{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T03:15:38Z","timestamp":1768792538471,"version":"3.49.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2009,11,29]],"date-time":"2009-11-29T00:00:00Z","timestamp":1259452800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Curr Psychiatry Rep"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1007\/s11920-009-0065-2","type":"journal-article","created":{"date-parts":[[2009,11,28]],"date-time":"2009-11-28T06:04:29Z","timestamp":1259388269000},"page":"429-436","source":"Crossref","is-referenced-by-count":40,"title":["Anxious depression: Clinical features and treatment"],"prefix":"10.1007","volume":"11","author":[{"given":"Sanjai","family":"Rao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,11,29]]},"reference":[{"key":"65_CR1","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1177\/070674370605101304","volume":"51","author":"M. Fava","year":"2006","unstructured":"Fava M, Rush AJ, Alpert JE, et al.: What clinical and symptom features and comorbid disorders characterize outpatients with anxious major depressive disorder: a replication and extension. Can J Psychiatry 2006, 51:823\u2013835.","journal-title":"Can J Psychiatry"},{"key":"65_CR2","doi-asserted-by":"crossref","first-page":"222","DOI":"10.4088\/PCC.v10n0307","volume":"10","author":"B.W. Dunlop","year":"2008","unstructured":"Dunlop BW, Davis PG: Combination treatment with benzodiazepines and SSRIs for comorbid anxiety and depression: a review. Prim Care Companion J Clin Psychiatry 2008, 10:222\u2013228.","journal-title":"Prim Care Companion J Clin Psychiatry"},{"key":"65_CR3","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1177\/0269881108093270","volume":"22","author":"S.H. Kennedy","year":"2008","unstructured":"Kennedy SH: Treating each and every depressed patient. J Psychopharmacol 2008, 22:19\u201323.","journal-title":"J Psychopharmacol"},{"key":"65_CR4","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/ajmg.c.30171","volume":"148C","author":"J.M. Hettema","year":"2008","unstructured":"Hettema JM: What is the genetic relationship between anxiety and depression? Am J Med Genet C Semin Med Genet 2008, 148C:140\u2013146.","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"65_CR5","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1017\/S0033291706009135","volume":"37","author":"K.S. Kendler","year":"2007","unstructured":"Kendler KS, Gardner CO, Gatz M, Pedersen NL: The sources of co-morbidity between major depression and generalized anxiety disorder in a Swedish national twin sample. Psychol Med 2007, 37:453\u2013462.","journal-title":"Psychol Med"},{"key":"65_CR6","doi-asserted-by":"crossref","first-page":"126","DOI":"10.4088\/JCP.v63n0207","volume":"63","author":"T.K. Melartin","year":"2002","unstructured":"Melartin TK, Rytsala HJ, Leskela US, et al.: Current comorbidity of psychiatric disorders among DSM-IV major depressive disorder patients in psychiatric care in the Vantaa Depression Study. J Clin Psychiatry 2002, 63:126\u2013134.","journal-title":"J Clin Psychiatry"},{"key":"65_CR7","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1176\/appi.ajp.157.8.1337","volume":"157","author":"M. Zimmerman","year":"2000","unstructured":"Zimmerman M, McDermut W, Mattia JI: Frequency of anxiety disorders in psychiatric outpatients with major depressive disorder. Am J Psychiatry 2000, 157:1337\u20131340.","journal-title":"Am J Psychiatry"},{"key":"65_CR8","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0010-440X(00)90140-8","volume":"41","author":"M. Fava","year":"2000","unstructured":"Fava M, Rankin MA, Wright EC, et al.: Anxiety disorders in major depression. Compr Psychiatry 2000, 41:97\u2013102.","journal-title":"Compr Psychiatry"},{"key":"65_CR9","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1001\/archpsyc.62.10.1097","volume":"62","author":"D.S. Hasin","year":"2005","unstructured":"Hasin DS, Goodwin RD, Stinson FS, Grant BF: Epidemiology of major depressive disorder: results from the National Epidemiologic Survey on Alcoholism and Related Conditions. Arch Gen Psychiatry 2005, 62:1097\u20131106.","journal-title":"Arch Gen Psychiatry"},{"key":"65_CR10","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1001\/archpsyc.1994.03950010008002","volume":"51","author":"R.C. Kessler","year":"1994","unstructured":"Kessler RC, McGonagle KA, Zhao S, et al.: Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey. Arch Gen Psychiatry 1994, 51:8\u201319.","journal-title":"Arch Gen Psychiatry"},{"key":"65_CR11","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1176\/ajp.150.8.1257","volume":"150","author":"R.T. Joffe","year":"1993","unstructured":"Joffe RT, Bagby RM, Levitt A: Anxious and nonanxious depression. Am J Psychiatry 1993, 150:1257\u20131258.","journal-title":"Am J Psychiatry"},{"key":"65_CR12","doi-asserted-by":"crossref","unstructured":"Brown GW, Harris TO, Eales MJ: Social factors and comorbidity of depressive and anxiety disorders. Br J Psychiatry Suppl 1996, June:50\u201357.","DOI":"10.1192\/S0007125000298413"},{"key":"65_CR13","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/S0006-3223(96)00440-4","volume":"42","author":"M. Fava","year":"1997","unstructured":"Fava M, Uebelacker LA, Alpert JE, et al.: Major depressive subtypes and treatment response. Biol Psychiatry 1997, 42:568\u2013576.","journal-title":"Biol Psychiatry"},{"key":"65_CR14","first-page":"50","volume":"55","author":"G.D. Tollefson","year":"1994","unstructured":"Tollefson GD, Holman SL, Sayler ME, Potvin JH: Fluoxetine, placebo, and tricyclic antidepressants in major depression with and without anxious features. J Clin Psychiatry 1994, 55:50\u201359.","journal-title":"J Clin Psychiatry"},{"key":"65_CR15","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1176\/ajp.148.11.1512","volume":"148","author":"P.J. Clayton","year":"1991","unstructured":"Clayton PJ, Grove WM, Coryell W, et al.: Follow-up and family study of anxious depression. Am J Psychiatry 1991, 148:1512\u20131517.","journal-title":"Am J Psychiatry"},{"issue":"Suppl2","key":"65_CR16","doi-asserted-by":"crossref","first-page":"10","DOI":"10.4088\/JCP.s.7002.02","volume":"70","author":"N.M. Simon","year":"2009","unstructured":"Simon NM: Generalized anxiety disorder and psychiatric comorbidities such as depression, bipolar disorder, and substance abuse. J Clin Psychiatry 2009, 70(Suppl 2):10\u201314.","journal-title":"J Clin Psychiatry"},{"key":"65_CR17","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1001\/archpsyc.64.6.651","volume":"64","author":"T.E. Moffitt","year":"2007","unstructured":"Moffitt TE, Harrington H, Caspi A, et al.: Depression and generalized anxiety disorder: cumulative and sequential comorbidity in a birth cohort followed prospectively to age 32 years. Arch Gen Psychiatry 2007, 64:651\u2013660.","journal-title":"Arch Gen Psychiatry"},{"key":"65_CR18","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1017\/S0033291706008452","volume":"36","author":"T. Slade","year":"2006","unstructured":"Slade T, Watson D: The structure of common DSM-IV and ICD-10 mental disorders in the Australian general population. Psychol Med 2006, 36:1593\u20131600.","journal-title":"Psychol Med"},{"key":"65_CR19","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.jpsychires.2006.08.004","volume":"41","author":"N.M. Simon","year":"2007","unstructured":"Simon NM, Zalta AK, Otto MW, et al.: The association of comorbid anxiety disorders with suicide attempts and suicidal ideation in outpatients with bipolar disorder. J Psychiatr Res 2007, 41:255\u2013264.","journal-title":"J Psychiatr Res"},{"key":"65_CR20","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1176\/appi.ajp.2007.06111868","volume":"165","author":"M. Fava","year":"2008","unstructured":"Fava M, Rush AJ, Alpert JE, et al.: Difference in treatment outcome in outpatients with anxious versus nonanxious depression: a STAR*D report. Am J Psychiatry 2008, 165:342\u2013351.","journal-title":"Am J Psychiatry"},{"key":"65_CR21","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1017\/S0033291704002612","volume":"34","author":"M. Fava","year":"2004","unstructured":"Fava M, Alpert JE, Carmin CN, et al.: Clinical correlates and symptom patterns of anxious depression among patients with major depressive disorder in STAR*D. Psychol Med 2004, 34:1299\u20131308.","journal-title":"Psychol Med"},{"key":"65_CR22","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/1520-6394(2001)13:1<18::AID-DA3>3.0.CO;2-M","volume":"13","author":"J.M. Russell","year":"2001","unstructured":"Russell JM, Koran LM, Rush J, et al.: Effect of concurrent anxiety on response to sertraline and imipramine in patients with chronic depression. Depress Anxiety 2001, 13:18\u201327.","journal-title":"Depress Anxiety"},{"key":"65_CR23","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/gps.2162","volume":"24","author":"G.M. Weele Van der","year":"2009","unstructured":"Van der Weele GM, Gussekloo J, De Waal MW, et al.: Co-occurrence of depression and anxiety in elderly subjects aged 90 years and its relationship with functional status, quality of life and mortality. Int J Geriatr Psychiatry 2009, 24:595\u2013601.","journal-title":"Int J Geriatr Psychiatry"},{"key":"65_CR24","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/gps.2233","volume":"24","author":"J.C. Nelson","year":"2009","unstructured":"Nelson JC, Delucchi K, Schneider LS: Anxiety does not predict response to antidepressant treatment in late life depression: results of a meta-analysis. Int J Geriatr Psychiatry 2009, 24:539\u2013544.","journal-title":"Int J Geriatr Psychiatry"},{"key":"65_CR25","doi-asserted-by":"crossref","unstructured":"Domschke K, Deckert J, Arolt V, Baune B: Anxious versus non-anxious depression: difference in treatment outcome. J Psychopharmacol 2008 Oct 6 (Epub ahead of print).","DOI":"10.1177\/0269881108097723"},{"key":"65_CR26","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1017\/S003329170600821X","volume":"36","author":"J.E. Helzer","year":"2006","unstructured":"Helzer JE, Kraemer HC, Krueger RF: The feasibility and need for dimensional psychiatric diagnoses. Psychol Med 2006, 36:1671\u20131680.","journal-title":"Psychol Med"},{"issue":"Suppl1","key":"65_CR27","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1002\/mpr.209","volume":"16","author":"D.A. Regier","year":"2007","unstructured":"Regier DA: Dimensional approaches to psychiatric classification: refining the research agenda for DSM-V: an introduction. Int J Methods Psychiatr Res 2007, 16(Suppl 1):S1\u2013S5.","journal-title":"Int J Methods Psychiatr Res"},{"key":"65_CR28","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1097\/00004850-200503000-00004","volume":"20","author":"A. Farabaugh","year":"2005","unstructured":"Farabaugh A, Mischoulon D, Fava M, et al.: The relationship between early changes in the HAMD-17 anxiety\/somatization factor items and treatment outcome among depressed outpatients. Int Clin Psychopharmacol 2005, 20:87\u201391.","journal-title":"Int Clin Psychopharmacol"},{"key":"65_CR29","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.2165\/00003495-200868120-00002","volume":"68","author":"R.A. Schoevers","year":"2008","unstructured":"Schoevers RA, Van HL, Koppelmans V, et al.: Managing the patient with co-morbid depression and an anxiety disorder. Drugs 2008, 68:1621\u20131634.","journal-title":"Drugs"},{"key":"65_CR30","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1080\/10401230590905317","volume":"17","author":"M.J. Panzer","year":"2005","unstructured":"Panzer MJ: Are SSRIs really more effective for anxious depression? Ann Clin Psychiatry 2005, 17:23\u201329.","journal-title":"Ann Clin Psychiatry"},{"key":"65_CR31","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/S0033-3182(85)72877-0","volume":"26","author":"S. Zisook","year":"1985","unstructured":"Zisook S: A clinical overview of monoamine oxidase inhibitors. Psychosomatics 1985, 26:240\u2013246, 251.","journal-title":"Psychosomatics"},{"key":"65_CR32","doi-asserted-by":"crossref","first-page":"208","DOI":"10.4088\/JCP.v64n0216","volume":"64","author":"J.D. Amsterdam","year":"2003","unstructured":"Amsterdam JD: A double-blind, placebo-controlled trial of the safety and efficacy of selegiline transdermal system without dietary restrictions in patients with major depressive disorder. J Clin Psychiatry 2003, 64:208\u2013214.","journal-title":"J Clin Psychiatry"},{"key":"65_CR33","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1176\/appi.ajp.161.7.1285","volume":"161","author":"M. Zimmerman","year":"2004","unstructured":"Zimmerman M, Posternak M, Friedman M, et al.: Which factors influence psychiatrists\u2019 selection of antidepressants? Am J Psychiatry 2004, 161:1285\u20131289.","journal-title":"Am J Psychiatry"},{"key":"65_CR34","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.4088\/JCP.v69n0812","volume":"69","author":"G.I. Papakostas","year":"2008","unstructured":"Papakostas GI, Stahl SM, Krishen A, et al.: Efficacy of bupropion and the selective serotonin reuptake inhibitors in the treatment of major depressive disorder with high levels of anxiety (anxious depression): a pooled analysis of 10 studies. J Clin Psychiatry 2008, 69:1287\u20131292.","journal-title":"J Clin Psychiatry"},{"key":"65_CR35","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.biopsych.2005.06.027","volume":"59","author":"S. Zisook","year":"2006","unstructured":"Zisook S, Rush AJ, Haight BR, et al.: Use of bupropion in combination with serotonin reuptake inhibitors. Biol Psychiatry 2006, 59:203\u2013210.","journal-title":"Biol Psychiatry"},{"key":"65_CR36","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2165\/00002512-200522020-00002","volume":"22","author":"A.J. Flint","year":"2005","unstructured":"Flint AJ: Generalised anxiety disorder in elderly patients: epidemiology, diagnosis and treatment options. Drugs Aging 2005, 22:101\u2013114.","journal-title":"Drugs Aging"},{"key":"65_CR37","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1176\/appi.ajp.2007.07121927","volume":"165","author":"J.C. Nelson","year":"2008","unstructured":"Nelson JC: Anxious depression and response to treatment. Am J Psychiatry 2008, 165:297\u2013299.","journal-title":"Am J Psychiatry"},{"key":"65_CR38","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1176\/ajp.153.11.1509-a","volume":"153","author":"C. Brown","year":"1996","unstructured":"Brown C, Schulberg HC, Madonia MJ, et al.: Treatment outcomes for primary care patients with major depression and lifetime anxiety disorders. Am J Psychiatry 1996, 153:1293\u20131300.","journal-title":"Am J Psychiatry"},{"key":"65_CR39","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.1001\/jama.288.22.2836","volume":"288","author":"J. Unutzer","year":"2002","unstructured":"Unutzer J, Katon W, Callahan CM, et al.: Collaborative care management of late-life depression in the primary care setting: a randomized controlled trial. JAMA 2002, 288:2836\u20132845.","journal-title":"JAMA"},{"key":"65_CR40","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0165-0327(98)00117-7","volume":"53","author":"S. Woody","year":"1999","unstructured":"Woody S, McLean PD, Taylor S, Koch WJ: Treatment of major depression in the context of panic disorder. J Affect Disord 1999, 53:163\u2013174.","journal-title":"J Affect Disord"},{"key":"65_CR41","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1037\/0022-006X.66.2.240","volume":"66","author":"P.D. McLean","year":"1998","unstructured":"McLean PD, Woody S, Taylor S, Koch WJ: Comorbid panic disorder and major depression: implications for cognitive-behavioral therapy. J Consult Clin Psychol 1998, 66:240\u2013247.","journal-title":"J Consult Clin Psychol"},{"key":"65_CR42","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1176\/ajp.161.10.1872","volume":"161","author":"G.A. Fava","year":"2004","unstructured":"Fava GA, Ruini C, Rafanelli C, et al.: Six-year outcome of cognitive behavior therapy for prevention of recurrent depression. Am J Psychiatry 2004, 161:1872\u20131876.","journal-title":"Am J Psychiatry"},{"key":"65_CR43","doi-asserted-by":"crossref","first-page":"455","DOI":"10.4088\/JCP.v66n0408","volume":"66","author":"S.D. Hollon","year":"2005","unstructured":"Hollon SD, Jarrett RB, Nierenberg AA, et al.: Psychotherapy and medication in the treatment of adult and geriatric depression: which monotherapy or combined treatment? J Clin Psychiatry 2005, 66:455\u2013468.","journal-title":"J Clin Psychiatry"},{"key":"65_CR44","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1001\/archgenpsychiatry.2008.555","volume":"66","author":"P.J. Veer-Tazelaar van\u2019t","year":"2009","unstructured":"van\u2019t Veer-Tazelaar PJ, van Marwijk HW, van Oppen P, et al.: Stepped-care prevention of anxiety and depression in late life: a randomized controlled trial. Arch Gen Psychiatry 2009, 66:297\u2013304.","journal-title":"Arch Gen Psychiatry"},{"key":"65_CR45","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1038\/sj.npp.1301390","volume":"32","author":"M.H. Trivedi","year":"2007","unstructured":"Trivedi MH, Rush AJ, Gaynes BN, et al.: Maximizing the adequacy of medication treatment in controlled trials and clinical practice: STAR(*)D measurement-based care. Neuropsychopharmacology 2007, 32:2479\u20132489.","journal-title":"Neuropsychopharmacology"},{"key":"65_CR46","doi-asserted-by":"crossref","first-page":"344","DOI":"10.4088\/JCP.07m03780","volume":"70","author":"A. Szegedi","year":"2009","unstructured":"Szegedi A, Jansen WT, van Willigenburg AP, et al.: Early improvement in the first 2 weeks as a predictor of treatment outcome in patients with major depressive disorder: a meta-analysis including 6562 patients. J Clin Psychiatry 2009, 70:344\u2013353.","journal-title":"J Clin Psychiatry"}],"container-title":["Current Psychiatry Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11920-009-0065-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11920-009-0065-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11920-009-0065-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T00:41:15Z","timestamp":1559436075000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11920-009-0065-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11,29]]},"references-count":46,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["65"],"URL":"https:\/\/doi.org\/10.1007\/s11920-009-0065-2","relation":{},"ISSN":["1523-3812","1535-1645"],"issn-type":[{"value":"1523-3812","type":"print"},{"value":"1535-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11,29]]}}}