{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:27:06Z","timestamp":1790303226752,"version":"4.1.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2003,11,1]],"date-time":"2003-11-01T00:00:00Z","timestamp":1067644800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Science Inc"],"published-print":{"date-parts":[[2003,11]]},"DOI":"10.1007\/s11916-003-0062-9","type":"journal-article","created":{"date-parts":[[2007,6,3]],"date-time":"2007-06-03T05:33:33Z","timestamp":1180848813000},"page":"460-465","source":"Crossref","is-referenced-by-count":45,"title":["Central and peripheral sensitization in tension-type headache"],"prefix":"10.1007","volume":"7","author":[{"given":"Lars","family":"Bendtsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"62_CR1","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/0895-4356(91)90147-2","volume":"44","author":"BK Rasmussen","year":"1991","unstructured":"Rasmussen BK, Jensen R, Schroll M, Olesen J: Epidemiology of headache in a general population: a prevalence study. J Clin Epidemiol 1991, 44:1147\u20131157.","journal-title":"J Clin Epidemiol"},{"key":"62_CR2","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1097\/00043764-199704000-00009","volume":"39","author":"BS Schwartz","year":"1997","unstructured":"Schwartz BS, Stewart WF, Lipton RB: Lost workdays and decreased work effectiveness associated with headache in the workplace. J Occup Environ Med 1997, 39:320\u2013327.","journal-title":"J Occup Environ Med"},{"key":"62_CR3","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1046\/j.1468-2982.1987.0704249.x","volume":"7","author":"M Langemark","year":"1987","unstructured":"Langemark M, Olesen J: Pericranial tenderness in tension headache: a blind, controlled study. Cephalalgia 1987, 7:249\u2013255.","journal-title":"Cephalalgia"},{"key":"62_CR4","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0304-3959(93)90131-8","volume":"52","author":"R Jensen","year":"1993","unstructured":"Jensen R, Rasmussen BK, Pedersen B, Olesen J: Muscle tenderness and pressure pain thresholds in headache: a population study. Pain 1993, 52:193\u2013199.","journal-title":"Pain"},{"key":"62_CR5","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1046\/j.1526-4610.1997.3706368.x","volume":"37","author":"GL Lipchik","year":"1997","unstructured":"Lipchik GL, Holroyd KA, Talbot F, Greer M: Pericranial muscle tenderness and exteroceptive suppression of temporalis muscle activity: a blind study of chronic tension-type headache. Headache 1997, 37:368\u2013376.","journal-title":"Headache"},{"key":"62_CR6","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1046\/j.1526-4610.1998.3801010.x","volume":"38","author":"R Jensen","year":"1998","unstructured":"Jensen R, Bendtsen L, Olesen J: Muscular factors are of importance in tension-type headache. Headache 1998, 38:10\u201317.","journal-title":"Headache"},{"key":"62_CR7","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1001\/archneur.1996.00550040113021","volume":"53","author":"L Bendtsen","year":"1996","unstructured":"Bendtsen L, Jensen R, Olesen J: Decreased pain detection and tolerance thresholds in chronic tension-type headache. Arch Neurol 1996, 53:373\u2013376.","journal-title":"Arch Neurol"},{"key":"62_CR8","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1046\/j.1468-2982.1999.019006602.x","volume":"19","author":"R Jensen","year":"1999","unstructured":"Jensen R: Pathophysiologic mechanisms of tension-type headache: a review of epidemiological and experimental studies. Cephalalgia 1999, 19:602\u2013621. Important review on peripheral and central pathophysiologic mechanisms in tension-type headache.","journal-title":"Cephalalgia"},{"key":"62_CR9","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1046\/j.1468-2982.1996.1603175.x","volume":"16","author":"R Jensen","year":"1996","unstructured":"Jensen R, Olesen J: Initiating mechanisms of experimentally induced tension-type headache. Cephalalgia 1996, 16:175\u2013182.","journal-title":"Cephalalgia"},{"key":"62_CR10","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1093\/brain\/118.2.523","volume":"118","author":"F Sakai","year":"1995","unstructured":"Sakai F, Ebihara S, Akiyama M, Horikawa M: Pericranial muscle hardness in tension-type headache: a noninvasive measurement method and its clinical application. Brain 1995, 118:523\u2013531.","journal-title":"Brain"},{"key":"62_CR11","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0304-3959(98)00167-5","volume":"79","author":"M Ashina","year":"1999","unstructured":"Ashina M, Bendtsen L, Jensen R, et al.: Muscle hardness in patients with chronic tension-type headache: relation to actual headache state. Pain 1999, 79:201\u2013205.","journal-title":"Pain"},{"key":"62_CR12","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1046\/j.1468-2982.2000.00070.x","volume":"20","author":"L Bendtsen","year":"2000","unstructured":"Bendtsen L: Central sensitization in tension-type headache: possible pathophysiologic mechanisms. Cephalalgia 2000, 20:486\u2013508. Thorough review of central and peripheral sensitization in tensiontype headache.","journal-title":"Cephalalgia"},{"key":"62_CR13","first-page":"423","volume-title":"Textbook of Pain","author":"DJ Newham","year":"1994","unstructured":"Newham DJ, Edwards RHT, Mills KR: Skeletal muscle pain. In Textbook of Pain. Edited by Wall PD, Melzack R. Edinburgh: Churchill Livingstone; 1994:423\u2013440."},{"key":"62_CR14","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0304-3959(93)90027-M","volume":"54","author":"S Mense","year":"1993","unstructured":"Mense S: Nociception from skeletal muscle in relation to clinical muscle pain. Pain 1993, 54:241\u2013289.","journal-title":"Pain"},{"key":"62_CR15","first-page":"579","volume-title":"The Headaches","author":"J Schoenen","year":"2000","unstructured":"Schoenen J, Bendtsen L: Neurophysiology of tension-type headache. In The Headaches. Edited by Olesen J, Tfelt-Hansen P, Welch KM. Philadelphia: Lippincott Williams and Wilkins; 2000:579\u2013587."},{"key":"62_CR16","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1097\/00007632-199310000-00015","volume":"18","author":"DR Hubbard","year":"1993","unstructured":"Hubbard DR, Berkoff GM: Myofascial trigger points show spontaneous needle EMG activity. Spine 1993, 18:1803\u20131807.","journal-title":"Spine"},{"key":"62_CR17","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1093\/brain\/awf029","volume":"125","author":"M Ashina","year":"2002","unstructured":"Ashina M, Stallknecht B, Bendtsen L, et al.: In vivo evidence of altered skeletal muscle blood flow in chronic tension-type headache. Brain 2002, 125:320\u2013326.","journal-title":"Brain"},{"key":"62_CR18","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/0196-9781(90)90141-Q","volume":"11","author":"K Jensen","year":"1990","unstructured":"Jensen K, Tuxen C, Pedersen BU, et al.: Pain and tenderness in human temporal muscle induced by bradykinin and 5-hydroxytryptamine. Peptides 1990, 11:1127\u20131132.","journal-title":"Peptides"},{"key":"62_CR19","doi-asserted-by":"crossref","unstructured":"Mork H, Ashina M, Bendtsen L, et al.: Possible mechanisms of pain perception in patients with episodic tension-type headache: a new model of myofascial pain. Cephalalgia 2003, in press. Interesting study investigating the role of inflammatory mediators for the muscular hypersensitivity in tension-type headache.","DOI":"10.1111\/j.1468-2982.2004.00709.x"},{"key":"62_CR20","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1046\/j.1468-1331.2003.00570.x","volume":"10","author":"H Mork","year":"2003","unstructured":"Mork H, Ashina M, Bendtsen L, et al.: Induction of prolonged tenderness in patients with tension-type headache by means of a new experimental model of myofascial pain. Eur J Neurol 2003, 10:249\u2013256.","journal-title":"Eur J Neurol"},{"key":"62_CR21","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1046\/j.1468-2982.2003.00520.x","volume":"23","author":"M Ashina","year":"2003","unstructured":"Ashina M, Stallknecht B, Bendtsen L, et al.: Tender points are not sites of ongoing inflammation: in vivo evidence in patients with chronic tension-type headache. Cephalalgia 2003, 23:109\u2013116.","journal-title":"Cephalalgia"},{"key":"62_CR22","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1046\/j.1468-2982.1992.1203142.x","volume":"12","author":"H G\u00f6bel","year":"1992","unstructured":"G\u00f6bel H, Weigle L, Kropp P, Soyka D: Pain sensitivity and pain reactivity of pericranial muscles in migraine and tensiontype headache. Cephalalgia 1992, 12:142\u2013151.","journal-title":"Cephalalgia"},{"key":"62_CR23","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0304-3959(92)90258-D","volume":"51","author":"G Bovim","year":"1992","unstructured":"Bovim G: Cervicogenic headache, migraine, and tension-type headache: pressure-pain threshold measurements. Pain 1992, 51:169\u2013173.","journal-title":"Pain"},{"key":"62_CR24","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0304-3959(95)00114-X","volume":"64","author":"R Jensen","year":"1996","unstructured":"Jensen R: Mechanisms of spontaneous tension-type headaches: an analysis of tenderness, pain thresholds, and EMG. Pain 1996, 64:251\u2013256.","journal-title":"Pain"},{"key":"62_CR25","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0304-3959(91)90198-7","volume":"47","author":"J Schoenen","year":"1991","unstructured":"Schoenen J, Bottin D, Hardy F, Gerard P: Cephalic and extracephalic pressure pain thresholds in chronic tensiontype headache. Pain 1991, 47:145\u2013149.","journal-title":"Pain"},{"key":"62_CR26","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0304-3959(89)90239-X","volume":"38","author":"M Langemark","year":"1989","unstructured":"Langemark M, Jensen K, Jensen TS, Olesen J: Pressure pain thresholds and thermal nociceptive thresholds in chronic tension-type headache. Pain 1989, 38:203\u2013210.","journal-title":"Pain"},{"key":"62_CR27","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1001\/archneur.1993.00540100056015","volume":"50","author":"M Langemark","year":"1993","unstructured":"Langemark M, Bach FW, Jensen TS, Olesen J: Decreased nociceptive flexion reflex threshold in chronic tension-type headache. Arch Neurol 1993, 50:1061\u20131064.","journal-title":"Arch Neurol"},{"key":"62_CR28","first-page":"165","volume-title":"Advances in Pain Research and Therapy","author":"K Jensen","year":"1990","unstructured":"Jensen K: Quantification of tenderness by palpation and use of pressure algometers. In Advances in Pain Research and Therapy. Edited by Fricton JR, Awad E. New York: Raven Press; 1990:165\u2013181."},{"key":"62_CR29","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0304-3959(95)00239-1","volume":"65","author":"L Bendtsen","year":"1996","unstructured":"Bendtsen L, Jensen R, Olesen J: Qualitatively altered nociception in chronic myofascial pain. Pain 1996, 65:259\u2013264.","journal-title":"Pain"},{"key":"62_CR30","first-page":"449","volume":"3","author":"L Bendtsen","year":"2002","unstructured":"Bendtsen L: Sensitization: its role in primary headache. Curr Opin Investig Drugs 2002, 3:449\u2013453.","journal-title":"Curr Opin Investig Drugs"},{"key":"62_CR31","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1001\/jama.285.17.2208","volume":"285","author":"KA Holroyd","year":"2001","unstructured":"Holroyd KA, O\u2019Donnell FJ, Stensland M, et al.: Management of chronic tension-type headache with tricyclic antidepressant medication, stress management therapy, and their combination: a randomized controlled trial. JAMA 2001, 285:2208\u20132215.","journal-title":"JAMA"},{"key":"62_CR32","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1136\/jnnp.61.3.285","volume":"61","author":"L Bendtsen","year":"1996","unstructured":"Bendtsen L, Jensen R, Olesen J: A non-selective (amitriptyline), but not a selective (citalopram), serotonin reuptake inhibitor is effective in the prophylactic treatment of chronic tension-type headache. J Neurol Neurosurg Psychiatry 1996, 61:285\u2013290.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"62_CR33","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1586\/14737175.3.2.165","volume":"3","author":"L Bendtsen","year":"2003","unstructured":"Bendtsen L: Amitriptyline in the treatment of primary headaches. Expert Rev Neurotherapeutics 2003, 3:165\u2013173.","journal-title":"Expert Rev Neurotherapeutics"},{"key":"62_CR34","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1046\/j.1468-2982.2000.00087.x","volume":"20","author":"L Bendtsen","year":"2000","unstructured":"Bendtsen L, Jensen R: Amitriptyline reduces myofascial tenderness in patients with chronic tension-type headache. Cephalalgia 2000, 20:603\u2013610.","journal-title":"Cephalalgia"},{"key":"62_CR35","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/0028-3908(93)90173-Z","volume":"32","author":"Y Watanabe","year":"1993","unstructured":"Watanabe Y, Saito H, Abe K: Tricyclic antidepressants block NMDA receptor-mediated synaptic responses and induction of long-term potentiation in rat hippocampal slices. Neuropharmacology 1993, 32:479\u2013486.","journal-title":"Neuropharmacology"},{"key":"62_CR36","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1097\/00000542-199511000-00018","volume":"83","author":"JC Eisenach","year":"1995","unstructured":"Eisenach JC, Gebhart GF: Intrathecal amitriptyline acts as an N-methyl-D-aspartate receptor antagonist in the presence of inflammatory hyperalgesia in rats. Anesthesiology 1995, 83:1046\u20131054.","journal-title":"Anesthesiology"},{"key":"62_CR37","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0140-6736(98)01079-4","volume":"353","author":"M Ashina","year":"1999","unstructured":"Ashina M, Lassen LH, Bendtsen L, et al.: Effect of inhibition of nitric oxide synthase on chronic tension-type headache: a randomised crossover trial. Lancet 1999, 353:287\u2013289. Important study demonstrating an analgesic effect of a drug that counteracts central sensitization in chronic tension-type headache.","journal-title":"Lancet"},{"key":"62_CR38","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1093\/brain\/122.9.1629","volume":"122","author":"M Ashina","year":"1999","unstructured":"Ashina M, Bendtsen L, Jensen R, et al.: Possible mechanisms of action of nitric oxide synthase inhibitors in chronic tensiontype headache. Brain 1999, 122:1629\u20131635.","journal-title":"Brain"},{"key":"62_CR39","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1093\/brain\/123.9.1830","volume":"123","author":"M Ashina","year":"2000","unstructured":"Ashina M, Bendtsen L, Jensen R, Olesen J: Nitric oxide-induced headache in patients with chronic tension-type headache. Brain 2000, 123:1830\u20131837.","journal-title":"Brain"}],"container-title":["Current Pain and Headache Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11916-003-0062-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11916-003-0062-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11916-003-0062-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T00:34:10Z","timestamp":1559435650000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11916-003-0062-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,11]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2003,11]]}},"alternative-id":["62"],"URL":"https:\/\/doi.org\/10.1007\/s11916-003-0062-9","relation":{},"ISSN":["1531-3433","1534-3081"],"issn-type":[{"value":"1531-3433","type":"print"},{"value":"1534-3081","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,11]]}}}