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Through analysis of the anti-Jo-1 antibody response in a patient with myositis at the onset of disease, this study demonstrates the process of affinity maturation indicative of an immune response driven by human histidyl-transfer RNA synthetase (Jo-1) rather than crossreactivity to foreign proteins.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"52_CR13","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1172\/JCI114461","volume":"85","author":"FW Miller","year":"1990","unstructured":"Miller FW, Twitty SA, Biswas T, Plotz PH: Origin and regulation of a disease-specific autoantibody response. 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[36] demonstrated a granzyme B cleavage site at amino acid 48 of histidyl-transfer RNA synthetase.","journal-title":"J Biol Chem"},{"key":"52_CR15","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1096\/fasebj.9.12.7672516","volume":"9","author":"A Martin","year":"1995","unstructured":"Martin A, Shulman MJ, Tsui FW: Epitope studies indicate that histidyl-tRNA synthetase is a stimulating antigen in idiopathic myositis. FASEB J 1995, 9:1226\u20131233.","journal-title":"FASEB J"},{"key":"52_CR16","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1002\/art.1780400803","volume":"40","author":"J Craft","year":"1997","unstructured":"Craft J, Fatenejad S: Self antigens and epitope spreading in systemic autoimmunity. 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Because CD4+ T cells and B cells from these patients recognize the same antigen (PDC-E2), this human disease provides a paradigm for the proposed role of Jo-1 in directing the humoral and cell-mediated immune responses of PM.","journal-title":"J Clin Invest"},{"key":"52_CR18","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1046\/j.1365-2362.2001.00847.x","volume":"31","author":"S Akbar","year":"2001","unstructured":"Akbar S, Yamamoto K, Miyaki H, et al.: Peripheral blood T-cell responses to pyruvate dehydrogenase complex in primary biliary cirrhosis: role of antigen-presenting dendritic cells. Eur J Clin Invest 2001, 31:639\u2013646.","journal-title":"Eur J Clin Invest"},{"key":"52_CR19","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1034\/j.1600-0528.2002.00021h.x","volume":"174","author":"S Yeaman","year":"2000","unstructured":"Yeaman S, Kirby J, Jones D: Autoreactive responses to pyruvate dehydrogenase complex in the pathogenesis of primary biliary cirrhosis. 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This animal model therefore supports a direct role for Jo-1 in the pathogenesis of myositis.","journal-title":"Hum Gene Ther"},{"key":"52_CR22","doi-asserted-by":"crossref","first-page":"9209","DOI":"10.1073\/pnas.97.16.9209","volume":"97","author":"K Nagaraju","year":"2000","unstructured":"Nagaraju K, Raben N, Loeffler L, et al.: Conditional upregulation of MHC class I in skeletal muscle leads to self-sustaining autoimmune myositis and myositis-specific antibodies. Proc Natl Acad Sci USA 2000, 97:9209\u20139214. This work describes a murine model of spontaneous PM resulting from inducible, tissue-specific upregulation of MHC class I expression. Characterized by predominant macrophage or monocyte infiltration of muscle as well as autoantibody formation, this experimental model suggests a potential mechanism for the breadown of tolerance leading to inflammatory muscle disease in humans.","journal-title":"Proc Natl Acad Sci USA"},{"key":"52_CR23","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.4049\/jimmunol.152.5.2569","volume":"152","author":"TP O\u2019Hanlon","year":"1994","unstructured":"O\u2019Hanlon TP, Dalakas MC, Plotz PH, Miller FW: Predominant TCR-ab variable and joining gene expression by muscleinfiltrating lymphocytes in the idiopathic inflammatory myopathies. 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Analysis of proliferative responses to fragments of Jo-1 presented by dendritic cells reveals an immudominant T cell epitope contained within the amino terminal 150 amino acids of this protein.","journal-title":"J Immunol"},{"key":"52_CR34","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S0006-291X(02)00525-9","volume":"294","author":"TP O\u2019Hanlon","year":"1995","unstructured":"O\u2019Hanlon TP, Miller FW: Genomic organization, transcriptional mapping, and evolutionary implications of the human bi-directional histidyl-tRNA synthetase locus (HARS\/ HARSL). Biochem Biophys Res Commun 1995, 294:609\u2013614.","journal-title":"Biochem Biophys Res Commun"},{"key":"52_CR35","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/sj.cdd.4400460","volume":"6","author":"A Rosen","year":"1999","unstructured":"Rosen A, Casciola-Rosen L: Autoantigens as substrates for apoptotic proteases: implications for the pathogenesis of systemic autoimmune disease. 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Elaborated during cytotoxic lymphocyte-mediated cell death, this enzyme is capable of generating novel epitopes that may contribute to the breakdown of tolerance and generation of autoimmunity.","journal-title":"J Exp Med"},{"key":"52_CR37","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1002\/1529-0131(199807)41:7<1152::AID-ART3>3.0.CO;2-L","volume":"41","author":"P Utz","year":"1998","unstructured":"Utz P, Anderson P: Postranslational protein modifications, apoptosis, and the bypass of tolerance to autoantigens. Arthritis Rheum 1998, 41:1152\u20131160. This review nicely summarizes how alterations in antigenic structure during apoptosis can result in tolerance breakdown.","journal-title":"Arthritis Rheum"},{"key":"52_CR38","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1126\/science.284.5411.147","volume":"284","author":"K Wakasugi","year":"1999","unstructured":"Wakasugi K, Schimmel P: Two distinct cytokines released from a human aminoacyl-tRNA synthetase. 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Because Jo-1 interacts with chemokine receptors on immature dendritic cells as well as T cells, the authors speculate that Jo-1 may be able to link the innate and adaptive immune response in PM.","journal-title":"J Exp Med"}],"container-title":["Current Rheumatology Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11926-003-0052-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11926-003-0052-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11926-003-0052-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T04:23:39Z","timestamp":1683865419000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11926-003-0052-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,12]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2003,12]]}},"alternative-id":["52"],"URL":"https:\/\/doi.org\/10.1007\/s11926-003-0052-2","relation":{},"ISSN":["1523-3774","1534-6307"],"issn-type":[{"value":"1523-3774","type":"print"},{"value":"1534-6307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,12]]}}}