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Rare variant studies implicated specific genes, including\n                      <jats:italic>CHD8<\/jats:italic>\n                      ,\n                      <jats:italic>CELSR3<\/jats:italic>\n                      ,\n                      <jats:italic>SLITRK5<\/jats:italic>\n                      , and\n                      <jats:italic>QRICH1<\/jats:italic>\n                      . Evidence from common and rare variants support brain- and immune-related pathways. Genetic overlap with obsessive compulsive symptoms and other psychiatric disorders indicate shared underlying biology. Current evidence is largely based on individuals of European ancestry, although global efforts are underway to improve ancestral diversity in OCD genetics. Given the urgent need for improved treatment, genetically informed clinical translation approaches hold promise, including pharmacogenetics and drug repurposing.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>Recent advances in OCD genetics support a highly polygenic architecture, implicate specific neuro-biological and immune pathways, and provide new opportunities for clinical translation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11920-026-01705-0","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T06:30:59Z","timestamp":1785479459000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Advancements in the Understanding of the Genetics of Obsessive-Compulsive Disorder (OCD)"],"prefix":"10.1007","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3682-1647","authenticated-orcid":false,"given":"A. 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