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Weight loss and exercise may effectively prevent migraine. Here, we review the evidence behind exercise and weight loss as migraine treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Recent Findings<\/jats:title>\n                    <jats:p>While metabolic syndrome and pain have long had a known association, only recently have strong studies demonstrated a higher risk of developing metabolic syndrome in people with migraine. Additionally, other sequelae of metabolic syndrome, obesity, hypertension, hypercoagulability, and diabetes also interplay with migraine. New medications like GLP-1 agonists may be a potential treatment for migraine as well as obesity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>For patients with migraine, metabolic syndrome, and obesity, care should be taken when selecting prophylactic medications, favoring those without a propensity to induce weight gain. Additionally, there is strong evidence for weight loss and exercise for improving migraine outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11916-026-01500-9","type":"journal-article","created":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T05:19:33Z","timestamp":1777699173000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Metabolic Dysfunction and Metabolic Management in Episodic Migraine"],"prefix":"10.1007","volume":"30","author":[{"given":"Delora E.","family":"Denney","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Marmura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,2]]},"reference":[{"key":"1500_CR1","doi-asserted-by":"crossref","unstructured":"Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. 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