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This well-designed study used crossover methodology, appropriate clinical endpoints, and the correct drug\/drug regimens to illustrate that NSAIDs seem to offer better symptom control than acetaminophen for patients with moderate to severe OA of the knee. The results of this trial reflect clinical practice.","journal-title":"Arthritis Rheum"},{"key":"63_CR10","doi-asserted-by":"publisher","first-page":"S339","DOI":"10.1002\/1529-0131(200007)43:7<1657::AID-ANR36>3.0.CO;2-7","volume":"43","author":"T Pincus","year":"2000","unstructured":"Pincus T, Sokka T: Analysis of worsening of osteoarthritis pain by \/>20% in a randomized controlled double-blind crossover clinical trial of diclofenac\/misoprostol (Arthrotec) compared to acetaminophen (ACTA). Abstract. 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The power of this large study allows differentiation of the better safer drug, in situations in which the overall adverse event rates are low.","journal-title":"Arthritis Rheum"},{"key":"63_CR14","first-page":"S220","volume":"43","author":"C van Kuijk","year":"2000","unstructured":"van Kuijk C, Cheng X, Hottya G, et al.: The effects of rofecoxib and diclofenac on knee osteoarthritis (OA) articular cartilage: The results from one-year prospective clinical trials. Abstract. Arthritis Rheum 2000, 43:S220\u2013924.","journal-title":"Arthritis Rheum"},{"key":"63_CR15","first-page":"S340","volume":"43","author":"JP Raynauld","year":"2000","unstructured":"Raynauld JP, Bellamy N, Goldsmith C, et al.: A prospective randomized health outcomes trial of Hylan GF-20 in the treatment of patients with knee osteoarthritis. Abstract. Arthritis Rheum 2000, 43:S340\u20131641. 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This paper is unique in that it looked at the effect of glucosamine on joint space narrowing. The results favored glucosamine. What was impressive was that the structure modification effects were analyzed by \"intent to treat.\"","journal-title":"Arthritis Rheum"},{"key":"63_CR19","doi-asserted-by":"publisher","first-page":"S336","DOI":"10.1002\/1529-0131(200002)43:2<336::AID-ANR13>3.0.CO;2-V","volume":"43","author":"M Dougados","year":"2000","unstructured":"Dougados M, Nguyen M, Berdah L, et al.: Effects of diacerein on the radiological progression of hip osteoarthritis: a three-year placebo-controlled study. Abstract. 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This trial is unique in that a recombinant human protein\/growth factor with potential to drive chondrocyte production of matrix protein was introduced to the joint space. 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