{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:13:53Z","timestamp":1792012433840,"version":"4.4.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2010,10,21]],"date-time":"2010-10-21T00:00:00Z","timestamp":1287619200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Curr Psychiatry Rep"],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1007\/s11920-010-0164-0","type":"journal-article","created":{"date-parts":[[2010,10,20]],"date-time":"2010-10-20T04:45:07Z","timestamp":1287549907000},"page":"18-25","source":"Crossref","is-referenced-by-count":39,"title":["Joint Hypermobility and Anxiety: The State of the Art"],"prefix":"10.1007","volume":"13","author":[{"given":"Javier","family":"Garcia-Campayo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Asso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Alda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,10,21]]},"reference":[{"key":"164_CR1","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4471-3900-3","volume-title":"Hypermobility of Joints","author":"PH Beighton","year":"1989","unstructured":"Beighton PH, Grahame R, Bird H: Hypermobility of Joints, edn 2. London: Springer-Verlag; 1989.","edition":"2"},{"key":"164_CR2","first-page":"67","volume":"21","author":"J Sutro","year":"1947","unstructured":"Sutro J: Hypermobility of knees due to overlengthed capsular and ligamentous tissues. Surgery 1947, 21:67\u201376.","journal-title":"Surgery"},{"key":"164_CR3","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1136\/ard.26.5.419","volume":"26","author":"JH Kirk","year":"1967","unstructured":"Kirk JH, Ansell B, Bywaters EGL: The hypermobility syndrome. Ann Rheum Dis 1967, 26:419\u2013425.","journal-title":"Ann Rheum Dis"},{"key":"164_CR4","first-page":"1","volume-title":"Rheumatology, vol II","author":"R Grahame","year":"1997","unstructured":"Grahame R: Hypermobility syndrome. In Rheumatology, vol II, edn 2. Edited by Kipplel JH, Dieppe PA. London: Mosby; 1997:1\u20136.","edition":"2"},{"key":"164_CR5","first-page":"689","volume":"64","author":"R Winne-Davies","year":"1971","unstructured":"Winne-Davies R: Familial joint laxity. Proc R Soc Med 1971, 64:689.","journal-title":"Proc R Soc Med"},{"key":"164_CR6","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1302\/0301-620X.46B1.40","volume":"46","author":"C Carter","year":"1964","unstructured":"Carter C, Wilkinson J: Persistent joint laxity and congenital dislocation of the hip. J Bone Joint Surg 1964, 46:40\u201345.","journal-title":"J Bone Joint Surg"},{"key":"164_CR7","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1136\/ard.32.5.413","volume":"32","author":"PH Beighton","year":"1973","unstructured":"Beighton PH, Solomon L, Soskolne CL: Articular mobility in an African population. Ann Rheum Dis 1973, 32:413\u2013418.","journal-title":"Ann Rheum Dis"},{"key":"164_CR8","first-page":"47","volume":"19","author":"PJ Coster De","year":"2005","unstructured":"De Coster PJ, Van den Berghe LI, Martens LC: Generalized joint hypermobility and temporomandibular disorders: inherited connective tissue disease as a model with maximum expression. J Orofac Pain 2005, 19:47\u201357.","journal-title":"J Orofac Pain"},{"key":"164_CR9","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1093\/rheumatology\/35.9.861","volume":"35","author":"MB Mishra","year":"1996","unstructured":"Mishra MB, Ryan P, Atkinson P, et al.: Extra-articular features of benign joint hypermobility syndrome. Br J Rheumatol 1996, 35:861\u2013866.","journal-title":"Br J Rheumatol"},{"key":"164_CR10","first-page":"11","volume":"4","author":"HA Bird","year":"1984","unstructured":"Bird HA: Articular and tissue laxity. Rheumatol Rev Rep 1984, 4:11\u201322.","journal-title":"Rheumatol Rev Rep"},{"key":"164_CR11","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/S0140-6736(82)92453-9","volume":"i","author":"Z Al-Rawi","year":"1982","unstructured":"Al-Rawi Z, Al-Rawi Z: Joint hypermobility in women with genital prolapse. Lancet 1982, i:1439\u20131441.","journal-title":"Lancet"},{"key":"164_CR12","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/(SICI)1522-7154(1996)2:2<80::AID-ANXI3>3.0.CO;2-H","volume":"2","author":"A Bulbena","year":"1996","unstructured":"Bulbena A, Mart\u00edn-Santos R, Porta M, et al.: Somatotype in panic patients. Anxiety 1996, 2:80\u201385.","journal-title":"Anxiety"},{"key":"164_CR13","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1136\/ard.37.3.203","volume":"37","author":"HA Bird","year":"1978","unstructured":"Bird HA, Tribe CR, Bacon PA: Joint hypermobility leading to osteoarthrosis and chondrocalcinosis. Ann Rheum Dis 1978, 37:203\u2013211.","journal-title":"Ann Rheum Dis"},{"key":"164_CR14","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1136\/ard.51.6.793","volume":"51","author":"AJ Bridges","year":"1992","unstructured":"Bridges AJ, Smith E, Reid J: Joint hypermobility in adults referred to rheumatologic clinics. Ann Rheum Dis 1992, 51:793\u2013796.","journal-title":"Ann Rheum Dis"},{"key":"164_CR15","first-page":"1","volume":"26","author":"S Gulbahar","year":"2005","unstructured":"Gulbahar S, Sahin E, Baydar M, et al.: Hypermobility syndrome increase the risk for low bone mass. Clin Rheumatol 2005, 26:1\u20134.","journal-title":"Clin Rheumatol"},{"key":"164_CR16","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0033-3182(10)70659-9","volume":"51","author":"J Garcia-Campayo","year":"2010","unstructured":"\u2022 Garcia-Campayo J, Asso E, Alda M, et al.: Association between joint hypermobility syndrome and panic disorder: a case-control study. Psychosomatics 2010, 51:55\u201361. The most recent study on the subject confirmed a higher prevalence of JHS in patients with panic disorder and the association of severity symptoms between anxiety and JHS.","journal-title":"Psychosomatics"},{"key":"164_CR17","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/art.1790110107","volume":"11","author":"M Acasuso-Diaz","year":"1998","unstructured":"Acasuso-Diaz M, Collantes-Estevez E: Joint hypermobility in patients with fibromyalgia syndrome. Arthritis Care Res 1998, 11:39\u201342.","journal-title":"Arthritis Care Res"},{"key":"164_CR18","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1136\/ard.40.6.541","volume":"40","author":"R Grahame","year":"1981","unstructured":"Grahame R, Edwards JC, Pitcher D, et al.: A clinical and echocardiographic study of patients with hypermobility syndrome. Ann Rheum Dis 1981, 40:541\u2013546.","journal-title":"Ann Rheum Dis"},{"key":"164_CR19","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1136\/ard.41.4.352","volume":"41","author":"D Pitcher","year":"1982","unstructured":"Pitcher D, Grahame R: Mitral valve prolapse and joint hypermobility: evidence for systemic connective tissue abnormality? Ann Rheum Dis 1982, 41:352\u2013354.","journal-title":"Ann Rheum Dis"},{"key":"164_CR20","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1097\/00001573-199503000-00003","volume":"10","author":"RB Devereux","year":"1995","unstructured":"Devereux RB: Recent developments in the diagnosis and management of mitral valve prolapse. Curr Opin Cardiol 1995, 10:107\u2013116.","journal-title":"Curr Opin Cardiol"},{"key":"164_CR21","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1016\/0002-9149(92)90909-I","volume":"69","author":"MA Alpert","year":"1992","unstructured":"Alpert MA, Sabati M, Kushner MG, et al.: Frequency of isolated panic attacks and panic disorder in mitral valve prolapse syndrome. Am J Cardiol 1992, 69:1489\u20131490.","journal-title":"Am J Cardiol"},{"key":"164_CR22","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1600-0447.1994.tb01486.x","volume":"89","author":"K Sivaramakrishnan","year":"1994","unstructured":"Sivaramakrishnan K, Alexander PJ, Saharsamaman N: Prevalence of panic disorder in mitral valve prolapse: a comparative study. Acta Psychiatr Scand 1994, 89:59\u201361.","journal-title":"Acta Psychiatr Scand"},{"key":"164_CR23","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1097\/00005053-199309000-00002","volume":"181","author":"DA Katerndahl","year":"1993","unstructured":"Katerndahl DA: Panic and prolapse: meta-analysis. J Nerv Ment Dis 1993, 181:539\u2013544.","journal-title":"J Nerv Ment Dis"},{"key":"164_CR24","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/S0140-6736(88)90514-4","volume":"2","author":"A Bulbena","year":"1988","unstructured":"Bulbena A, Duro JC, Porta M, Vallejo J: Anxiety disorders in the joint hypermobility syndrome. Lancet 1988, 2:694.","journal-title":"Lancet"},{"key":"164_CR25","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0165-1781(93)90008-5","volume":"43","author":"A Bulbena","year":"1993","unstructured":"Bulbena A, Dur\u00f3 JC, Porta M, et al.: Anxiety disorder in the joint hypermobility syndrome. Psychiatry Res 1993, 43:59\u201368.","journal-title":"Psychiatry Res"},{"key":"164_CR26","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1176\/ajp.155.11.1578","volume":"155","author":"R Mart\u00edn-Santos","year":"1998","unstructured":"Mart\u00edn-Santos R, Bulbena A, Porta M, Molina LI: Association between joint hypermobility syndrome and panic disorder. Am J Psychiatry 1998, 155:1578\u20131583.","journal-title":"Am J Psychiatry"},{"key":"164_CR27","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1176\/appi.psy.45.5.432","volume":"45","author":"A Bulbena","year":"2004","unstructured":"Bulbena A, Agull\u00f3 A, Pailhez G, et al.: Is joint hypermobility related to anxiety in a non-clinical population also? Psychosomatics 2004, 45:432\u2013437.","journal-title":"Psychosomatics"},{"key":"164_CR28","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/hup.234","volume":"16","author":"J Benjamin","year":"2001","unstructured":"Benjamin J, Ben-Zion IZ, Dannon P, et al.: Lack of association between joint hyperlaxity and I: panic disorder, and II: reactivity to carbon dioxide in healthy volunteers. Hum Psychopharmacol 2001, 16:189\u2013192.","journal-title":"Hum Psychopharmacol"},{"key":"164_CR29","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.pnpbp.2004.05.014","volume":"28","author":"D Gulpek","year":"2004","unstructured":"Gulpek D, Bayraktar E, Akbay SP, et al.: Joint hypermobility syndrome and mitral valve prolapse in panic disorder. Prog Neuropsychopharmacol Biol Psychiatry 2004, 28:969\u2013973.","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"164_CR30","first-page":"165","volume":"44","author":"M G\u00fcls\u00fcn","year":"2006","unstructured":"G\u00fcls\u00fcn M, Doruk A, Uzun \u00d6, et al.: Hipermobilite sendromu olan klinik disi erkek \u00d6 rnekleminde anksiyete bozukluklari [in Turkish]. Yeni Symp J 2006, 44:165\u2013168.","journal-title":"Yeni Symp J"},{"key":"164_CR31","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0092-8674(01)00447-0","volume":"106","author":"M Gratac\u00f2s","year":"2001","unstructured":"Gratac\u00f2s M, Nadal M, Martin-Santos R, et al.: A polymorphic genomic duplication on human chromosome 15 is a susceptibility factor for panic and phobic disorders. Cell 2001, 106:367\u2013379.","journal-title":"Cell"},{"key":"164_CR32","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1086\/367777","volume":"72","author":"M Tabiner","year":"2003","unstructured":"Tabiner M, Youings S, Dennis N, et al.: Failure to find DUP25 in patients with anxiety disorders, in control individuals, or in previously reported positive control cell lines. Am J Hum Genet 2003, 72:535\u2013538.","journal-title":"Am J Hum Genet"},{"key":"164_CR33","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1086\/375168","volume":"72","author":"Y Weiland","year":"2003","unstructured":"Weiland Y, Kraus J, Speicher MR: A multiclot FISH assay does not detect DUP25 in control individuals or in reported positive control cells. Am J Hum Genet 2003, 72:1349\u20131352.","journal-title":"Am J Hum Genet"},{"key":"164_CR34","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.genhosppsych.2007.12.006","volume":"30","author":"PP Roy-Byrne","year":"2008","unstructured":"\u2022 Roy-Byrne PP, Davidson KW, Kessler RC, et al.: Anxiety disorders and comorbid medical illness. Gen Hosp Psychiatry 2008, 30:208\u2013225. This recent review describes the many physical symptoms that can accompany anxiety and the long list of medical disorders than can explain them.","journal-title":"Gen Hosp Psychiatry"},{"key":"164_CR35","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jad.2009.03.014","volume":"119","author":"M Roca","year":"2009","unstructured":"Roca M, Gili M, Garcia-Garcia M, et al.: Prevalence and comorbidity of common mental disorders in primary care. J Affect Disord 2009, 119:52\u201358.","journal-title":"J Affect Disord"},{"key":"164_CR36","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jad.2009.06.031","volume":"122","author":"J Garc\u00eda-Campayo","year":"2010","unstructured":"Garc\u00eda-Campayo J, Arevalo E, Claraco LM, et al.: A prevention programme for somatoform disorders is effective for affective disorders. J Affect Disord 2010, 122:124\u2013132.","journal-title":"J Affect Disord"},{"key":"164_CR37","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.genhosppsych.2008.08.009","volume":"31","author":"G Pailhez","year":"2009","unstructured":"\u2022 Pailhez G, Bulbena A, Fullana MA, Casta\u00f1o J: Anxiety disorders and joint hypermobility syndrome: the role of collagen tissue. Gen Hosp Psychiatry 2009, 31:299. This short letter emphasizes that most medical symptoms presented by patients with anxiety could be explained by a collagen tissue disorder such as JHS.","journal-title":"Gen Hosp Psychiatry"},{"key":"164_CR38","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0092-8674(01)00447-0","volume":"106","author":"M Gratac\u00f2s","year":"2001","unstructured":"Gratac\u00f2s M, Nadal M, Mart\u00edn-Santos R, et al.: A polymorphic genomic duplication on human chromosome 15 is a susceptibility factor for panic and phobic disorders. Cell 2001, 106:367\u2013379.","journal-title":"Cell"},{"key":"164_CR39","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.biopsych.2007.07.021","volume":"63","author":"A Talati","year":"2008","unstructured":"\u2022 Talati A, Ponniah K, Strug LJ, et al.: Panic disorder, social anxiety disorder, and a possible medical syndrome previously linked to chromosome 13. Biol Psychiatry 2008, 63:594\u2013601. This study confirmed that patients with panic disorder or social anxiety disorder, as compared with controls, reported significantly more interstitial cystitis and MVP. First-degree relatives of probands with panic disorder or social anxiety disorder were also at increased risk of interstitial cystitis, MVP, thyroid problems, and headaches, regardless of whether the proband reported the same condition.","journal-title":"Biol Psychiatry"},{"key":"164_CR40","volume-title":"Hypermobility Syndrome","author":"R Keer","year":"2003","unstructured":"Keer R, Grahame R: Hypermobility Syndrome. New York: Butterworth Heinemann; 2003."},{"key":"164_CR41","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1176\/jnp.9.3.382","volume":"9","author":"M Davis","year":"1997","unstructured":"Davis M: Neurobiology of fear responses: the role of the amygdala. J Neuropsychiatry Clin Neurosci 1997, 9:382\u2013402.","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"164_CR42","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1176\/jnp.9.2.198","volume":"9","author":"G Grove","year":"1997","unstructured":"Grove G, Coplan JD, Hollander E: The neuroanatomy of 5-HT dysregulation and panic disorder. J Neuropsychiatry Clin Neurosci 1997, 9:198\u2013208.","journal-title":"J Neuropsychiatry Clin Neurosci"},{"issue":"Suppl 11","key":"164_CR43","first-page":"5","volume":"52","author":"JF Rosenbaum","year":"1991","unstructured":"Rosenbaum JF, Biederman J, Hirshfeld DR, et al.: Behavioral inhibition in children: a possible precursor to panic disorder or social phobia. J Clin Psychiatry 1991; 52(Suppl 11):5\u20139.","journal-title":"J Clin Psychiatry"},{"key":"164_CR44","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1001\/archpsyc.1993.01820160076009","volume":"50","author":"DF Klein","year":"1993","unstructured":"Klein DF: False suffocation alarms, spontaneous panics, and related conditions: an integrative hypothesis. Arch Gen Psychiatry 1993, 50:306\u2013317.","journal-title":"Arch Gen Psychiatry"},{"key":"164_CR45","first-page":"115","volume":"19","author":"A Bulbena","year":"1992","unstructured":"Bulbena A, Dur\u00f3 JC, Porta M, et al.: Clinical assessment of hypermobility of joints: assembling criteria. J Rheumatol 1992, 19:115\u2013122.","journal-title":"J Rheumatol"},{"key":"164_CR46","first-page":"1777","volume":"27","author":"R Grahame","year":"2000","unstructured":"Grahame R: Brighton diagnosis criteria for the benign joint hypermobility syndrome. Br J Rheumatol 2000, 27:1777\u20131779.","journal-title":"Br J Rheumatol"}],"container-title":["Current Psychiatry Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11920-010-0164-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11920-010-0164-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11920-010-0164-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T20:41:17Z","timestamp":1559421677000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11920-010-0164-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,21]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["164"],"URL":"https:\/\/doi.org\/10.1007\/s11920-010-0164-0","relation":{},"ISSN":["1523-3812","1535-1645"],"issn-type":[{"value":"1523-3812","type":"print"},{"value":"1535-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10,21]]}}}