{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:47:53Z","timestamp":1762102073467},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Curr Pain Headache Rep"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1007\/s11916-017-0638-4","type":"journal-article","created":{"date-parts":[[2017,8,4]],"date-time":"2017-08-04T03:37:04Z","timestamp":1501817824000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["New Developments in the Prophylactic Drug Treatment of Pediatric Migraine: What Is New in 2017 and Where Does It Leave Us?"],"prefix":"10.1007","volume":"21","author":[{"given":"Joanne","family":"Kacperski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allyson","family":"Bazarsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,8,4]]},"reference":[{"key":"638_CR1","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1136\/bmj.309.6957.765","volume":"309","author":"I Abu-Arafeh","year":"1994","unstructured":"Abu-Arafeh I, Russell G. Prevalence of headache and migraine in schoolchildren. Br Med J. 1994;309:765\u20139. doi:\n10.1136\/bmj.309.6957.765\n\n.","journal-title":"Br Med J"},{"key":"638_CR2","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1046\/j.1526-4610.1999.3907494.x","volume":"39","author":"W Split","year":"1999","unstructured":"Split W, Neuman W. Epidemiology of migraine among students from randomly selected secondary schools in Lodz. Headache. 1999;39:494\u2013501. doi:\n10.1046\/j.1526-4610.1999.3907494.x\n\n.","journal-title":"Headache"},{"issue":"5","key":"638_CR3","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1111\/head.12105","volume":"53","author":"AD Hershey","year":"2013","unstructured":"\u2022 Hershey AD, Powers SW, Coffey CS, Eklund DD, Chamberlin LA, Korbee LL, et al. Childhood and Adolescent Migraine Prevention (CHAMP) study: a double-blinded, placebo-controlled, comparative effectiveness study of amitriptyline, topiramate, and placebo in the prevention of childhood and adolescent migraine. Headache. 2013;53(5):799\u2013816. doi:\n10.1111\/head.12105\n\n. The authors discuss the goals of CHAMP study in detail including its study design aimed to obtain level 1 evidence for the effectiveness of amitriptyline and topiramate in the prevention of migraine in children and adolescents and to provide information to the practicing physician as how to best prevent migraine in children and adolescents and subsequently improve the disability and outcomes. The study population is described in detail.","journal-title":"Headache"},{"key":"638_CR4","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1097\/MOP.0b013e3282f1a07f","volume":"19","author":"AD Hershey","year":"2007","unstructured":"Hershey AD, Winner P, Kabbouche MA, Powers SA. Headaches. Curr Opin Pediatr. 2007;19:663\u20139. doi:\n10.1097\/MOP.0b013e3282f1a07f\n\n.","journal-title":"Curr Opin Pediatr"},{"key":"638_CR5","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.spen.2010.10.004","volume":"17","author":"KS Lewis","year":"2010","unstructured":"Lewis KS. Pediatric headache. Semin Pediatr Neurol. 2010;17:224\u20139. doi:\n10.1016\/j.spen.2010.10.004\n\n.","journal-title":"Semin Pediatr Neurol"},{"key":"638_CR6","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1111\/j.1468-2982.2004.00652.x","volume":"24","author":"SW Powers","year":"2004","unstructured":"Powers SW, Patton SR, Hommel KA, Hershey AD. Quality of life in pediatric migraine: characterization of age-related effects using Peds QL 4.0. Cephalalgia. 2004;24:120. doi:\n10.1111\/j.1468-2982.2004.00652.x\n\n.","journal-title":"Cephalalgia"},{"key":"638_CR7","volume-title":"Wolff\u2019s headache and other headache pain","year":"2001","unstructured":"Silberstein SD, Lipton RB, Dalessio DJ, editors. Wolff\u2019s headache and other headache pain. 7th ed. Oxford: Oxford University Press; 2001.","edition":"7"},{"issue":"4","key":"638_CR8","doi-asserted-by":"publisher","first-page":"385","DOI":"10.2217\/fnl.12.32","volume":"7","author":"J Kacperski","year":"2012","unstructured":"Kacperski J, O\u2019Brien HL. Triptan use in pediatric migraine: focus on rizatriptan. Futures Neurol. 2012;7(4):385\u201394. doi:\n10.2217\/fnl.12.32\n\n.","journal-title":"Futures Neurol"},{"key":"638_CR9","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.1111\/j.1526-4610.2006.00577.x","volume":"46","author":"ME Bigal","year":"2006","unstructured":"Bigal ME, Lipton RB. Modifiable risk factors for migraine progression. Headache. 2006;46:1334\u201343. doi:\n10.1111\/j.1526-4610.2006.00577.x\n\n.","journal-title":"Headache"},{"issue":"4","key":"638_CR10","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1056\/NEJMra010917","volume":"346","author":"PJ Goadsby","year":"2002","unstructured":"Goadsby PJ, Lipton RB, Ferrari MD. Migraine\u2014current understanding and treatment. NEJM. 2002;346(4):257\u201370. doi:\n10.1056\/NEJMra010917\n\n.","journal-title":"NEJM"},{"issue":"12","key":"638_CR11","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1111\/j.1469-8749.2010.03793.x","volume":"52","author":"I Abu-Arafeh","year":"2010","unstructured":"Abu-Arafeh I, Razak S, Sivaraman B, Graham C. Prevalence of headache and migraine in children and adolescents: a systematic review of population-based studies. Dev Med Child Neurol. 2010;52(12):1088\u201397. doi:\n10.1111\/j.1469-8749.2010.03793.x\n\n.","journal-title":"Dev Med Child Neurol"},{"issue":"3","key":"638_CR12","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1097\/WCO.0b013e3282fe205b","volume":"21","author":"P Winner","year":"2008","unstructured":"Winner P. Pediatric headache. Curr Opin Neurol. 2008;21(3):316\u201322. doi:\n10.1097\/WCO.0b013e3282fe205b\n\n.","journal-title":"Curr Opin Neurol"},{"issue":"7","key":"638_CR13","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1517\/14656566.2012.677434","volume":"13","author":"HL O\u2019Brien","year":"2012","unstructured":"O\u2019Brien HL, Kabbouche MA, Hershey AD. Treating pediatric migraine: an expert opinion. Expert Opin Pharmacother. 2012;13(7):959\u201366. doi:\n10.1517\/14656566.2012.677434\n\n.","journal-title":"Expert Opin Pharmacother"},{"key":"638_CR14","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1111\/head.12858","volume":"56","author":"TE Markus","year":"2016","unstructured":"Markus TE, Moad B, Haimi-Cohen Y, Zeharia A. Factors influencing response to pharmacologic treatment of migraine in a pediatric headache clinic. Headache. 2016;56:1120\u201331. doi:\n10.1111\/head.12858\n\n.","journal-title":"Headache"},{"key":"638_CR15","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s10194-010-0256-6","volume":"12","author":"C Termine","year":"2011","unstructured":"Termine C, Ozge A, Antonacci F, Natriashvili S, Guidetti V, Wober-Bingol C. Overview of diagnosis and management of pediatric headache. Part II: therapeutic management. J Headache Pain. 2011;12:25\u201334. doi:\n10.1007\/s10194-010-0256-6\n\n.","journal-title":"J Headache Pain"},{"issue":"4","key":"638_CR16","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1097\/01.nrl.0000219666.65101.a9","volume":"12","author":"ME Bigal","year":"2006","unstructured":"Bigal ME, Lipton RB. The preventative treatment of migraine. Neurologist. 2006;12(4):204\u201313. doi:\n10.1097\/01.nrl.0000219666.65101.a9\n\n.","journal-title":"Neurologist"},{"issue":"2","key":"638_CR17","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1056\/NEJMoa1610384","volume":"376","author":"SW Powers","year":"2017","unstructured":"\u2022\u2022 Powers SW, Coffey CS, Chamberlin LA, Ecklund DJ, Klingner EA, Yankey JW, et al. Trial of amitriptyline, topiramate, and placebo for pediatric migraine. N Engl J Med. 2017;376(2):115\u201324. doi:\n10.1056\/NEJMoa1610384\n\n. One of the largest NIH-funded pediatric studies in the US, the CHAMP study demonstrated that there were no significant differences in reduction in headache frequency or headache-related disability in childhood and adolescent migraine with amitriptyline, topiramate, or placebo over a period of 24 weeks. In addition, the active drugs were associated with higher rates of adverse events.","journal-title":"N Engl J Med"},{"key":"638_CR18","doi-asserted-by":"publisher","unstructured":"\u2022 Powers SW, Hershey AD, Coffey CS, Chamberlin LA, Ecklund D, Sullivan SM, et al. The Childhood and Adolescent Migraine Prevention (CHAMP) study: a report on baseline characteristics of participants. Headache. 2016;56:859\u201370. doi:\n10.1111\/head.12810\n\n. Outlines the characteristics of the participants in CHAMP and highlights the importance of recruiting a population representive of those children suffering with chronic and episodic migraines.","DOI":"10.1111\/head.12810"},{"key":"638_CR19","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.1212\/01.WNL.0000147332.41993.90","volume":"63","author":"D Lewis","year":"2004","unstructured":"Lewis D, Ashwal S, Hershey A, Hirtz D, Yonker M, Silberstein S. Practice parameter: pharmacological treatment of migraine headache in children and adolescents: report of the American Academy of Neurology Quality Standards Subcommittee and the Practice Committee of the Child Neurology Society. Neurology. 2004;63:2215\u201324. doi:\n10.1212\/01.WNL.0000147332.41993.90\n\n.","journal-title":"Neurology"},{"key":"638_CR20","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/S1474-4422(09)70303-5","volume":"9","author":"AD Hershey","year":"2010","unstructured":"Hershey AD. Current approaches to the diagnosis and management of pediatric migraine. Lancet Neurol. 2010;9:190\u2013204. doi:\n10.1016\/S1474-4422(09)70303-5\n\n.","journal-title":"Lancet Neurol"},{"key":"638_CR21","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1212\/WNL.26.2.121","volume":"26","author":"JR Couch","year":"1976","unstructured":"Couch JR, Ziegler DK, Hassanein R. Amitriptyline in the prophylaxis of migraine. Effectiveness and relationship of antimigraine and antidepressant effects. Neurology. 1976;26:121\u20137.","journal-title":"Neurology"},{"key":"638_CR22","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1001\/archneur.1979.00500470065013","volume":"36","author":"JR Couch","year":"1979","unstructured":"Couch JR, Hassanein RS. Amitriptyline in migraine prophylaxis. Arch Neurol. 1979;36:695\u20139. doi:\n10.1001\/archneur.1979.00500470065013\n\n.","journal-title":"Arch Neurol"},{"key":"638_CR23","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1046\/j.1526-4610.2000.00085.x","volume":"40","author":"AD Hershey","year":"2000","unstructured":"Hershey AD, Powers SW, Bentti AL, DeGrauw TJ. Effectiveness of amitriptyline in the prophylactic management of childhood headaches. Headache. 2000;40:539\u201349. doi:\n10.1046\/j.1526-4610.2000.00085.x\n\n.","journal-title":"Headache"},{"key":"638_CR24","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1111\/j.1526-4610.2004.04052.x","volume":"44","author":"DW Lewis","year":"2004","unstructured":"Lewis DW, Diamond S, Scott D, Jones V. Prophylactic treatment of pediatric migraine. Headache. 2004;44:230\u20137. doi:\n10.1111\/j.1526-4610.2004.04052.x\n\n.","journal-title":"Headache"},{"key":"638_CR25","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1046\/j.1526-4610.2001.01190.x","volume":"41","author":"JR Storey","year":"2001","unstructured":"Storey JR, Calder CS, Hart DE, Potter DL. Topiramate in migraine prevention: a double-blind, placebo-controlled study. Headache. 2001;41:968\u201375. doi:\n10.1046\/j.1526-4610.2001.01190.x\n\n.","journal-title":"Headache"},{"issue":"5","key":"638_CR26","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1177\/1060028014521128","volume":"48","author":"TL Deaton","year":"2014","unstructured":"Deaton TL, Mauro LS. Topiramate for migraine prophylaxis in pediatric patients. Ann Pharmacother. 2014;48(5):638\u201343. doi:\n10.1177\/1060028014521128\n\n.","journal-title":"Ann Pharmacother"},{"issue":"10","key":"638_CR27","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1111\/j.1526-4610.2005.00262.x","volume":"45","author":"P Winner","year":"2005","unstructured":"Winner P, Pearlman EM, Linder SL, Jordan DM, Fisher AC, Hulihan J. Topiramate for migraine prevention in children: a randomized, double-blind, placebo-controlled trial. Headache. 2005;45(10):1304\u201312. doi:\n10.1111\/j.1526-4610.2005.00262.x\n\n.","journal-title":"Headache"},{"issue":"Suppl 1","key":"638_CR28","first-page":"9","volume":"24","author":"Headache Classification Subcommittee of the International Headache Society","year":"2004","unstructured":"Headache Classification Subcommittee of the International Headache Society. The international classification of headache disorders. 2nd ed. Cephalalgia. 2004;24(Suppl 1):9\u2013160.","journal-title":"Cephalalgia"},{"issue":"11","key":"638_CR29","doi-asserted-by":"publisher","first-page":"2034","DOI":"10.1212\/WNL.57.11.2034","volume":"57","author":"AD Hershey","year":"2001","unstructured":"Hershey AD, Powers SW, Vockell AL, LeCates S, Kabbouche MA, Maynard MK. PedMIDAS: development of a questionnaire to assess disability of migraines in children. Neurology. 2001;57(11):2034\u20139. doi:\n10.1212\/WNL.57.11.2034\n\n.","journal-title":"Neurology"},{"key":"638_CR30","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1111\/j.1468-2982.2008.01752.x","volume":"29","author":"S Evers","year":"2009","unstructured":"Evers S, Marziniak M, Frese A, Gralow I. Placebo efficacy in childhood and adolescence migraine: an analysis of double blind and placebo-controlled studies. Cephalalgia. 2009;29:436\u201344. doi:\n10.1111\/j.1468-2982.2008.01752.x\n\n.","journal-title":"Cephalalgia"},{"key":"638_CR31","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/j.jpeds.2014.06.040","volume":"165","author":"V Faria","year":"2014","unstructured":"Faria V, Linnman C, Lebel A, Borsook D. Harnessing the placebo effect in pediatric migraine clinic. J Pediatr. 2014;165:659\u201365. doi:\n10.1016\/j.jpeds.2014.06.040\n\n.","journal-title":"J Pediatr"},{"key":"638_CR32","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/S0304-3959(01)00296-2","volume":"93","author":"A Pollo","year":"2001","unstructured":"Pollo A, Amanzio M, Arslanian A, Casadio C, Maggi G, Benedetti F. Response expectancies in placebo analgesia and their clinical relevance. Pain. 2001;93:77\u201384. doi:\n10.1016\/S0304-3959(01)00296-2\n\n.","journal-title":"Pain"},{"key":"638_CR33","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.euroneuro.2008.03.002","volume":"18","author":"V Faria","year":"2008","unstructured":"Faria V, Fredrikson M, Furmark T. Imaging the placebo response: a neurofunctional review. Eur Neuropsychopharmacol. 2008;18:473\u201385. doi:\n10.1016\/j.euroneuro.2008.03.002\n\n.","journal-title":"Eur Neuropsychopharmacol"},{"issue":"2","key":"638_CR34","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1111\/head.13025","volume":"57","author":"SW Powers","year":"2017","unstructured":"\u2022 Powers SW, Hershey AD, Coffey CS. The Childhood and Adolescent Migraine Prevention (CHAMP) study: \u201cWhat do we do now?\u201d. Headache. 2017;57(2):180\u20133. doi:\n10.1111\/head.13025\n\n. Briefly and succinctly discussed the implications of the CHAMP study and discusses directions for future research.","journal-title":"Headache"},{"key":"638_CR35","doi-asserted-by":"publisher","first-page":"2616","DOI":"10.1097\/j.pain.0000000000000333","volume":"156","author":"AH Tuttle","year":"2015","unstructured":"Tuttle AH, Tohyama S, Ramsay T, et al. Increasing placebo responses over time in U.S. clinical trials of neuropathic pain. Pain. 2015;156:2616\u201326. doi:\n10.1097\/j.pain.0000000000000333\n\n.","journal-title":"Pain"}],"container-title":["Current Pain and Headache Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11916-017-0638-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11916-017-0638-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11916-017-0638-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,9]],"date-time":"2017-08-09T05:18:38Z","timestamp":1502255918000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11916-017-0638-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":35,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["638"],"URL":"https:\/\/doi.org\/10.1007\/s11916-017-0638-4","relation":{},"ISSN":["1531-3433","1534-3081"],"issn-type":[{"value":"1531-3433","type":"print"},{"value":"1534-3081","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8]]},"article-number":"38"}}