{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:23:18Z","timestamp":1791091398942,"version":"4.1.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2011,11,12]],"date-time":"2011-11-12T00:00:00Z","timestamp":1321056000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Curr Pain Headache Rep"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1007\/s11916-011-0231-1","type":"journal-article","created":{"date-parts":[[2011,11,11]],"date-time":"2011-11-11T04:29:39Z","timestamp":1320985779000},"page":"93-100","source":"Crossref","is-referenced-by-count":103,"title":["Cortical Excitability in Chronic Migraine"],"prefix":"10.1007","volume":"16","author":[{"given":"Gianluca","family":"Coppola","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Schoenen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,11,12]]},"reference":[{"issue":"6","key":"231_CR1","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1111\/j.1468-2982.2006.01172.x","volume":"26","author":"J Olesen","year":"2006","unstructured":"Olesen J, Bousser MG, Diener HC, et al. New appendix criteria open for a broader concept of chronic migraine. Cephalalgia. 2006;26(6):742\u20136.","journal-title":"Cephalalgia"},{"issue":"8","key":"231_CR2","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S1474-4422(04)00824-5","volume":"3","author":"HC Diener","year":"2004","unstructured":"Diener HC, Limmroth V. Medication-overuse headache: a worldwide problem. Lancet Neurol. 2004;3(8):475\u201383.","journal-title":"Lancet Neurol"},{"issue":"6","key":"231_CR3","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1111\/j.1468-2982.2005.00878.x","volume":"25","author":"SD Silberstein","year":"2005","unstructured":"Silberstein SD, Olesen J, Bousser MG, et al. International Headache Society: the International Classification of Headache Disorders, 2nd Edition (ICHD-II)\u2013revision of criteria for 8.2 Medication-overuse headache. Cephalalgia. 2005;25(6):460\u20135.","journal-title":"Cephalalgia"},{"issue":"2","key":"231_CR4","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1212\/WNL.54.2.314","volume":"54","author":"SJ Wang","year":"2000","unstructured":"Wang SJ, Fuh JL, Lu SR, et al. Chronic daily headache in Chinese elderly: prevalence, risk factors, and biannual follow-up. Neurology. 2000;54(2):314\u20139.","journal-title":"Neurology."},{"issue":"9","key":"231_CR5","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1111\/j.1526-4610.2006.00577.x","volume":"46","author":"ME Bigal","year":"2006","unstructured":"Bigal ME, Lipton RB. Modifiable risk factors for migraine progression. Headache. 2006;46(9):1334\u201343.","journal-title":"Headache"},{"issue":"12","key":"231_CR6","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1111\/j.1468-2982.2007.01500.x","volume":"27","author":"G Coppola","year":"2007","unstructured":"Coppola G, Pierelli F, Schoenen J. Is the cerebral cortex hyperexcitable or hyperresponsive in migraine? Cephalalgia. 2007;27(12):1427\u201339.","journal-title":"Cephalalgia"},{"issue":"6","key":"231_CR7","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.neucli.2003.10.009","volume":"33","author":"R Treede","year":"2003","unstructured":"Treede R, Lorenz J, Baumg\u00e4rtner U. Clinical usefulness of laser-evoked potentials. Neurophysiol Clin. 2003;33(6):303\u201314.","journal-title":"Neurophysiol Clin."},{"issue":"3","key":"231_CR8","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s10194-007-0385-8","volume":"8","author":"M Tommaso de","year":"2007","unstructured":"de Tommaso M, Difruscolo O, Sardaro M, et al. Effects of remote cutaneous pain on trigeminal laser-evoked potentials in migraine patients. J Headache Pain. 2007;8(3):167\u201374.","journal-title":"J Headache Pain"},{"issue":"1\u20132","key":"231_CR9","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0304-3959(02)00299-3","volume":"101","author":"M Tommaso de","year":"2003","unstructured":"de Tommaso M, Valeriani M, Guido M, et al. Abnormal brain processing of cutaneous pain in patients with chronic migraine. Pain. 2003;101(1\u20132):25\u201332.","journal-title":"Pain"},{"issue":"3","key":"231_CR10","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1111\/j.1526-4610.2007.00857.x","volume":"48","author":"M Tommaso de","year":"2008","unstructured":"de Tommaso M, Baumgartner U, Sardaro M, et al. Effects of distraction versus spatial discrimination on laser-evoked potentials in migraine. Headache. 2008;48(3):408\u201316.","journal-title":"Headache"},{"issue":"9","key":"231_CR11","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1111\/j.1526-4610.2005.00244.x","volume":"45","author":"M Tommaso de","year":"2005","unstructured":"de Tommaso M, Losito L, Difruscolo O, et al. Changes in cortical processing of pain in chronic migraine. Headache. 2005;45(9):1208\u201318.","journal-title":"Headache"},{"issue":"9","key":"231_CR12","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1111\/j.1468-2982.2006.01183.x","volume":"26","author":"I Ayzenberg","year":"2006","unstructured":"Ayzenberg I, Obermann M, Nyhuis P, et al. Central sensitization of the trigeminal and somatic nociceptive systems in medication overuse headache mainly involves cerebral supraspinal structures. Cephalalgia. 2006;26(9):1106\u201314.","journal-title":"Cephalalgia"},{"issue":"5","key":"231_CR13","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1037\/h0029810","volume":"77","author":"PM Groves","year":"1970","unstructured":"Groves PM, Thompson RF. Habituation: a dual-process theory. Psychol Rev. 1970;77(5):419\u201350.","journal-title":"Psychol Rev"},{"issue":"2","key":"231_CR14","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.nlm.2008.09.012","volume":"92","author":"CH Rankin","year":"2009","unstructured":"Rankin CH, Abrams T, Barry RJ, et al. Habituation revisited: an updated and revised description of the behavioral characteristics of habituation. Neurobiol Learn Mem. 2009;92(2):135\u20138.","journal-title":"Neurobiol Learn Mem"},{"issue":"3","key":"231_CR15","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1046\/j.1468-1331.2002.00387.x","volume":"9","author":"Y Ozkul","year":"2002","unstructured":"Ozkul Y, Uckardes A. Median nerve somatosensory evoked potentials in migraine. Eur J Neurol. 2002;9(3):227\u201332.","journal-title":"Eur J Neurol"},{"key":"231_CR16","doi-asserted-by":"crossref","unstructured":"\u2022\u2022 Coppola G, Curr\u00e0 A, Di Lorenzo C, et al: Abnormal cortical responses to somatosensory stimulation in medication-overuse headache. BMC Neurol 2010, 10:126. This study showed that the somatosensory cortex becomes persistently sensitized with medication overuse. The sensitization is obvious in patients overusing NSAIDs and almost nonexistent or masked in those who overuse only triptans.","DOI":"10.1186\/1471-2377-10-126"},{"issue":"1","key":"231_CR17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.1990.70.1.1","volume":"70","author":"N Birbaumer","year":"1990","unstructured":"Birbaumer N, Elbert T, Canavan AG, Rockstroh B. Slow potentials of the cerebral cortex and behavior. Physiol Rev. 1990;70(1):1\u201341.","journal-title":"Physiol Rev"},{"key":"231_CR18","doi-asserted-by":"crossref","unstructured":"Siniatchkin M, Gerber WD, Kropp P, Vein A: Contingent negative variation in patients with chronic daily headache. Cephalalgia 1998, 18(8):565\u20139; discussion 531.","DOI":"10.1046\/j.1468-2982.1998.1808565.x"},{"key":"231_CR19","doi-asserted-by":"crossref","unstructured":"\u2022\u2022 Chen WT, Wang SJ, Fuh JL, et al: Persistent ictal-like visual cortical excitability in chronic migraine. Pain. 2011, 152(2):254\u2013258. This study showed, for the first time, that the response pattern of the visual cortex in patients with CM is similar to that found during a common migraine attack in patients with episodic migraine.","DOI":"10.1016\/j.pain.2010.08.047"},{"issue":"Pt 8","key":"231_CR20","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1093\/brain\/awr157","volume":"134","author":"WT Chen","year":"2011","unstructured":"Chen WT, Lin YY, Fuh JL, et al. Sustained visual cortex hyperexcitability in migraine with persistent visual aura. Brain. 2011;134(Pt 8):2387\u201395.","journal-title":"Brain"},{"issue":"5","key":"231_CR21","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/j.1526-4610.2005.05108.x","volume":"45","author":"S Aurora","year":"2005","unstructured":"Aurora S, Barrodale P, Chronicle E, Mulleners W. Cortical inhibition is reduced in chronic and episodic migraine and demonstrates a spectrum of illness. Headache. 2005;45(5):546\u201352.","journal-title":"Headache."},{"issue":"7","key":"231_CR22","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1111\/j.1526-4610.2007.00853.x","volume":"47","author":"S Aurora","year":"2007","unstructured":"Aurora S, Barrodale P, Tipton R, Khodavirdi A. Brainstem dysfunction in chronic migraine as evidenced by neurophysiological and positron emission tomography studies. Headache. 2007;47(7):996\u20131003.","journal-title":"Headache."},{"issue":"1","key":"231_CR23","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jns.2004.08.008","volume":"227","author":"F Brighina","year":"2004","unstructured":"Brighina F, Piazza A, Vitello G, et al. rTMS of the prefrontal cortex in the treatment of chronic migraine: a pilot study. J Neurol Sci. 2004;227(1):67\u201371.","journal-title":"J Neurol Sci."},{"issue":"12","key":"231_CR24","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1177\/0333102411415877","volume":"31","author":"A Curr\u00e0","year":"2011","unstructured":"Curr\u00e0 A, Coppola G, Gorini M, et al. Drug-induced changes in cortical inhibition in medication overuse headache. Cephalalgia. 2011;31(12):1282\u201390.","journal-title":"Cephalalgia."},{"issue":"4","key":"231_CR25","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/(SICI)1097-4598(199704)20:4<418::AID-MUS3>3.0.CO;2-D","volume":"20","author":"G Cruccu","year":"1997","unstructured":"Cruccu G, Inghilleri M, Berardelli A, et al. Cortical mechanisms mediating the inhibitory period after magnetic stimulation of the facial motor area. Muscle Nerve. 1997;20(4):418\u201324.","journal-title":"Muscle Nerve"},{"issue":"5","key":"231_CR26","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s10194-008-0058-2","volume":"9","author":"A Panconesi","year":"2008","unstructured":"Panconesi A. Serotonin and migraine: a reconsideration of the central theory. J Headache Pain. 2008;9(5):267\u201376.","journal-title":"J Headache Pain"},{"issue":"3","key":"231_CR27","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1046\/j.1468-2982.1993.1303151.x","volume":"13","author":"MD Ferrari","year":"1993","unstructured":"Ferrari MD, Saxena PR. On serotonin and migraine: a clinical and pharmacological review. Cephalalgia. 1993;13(3):151\u201365.","journal-title":"Cephalalgia"},{"issue":"5","key":"231_CR28","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1046\/j.1468-2982.1999.019005485.x","volume":"19","author":"S Evers","year":"1999","unstructured":"Evers S, Quibeldey F, Grotemeyer KH, et al. Dynamic changes of cognitive habituation and serotonin metabolism during the migraine interval. Cephalalgia. 1999;19(5):485\u201391.","journal-title":"Cephalalgia"},{"issue":"7","key":"231_CR29","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/nm0795-658","volume":"1","author":"C Weiller","year":"1995","unstructured":"Weiller C, May A, Limmroth V, et al. Brain stem activation in spontaneous human migraine attacks. Nat Med. 1995;1(7):658\u201360.","journal-title":"Nat Med"},{"issue":"9261","key":"231_CR30","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/S0140-6736(00)04250-1","volume":"357","author":"A Bahra","year":"2001","unstructured":"Bahra A, Matharu MS, Buchel C, et al. Brainstem activation specific to migraine headache. Lancet. 2001;357(9261):1016\u20137.","journal-title":"Lancet"},{"issue":"Pt 1","key":"231_CR31","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1093\/brain\/awh022","volume":"127","author":"MS Matharu","year":"2004","unstructured":"Matharu MS, Bartsch T, Ward N, et al. Central neuromodulation in chronic migraine patients with suboccipital stimulators: a PET study. Brain. 2004;127(Pt 1):220\u201330.","journal-title":"Brain"},{"issue":"2","key":"231_CR32","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.pain.2010.12.002","volume":"152","author":"J Schoenen","year":"2011","unstructured":"Schoenen J. Is chronic migraine a never-ending migraine attack? Pain. 2011;152(2):239\u201340.","journal-title":"Pain"},{"issue":"6","key":"231_CR33","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/S1388-2457(00)00271-6","volume":"111","author":"J Afra","year":"2000","unstructured":"Afra J, Proietti Cecchini A, S\u00e1ndor PS, Schoenen J. Comparison of visual and auditory evoked cortical potentials in migraine patients between attacks. Clin Neurophysiol. 2000;111(6):1124\u20139.","journal-title":"Clin Neurophysiol"},{"issue":"Pt 8","key":"231_CR34","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1093\/brain\/123.8.1703","volume":"123","author":"R Burstein","year":"2000","unstructured":"Burstein R, Cutrer MF, Yarnitsky D. The development of cutaneous allodynia during a migraine attack clinical evidence for the sequential recruitment of spinal and supraspinal nociceptive neurons in migraine. Brain. 2000;123(Pt 8):1703\u20139.","journal-title":"Brain"},{"issue":"8","key":"231_CR35","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1212\/WNL.58.8.1234","volume":"58","author":"H Kaube","year":"2002","unstructured":"Kaube H, Katsarava Z, Przywara S, et al. Acute migraine headache: possible sensitization of neurons in the spinal trigeminal nucleus? Neurology. 2002;58(8):1234\u20138.","journal-title":"Neurology"},{"issue":"2","key":"231_CR36","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/j.1526-4610.2007.00998.x","volume":"48","author":"C Lovati","year":"2008","unstructured":"Lovati C, D'Amico D, Bertora P, et al. Acute and interictal allodynia in patients with different headache forms: an Italian pilot study. Headache. 2008;48(2):272\u20137.","journal-title":"Headache"},{"issue":"17","key":"231_CR37","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1212\/01.wnl.0000310645.31020.b1","volume":"70","author":"ME Bigal","year":"2008","unstructured":"Bigal ME, Ashina S, Burstein R, et al. Prevalence and characteristics of allodynia in headache sufferers: a population study. Neurology. 2008;70(17):1525\u201333.","journal-title":"Neurology"},{"key":"231_CR38","doi-asserted-by":"crossref","first-page":"S182","DOI":"10.1111\/j.1526-4610.2006.00602.x","volume":"4","author":"D Dodick","year":"2006","unstructured":"Dodick D, Silberstein S. Central sensitization theory of migraine: clinical implications. Headache. 2006;4:S182\u201391.","journal-title":"Headache."},{"issue":"9","key":"231_CR39","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1212\/01.wnl.0000183067.94400.80","volume":"65","author":"T Schmidt-Wilcke","year":"2005","unstructured":"Schmidt-Wilcke T, Leinisch E, Straube A, et al. Gray matter decrease in patients with chronic tension type headache. Neurology. 2005;65(9):1483\u20136.","journal-title":"Neurology"},{"issue":"Pt 2","key":"231_CR40","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1093\/brain\/awh691","volume":"129","author":"A Fumal","year":"2006","unstructured":"Fumal A, Laureys S, Di Clemente L, et al. Orbitofrontal cortex involvement in chronic analgesic-overuse headache evolving from episodic migraine. Brain. 2006;129(Pt 2):543\u201350.","journal-title":"Brain"},{"issue":"5","key":"231_CR41","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1523\/JNEUROSCI.06-05-01433.1986","volume":"6","author":"CJ Woolf","year":"1986","unstructured":"Woolf CJ, Wall PD. Relative effectiveness of C primary afferent fibers of different origins in evoking a prolonged facilitation of the flexor reflex in the rat. J Neurosci. 1986;6(5):1433\u201342.","journal-title":"J Neurosci"},{"issue":"1","key":"231_CR42","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1037\/h0022681","volume":"73","author":"RF Thompson","year":"1966","unstructured":"Thompson RF, Spencer WA. Habituation: a model phenomenon for the study of neuronal substrates of behavior. Psychol Rev. 1966;73(1):16\u201343.","journal-title":"Psychol Rev"},{"issue":"7","key":"231_CR43","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1212\/WNL.59.7.1011","volume":"59","author":"V Limmroth","year":"2002","unstructured":"Limmroth V, Katsarava Z, Fritsche G, et al. Features of medication overuse headache following overuse of different acute headache drugs. Neurology. 2002;59(7):1011\u20134.","journal-title":"Neurology"},{"issue":"Pt 8","key":"231_CR44","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1093\/brain\/awq159","volume":"133","author":"M Felice De","year":"2010","unstructured":"De Felice M, Ossipov MH, Wang R, et al. Triptan-induced enhancement of neuronal nitric oxide synthase in trigeminal ganglion dural afferents underlies increased responsiveness to potential migraine triggers. Brain. 2010;133(Pt 8):2475\u201388.","journal-title":"Brain"},{"issue":"9","key":"231_CR45","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1212\/WNL.57.9.1694","volume":"57","author":"Z Katsarava","year":"2001","unstructured":"Katsarava Z, Fritsche G, Muessig M, et al. Clinical features of withdrawal headache following overuse of triptans and other headache drugs. Neurology. 2001;57(9):1694\u20138.","journal-title":"Neurology"},{"issue":"1\u20132","key":"231_CR46","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.pain.2009.03.010","volume":"145","author":"A Stankewitz","year":"2009","unstructured":"Stankewitz A, May A. The phenomenon of changes in cortical excitability in migraine is not migraine-specific\u2013a unifying thesis. Pain. 2009;145(1\u20132):14\u20137.","journal-title":"Pain."}],"container-title":["Current Pain and Headache Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11916-011-0231-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11916-011-0231-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11916-011-0231-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T11:25:49Z","timestamp":1560943549000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11916-011-0231-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,12]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["231"],"URL":"https:\/\/doi.org\/10.1007\/s11916-011-0231-1","relation":{},"ISSN":["1531-3433","1534-3081"],"issn-type":[{"value":"1531-3433","type":"print"},{"value":"1534-3081","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,12]]}}}