{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T12:10:38Z","timestamp":1791720638289,"version":"4.3.4"},"reference-count":75,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Science Inc"],"published-print":{"date-parts":[[2005,12]]},"DOI":"10.1007\/s11916-005-0021-8","type":"journal-article","created":{"date-parts":[[2007,6,3]],"date-time":"2007-06-03T02:08:06Z","timestamp":1180836486000},"page":"415-422","source":"Crossref","is-referenced-by-count":101,"title":["Pathophysiology of tension-type headache"],"prefix":"10.1007","volume":"9","author":[{"given":"Sait","family":"Ashina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Bendtsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Messoud","family":"Ashina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"21_CR1","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1016\/0895-4356(91)90147-2","volume":"44","author":"BK Rasmussen","year":"1991","unstructured":"Rasmussen BK, Jensen R, Schroll M, et al.: Epidemiology of headache in a general population: a prevalence study. J Clin Epidemiol 1991, 44:1147\u20131157.","journal-title":"J Clin Epidemiol"},{"issue":"suppl 1","key":"21_CR2","first-page":"9","volume":"24","author":"Headache Classification Subcommittee of the International Headache Society","year":"2004","unstructured":"Headache Classification Subcommittee of the International Headache Society: The International Classification of Headache Disorders, edn 2. Cephalalgia 2004, 24(suppl 1):9\u2013160.","journal-title":"Cephalalgia"},{"key":"21_CR3","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1007\/s11916-003-0063-8","volume":"7","author":"S Ashina","year":"2003","unstructured":"Ashina S, Ashina M: Current and potential future drug therapies for tension-type headache. Curr Pain Headache Rep 2003, 7:466\u2013474.","journal-title":"Curr Pain Headache Rep"},{"key":"21_CR4","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1111\/j.1468-2982.2003.00644.x","volume":"24","author":"M Ashina","year":"2004","unstructured":"Ashina M: Neurobiology of chronic tension-type headache. Cephalalgia 2004, 24:161\u2013172. A review on the role of NO and neuropeptides in CTTH.","journal-title":"Cephalalgia"},{"key":"21_CR5","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1046\/j.1468-2982.2000.00070.x","volume":"20","author":"L Bendtsen","year":"2000","unstructured":"Bendtsen L: Central sensitization in tension-type headache: possible pathophysiological mechanisms. Cephalalgia 2000, 20:486\u2013508. An important and comprehensive review on the role of central sensitization in the pathophysiology of CTTH.","journal-title":"Cephalalgia"},{"key":"21_CR6","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.pain.2004.07.009","volume":"111","author":"J Schoenen","year":"2004","unstructured":"Schoenen J: Depression in tension-type headache sufferers: bystander or villain? Pain 2004, 111:225.","journal-title":"Pain"},{"key":"21_CR7","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1046\/j.1526-4610.2001.041006554.x","volume":"41","author":"EL Spierings","year":"2001","unstructured":"Spierings EL, Ranke AH, Honkoop PC: Precipitating and aggravating factors of migraine versus tension-type headache. Headache 2001, 41:554\u2013558.","journal-title":"Headache"},{"key":"21_CR8","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/0304-3959(93)90057-V","volume":"53","author":"BK Rasmussen","year":"1993","unstructured":"Rasmussen BK: Migraine and tension-type headache in a general population: precipitating factors, female hormones, sleep pattern and relation to lifestyle. Pain 1993, 53:65\u201372.","journal-title":"Pain"},{"key":"21_CR9","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1046\/j.1468-2982.1995.1506511.x","volume":"15","author":"GT Clark","year":"1995","unstructured":"Clark GT, Sakai S, Merrill R, et al.: Cross-correlation between stress, pain, physical activity, and temporalis muscle EMG in tension-type headache. Cephalalgia 1995, 15:511\u2013518.","journal-title":"Cephalalgia"},{"key":"21_CR10","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1007\/BF00846479","volume":"10","author":"LR Gannon","year":"1987","unstructured":"Gannon LR, Haynes SN, Cuevas J, et al.: Psychophysiological correlates of induced headaches. J Behav Med 1987, 10:411\u2013423.","journal-title":"J Behav Med"},{"key":"21_CR11","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s11916-002-0083-9","volume":"6","author":"KA Holroyd","year":"2002","unstructured":"Holroyd KA: Behavioral and psychologic aspects of the pathophysiology and management of tension-type headache. Curr Pain Headache Rep 2002, 6:401\u2013407. A review on the importance of behavioral and psychologic factors in pathophysiology and treatment of TTH.","journal-title":"Curr Pain Headache Rep"},{"key":"21_CR12","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.pain.2004.06.007","volume":"111","author":"EA Janke","year":"2004","unstructured":"Janke EA, Holroyd KA, Romanek K: Depression increases onset of tension-type headache following laboratory stress. Pain 2004, 111:230\u2013238.","journal-title":"Pain"},{"key":"21_CR13","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1046\/j.1468-2982.2000.00105.x","volume":"20","author":"GL Lipchik","year":"2000","unstructured":"Lipchik GL, Holroyd KA, O\u2019Donnell FJ, et al.: Exteroceptive suppression periods and pericranial muscle tenderness in chronic tension-type headache: effects of psychopathology, chronicity and disability. Cephalalgia 2000, 20:638\u2013646.","journal-title":"Cephalalgia"},{"key":"21_CR14","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1212\/01.WNL.0000129498.50793.8A","volume":"62","author":"V Ulrich","year":"2004","unstructured":"Ulrich V, Gervil M, Olesen J: The relative influence of environment and genes in episodic tension-type headache. Neurology 2004, 62:2065\u20132069.","journal-title":"Neurology"},{"key":"21_CR15","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1136\/bmj.314.7087.1092","volume":"314","author":"S Ostergaard","year":"1997","unstructured":"Ostergaard S, Russell MB, Bendtsen L, et al.: Comparison of first degree relatives and spouses of people with chronic tension headache. BMJ 1997, 314:1092\u20131093.","journal-title":"BMJ"},{"key":"21_CR16","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1046\/j.1468-2982.1999.019004207.x","volume":"19","author":"MB Russell","year":"1999","unstructured":"Russell MB, Ostergaard S, Bendtsen L, et al.: Familial occurrence of chronic tension-type headache. Cephalalgia 1999, 19:207\u2013210.","journal-title":"Cephalalgia"},{"key":"21_CR17","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1007\/s004390050666","volume":"102","author":"MB Russell","year":"1998","unstructured":"Russell MB, Iselius L, Ostergaard S, et al.: Inheritance of chronic tension-type headache investigated by complex segregation analysis. Hum Genet 1998, 102:138\u2013140.","journal-title":"Hum Genet"},{"key":"21_CR18","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1001\/archneur.1996.00550040113021","volume":"53","author":"L Bendtsen","year":"1996","unstructured":"Bendtsen L, Jensen R, Olesen J: Decreased pain detection and tolerance thresholds in chronic tension-type headache. Arch Neurol 1996, 53:373\u2013376.","journal-title":"Arch Neurol"},{"key":"21_CR19","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/0304-3959(93)90131-8","volume":"52","author":"R Jensen","year":"1993","unstructured":"Jensen R, Rasmussen BK, Pedersen B, et al.: Muscle tenderness and pressure pain thresholds in headache: a population study. Pain 1993, 52:193\u2013199.","journal-title":"Pain"},{"key":"21_CR20","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1046\/j.1526-4610.1998.3801010.x","volume":"38","author":"R Jensen","year":"1998","unstructured":"Jensen R, Bendtsen L, Olesen J: Muscular factors are of importance in tension-type headache. Headache 1998, 38:10\u201317.","journal-title":"Headache"},{"key":"21_CR21","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1046\/j.1468-2982.1987.0704249.x","volume":"7","author":"M Langemark","year":"1987","unstructured":"Langemark M, Olesen J: Pericranial tenderness in tension headache: a blind, controlled study. Cephalalgia 1987, 7:249\u2013255.","journal-title":"Cephalalgia"},{"key":"21_CR22","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1046\/j.1526-4610.1997.3706368.x","volume":"37","author":"GL Lipchik","year":"1997","unstructured":"Lipchik GL, Holroyd KA, Talbot F, et al.: Pericranial muscle tenderness and exteroceptive suppression of temporalis muscle activity: a blind study of chronic tension-type headache. Headache 1997, 37:368\u2013376.","journal-title":"Headache"},{"key":"21_CR23","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1111\/j.1526-4610.1984.hed2404186.x","volume":"24","author":"H Pikoff","year":"1984","unstructured":"Pikoff H: Is the muscular model of headache still viable? A review of conflicting data. Headache 1984, 24:186\u2013198.","journal-title":"Headache"},{"key":"21_CR24","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1046\/j.1468-2982.1999.019006602.x","volume":"19","author":"R Jensen","year":"1999","unstructured":"Jensen R: Pathophysiological mechanisms of tension-type headache: a review of epidemiological and experimental studies. Cephalalgia 1999, 19:602\u2013621.","journal-title":"Cephalalgia"},{"key":"21_CR25","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/S0304-3959(98)00167-5","volume":"79","author":"M Ashina","year":"1999","unstructured":"Ashina M, Bendtsen L, Jensen R, et al.: Muscle hardness in patients with chronic tension-type headache: relation to actual headache state. Pain 1999, 79:201\u2013205.","journal-title":"Pain"},{"key":"21_CR26","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1093\/brain\/118.2.523","volume":"118","author":"F Sakai","year":"1995","unstructured":"Sakai F, Ebihara S, Akiyama M, et al.: Pericranial muscle hardness in tension-type headache: a non-invasive measurement method and its clinical application. Brain 1995, 118:523\u2013531.","journal-title":"Brain"},{"key":"21_CR27","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s11916-003-0057-6","volume":"7","author":"S Mense","year":"2003","unstructured":"Mense S: The pathogenesis of muscle pain. Curr Pain Headache Rep 2003, 7:419\u2013425.","journal-title":"Curr Pain Headache Rep"},{"key":"21_CR28","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1046\/j.1468-2982.1996.1603175.x","volume":"16","author":"R Jensen","year":"1996","unstructured":"Jensen R, Olesen J: Initiating mechanisms of experimentally induced tension-type headache. Cephalalgia 1996, 16:175\u2013182.","journal-title":"Cephalalgia"},{"key":"21_CR29","doi-asserted-by":"crossref","unstructured":"Christensen MB, Bendtsen L, Ashina M, et al.: Experimental induction of muscle tenderness and headache in tensiontype headache patients. Cephalalgia 2005, in press.","DOI":"10.1111\/j.1468-2982.2005.00962.x"},{"key":"21_CR30","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1046\/j.1468-2982.1992.1203142.x","volume":"12","author":"H Gobel","year":"1992","unstructured":"Gobel H, Weigle L, Kropp P, et al.: Pain sensitivity and pain reactivity of pericranial muscles in migraine and tensiontype headache. Cephalalgia 1992, 12:142\u2013151.","journal-title":"Cephalalgia"},{"key":"21_CR31","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/0304-3959(92)90140-7","volume":"49","author":"JP Hatch","year":"1992","unstructured":"Hatch JP, Moore PJ, Cyr-Provost M, et al.: The use of electromyography and muscle palpation in the diagnosis of tension-type headache with and without pericranial muscle involvement. Pain 1992, 49:175\u2013178.","journal-title":"Pain"},{"key":"21_CR32","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1046\/j.1468-2982.1994.1406451.x","volume":"14","author":"G Sandrini","year":"1994","unstructured":"Sandrini G, Antonaci F, Pucci E, et al.: Comparative study with EMG, pressure algometry, and manual palpation in tensiontype headache and migraine. Cephalalgia 1994, 14:451\u2013457.","journal-title":"Cephalalgia"},{"key":"21_CR33","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.1097\/00007632-199310000-00015","volume":"18","author":"DR Hubbard","year":"1993","unstructured":"Hubbard DR, Berkoff GM: Myofascial trigger points show spontaneous needle EMG activity. Spine 1993, 18:1803\u20131807.","journal-title":"Spine"},{"key":"21_CR34","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1093\/brain\/117.5.1001","volume":"117","author":"HO Karnath","year":"1994","unstructured":"Karnath HO: Subjective body orientation in neglect and the interactive contribution of neck muscle proprioception and vestibular stimulation. Brain 1994, 117:1001\u20131012.","journal-title":"Brain"},{"key":"21_CR35","doi-asserted-by":"crossref","first-page":"440","DOI":"10.3109\/00016489509125293","volume":"520","author":"M Karlberg","year":"1995","unstructured":"Karlberg M, Persson L, Magnusson M: Impaired postural control in patients with cervico-brachial pain. Acta Otolaryngol Suppl 1995, 520:440\u2013442.","journal-title":"Acta Otolaryngol Suppl"},{"key":"21_CR36","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/j.ejpain.2004.02.004","volume":"8","author":"PG Giacomini","year":"2004","unstructured":"Giacomini PG, Alessandrini M, Evangelista M, et al.: Impaired postural control in patients affected by tension-type headache. Eur J Pain 2004, 8:579\u2013583.","journal-title":"Eur J Pain"},{"key":"21_CR37","first-page":"97","volume-title":"Tension-type Headache: Classification, Mechanisms, and Treatment","author":"K Henriksson","year":"1993","unstructured":"Henriksson K, Lindman R: Morphologic, physiologic, and biochemical changes in tender and painful muscle. In Tension-type Headache: Classification, Mechanisms, and Treatment, vol 3. Edited by Olesen J, Schoenen J. New York: Raven Press; 1993:97\u2013107."},{"key":"21_CR38","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1001\/archneur.1990.00530060064020","volume":"47","author":"M Langemark","year":"1990","unstructured":"Langemark M, Jensen K, Olesen J: Temporal muscle blood flow in chronic tension-type headache. Arch Neurol 1990, 47:654\u2013658.","journal-title":"Arch Neurol"},{"key":"21_CR39","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1093\/brain\/awf029","volume":"125","author":"M Ashina","year":"2002","unstructured":"Ashina M, Stallknecht B, Bendtsen L, et al.: In vivo evidence of altered skeletal muscle blood flow in chronic tension-type headache. Brain 2002, 125:320\u2013326.","journal-title":"Brain"},{"key":"21_CR40","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1111\/j.1468-2982.2004.00709.x","volume":"24","author":"H Mork","year":"2004","unstructured":"Mork H, Ashina M, Bendtsen L, et al.: Possible mechanisms of pain perception in patients with episodic tension-type headache: a new experimental model of myofascial pain. Cephalalgia 2004, 24:466\u2013475.","journal-title":"Cephalalgia"},{"key":"21_CR41","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1046\/j.1468-1331.2003.00570.x","volume":"10","author":"H Mork","year":"2003","unstructured":"Mork H, Ashina M, Bendtsen L, et al.: Induction of prolonged tenderness in patients with tension-type headache by means of a new experimental model of myofascial pain. Eur J Neurol 2003, 10:249\u2013256.","journal-title":"Eur J Neurol"},{"key":"21_CR42","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1046\/j.1468-2982.2003.00520.x","volume":"23","author":"M Ashina","year":"2003","unstructured":"Ashina M, Stallknecht B, Bendtsen L, et al.: Tender points are not sites of ongoing inflammation: in vivo evidence in patients with chronic tension-type headache. Cephalalgia 2003, 23:109\u2013116.","journal-title":"Cephalalgia"},{"key":"21_CR43","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1111\/j.1468-1331.2005.01023.x","volume":"12","author":"S Ashina","year":"2005","unstructured":"Ashina S, Babenko L, Jensen R, et al.: Increased muscular and cutaneous pain sensitivity in cephalic region in patients with chronic tension-type headache. Eur J Neurol 2005, 12:543\u2013549.","journal-title":"Eur J Neurol"},{"key":"21_CR44","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/0304-3959(89)90239-X","volume":"38","author":"M Langemark","year":"1989","unstructured":"Langemark M, Jensen K, Jensen TS, et al.: Pressure pain thresholds and thermal nociceptive thresholds in chronic tensiontype headache. Pain 1989, 38:203\u2013210.","journal-title":"Pain"},{"key":"21_CR45","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/0304-3959(91)90198-7","volume":"47","author":"J Schoenen","year":"1991","unstructured":"Schoenen J, Bottin D, Hardy F, et al.: Cephalic and extracephalic pressure pain thresholds in chronic tension-type headache. Pain 1991, 47:145\u2013149.","journal-title":"Pain"},{"key":"21_CR46","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/S0304-3959(02)00485-2","volume":"104","author":"M de Tommaso","year":"2003","unstructured":"de TommasoM, Libro G, Guido M, et al.: Heat pain thresholds and cerebral event-related potentials following painful CO2 laser stimulation in chronic tension-type headache. Pain 2003, 104:111\u2013119.","journal-title":"Pain"},{"key":"21_CR47","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/0304-3959(86)90235-6","volume":"25","author":"K Jensen","year":"1986","unstructured":"Jensen K, Andersen HO, Olesen J, et al.: Pressure-pain threshold in human temporal region: evaluation of a new pressure algometer. Pain 1986, 25:313\u2013323.","journal-title":"Pain"},{"key":"21_CR48","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/0304-3959(95)00239-1","volume":"65","author":"L Bendtsen","year":"1996","unstructured":"Bendtsen L, Jensen R, Olesen J: Qualitatively altered nociception in chronic myofascial pain. Pain 1996, 65:259\u2013264.","journal-title":"Pain"},{"key":"21_CR49","doi-asserted-by":"crossref","unstructured":"Ashina S, Bendtsen L, Ashina M, et al.: Evidence for generalized muscular and cutaneous hyperalgesia in patients with chronic tension-type headache. Abstract presented at the 14th International Headache Research Seminar. Copenhagen: March 11\u201313, 2005.","DOI":"10.1093\/oso\/9780198569817.003.0020"},{"key":"21_CR50","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1152\/jn.1989.62.5.1028","volume":"62","author":"JC Willer","year":"1989","unstructured":"Willer JC, De Broucker T, Le Bars D: Encoding of nociceptive thermal stimuli by diffuse noxious inhibitory controls in humans. J Neurophysiol 1989, 62:1028\u20131038.","journal-title":"J Neurophysiol"},{"key":"21_CR51","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/S0165-0173(02)00186-8","volume":"40","author":"D Le Bars","year":"2002","unstructured":"Le Bars D: The whole body receptive field of dorsal horn multireceptive neurones. Brain Res Brain Res Rev 2002, 40:29\u201344.","journal-title":"Brain Res Brain Res Rev"},{"key":"21_CR52","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1001\/archneur.1993.00540100056015","volume":"50","author":"M Langemark","year":"1993","unstructured":"Langemark M, Bach FW, Jensen TS, et al.: Decreased nociceptive flexion reflex threshold in chronic tension-type headache. Arch Neurol 1993, 50:1061\u20131064.","journal-title":"Arch Neurol"},{"key":"21_CR53","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/0166-4328(96)00072-1","volume":"73","author":"J Sawynok","year":"1996","unstructured":"Sawynok J, Reid A: Interactions of descending serotonergic systems with other neurotransmitters in the modulation of nociception. Behav Brain Res 1996, 73:63\u201368.","journal-title":"Behav Brain Res"},{"key":"21_CR54","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1046\/j.1468-2982.1997.1708843.x","volume":"17","author":"L Bendtsen","year":"1997","unstructured":"Bendtsen L, Jensen R, Hindberg I, et al.: Serotonin metabolism in chronic tension-type headache. Cephalalgia 1997, 17:843\u2013848.","journal-title":"Cephalalgia"},{"key":"21_CR55","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1046\/j.1468-2982.1994.1405320.x","volume":"14","author":"L Edvinsson","year":"1994","unstructured":"Edvinsson L, Goadsby PJ: Neuropeptides in migraine and cluster headache. Cephalalgia 1994, 14:320\u2013327.","journal-title":"Cephalalgia"},{"key":"21_CR56","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/S0304-3959(99)00159-1","volume":"83","author":"M Ashina","year":"1999","unstructured":"Ashina M, Bendtsen L, Jensen R, et al.: Plasma levels of substance P, neuropeptide Y, and vasoactive intestinal polypeptide in patients with chronic tension-type headache. Pain 1999, 83:541\u2013547.","journal-title":"Pain"},{"key":"21_CR57","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/0143-4179(94)90053-1","volume":"27","author":"FW Bach","year":"1994","unstructured":"Bach FW, Langemark M, Ekman R, et al.: Effect of sulpiride or paroxetine on cerebrospinal fluid neuropeptide concentrations in patients with chronic tension-type headache. Neuropeptides 1994, 27:129\u2013136.","journal-title":"Neuropeptides"},{"key":"21_CR58","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1212\/WNL.55.9.1335","volume":"55","author":"M Ashina","year":"2000","unstructured":"Ashina M, Bendtsen L, Jensen R, et al.: Plasma levels of calcitonin gene-related peptide in chronic tension-type headache. Neurology 2000, 55:1335\u20131340.","journal-title":"Neurology"},{"key":"21_CR59","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/S0022-510X(98)00023-9","volume":"156","author":"Z Alam","year":"1998","unstructured":"Alam Z, Coombes N, Waring RH, et al.: Plasma levels of neuroexcitatory amino acids in patients with migraine or tension headache. J Neurol Sci 1998, 156:102\u2013106.","journal-title":"J Neurol Sci"},{"key":"21_CR60","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/S0022-510X(02)00035-7","volume":"198","author":"P Sarchielli","year":"2002","unstructured":"Sarchielli P, Alberti A, Floridi A, et al.: L-Arginine\/nitric oxide pathway in chronic tension-type headache: relation with serotonin content and secretion and glutamate content. J Neurol Sci 2002, 198:9\u201315.","journal-title":"J Neurol Sci"},{"key":"21_CR61","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/0304-3959(95)00020-S","volume":"63","author":"M Langemark","year":"1995","unstructured":"Langemark M, Bach FW, Ekman R, et al.: Increased cerebrospinal fluid Met-enkephalin immunoreactivity in patients with chronic tension-type headache. Pain 1995, 63:103\u2013107.","journal-title":"Pain"},{"key":"21_CR62","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1046\/j.1526-4610.1997.3709565.x","volume":"37","author":"G Mazzotta","year":"1997","unstructured":"Mazzotta G, Sarchielli P, Gaggioli A, et al.: Study of pressure pain and cellular concentration of neurotransmitters related to nociception in episodic tension-type headache patients. Headache 1997, 37:565\u2013571.","journal-title":"Headache"},{"key":"21_CR63","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1136\/jnnp.61.3.285","volume":"61","author":"L Bendtsen","year":"1996","unstructured":"Bendtsen L, Jensen R, Olesen J: A non-selective (amitriptyline), but not a selective (citalopram), serotonin reuptake inhibitor is effective in the prophylactic treatment of chronic tensiontype headache. J Neurol Neurosurg Psychiatry 1996, 61:285\u2013290.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"21_CR64","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.pain.2003.12.012","volume":"108","author":"S Ashina","year":"2004","unstructured":"Ashina S, Bendtsen L, Jensen R: Analgesic effect of amitriptyline in chronic tension-type headache is not directly related to serotonin reuptake inhibition. Pain 2004, 108:108\u2013114.","journal-title":"Pain"},{"key":"21_CR65","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/0924-980X(96)96532-7","volume":"101","author":"L Bendtsen","year":"1996","unstructured":"Bendtsen L, Jensen R, Olesen J: Amitriptyline, a combined serotonin and noradrenaline re-uptake inhibitor, reduces exteroceptive suppression of temporal muscle activity in patients with chronic tension-type headache. Electroencephalogr Clin Neurophysiol 1996, 101:418\u2013422.","journal-title":"Electroencephalogr Clin Neurophysiol"},{"key":"21_CR66","first-page":"21","volume":"26","author":"J Sawynok","year":"2001","unstructured":"Sawynok J, Esser MJ, Reid AR: Antidepressants as analgesics: an overview of central and peripheral mechanisms of action. J Psychiatry Neurosci 2001, 26:21\u201329.","journal-title":"J Psychiatry Neurosci"},{"key":"21_CR67","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/0028-3908(93)90173-Z","volume":"32","author":"Y Watanabe","year":"1993","unstructured":"Watanabe Y, Saito H, Abe K: Tricyclic antidepressants block NMDA receptor-mediated synaptic responses and induction of long-term potentiation in rat hippocampal slices. Neuropharmacology 1993, 32:479\u2013486.","journal-title":"Neuropharmacology"},{"key":"21_CR68","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1016\/j.tins.2003.09.017","volume":"26","author":"RR Ji","year":"2003","unstructured":"Ji RR, Kohno T, Moore KA, et al.: Central sensitization and LTP: Do pain and memory share similar mechanisms? Trends Neurosci 2003, 26:696\u2013705.","journal-title":"Trends Neurosci"},{"key":"21_CR69","first-page":"37","volume":"26","author":"P Blier","year":"2001","unstructured":"Blier P, Abbott FV: Putative mechanisms of action of antidepressant drugs in affective and anxiety disorders and pain. J Psychiatry Neurosci 2001, 26:37\u201343.","journal-title":"J Psychiatry Neurosci"},{"key":"21_CR70","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1046\/j.1468-2982.2000.00087.x","volume":"20","author":"L Bendtsen","year":"2000","unstructured":"Bendtsen L, Jensen R: Amitriptyline reduces myofascial tenderness in patients with chronic tension-type headache. Cephalalgia 2000, 20:603\u2013610.","journal-title":"Cephalalgia"},{"key":"21_CR71","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1212\/01.WNL.0000127282.90920.8C","volume":"62","author":"L Bendtsen","year":"2004","unstructured":"Bendtsen L, Jensen R: Mirtazapine is effective in the prophylactic treatment of chronic tension-type headache. Neurology 2004, 62:1706\u20131711.","journal-title":"Neurology"},{"key":"21_CR72","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/S0140-6736(98)01079-4","volume":"353","author":"M Ashina","year":"1999","unstructured":"Ashina M, Lassen LH, Bendtsen L, et al.: Effect of inhibition of nitric oxide synthase on chronic tension-type headache: a randomized, crossover trial. Lancet 1999, 353:287\u2013289. An important study demonstrating the antinociceptive effect of NOS inhibitor that counteracts central sensitization in CTTH.","journal-title":"Lancet"},{"key":"21_CR73","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1093\/brain\/122.9.1629","volume":"122","author":"M Ashina","year":"1999","unstructured":"Ashina M, Bendtsen L, Jensen R, et al.: Possible mechanisms of action of nitric oxide synthase inhibitors in chronic tensiontype headache. Brain 1999, 122:1629\u20131635.","journal-title":"Brain"},{"key":"21_CR74","doi-asserted-by":"publisher","first-page":"1830","DOI":"10.1093\/brain\/123.9.1830","volume":"123","author":"M Ashina","year":"2000","unstructured":"Ashina M, Bendtsen L, Jensen R, et al.: Nitric oxide-induced headache in patients with chronic tension-type headache. Brain 2000, 123:1830\u20131837.","journal-title":"Brain"},{"key":"21_CR75","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1111\/j.1468-2982.2004.00815.x","volume":"25","author":"A Makowska","year":"2005","unstructured":"Makowska A, Panfil C, Ellrich J: Long-term potentiation of orofacial sensorimotor processing by noxious input from the semispinal neck muscle in mice. Cephalalgia 2005, 25:109\u2013116.","journal-title":"Cephalalgia"}],"container-title":["Current Pain and Headache Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11916-005-0021-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11916-005-0021-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11916-005-0021-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11916-005-0021-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T19:05:39Z","timestamp":1707937539000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11916-005-0021-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12]]},"references-count":75,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["21"],"URL":"https:\/\/doi.org\/10.1007\/s11916-005-0021-8","relation":{},"ISSN":["1531-3433","1534-3081"],"issn-type":[{"value":"1531-3433","type":"print"},{"value":"1534-3081","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,12]]}}}