{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:22:55Z","timestamp":1791912175264,"version":"4.3.4"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2001,10,1]],"date-time":"2001-10-01T00:00:00Z","timestamp":1001894400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Science Inc"],"published-print":{"date-parts":[[2001,10]]},"DOI":"10.1007\/s11916-001-0060-8","type":"journal-article","created":{"date-parts":[[2007,6,2]],"date-time":"2007-06-02T22:27:59Z","timestamp":1180823279000},"page":"472-478","source":"Crossref","is-referenced-by-count":17,"title":["The use of ibuprofen plus caffeine to treat tension-type headache"],"prefix":"10.1007","volume":"5","author":[{"given":"Seymour","family":"Diamond","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick G.","family":"Freitag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"60_CR1","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/0002-9343(83)90526-0","volume":"74","author":"BH Peters","year":"1983","unstructured":"Peters BH, Frain CJ, Masel BE: Comparison of 650 mg aspirin and 1000 mg acetaminophen with each other, and with placebo in the treatment of muscle-contraction headache. Am J Med 1983, 74:36\u201342.","journal-title":"Am J Med"},{"key":"60_CR2","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/j.1526-4610.1987.hed2707392.x","volume":"27","author":"DS Miller","year":"1987","unstructured":"Miller DS, Talbot CA, Simpson W, Korey A: A comparison of naproxen sodium, acetaminophen and placebo in the treatment of muscle-contraction headache. Headache 1987, 27:36\u201339.","journal-title":"Headache"},{"key":"60_CR3","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1002\/j.1552-4604.1996.tb04165.x","volume":"36","author":"BP Schachtel","year":"1996","unstructured":"Schachtel BP, Furey SA, Thoden WR: Nonprescription ibuprofen and acetaminophen in the treatment of tensiontype headache. J Clin Pharmacol 1996, 36:1120\u20131125.","journal-title":"J Clin Pharmacol"},{"key":"60_CR4","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1046\/j.1468-2982.1996.1602117.x","volume":"16","author":"CG Dahlof","year":"1996","unstructured":"Dahlof CG, Jacobs LD: Ketoprofen, paracetamol and placebo in the treatment of episodic tension-type headache. Cephalalgia 1996, 16:117\u2013123.","journal-title":"Cephalalgia"},{"key":"60_CR5","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.1526-4610.1983.hed2305206.x","volume":"23","author":"S Diamond","year":"1983","unstructured":"Diamond S: Ibuprofen versus aspirin and placebo in the treatment of muscle-contraction headache. Headache 1983, 23:206\u2013210.","journal-title":"Headache"},{"key":"60_CR6","first-page":"199","volume":"33","author":"TJ Vecchio","year":"1983","unstructured":"Vecchio TJ, Heilman CJ, O\u2019Connell MJ: Efficacy of ibuprofen in muscle contraction headache [abstract]. Clin Pharmacol Ther 1983, 33:199.","journal-title":"Clin Pharmacol Ther"},{"key":"60_CR7","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/j.1526-4610.1976.hed1606280.x","volume":"17","author":"RE Ryan","year":"1977","unstructured":"Ryan RE: Motrin-a new agent for the symptomatic treatment of muscle contraction headache. Headache 1977, 17:280\u2013283.","journal-title":"Headache"},{"key":"60_CR8","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/j.1526-4610.1988.hed2807471.x","volume":"28","author":"BP Schachtel","year":"1988","unstructured":"Schachtel BP, Thoden WR: Onset of action of ibuprofen in the treatment of muscle contraction headache. Headache 1988, 28:471\u2013474.","journal-title":"Headache"},{"key":"60_CR9","first-page":"89","volume":"21","author":"R Lange","year":"1995","unstructured":"Lange R, Lentz R: Comparison of ketoprofen, ibuprofen and naproxen sodium in the treatment of tension-type headache. Drugs Exp Clin Res 1995, 21:89\u201396.","journal-title":"Drugs Exp Clin Res"},{"key":"60_CR10","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1046\/j.1468-2982.1998.1801038.x","volume":"18","author":"TJ Steiner","year":"1998","unstructured":"Steiner TJ, Lange R: Ketoprofen (25 mg) in the symptomatic treatment of episodic tension-type headache: double blind placebo-controlled comparison with acetaminophen (1000 mg). Cephalalgia 1998, 18:38\u201343. This is one of the recent studies to examine simple analgesics using the tension-type headache model.","journal-title":"Cephalalgia"},{"key":"60_CR11","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1046\/j.1526-4610.2000.00087.x","volume":"40","author":"B Packman","year":"2000","unstructured":"Packman B, Packman E, Doyle E, et al.: Solubilized ibuprofen: Evaluation of onset, relief and safety of a noel formulation in the treatment of episodic tension-type headache. Headache 2000, 40:561\u2013567. This study of simple analgesic treatment of tension-type headache used similar newer modalities for assessment of pain in the tensiontype headache module. It verified many of the methods that were used in the studies, discussed in detail in this paper.","journal-title":"Headache"},{"key":"60_CR12","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1001\/jama.1984.03340370043028","volume":"251","author":"EM Laska","year":"1984","unstructured":"Laska EM, Sunshine A, Mueller F, et al.: Caffeine as an analgesic adjuvant. JAMA 1984, 251:1711\u20131718.","journal-title":"JAMA"},{"key":"60_CR13","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0304-3959(91)90129-L","volume":"44","author":"N Ward","year":"1991","unstructured":"Ward N, Whitney C, Avery D, Dunner D: The analgesic effects of caffeine in headache. Pain 1991, 44:151\u2013155.","journal-title":"Pain"},{"key":"60_CR14","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/clpt.1994.179","volume":"56","author":"JR Migliardi","year":"1994","unstructured":"Migliardi JR, Armellino JJ, Friedman M, et al.: Caffeine as an analgesic adjuvant in tension headache. Clin Pharmacol Ther 1994, 56:576\u2013586.","journal-title":"Clin Pharmacol Ther"},{"key":"60_CR15","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/cpt1976202241","volume":"20","author":"SA Cooper","year":"1976","unstructured":"Cooper SA, Beaver WT: A model to evaluate mild analgesics in oral surgery outpatients. Clin Pharmacol Ther 1976, 20:241\u2013250.","journal-title":"Clin Pharmacol Ther"},{"key":"60_CR16","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1002\/cpt1974156565","volume":"15","author":"SS Bloomfield","year":"1974","unstructured":"Bloomfield SS, Barden TP, Mitchell S: Comparative efficacy of ibuprofen and aspirin in episiotomy pain. Clin Pharmacol Ther 1974, 15:565\u2013570.","journal-title":"Clin Pharmacol Ther"},{"key":"60_CR17","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/BF00716382","volume":"14","author":"T Janbu","year":"1978","unstructured":"Janbu T, Lokken P, Neshein BL: Effect of acetylsalicylic acid, paracetamol and placebo in pain and blood loss in dysmenorrheic women. Eur J Clin Pharmacol 1978, 14:413\u2013416.","journal-title":"Eur J Clin Pharmacol"},{"key":"60_CR18","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/clpt.1991.143","volume":"50","author":"BP Schachtel","year":"1991","unstructured":"Schachtel BP, Thoden WR, Konerman JP, et al.: Headache pain model for assessing and comparing the efficacy of overthe-counter analgesic agents. Clin Pharmacol Ther 1991, 50:322\u2013329.","journal-title":"Clin Pharmacol Ther"},{"key":"60_CR19","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1067\/mcp.2000.109353","volume":"68","author":"S Diamond","year":"2000","unstructured":"Diamond S, Balm TK, Freitag FG: Ibuprofen plus caffeine in the treatment of tension-type headache. Clin Pharmacol Ther 2000, 68:312\u2013319. This study was important for several reasons. First, it used the newer methods for assessing pain in the setting of tension-type headache. Thus validating the current modern techniques of pain assessment and verifying the potential for tension-type headache to be used as a model for measuring pain. Additionally, it demonstrated clearly that caffeine does indeed have analgesic activity that can be differentiated from that of established analgesics.","journal-title":"Clin Pharmacol Ther"},{"key":"60_CR20","unstructured":"Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Headache Classification Committee of the International Headache Society [no authors listed]. Cephalalgia 1988, 8(suppl 7):1\u201396."},{"key":"60_CR21","volume-title":"SAS\/STAT User\u2019s Guide","author":"SAS Institute Inc.","year":"1989","unstructured":"SAS Institute Inc. SAS\/STAT User\u2019s Guide, version 6, edn 4, vol 1. Cary, NC: SAS Institute Inc.; 1989.","edition":"edn 4"}],"container-title":["Current Pain and Headache Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11916-001-0060-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11916-001-0060-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11916-001-0060-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T20:34:03Z","timestamp":1559421243000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11916-001-0060-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,10]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2001,10]]}},"alternative-id":["60"],"URL":"https:\/\/doi.org\/10.1007\/s11916-001-0060-8","relation":{},"ISSN":["1531-3433","1534-3081"],"issn-type":[{"value":"1531-3433","type":"print"},{"value":"1534-3081","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,10]]}}}