{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T20:23:45Z","timestamp":1769545425464,"version":"3.49.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Curr Pain Headache Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11916-026-01465-9","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T06:34:24Z","timestamp":1769495664000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pain-Related Social and Behavioral Changes: a Complex Interplay"],"prefix":"10.1007","volume":"30","author":[{"given":"Alaa","family":"Abd-Elsayed","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neha","family":"Pawar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamal","family":"Hasoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Pritzlaff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wael","family":"Saasouh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuliano Lo","family":"Bianco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,1,27]]},"reference":[{"key":"1465_CR1","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1002\/j.0022-0337.2001.65.12.tb03497.x","volume":"65","author":"R Melzack","year":"2001","unstructured":"Melzack R. Pain and the neuromatrix in the brain. J Dent Educ. 2001;65:1378\u201382.","journal-title":"J Dent Educ"},{"key":"1465_CR2","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1007\/s40122-020-00208-y","volume":"9","author":"C De Felice","year":"2020","unstructured":"De Felice C, Bonezzi C. Not all pain is created equal: basic definitions and diagnostic work-up. Pain Ther. 2020;9:657\u201369. https:\/\/doi.org\/10.1007\/s40122-020-00208-y.","journal-title":"Pain Ther"},{"key":"1465_CR3","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/nrn3231","volume":"13","author":"NI Eisenberger","year":"2012","unstructured":"Eisenberger NI. The pain of social disconnection: examining the shared neural underpinnings of physical and social pain. Nat Rev Neurosci. 2012;13:421\u201334. https:\/\/doi.org\/10.1038\/nrn3231.","journal-title":"Nat Rev Neurosci"},{"key":"1465_CR4","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1037\/0033-2909.125.3.356","volume":"125","author":"C Eccleston","year":"1999","unstructured":"Eccleston C, Crombez G. Pain demands attention: a cognitive-affective model. Psychol Bull. 1999;125:356\u201366. https:\/\/doi.org\/10.1037\/0033-2909.125.3.356.","journal-title":"Psychol Bull"},{"issue":"7","key":"1465_CR5","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1097\/j.pain.0000000000003515","volume":"166","author":"SN Garfinkel","year":"2025","unstructured":"Garfinkel SN, Eccleston C. Interoception and pain: body\u2013mind integration, rupture, and repair. Pain. 2025;166(7):1470\u20134. https:\/\/doi.org\/10.1097\/j.pain.0000000000003515.","journal-title":"Pain"},{"key":"1465_CR6","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1111\/papr.13260","volume":"23","author":"AM Gonz\u00e1lez-Rold\u00e1n","year":"2023","unstructured":"Gonz\u00e1lez-Rold\u00e1n AM, Bustan S, Kamping S, Flor H, Anton F. Pain and related suffering reduce attention toward others. Pain Pract. 2023;23:873\u201385. https:\/\/doi.org\/10.1111\/papr.13260.","journal-title":"Pain Pract"},{"key":"1465_CR7","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1027\/2151-2604\/a000279","volume":"41","author":"MLR Brunner","year":"2017","unstructured":"Brunner MLR. Assessing suffering in experimental pain models. Appl Psychol Meas. 2017;41:114\u201328. https:\/\/doi.org\/10.1027\/2151-2604\/a000279.","journal-title":"Appl Psychol Meas"},{"key":"1465_CR8","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.genhosppsych.2021.01.009","volume":"69","author":"S Bannon","year":"2021","unstructured":"Bannon S, Greenberg J, Mace RA, Locascio JJ, Vranceanu AM. The role of social isolation in physical and emotional outcomes among patients with chronic pain. Gen Hosp Psychiatry. 2021;69:50\u20134. https:\/\/doi.org\/10.1016\/j.genhosppsych.2021.01.009.","journal-title":"Gen Hosp Psychiatry"},{"key":"1465_CR9","doi-asserted-by":"publisher","first-page":"2745","DOI":"10.3390\/biomedicines10112745","volume":"10","author":"JA Lee","year":"2022","unstructured":"Lee JA, Chen Q, Zhuo M. Synaptic plasticity in the pain-related cingulate and insular cortex. Biomedicines. 2022;10:2745. https:\/\/doi.org\/10.3390\/biomedicines10112745.","journal-title":"Biomedicines"},{"key":"1465_CR10","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2013.0146","volume":"369","author":"M Zhuo","year":"2014","unstructured":"Zhuo M. Long-term potentiation in the anterior cingulate cortex and chronic pain. Philos Trans R Soc Lond B Biol Sci. 2014;369:20130146. https:\/\/doi.org\/10.1098\/rstb.2013.0146.","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"1465_CR11","doi-asserted-by":"publisher","first-page":"2097","DOI":"10.1016\/j.pain.2012.06.031","volume":"153","author":"CS Chiou","year":"2012","unstructured":"Chiou CS, Huang CC, Liang YC, Tsai YC, Hsu KS. Impairment of long-term depression in the anterior cingulate cortex of mice with bone cancer pain. Pain. 2012;153:2097\u2013108. https:\/\/doi.org\/10.1016\/j.pain.2012.06.031.","journal-title":"Pain"},{"key":"1465_CR12","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1038\/nrn2333","volume":"9","author":"S Leknes","year":"2008","unstructured":"Leknes S, Tracey I. A common neurobiology for pain and pleasure. Nat Rev Neurosci. 2008;9:314\u201320. https:\/\/doi.org\/10.1038\/nrn2333.","journal-title":"Nat Rev Neurosci"},{"key":"1465_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2020.108052","volume":"170","author":"V Neugebauer","year":"2020","unstructured":"Neugebauer V, Mazzitelli M, Cragg B, Ji G, Navratilova E, Porreca F. Amygdala, neuropeptides, and chronic pain-related affective behaviors. Neuropharmacology. 2020;170:108052. https:\/\/doi.org\/10.1016\/j.neuropharm.2020.108052.","journal-title":"Neuropharmacology"},{"key":"1465_CR14","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.jpain.2022.08.010","volume":"24","author":"RR Edwards","year":"2023","unstructured":"Edwards RR, Schreiber KL, Dworkin RH, et al. Optimizing and accelerating the development of precision pain treatments for chronic pain: IMMPACT review and recommendations. J Pain. 2023;24:204\u201325. https:\/\/doi.org\/10.1016\/j.jpain.2022.08.010.","journal-title":"J Pain"},{"key":"1465_CR15","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci13050776","volume":"13","author":"M Pagliusi Jr","year":"2023","unstructured":"Pagliusi M Jr, Gomes FV. The role of the rostral ventromedial medulla in stress responses. Brain Sci. 2023;13:776. https:\/\/doi.org\/10.3390\/brainsci13050776.","journal-title":"Brain Sci"},{"key":"1465_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0304-3959(03)00132-5","volume":"103","author":"KA Greenwood","year":"2003","unstructured":"Greenwood KA, Thurston R, Rumble M, Waters SJ, Keefe FJ. Anger and persistent pain: current status and future directions. Pain. 2003;103:1\u20135. https:\/\/doi.org\/10.1016\/S0304-3959(03)00132-5.","journal-title":"Pain"},{"key":"1465_CR17","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsad001","volume":"18","author":"Y Wang","year":"2023","unstructured":"Wang Y, Li L, Cai J, Li H, Wang C. Incidental physical pain reduces brain activities associated with affective social feedback and increases aggression. Soc Cogn Affect Neurosci. 2023;18:nsad001. https:\/\/doi.org\/10.1093\/scan\/nsad001.","journal-title":"Soc Cogn Affect Neurosci"},{"key":"1465_CR18","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.rehab.2016.01.009","volume":"59","author":"C Palazzo","year":"2016","unstructured":"Palazzo C, Klinger E, Dorner V, et al. Barriers to home-based exercise program adherence with chronic low back pain: patient expectations regarding new technologies. Ann Phys Rehabil Med. 2016;59:107\u201313. https:\/\/doi.org\/10.1016\/j.rehab.2016.01.009.","journal-title":"Ann Phys Rehabil Med"},{"key":"1465_CR19","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1046\/j.1460-9568.2003.02627.x","volume":"17","author":"CR Monassi","year":"2003","unstructured":"Monassi CR, Bandler R, Keay KA. A subpopulation of rats show social and sleep-waking changes typical of chronic neuropathic pain following peripheral nerve injury. Eur J Neurosci. 2003;17:1907\u201320. https:\/\/doi.org\/10.1046\/j.1460-9568.2003.02627.x.","journal-title":"Eur J Neurosci"},{"key":"1465_CR20","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/j.neuropharm.2013.10.023","volume":"77","author":"A Bilkei-Gorzo","year":"2014","unstructured":"Bilkei-Gorzo A, Mauer D, Michel K, Zimmer A. Dynorphins regulate the strength of social memory. Neuropharmacology. 2014;77:406\u201313. https:\/\/doi.org\/10.1016\/j.neuropharm.2013.10.023.","journal-title":"Neuropharmacology"},{"key":"1465_CR21","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1001\/jamainternmed.2017.1622","volume":"177","author":"EL Whitlock","year":"2017","unstructured":"Whitlock EL, Diaz-Ramirez LG, Glymour MM, Boscardin WJ, Covinsky KE, Smith AK. Association between persistent pain and memory decline and dementia in a longitudinal cohort of elders. JAMA Intern Med. 2017;177:1146\u201353. https:\/\/doi.org\/10.1001\/jamainternmed.2017.1622.","journal-title":"JAMA Intern Med"},{"key":"1465_CR22","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.jpain.2007.12.002","volume":"9","author":"AE L\u00f3pez-Mart\u00ednez","year":"2008","unstructured":"L\u00f3pez-Mart\u00ednez AE, Esteve-Zarazaga R, Ram\u00edrez-Maestre C. Perceived social support and coping responses are independent variables explaining pain adjustment among chronic pain patients. J Pain. 2008;9:373\u20139. https:\/\/doi.org\/10.1016\/j.jpain.2007.12.002.","journal-title":"J Pain"},{"key":"1465_CR23","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/0304-3959(87)91037-2","volume":"29","author":"KM Gil","year":"1987","unstructured":"Gil KM, Keefe FJ, Crisson JE, Van Dalfsen PJ. Social support and pain behavior. Pain. 1987;29:209\u201317. https:\/\/doi.org\/10.1016\/0304-3959(87)91037-2.","journal-title":"Pain"},{"key":"1465_CR24","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1097\/00002508-200103000-00008","volume":"17","author":"MJ Sullivan","year":"2001","unstructured":"Sullivan MJ, Thorn B, Haythornthwaite JA, et al. Theoretical perspectives on the relation between catastrophizing and pain. Clin J Pain. 2001;17:52\u201364. https:\/\/doi.org\/10.1097\/00002508-200103000-00008.","journal-title":"Clin J Pain"},{"key":"1465_CR25","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.pain.2003.11.003","volume":"107","author":"MJL Sullivan","year":"2004","unstructured":"Sullivan MJL, Adams H, Sullivan ME. Communicative dimensions of pain catastrophizing: social cueing effects on pain behaviour and coping. Pain. 2004;107:220\u20136. https:\/\/doi.org\/10.1016\/j.pain.2003.11.003.","journal-title":"Pain"},{"key":"1465_CR26","doi-asserted-by":"publisher","first-page":"1885","DOI":"10.1007\/s11136-018-1842-3","volume":"27","author":"RD Hays","year":"2018","unstructured":"Hays RD, Spritzer KL, Schalet BD, Cella D. PROMIS-29 v2.0 profile physical and mental health summary scores. Qual Life Res. 2018;27:1885\u201391. https:\/\/doi.org\/10.1007\/s11136-018-1842-3.","journal-title":"Qual Life Res"},{"key":"1465_CR27","doi-asserted-by":"publisher","unstructured":"Sarno DL, Gureck AE, Cardenas-Rojas A, et al. An interdisciplinary virtual group program addressing the FINER points of chronic pain management: an exploratory analysis of functional outcomes. Pain Pract. 2025;25:e70011. https:\/\/doi.org\/10.1111\/papr.70011.","DOI":"10.1111\/papr.70011"},{"key":"1465_CR28","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1177\/15291006211008157","volume":"22","author":"MA Driscoll","year":"2021","unstructured":"Driscoll MA, Edwards RR, Becker WC, Kaptchuk TJ, Kerns RD. Psychological interventions for treatment of chronic pain in adults. Psychol Sci Public Interest. 2021;22:52\u201395. https:\/\/doi.org\/10.1177\/15291006211008157.","journal-title":"Psychol Sci Public Interest"},{"key":"1465_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.drugalcdep.2014.10.023","volume":"146","author":"A Wachholtz","year":"2015","unstructured":"Wachholtz A, Foster S, Cheatle M. Psychophysiology of pain and opioid use: implications for managing pain in patients with an opioid use disorder. Drug Alcohol Depend. 2015;146:1\u20136. https:\/\/doi.org\/10.1016\/j.drugalcdep.2014.10.023.","journal-title":"Drug Alcohol Depend"},{"key":"1465_CR30","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1037\/amp0000678","volume":"75","author":"RV Aaron","year":"2020","unstructured":"Aaron RV, Finan PH, Wegener ST, Keefe FJ, Lumley MA. Emotion regulation as a transdiagnostic factor underlying co-occurring chronic pain and problematic opioid use. Am Psychol. 2020;75:796\u2013810. https:\/\/doi.org\/10.1037\/amp0000678.","journal-title":"Am Psychol"},{"key":"1465_CR31","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.1038\/s41591-023-02430-4","volume":"29","author":"C Tanguay-Sabourin","year":"2023","unstructured":"Tanguay-Sabourin C, Fillingim M, Guglietti GV, et al. A prognostic risk score for development and spread of chronic pain. Nat Med. 2023;29:1821\u201331. https:\/\/doi.org\/10.1038\/s41591-023-02430-4.","journal-title":"Nat Med"},{"key":"1465_CR32","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1097\/j.pain.0000000000002467","volume":"163","author":"DJ Burek","year":"2022","unstructured":"Burek DJ, Massaly N, Yoon HJ, Doering M, Mor\u00f3n JA. Behavioral outcomes of complete Freund adjuvant\u2013induced inflammatory pain in the rodent Hind paw: a systematic review and meta-analysis. Pain. 2022;163:809\u201319. https:\/\/doi.org\/10.1097\/j.pain.0000000000002467.","journal-title":"Pain"}],"container-title":["Current Pain and Headache Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11916-026-01465-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11916-026-01465-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11916-026-01465-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T06:34:24Z","timestamp":1769495664000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11916-026-01465-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,27]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["1465"],"URL":"https:\/\/doi.org\/10.1007\/s11916-026-01465-9","relation":{},"ISSN":["1531-3433","1534-3081"],"issn-type":[{"value":"1531-3433","type":"print"},{"value":"1534-3081","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,27]]},"assertion":[{"value":"21 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All reported studies\/experiments with human or animal subjects performed by the authors have been previously published and complied with all applicable ethical standards (including the Helsinki declaration and its amendments, institutional\/national research committee standards, and international\/national\/institutional guidelines).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and Animal Rights"}}],"article-number":"24"}}