first-page":"750","DOI":"10.5534\/wjmh.200099","volume":"39","author":"M De Martinis","year":"2021","unstructured":"De Martinis M, Sirufo MM, Polsinelli M, Placidi G, Di Silvestre D, Ginaldi L. Gender differences in osteoporosis: a single-center observational study. World J Mens Health. 2021;39(4):750\u20139.","journal-title":"World J Mens Health"},{"issue":"6","key":"939_CR37","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1016\/0002-9343(83)90878-1","volume":"75","author":"E Seeman","year":"1983","unstructured":"Seeman E, Melton LJ 3rd, O\u2019Fallon WM, Riggs BL. Risk factors for spinal osteoporosis in men. Am J Med. 1983;75(6):977\u201383.","journal-title":"Am J Med"},{"key":"939_CR38","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/s11657-012-0113-0","volume":"7","author":"K Alswat","year":"2012","unstructured":"Alswat K, Adler SM. Gender differences in osteoporosis screening: retrospective analysis. Arch Osteoporos. 2012;7:311\u20133.","journal-title":"Arch Osteoporos"},{"issue":"1","key":"939_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jhsa.2023.07.006","volume":"49","author":"M Russo","year":"2024","unstructured":"Russo M, Liu C, Liu Y, Mahar S, Rozental TD, Harper CM. Evaluating male patients\u2019 understanding of osteoporosis evaluation and treatment following a distal radius fracture. J Hand Surg Am. 2024;49(1):1\u20137.","journal-title":"J Hand Surg Am"},{"issue":"1","key":"939_CR40","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.maturitas.2010.08.013","volume":"68","author":"JM Gaines","year":"2011","unstructured":"Gaines JM, Marx KA. Older men\u2019s knowledge about osteoporosis and educational interventions to increase osteoporosis knowledge in older men: a systematic review. Maturitas. 2011;68(1):5\u201312.","journal-title":"Maturitas"},{"issue":"4","key":"939_CR41","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1111\/j.1742-1241.2009.02290.x","volume":"64","author":"RM Pinkhasov","year":"2010","unstructured":"Pinkhasov RM, Wong J, Kashanian J, Lee M, Samadi DB, Pinkhasov MM, et al. Are men shortchanged on health? Perspective on health care utilization and health risk behavior in men and women in the United States. Int J Clin Pract. 2010;64(4):475\u201387.","journal-title":"Int J Clin Pract"},{"issue":"6","key":"939_CR42","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1007\/s00223-019-00607-z","volume":"105","author":"C Beauvais","year":"2019","unstructured":"Beauvais C, Poivret D, Lespessailles E, Thevenot C, Aubraye D, Euller Ziegler L, et al. Understanding patients\u2019 perspectives and educational needs by type of osteoporosis in men and women and people with glucocorticosteroid-induced osteoporosis: a qualitative study to improve disease management. Calcif Tissue Int. 2019;105(6):589\u2013608.","journal-title":"Calcif Tissue Int"},{"key":"939_CR43","doi-asserted-by":"crossref","unstructured":"Force USPST, Nicholson WK, Silverstein M, Wong JB, Chelmow D, Coker TR, et al. Screening for Osteoporosis to Prevent Fractures: US Preventive Services Task Force Recommendation Statement. JAMA. 2025;333(6):498\u2013508.","DOI":"10.1001\/jama.2024.27154"},{"issue":"3","key":"939_CR44","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1007\/s00198-014-2997-6","volume":"26","author":"AN Damji","year":"2015","unstructured":"Damji AN, Bies K, Alibhai SM, Jones JM. Bone health management in men undergoing ADT: examining enablers and barriers to care. Osteoporos Int. 2015;26(3):951\u20139.","journal-title":"Osteoporos Int"},{"issue":"6","key":"939_CR45","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.1210\/jc.2011-3045","volume":"97","author":"NB Watts","year":"2012","unstructured":"Watts NB, Adler RA, Bilezikian JP, Drake MT, Eastell R, Orwoll ES, et al. Osteoporosis in men: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2012;97(6):1802\u201322.","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"939_CR46","doi-asserted-by":"publisher","first-page":"2049","DOI":"10.1007\/s00198-021-05900-y","volume":"33","author":"MS LeBoff","year":"2022","unstructured":"LeBoff MS, Greenspan SL, Insogna KL, Lewiecki EM, Saag KG, Singer AJ, et al. The clinician\u2019s guide to prevention and treatment of osteoporosis. Osteoporos Int. 2022;33(10):2049\u2013102.","journal-title":"Osteoporos Int"},{"issue":"1","key":"939_CR47","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2023.101435","volume":"27","author":"C Shuhart","year":"2024","unstructured":"Shuhart C, Cheung A, Gill R, Gani L, Goel H, Szalat A. Executive summary of the 2023 Adult Position Development Conference of the International Society for Clinical Densitometry: DXA reporting, follow-up BMD testing and trabecular bone score application and reporting. J Clin Densitom. 2024;27(1):101435.","journal-title":"J Clin Densitom"},{"issue":"10","key":"939_CR48","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1359\/jbmr.060708","volume":"21","author":"SR Cummings","year":"2006","unstructured":"Cummings SR, Cawthon PM, Ensrud KE, Cauley JA, Fink HA, Orwoll ES. BMD and risk of hip and nonvertebral fractures in older men: a prospective study and comparison with older women. J Bone Miner Res. 2006;21(10):1550\u20136.","journal-title":"J Bone Miner Res"},{"issue":"2","key":"939_CR49","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1359\/jbmr.061017","volume":"22","author":"CE Lewis","year":"2007","unstructured":"Lewis CE, Ewing SK, Taylor BC, Shikany JM, Fink HA, Ensrud KE, et al. Predictors of non-spine fracture in elderly men: the MrOS study. J Bone Miner Res. 2007;22(2):211\u20139.","journal-title":"J Bone Miner Res"},{"issue":"24","key":"939_CR50","doi-asserted-by":"publisher","first-page":"2532","DOI":"10.1001\/jama.2018.6537","volume":"319","author":"M Viswanathan","year":"2018","unstructured":"Viswanathan M, Reddy S, Berkman N, Cullen K, Middleton JC, Nicholson WK, et al. Screening to prevent osteoporotic fractures: updated evidence report and systematic review for the US preventive services task force. JAMA. 2018;319(24):2532\u201351.","journal-title":"JAMA"},{"issue":"5","key":"939_CR51","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1007\/s00198-009-1026-7","volume":"21","author":"SK Sandhu","year":"2010","unstructured":"Sandhu SK, Nguyen ND, Center JR, Pocock NA, Eisman JA, Nguyen TV. Prognosis of fracture: evaluation of predictive accuracy of the FRAX algorithm and Garvan nomogram. Osteoporos Int. 2010;21(5):863\u201371.","journal-title":"Osteoporos Int"},{"key":"939_CR52","first-page":"1","volume":"103","author":"AC Looker","year":"2017","unstructured":"Looker AC, SarafraziIsfahani N, Fan B, Shepherd JA. FRAX-based estimates of 10-year probability of hip and major osteoporotic fracture among adults aged 40 and over: United States, 2013 and 2014. Natl Health Stat Report. 2017;103:1\u201316.","journal-title":"Natl Health Stat Report"},{"issue":"9","key":"939_CR53","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1056\/NEJM200008313430902","volume":"343","author":"E Orwoll","year":"2000","unstructured":"Orwoll E, Ettinger M, Weiss S, Miller P, Kendler D, Graham J, et al. Alendronate for the treatment of osteoporosis in men. N Engl J Med. 2000;343(9):604\u201310.","journal-title":"N Engl J Med"},{"issue":"2","key":"939_CR54","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1007\/PL00004182","volume":"11","author":"YV Ho","year":"2000","unstructured":"Ho YV, Frauman AG, Thomson W, Seeman E. Effects of alendronate on bone density in men with primary and secondary osteoporosis. Osteoporos Int. 2000;11(2):98\u2013101.","journal-title":"Osteoporos Int"},{"issue":"11","key":"939_CR55","doi-asserted-by":"publisher","first-page":"5252","DOI":"10.1210\/jcem.86.11.7988","volume":"86","author":"JD Ringe","year":"2001","unstructured":"Ringe JD, Faber H, Dorst A. Alendronate treatment of established primary osteoporosis in men: results of a 2-year prospective study. J Clin Endocrinol Metab. 2001;86(11):5252\u20135.","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"939_CR56","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1007\/s00296-003-0388-y","volume":"24","author":"JD Ringe","year":"2004","unstructured":"Ringe JD, Dorst A, Faber H, Ibach K. Alendronate treatment of established primary osteoporosis in men: 3-year results of a prospective, comparative, two-arm study. Rheumatol Int. 2004;24(2):110\u20133.","journal-title":"Rheumatol Int"},{"issue":"2","key":"939_CR57","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/s00223-002-1085-7","volume":"73","author":"S Gonnelli","year":"2003","unstructured":"Gonnelli S, Cepollaro C, Montagnani A, Bruni D, Caffarelli C, Breschi M, et al. Alendronate treatment in men with primary osteoporosis: a three-year longitudinal study. Calcif Tissue Int. 2003;73(2):133\u20139.","journal-title":"Calcif Tissue Int"},{"issue":"3","key":"939_CR58","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1007\/s00774-009-0136-9","volume":"28","author":"JS Hwang","year":"2010","unstructured":"Hwang JS, Liou MJ, Ho C, Lin JD, Huang YY, Wang CJ, et al. The effects of weekly alendronate therapy in Taiwanese males with osteoporosis. J Bone Miner Metab. 2010;28(3):328\u201333.","journal-title":"J Bone Miner Metab"},{"issue":"4","key":"939_CR59","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1359\/jbmr.081214","volume":"24","author":"S Boonen","year":"2009","unstructured":"Boonen S, Orwoll ES, Wenderoth D, Stoner KJ, Eusebio R, Delmas PD. Once-weekly risedronate in men with osteoporosis: results of a 2-year, placebo-controlled, double-blind, multicenter study. J Bone Miner Res. 2009;24(4):719\u201325.","journal-title":"J Bone Miner Res"},{"issue":"5","key":"939_CR60","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1007\/s00296-005-0004-4","volume":"26","author":"JD Ringe","year":"2006","unstructured":"Ringe JD, Faber H, Farahmand P, Dorst A. Efficacy of risedronate in men with primary and secondary osteoporosis: results of a 1-year study. Rheumatol Int. 2006;26(5):427\u201331.","journal-title":"Rheumatol Int"},{"issue":"3","key":"939_CR61","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/s00296-008-0689-2","volume":"29","author":"JD Ringe","year":"2009","unstructured":"Ringe JD, Farahmand P, Faber H, Dorst A. Sustained efficacy of risedronate in men with primary and secondary osteoporosis: results of a 2-year study. Rheumatol Int. 2009;29(3):311\u20135.","journal-title":"Rheumatol Int"},{"issue":"4","key":"939_CR62","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1016\/j.bone.2009.12.034","volume":"46","author":"ES Orwoll","year":"2010","unstructured":"Orwoll ES, Binkley NC, Lewiecki EM, Gruntmanis U, Fries MA, Dasic G. Efficacy and safety of monthly ibandronate in men with low bone density. Bone. 2010;46(4):970\u20136.","journal-title":"Bone"},{"issue":"8","key":"939_CR63","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1007\/BF03347354","volume":"26","author":"O Lamy","year":"2003","unstructured":"Lamy O, Sandini L, Pache I, Fatio S, Burnand J, Burckhardt P. Intravenous ibandronate in men with osteoporosis: an open pilot study over 2 years. J Endocrinol Invest. 2003;26(8):728\u201332.","journal-title":"J Endocrinol Invest"},{"issue":"18","key":"939_CR64","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.1056\/NEJMoa1204061","volume":"367","author":"S Boonen","year":"2012","unstructured":"Boonen S, Reginster JY, Kaufman JM, Lippuner K, Zanchetta J, Langdahl B, et al. Fracture risk and zoledronic acid therapy in men with osteoporosis. N Engl J Med. 2012;367(18):1714\u201323.","journal-title":"N Engl J Med"},{"issue":"11","key":"939_CR65","doi-asserted-by":"publisher","first-page":"2084","DOI":"10.1111\/j.1532-5415.2011.03666.x","volume":"59","author":"S Boonen","year":"2011","unstructured":"Boonen S, Orwoll E, Magaziner J, Colon-Emeric CS, Adachi JD, Bucci-Rechtweg C, et al. Once-yearly zoledronic acid in older men compared with women with recent hip fracture. J Am Geriatr Soc. 2011;59(11):2084\u201390.","journal-title":"J Am Geriatr Soc"},{"issue":"9","key":"939_CR66","doi-asserted-by":"publisher","first-page":"3161","DOI":"10.1210\/jc.2012-1569","volume":"97","author":"E Orwoll","year":"2012","unstructured":"Orwoll E, Teglbjaerg CS, Langdahl BL, Chapurlat R, Czerwinski E, Kendler DL, et al. A randomized, placebo-controlled study of the effects of denosumab for the treatment of men with low bone mineral density. J Clin Endocrinol Metab. 2012;97(9):3161\u20139.","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"939_CR67","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1359\/jbmr.2003.18.1.9","volume":"18","author":"ES Orwoll","year":"2003","unstructured":"Orwoll ES, Scheele WH, Paul S, Adami S, Syversen U, Diez-Perez A, et al. The effect of teriparatide [human parathyroid hormone (1\u201334)] therapy on bone density in men with osteoporosis. J Bone Miner Res. 2003;18(1):9\u201317.","journal-title":"J Bone Miner Res"},{"issue":"5","key":"939_CR68","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1007\/s00198-004-1713-3","volume":"16","author":"JM Kaufman","year":"2005","unstructured":"Kaufman JM, Orwoll E, Goemaere S, San Martin J, Hossain A, Dalsky GP, et al. Teriparatide effects on vertebral fractures and bone mineral density in men with osteoporosis: treatment and discontinuation of therapy. Osteoporos Int. 2005;16(5):510\u20136.","journal-title":"Osteoporos Int"},{"issue":"9","key":"939_CR69","first-page":"3069","volume":"85","author":"ES Kurland","year":"2000","unstructured":"Kurland ES, Cosman F, McMahon DJ, Rosen CJ, Lindsay R, Bilezikian JP. Parathyroid hormone as a therapy for idiopathic osteoporosis in men: effects on bone mineral density and bone markers. J Clin Endocrinol Metab. 2000;85(9):3069\u201376.","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"939_CR70","doi-asserted-by":"publisher","first-page":"2435","DOI":"10.1002\/jbmr.4719","volume":"37","author":"E Czerwinski","year":"2022","unstructured":"Czerwinski E, Cardona J, Plebanski R, Recknor C, Vokes T, Saag KG, et al. The efficacy and safety of abaloparatide-SC in men with osteoporosis: a randomized clinical trial. J Bone Miner Res. 2022;37(12):2435\u201342.","journal-title":"J Bone Miner Res"},{"issue":"2","key":"939_CR71","doi-asserted-by":"publisher","DOI":"10.1093\/jbmrpl\/ziae009","volume":"8","author":"R Dhaliwal","year":"2024","unstructured":"Dhaliwal R, Kendler D, Saag K, Ing SW, Singer A, Adler RA, et al. Response rates for lumbar spine, total hip, and femoral neck bone mineral density in men treated with abaloparatide: results from the ATOM study. JBMR Plus. 2024;8(2):ziae009.","journal-title":"JBMR Plus"},{"issue":"9","key":"939_CR72","doi-asserted-by":"publisher","first-page":"3183","DOI":"10.1210\/jc.2017-02163","volume":"103","author":"EM Lewiecki","year":"2018","unstructured":"Lewiecki EM, Blicharski T, Goemaere S, Lippuner K, Meisner PD, Miller PD, et al. A phase III randomized placebo-controlled trial to evaluate efficacy and safety of Romosozumab in men with osteoporosis. J Clin Endocrinol Metab. 2018;103(9):3183\u201393.","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"939_CR73","doi-asserted-by":"publisher","first-page":"e3143","DOI":"10.1210\/clinem\/dgab149","volume":"106","author":"M Ng Tang Fui","year":"2021","unstructured":"Ng Tang Fui M, Hoermann R, Bracken K, Handelsman DJ, Inder WJ, Stuckey BGA, et al. Effect of testosterone treatment on bone microarchitecture and bone mineral density in men: a 2-year RCT. J Clin Endocrinol Metab. 2021;106(8):e3143\u201358.","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"939_CR74","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1056\/NEJMoa2308836","volume":"390","author":"PJ Snyder","year":"2024","unstructured":"Snyder PJ, Bauer DC, Ellenberg SS, Cauley JA, Buhr KA, Bhasin S, et al. Testosterone treatment and fractures in men with hypogonadism. N Engl J Med. 2024;390(3):203\u201311.","journal-title":"N Engl J Med"},{"issue":"1","key":"939_CR75","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1002\/jbmr.4433","volume":"37","author":"R Eastell","year":"2022","unstructured":"Eastell R, Vittinghoff E, Lui LY, McCulloch CE, Pavo I, Chines A, et al. Validation of the surrogate threshold effect for change in bone mineral density as a surrogate endpoint for fracture outcomes: the FNIH-ASBMR SABRE project. J Bone Miner Res. 2022;37(1):29\u201335.","journal-title":"J Bone Miner Res"},{"issue":"10","key":"939_CR76","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1093\/jbmr\/zjae090","volume":"39","author":"TM Keaveny","year":"2024","unstructured":"Keaveny TM, Adams AL, Orwoll ES, Khosla S, Siris ES, McClung MR, et al. Osteoporosis treatment prevents hip fracture similarly in both sexes: the FOCUS observational study. J Bone Miner Res. 2024;39(10):1424\u201333.","journal-title":"J Bone Miner Res"},{"issue":"10","key":"939_CR77","doi-asserted-by":"publisher","first-page":"2239","DOI":"10.1002\/jbmr.119","volume":"25","author":"ES Orwoll","year":"2010","unstructured":"Orwoll ES, Miller PD, Adachi JD, Brown J, Adler RA, Kendler D, et al. Efficacy and safety of a once-yearly i.v. infusion of zoledronic acid 5 mg versus a once-weekly 70-mg oral alendronate in the treatment of male osteoporosis: a randomized, multicenter, double-blind, active-controlled study. J Bone Miner Res. 2010;25(10):2239\u201350.","journal-title":"J Bone Miner Res"},{"issue":"10","key":"939_CR78","doi-asserted-by":"publisher","first-page":"2199","DOI":"10.4314\/tjpr.v20i10.26","volume":"20","author":"YWW Qi","year":"2021","unstructured":"Qi YWW, Sun W, Pan Q. Comparative efficacy and safety of alendronate and teriparatide in bone loss reduction and prevention of vertebral fracture in osteoporotic Chinese patients. Trop J Pharm Res. 2021;20(10):2199\u2013204.","journal-title":"Trop J Pharm Res"},{"issue":"1","key":"939_CR79","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-73398-5","volume":"14","author":"T Kobayakawa","year":"2024","unstructured":"Kobayakawa T, Kanayama Y, Hirano Y, Nakamura Y. Comparison of denosumab with romosozumab in the treatment of male osteoporosis: a retrospective cohort study. Sci Rep. 2024;14(1):22785.","journal-title":"Sci Rep"},{"issue":"1","key":"939_CR80","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1007\/s12020-012-9819-4","volume":"44","author":"MD Walker","year":"2013","unstructured":"Walker MD, Cusano NE, Sliney J Jr, Romano M, Zhang C, McMahon DJ, et al. Combination therapy with risedronate and teriparatide in male osteoporosis. Endocrine. 2013;44(1):237\u201346.","journal-title":"Endocrine"},{"issue":"13","key":"939_CR81","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1056\/NEJMoa035725","volume":"349","author":"JS Finkelstein","year":"2003","unstructured":"Finkelstein JS, Hayes A, Hunzelman JL, Wyland JJ, Lee H, Neer RM. The effects of parathyroid hormone, alendronate, or both in men with osteoporosis. N Engl J Med. 2003;349(13):1216\u201326.","journal-title":"N Engl J Med"},{"issue":"8","key":"939_CR82","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1007\/s11606-009-1031-8","volume":"24","author":"JR Curtis","year":"2009","unstructured":"Curtis JR, McClure LA, Delzell E, Howard VJ, Orwoll E, Saag KG, et al. Population-based fracture risk assessment and osteoporosis treatment disparities by race and gender. J Gen Intern Med. 2009;24(8):956\u201362.","journal-title":"J Gen Intern Med"},{"issue":"2","key":"939_CR83","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.jocd.2010.01.004","volume":"13","author":"JM Gaines","year":"2010","unstructured":"Gaines JM, Marx KA, Caudill J, Parrish S, Landsman J, Narrett M, et al. Older men\u2019s knowledge of osteoporosis and the prevalence of risk factors. J Clin Densitom. 2010;13(2):204\u20139.","journal-title":"J Clin Densitom"},{"key":"939_CR84","doi-asserted-by":"crossref","unstructured":"Nigh E, Summers S, Nguyen D, Conway S. Calcium and vitamin D supplementation in osteoporosis and fragility hip fracture patients: a retrospective NHANES study. J Hip Surg. 2021.","DOI":"10.1055\/s-0040-1722280"},{"key":"939_CR85","doi-asserted-by":"crossref","unstructured":"Jennings LA, Auerbach AD, Maselli J, Pekow PS, Lindenauer PK, Lee SJ. Missed opportunities for osteoporosis treatment in patients hospitalized for hip fracture. J Am Geriatr Soc. 2010;58(4):650\u20137.","DOI":"10.1111\/j.1532-5415.2010.02769.x"},{"issue":"7","key":"939_CR86","doi-asserted-by":"publisher","first-page":"3872","DOI":"10.1007\/s12325-021-01792-w","volume":"38","author":"S Ramachandran","year":"2021","unstructured":"Ramachandran S, Williams SA, Weiss RJ, Wang Y, Zhang Y, Nsiah I, et al. Gender disparities in osteoporosis screening and management among older adults. Adv Ther. 2021;38(7):3872\u201387.","journal-title":"Adv Ther"},{"key":"939_CR87","doi-asserted-by":"publisher","DOI":"10.1177\/2151459319828618","volume":"10","author":"GE Lee","year":"2019","unstructured":"Lee GE, Muffly S, Golladay GJ. Management of fragility hip fractures: our institutional experience. Geriatr Orthop Surg Rehabil. 2019;10:2151459319828618.","journal-title":"Geriatr Orthop Surg Rehabil"},{"issue":"12","key":"939_CR88","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0278368","volume":"17","author":"G Hoit","year":"2022","unstructured":"Hoit G, Whelan DB, Atrey A, Ravi B, Ryan G, Bogoch E, et al. Association of age, sex and race with prescription of anti-osteoporosis medications following low-energy hip fracture in a retrospective registry cohort. PLoS ONE. 2022;17(12):e0278368.","journal-title":"PLoS ONE"},{"issue":"8","key":"939_CR89","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1007\/s00198-018-4553-2","volume":"29","author":"ET Nguyen","year":"2018","unstructured":"Nguyen ET, Posas-Mendoza T, Siu AM, Ahn HJ, Choi SY, Lim SY. Low rates of osteoporosis treatment after hospitalization for hip fracture in Hawaii. Osteoporos Int. 2018;29(8):1827\u201332.","journal-title":"Osteoporos Int"},{"issue":"3","key":"939_CR90","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.afos.2021.08.002","volume":"7","author":"L Taylor","year":"2021","unstructured":"Taylor L, Kimata C, Siu AM, Andrews SN, Purohit P, Yamauchi M, et al. Osteoporosis treatment rates after hip fracture 2011\u20132019 in Hawaii: undertreatment of men after hip fractures. Osteoporos Sarcopenia. 2021;7(3):103\u20139.","journal-title":"Osteoporos Sarcopenia"},{"issue":"4","key":"939_CR91","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1001\/jama.297.4.387","volume":"297","author":"JR Center","year":"2007","unstructured":"Center JR, Bliuc D, Nguyen TV, Eisman JA. Risk of subsequent fracture after low-trauma fracture in men and women. JAMA. 2007;297(4):387\u201394.","journal-title":"JAMA"},{"issue":"4","key":"939_CR92","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1007\/s40273-022-01239-2","volume":"41","author":"N Li","year":"2023","unstructured":"Li N, Beaudart C, Cauley JA, Ing SW, Lane NE, Reginster JY, et al. Cost effectiveness analyses of interventions for osteoporosis in men: a systematic literature review. Pharmacoeconomics. 2023;41(4):363\u201391.","journal-title":"Pharmacoeconomics"},{"issue":"5","key":"939_CR93","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1007\/s00198-015-3025-1","volume":"26","author":"S Nayak","year":"2015","unstructured":"Nayak S, Edwards DL, Saleh AA, Greenspan SL. Systematic review and meta-analysis of the performance of clinical risk assessment instruments for screening for osteoporosis or low bone density. Osteoporos Int. 2015;26(5):1543\u201354.","journal-title":"Osteoporos Int"},{"issue":"12","key":"939_CR94","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.27584","volume":"3","author":"K Ito","year":"2020","unstructured":"Ito K. Cost-effectiveness of screening for osteoporosis in older men with a history of falls. JAMA Netw Open. 2020;3(12):e2027584.","journal-title":"JAMA Netw Open"},{"issue":"6","key":"939_CR95","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1001\/jama.298.6.629","volume":"298","author":"JT Schousboe","year":"2007","unstructured":"Schousboe JT, Taylor BC, Fink HA, Kane RL, Cummings SR, Orwoll ES, et al. Cost-effectiveness of bone densitometry followed by treatment of osteoporosis in older men. JAMA. 2007;298(6):629\u201337.","journal-title":"JAMA"}],"container-title":["Current Osteoporosis Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11914-025-00939-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11914-025-00939-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11914-025-00939-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T10:53:14Z","timestamp":1768474394000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11914-025-00939-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,28]]},"references-count":95,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["939"],"URL":"https:\/\/doi.org\/10.1007\/s11914-025-00939-w","relation":{},"ISSN":["1544-1873","1544-2241"],"issn-type":[{"value":"1544-1873","type":"print"},{"value":"1544-2241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,28]]},"assertion":[{"value":"2 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"RJRD, AG, SA: None; RD: research grant (to the institution) from Alexion, Amgen, Shire, Takeda and Radius Health and scientific advisor\/consultant for Amgen, Alexion, Ascendis, Kyowa Kirin, Radius Health, and Ultragenyx.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interest"}}],"article-number":"49"}}