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Recent animal models are starting to elucidate these mechanisms, but effective treatment will also likely rely on the identification of patients who are most at risk for persistent PTH. Trials of early, targeted therapy for at-risk patients will be needed to validate these hypotheses. Additionally, high powered clinical trials are lacking in the field of persistent PTH for medications that are known to be effective in primary headache disorders. Effective treatment for persistent PTH also requires understanding how headache interacts with the complex nature of persistent post-concussion symptoms, as this disease often necessitates a multi-disciplinary approach. Regardless, with the knowledge gained by new PTH models cited in this paper, and an increasing availability of novel headache medications, more effective treatment models are on the horizon.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s11916-021-00970-3","type":"journal-article","created":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T10:02:58Z","timestamp":1623664978000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Models for Treating Post-traumatic Headache"],"prefix":"10.1007","volume":"25","author":[{"given":"Joshua","family":"Kamins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,14]]},"reference":[{"key":"970_CR1","doi-asserted-by":"publisher","unstructured":"Lucas S, Hoffman JM, Bell KR, Dikmen S. 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