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This recent investigation of fasting plasma OXT levels confirmed lower OXT levels in women with AN than those with BN and HC without differences between AN subtypes.","journal-title":"Eur Eat Disord Rev"},{"issue":"11","key":"957_CR50","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.4088\/JCP.10m06617","volume":"72","author":"EA Lawson","year":"2011","unstructured":"Lawson EA, Donoho DA, Blum JI, Meenaghan EM, Misra M, Herzog DB, et al. Decreased nocturnal oxytocin levels in anorexia nervosa are associated with low bone mineral density and fat mass. 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This study showed that fasting plasma OXT levels in women with weight-recovered AN were related to more pronounced ED pathology and higher state and trait anxiety.","journal-title":"The Journal of Clinical Psychiatry"},{"issue":"11","key":"957_CR52","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1016\/0026-0495(91)90220-Q","volume":"40","author":"P Chiodera","year":"1991","unstructured":"Chiodera P, Volpi R, Capretti L, Marchesi C, d'Amato L, De Ferri A, et al. Effect of estrogen or insulin-induced hypoglycemia on plasma oxytocin levels in bulimia and anorexia nervosa. Metabolism. 1991;40(11):1226\u201330.","journal-title":"Metabolism"},{"issue":"10","key":"957_CR53","doi-asserted-by":"publisher","first-page":"E1898","DOI":"10.1210\/jc.2012-1702","volume":"97","author":"EA Lawson","year":"2012","unstructured":"Lawson EA, Holsen LM, Santin M, Meenaghan E, Eddy KT, Becker AE, et al. 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This randomized, double-blind, placebo-controlled study of daily OXT administration over 4\u20136 weeks is the first investigation of repeated OXT administration in individuals with AN.","journal-title":"Psychoneuroendocrinology"},{"issue":"3","key":"957_CR60","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1016\/j.psychres.2015.05.040","volume":"228","author":"SF Acevedo","year":"2015","unstructured":"\u2022 Acevedo SF, Valencia C, Lutter M, McAdams CJ. Severity of eating disorder symptoms related to oxytocin receptor polymorphisms in anorexia nervosa. Psychiatry Res. 2015;228(3):641\u20138. \n                      https:\/\/doi.org\/10.1016\/j.psychres.2015.05.040\n                      \n                    . This investigation of OXTR SNPs showed that A allele carriers of the rs53576 and rs2254298 displayed more pronounced symptoms than GG carriers.","journal-title":"Psychiatry Res"},{"issue":"1","key":"957_CR61","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1002\/erv.2486","volume":"25","author":"N Micali","year":"2017","unstructured":"\u2022\u2022 Micali N, Crous-Bou M, Treasure J, Lawson EA. Association between oxytocin receptor genotype, maternal care, and eating disorder behaviours in a community sample of women. Eur Eat Disord Rev. 2017;25(1):19\u201325. \n                      https:\/\/doi.org\/10.1002\/erv.2486\n                      \n                    . This is the first study of gene-environment interactions in the development of ED pathology. It provides evidence for maternal care interacting with OXTR genotype in determining lifetime occurrence of ED pathology in a community sample of women.","journal-title":"Eur Eat Disord Rev"},{"issue":"3","key":"957_CR62","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1002\/erv.2354","volume":"23","author":"YR Kim","year":"2015","unstructured":"\u2022\u2022 Kim YR, Kim JH, Kim CH, Shin JG, Treasure J. Association between the oxytocin receptor gene polymorphism (rs53576) and bulimia nervosa. Eur Eat Disord Rev. 2015;23(3):171\u20138. \n                      https:\/\/doi.org\/10.1002\/erv.2354\n                      \n                    . This study showed that the rs53576 GG genotype is more common in individuals with BN than HC.","journal-title":"Eur Eat Disord Rev"},{"issue":"3","key":"957_CR63","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090465","volume":"9","author":"JJ Connelly","year":"2014","unstructured":"Connelly JJ, Golding J, Gregory SP, Ring SM, Davis JM, Davey Smith G, et al. Personality, behavior and environmental features associated with OXTR genetic variants in British mothers. PLoS One. 2014;9(3):e90465. \n                      https:\/\/doi.org\/10.1371\/journal.pone.0090465\n                      \n                    .","journal-title":"PLoS One"},{"issue":"5","key":"957_CR64","doi-asserted-by":"publisher","first-page":"e279","DOI":"10.1038\/nutd.2017.24","volume":"7","author":"C Davis","year":"2017","unstructured":"\u2022 Davis C, Patte K, Zai C, Kennedy JL. Polymorphisms of the oxytocin receptor gene and overeating: the intermediary role of endophenotypic risk factors. 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Oxytocin receptors (OXTR) and early parental care: an interaction that modulates psychiatric disorders. Res Dev Disabil. 2017; \n                      https:\/\/doi.org\/10.1016\/j.ridd.2017.10.007\n                      \n                    .","DOI":"10.1016\/j.ridd.2017.10.007"},{"issue":"2","key":"957_CR67","doi-asserted-by":"publisher","first-page":"e88673","DOI":"10.1371\/journal.pone.0088673","volume":"9","author":"YR Kim","year":"2014","unstructured":"Kim YR, Kim JH, Kim MJ, Treasure J. Differential methylation of the oxytocin receptor gene in patients with anorexia nervosa: a pilot study. 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This is the first randomized, double-blind, placebo-controlled crossover study showing that exogeneous OXT decreased reported total calorie consumption over 24 h in individuals with BN.","journal-title":"PLoS One"},{"key":"957_CR69","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.psyneuen.2014.02.019","volume":"44","author":"YR Kim","year":"2014","unstructured":"Kim YR, Kim CH, Cardi V, Eom JS, Seong Y, Treasure J. Intranasal oxytocin attenuates attentional bias for eating and fat shape stimuli in patients with anorexia nervosa. 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This study showed that a single dose of intranasal OXT reduced salivary cortisol levels and altered attentional bias in women with AN.","journal-title":"Psychoneuroendocrinology"},{"key":"957_CR71","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.psyneuen.2018.02.029","volume":"91","author":"YR Kim","year":"2018","unstructured":"\u2022 Kim YR, Eom JS, Leppanen J, Leslie M, Treasure J. Effects of intranasal oxytocin on the attentional bias to emotional stimuli in patients with bulimia nervosa. Psychoneuroendocrinology. 2018;91:75\u20138. \n                      https:\/\/doi.org\/10.1016\/j.psyneuen.2018.02.029\n                      \n                    . This study reported a positive impact of exogeneous OXT on selective attention to angry faces in BN that was comparable to the effects of HC.","journal-title":"Psychoneuroendocrinology"},{"issue":"6","key":"957_CR72","doi-asserted-by":"publisher","first-page":"e90721","DOI":"10.1371\/journal.pone.0090721","volume":"9","author":"YR Kim","year":"2014","unstructured":"Kim YR, Kim CH, Park JH, Pyo J, Treasure J. The impact of intranasal oxytocin on attention to social emotional stimuli in patients with anorexia nervosa: a double blind within-subject cross-over experiment. 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King Trust Postdoctoral Research Fellowship Program, Bank of America, N.A., Co-Trustees.Kamryn T. Eddy reports grants from the National Institutes of Health.Elizabeth A. Lawson reports grants from the National Institutes of Health and personal fees from OXT Therapeutics. EAL is on the scientific advisory board and has a financial interest in OXT Therapeutics, a company developing an intranasal oxytocin and long-acting analogs of oxytocin to treat obesity and metabolic disease. EAL\u2019s interests were reviewed and are managed by Massachusetts General Hospital and Partners HealthCare in accordance with their conflict of interest policies. This company was not involved in any way in this research.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"This article does not contain any studies with human or animal subjects performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and Animal Rights and Informed Consent"}}],"article-number":"91"}}