{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T11:08:12Z","timestamp":1791112092171,"version":"4.1.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2007,6,20]],"date-time":"2007-06-20T00:00:00Z","timestamp":1182297600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2007,6,20]],"date-time":"2007-06-20T00:00:00Z","timestamp":1182297600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Curr Rheumatol Rep"],"published-print":{"date-parts":[[2007,7]]},"DOI":"10.1007\/s11926-007-0039-5","type":"journal-article","created":{"date-parts":[[2007,6,19]],"date-time":"2007-06-19T00:30:51Z","timestamp":1182213051000},"page":"243-250","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Recent developments in crystal-induced inflammation pathogenesis and management"],"prefix":"10.1007","volume":"9","author":[{"given":"Fr\u00e9d\u00e9ric","family":"Liot\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang-Korng","family":"Ea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2007,6,20]]},"reference":[{"key":"39_CR1","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.rhum.2006.12.006","volume":"74","author":"F. Liot\u00e9","year":"2007","unstructured":"Liot\u00e9 F, Ea HK: Pathogenesis of crystal-induced inflammation. Rev Rhum 2007, 74:131\u2013137.","journal-title":"Rev Rhum"},{"key":"39_CR2","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.jbspin.2004.12.010","volume":"72","author":"R. Liu-Bryan","year":"2005","unstructured":"Liu-Bryan R, Liot\u00e9 F: Monosodium urate and calcium pyrophosphate dihydrate (CPPD) crystals, inflammation, and cellular signaling. Joint Bone Spine 2005, 72:295\u2013302.","journal-title":"Joint Bone Spine"},{"key":"39_CR3","doi-asserted-by":"publisher","first-page":"R915","DOI":"10.1186\/ar1763","volume":"7","author":"H.K. Ea","year":"2005","unstructured":"Ea HK, Uzan B, Rey C, Liot\u00e9 F: Octacalcium phosphate crystals directly stimulate expression of inducible nitric oxide synthase through p38 and JNK mitogen-activated protein kinases in articular chondrocytes. Arthritis Res Ther 2005, 7:R915\u2013926.","journal-title":"Arthritis Res Ther"},{"key":"39_CR4","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1097\/01.LAB.0000029206.27080.D2","volume":"82","author":"K. Fujiwara","year":"2002","unstructured":"Fujiwara K, Ohkawara S, Takagi K, et al.: Involvement of CXC chemokine growth-related oncogene-alpha in monosodium urate crystal-induced arthritis in rabbits. Lab Invest 2002, 82:1297\u20131304.","journal-title":"Lab Invest"},{"key":"39_CR5","doi-asserted-by":"crossref","first-page":"499","DOI":"10.7326\/0003-4819-143-7-200510040-00009","volume":"143","author":"H.K. Choi","year":"2005","unstructured":"Choi HK, Mount DB, Reginato AM: Pathogenesis of gout. Ann Intern Med 2005, 143:499\u2013516.","journal-title":"Ann Intern Med"},{"key":"39_CR6","doi-asserted-by":"publisher","first-page":"2633","DOI":"10.1002\/art.20386","volume":"50","author":"N. Tramontini","year":"2004","unstructured":"Tramontini N, Huber C, Liu-Bryan R, et al.: Central role of complement membrane attack complex in monosodium urate crystal-induced neutrophilic rabbit knee synovitis. Arthritis Rheum 2004, 50:2633\u20132639.","journal-title":"Arthritis Rheum"},{"key":"39_CR7","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1038\/nature01991","volume":"425","author":"Y. Shi","year":"2003","unstructured":"Shi Y, Evans JE, Rock KL: Molecular identification of a danger signal that alerts the immune system to dying cells. Nature 2003, 425:516\u2013521.","journal-title":"Nature"},{"key":"39_CR8","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/s00281-004-0173-3","volume":"26","author":"K.L. Rock","year":"2005","unstructured":"Rock KL, Hearn A, Chen CJ, et al.: Natural endogenous adjuvants. Spinger Semin Immunopathol 2005, 26:231\u2013246.","journal-title":"Spinger Semin Immunopathol"},{"key":"39_CR9","doi-asserted-by":"publisher","first-page":"2936","DOI":"10.1002\/art.21238","volume":"52","author":"R. Liu-Bryan","year":"2005","unstructured":"Liu-Bryan R, Scott P, Sydlaske A, et al.: Innate immunity conferred by Toll-like receptors 2 and 4 and myeloid differentiation factor 88 expression is pivotal to monosodium urate monohydrate crystal-induced inflammation. Arthritis Rheum 2005, 52:2936\u20132946.","journal-title":"Arthritis Rheum"},{"key":"39_CR10","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.biomaterials.2006.09.015","volume":"28","author":"A. Grandjean-Laquerriere","year":"2007","unstructured":"Grandjean-Laquerriere A, Tabary O, Jacquot J, et al.: Involvement of toll-like receptor 4 in the inflammatory reaction induced by hydroxyapatite particles. Biomaterials 2007, 28:400\u2013404.","journal-title":"Biomaterials"},{"key":"39_CR11","doi-asserted-by":"crossref","first-page":"5016","DOI":"10.4049\/jimmunol.174.8.5016","volume":"174","author":"R. Liu-Bryan","year":"2005","unstructured":"Liu-Bryan R, Pritzker K, Firestein GS, Terkeltaub R: TLR2 signaling in chondrocytes drives calcium pyrophosphate dihydrate and monodium urate crystal-induced nitric oxide generation. J Immunol 2005, 174:5016\u20135023.","journal-title":"J Immunol"},{"key":"39_CR12","doi-asserted-by":"crossref","first-page":"6370","DOI":"10.4049\/jimmunol.177.9.6370","volume":"177","author":"P. Scott","year":"2006","unstructured":"Scott P, Ma H, Viriyakosol S, et al.: Engagement of CD14 mediates the inflammatory potential of monosodium urate crystals. J Immunol 2006, 177:6370\u20136378.","journal-title":"J Immunol"},{"key":"39_CR13","doi-asserted-by":"publisher","first-page":"2262","DOI":"10.1172\/JCI28075","volume":"116","author":"C.J. Chen","year":"2006","unstructured":"Chen CJ, Shi Y, Hearn A, et al.: MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals. J Clin Invest 2006, 116:2262\u20132271.","journal-title":"J Clin Invest"},{"key":"39_CR14","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1038\/nature04516","volume":"440","author":"F. Martinon","year":"2006","unstructured":"Martinon F, Petrilli V, Mayor A, et al.: Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 2006, 440:237\u2013241.","journal-title":"Nature"},{"key":"39_CR15","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1002\/art.21633","volume":"54","author":"Y. Murakami","year":"2006","unstructured":"Murakami Y, Akohoshi T, Hayashi T, et al.: Induction of triggering receptor expressed on myeloid cells 1 in murine resident peritoneal macrophages by monosodium urate monohydrate crystals. Arthritis Rheum 2006, 54:455\u2013464.","journal-title":"Arthritis Rheum"},{"key":"39_CR16","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1002\/art.21634","volume":"54","author":"R. Liu-Bryan","year":"2006","unstructured":"Liu-Bryan R, Terkeltaub R: Evil humors take their Toll as innate immunity makes gouty joints TREM-ble. Arthritis Rheum 2006, 54:383\u2013386.","journal-title":"Arthritis Rheum"},{"key":"39_CR17","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/nrm1019","volume":"4","author":"J. Tschopp","year":"2003","unstructured":"Tschopp J, Martinon F, Burns K: NALPS: a novel protein family involved in inflammation. Nat Rev Mol Cell Biol 2003, 4:95\u2013104.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"39_CR18","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.it.2005.06.004","volume":"26","author":"F. Martinon","year":"2005","unstructured":"Martinon F, Tschopp J: NLRs join TLRs as innate sensors of pathogens. Trends Immunol 2005, 26:447\u2013454.","journal-title":"Trends Immunol"},{"key":"39_CR19","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/s11926-996-0027-1","volume":"8","author":"D.M. Rose","year":"2006","unstructured":"Rose DM, Liu-Bryan R: Innate immunity in triggering and resolution of acute gouty inflammation. Curr Rheumatol Rep 2006, 8:209\u2013214.","journal-title":"Curr Rheumatol Rep"},{"key":"39_CR20","doi-asserted-by":"publisher","first-page":"3026","DOI":"10.1002\/art.10614","volume":"46","author":"R.C. Landis","year":"2002","unstructured":"Landis RC, Yagnik DR, Florey O, et al.: Safe disposal of inflammatory monosodium urate monohydrate crystals by differenciated macrophages. Arthritis Rheum 2002, 46:3026\u20133033.","journal-title":"Arthritis Rheum"},{"key":"39_CR21","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.rdc.2006.03.001","volume":"32","author":"F. Liot\u00e9","year":"2006","unstructured":"Liot\u00e9 F, Ea HK: Gout: update on some pathogenic and clinical aspects. Rheum Dis Clin North Am 2006, 32:295\u2013311, vi.","journal-title":"Rheum Dis Clin North Am"},{"key":"39_CR22","doi-asserted-by":"publisher","first-page":"3363","DOI":"10.1002\/art.22137","volume":"54","author":"D.M. Rose","year":"2006","unstructured":"Rose DM, Sydlaske AD, Agha-Babakhani A, et al.: Transglutaminase 2 limits murine peritoneal acute gout-like inflammation by regulating macrophage clearance of apoptotic neutrophils. Arthritis Rheum 2006, 54:3363\u20133371.","journal-title":"Arthritis Rheum"},{"key":"39_CR23","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1136\/ard.2006.055269","volume":"65","author":"W. Zhang","year":"2006","unstructured":"Zhang W, Doherty M, Bardin T, et al.: EULAR Standing Committee for International Clinical Studies Including Therapeutics. EULAR evidence based recommendations for gout. Part II: Management. Report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). Ann Rheum Dis 2006, 65:1312\u20131324.","journal-title":"Ann Rheum Dis"},{"key":"39_CR24","first-page":"331","volume":"29","author":"N. Schlesinger","year":"2002","unstructured":"Schlesinger N, Detry MA, Holland BK, et al.: Local ice therapy during bouts of acute gouty arthritis. J Rheumatol 2002, 29:331\u2013334.","journal-title":"J Rheumatol"},{"key":"39_CR25","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1097\/01.rhu.0000249864.95389.cf","volume":"12","author":"N. Schlesinger","year":"2006","unstructured":"Schlesinger N: Response to application of ice may help differentiate between gouty arthritis and other inflammatory arthritides. J Clin Rheumatol 2006, 12:275\u2013276.","journal-title":"J Clin Rheumatol"},{"key":"39_CR26","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1016\/j.jbspin.2006.03.006","volume":"73","author":"E. Niel","year":"2006","unstructured":"Niel E, Scherrmann JM: Colchicine today. Joint Bone Spine 2006, 73:672\u2013678.","journal-title":"Joint Bone Spine"},{"key":"39_CR27","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1002\/art.20007","volume":"50","author":"B.R. Rubin","year":"2004","unstructured":"Rubin BR, Burton R, Navarra S, et al.: Efficacy and safety profile of treatment with etoricoxib 120 mg once daily compared with indomethacin 50 mg three times daily in acute gout. Arthritis Rheum 2004, 50:598\u2013606.","journal-title":"Arthritis Rheum"},{"key":"39_CR28","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.ejheart.2004.02.005","volume":"6","author":"T. Juhlin","year":"2004","unstructured":"Juhlin T, Bjorkman S, Gunnarsson B, et al.: Acute administration of diclofenac, but possibly not long term low dose aspirin, causes detrimental renal effects in heart failure patients treated with ACE-inhibitors. Eur J Heart Fail 2004, 6:909\u2013916.","journal-title":"Eur J Heart Fail"},{"key":"39_CR29","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1093\/rheumatology\/keg305","volume":"42","author":"M. Rull","year":"2003","unstructured":"Rull M, Clayburne G, Sieck M, Schumacher HR: Intra-articular corticosteroid preparations: different characteristics and their effect during inflammation induced by monosodium urate crystals in the rat subcutaneous air pouch. Rheumatology (Oxford) 2003, 42:1093\u20131100.","journal-title":"Rheumatology (Oxford)"},{"key":"39_CR30","doi-asserted-by":"publisher","first-page":"2765","DOI":"10.1002\/art.10526","volume":"46","author":"S.J. Getting","year":"2002","unstructured":"Getting SJ, Christian HC, Flower RJ, Perretti M: Activation of melanocortin type 3 receptor as a molecular mechanism for adrenocorticotropic hormone efficacy in gouty arthritis. Arthritis Rheum 2002, 46:2765\u20132775.","journal-title":"Arthritis Rheum"},{"key":"39_CR31","doi-asserted-by":"publisher","first-page":"S339","DOI":"10.1002\/art.11493","volume":"50","author":"T. Neogy","year":"2004","unstructured":"Neogy T, Hunter DJ, Chasson CE, et al.: Frequency of innapropriate management of gout attacks. Arthritis Rheum 2004, 50:S339.","journal-title":"Arthritis Rheum"},{"key":"39_CR32","first-page":"2041","volume":"33","author":"W. Fang","year":"2006","unstructured":"Fang W, Zeng X, Li M, et al.: The management of gout at an academic healthcare center in Beijing: a physician survey. J Rheumatol 2006, 33:2041\u20132049.","journal-title":"J Rheumatol"},{"key":"39_CR33","doi-asserted-by":"crossref","unstructured":"Perez-Ruiz F, Liot\u00e9 F: Lowering sUA levels: what is the optimal target for improving clinical outcomes in gout?\n                           Arthritis Care Res 2007, in press.","DOI":"10.1002\/art.23007"},{"key":"39_CR34","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1136\/ard.2003.015925","volume":"63","author":"F. Richy","year":"2004","unstructured":"Richy F, Bruyere O, Ethgen O, et al.: Time dependent risk of gastrointestinal complications induced by non-steroidal anti-inflammatory drug use: a consensus statement using a meta-analytic approach. Ann Rheum Dis 2004, 63:759\u2013766.","journal-title":"Ann Rheum Dis"},{"key":"39_CR35","first-page":"804","volume":"13","author":"A. Alejandro","year":"1986","unstructured":"Alejandro A, Spilberg I: Colchicine prophylaxis in pseudogout. J Rheumatol 1986, 13:804\u2013805.","journal-title":"J Rheumatol"},{"key":"39_CR36","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1002\/art.22389","volume":"56","author":"A. Chollet-Janin","year":"2007","unstructured":"Chollet-Janin A, Finckh A, Dudler J, Guerne PA: Methotrexate as an alternative therapy for chronic calcium pyrophosphate deposition disease: analysis. Arthritis Rheum 2007, 56:688\u2013692.","journal-title":"Arthritis Rheum"},{"key":"39_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pharmthera.2005.06.022","volume":"111","author":"S.J. Getting","year":"2006","unstructured":"Getting SJ: Targeting melanocortin receptors as potential novel therapeutics. Pharmacol Ther 2006, 111:1\u201315.","journal-title":"Pharmacol Ther"},{"key":"39_CR38","doi-asserted-by":"crossref","unstructured":"Schlesinger N, Schumacher R, Catton M, Maxwell L: Colchicine for acute gout. Cochrane Database Syst Rev 2006, (4): CD006190.","DOI":"10.1002\/14651858.CD006190"}],"container-title":["Current Rheumatology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11926-007-0039-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11926-007-0039-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11926-007-0039-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11926-007-0039-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,15]],"date-time":"2022-05-15T12:48:08Z","timestamp":1652618888000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11926-007-0039-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6,20]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,7]]}},"alternative-id":["39"],"URL":"https:\/\/doi.org\/10.1007\/s11926-007-0039-5","relation":{},"ISSN":["1523-3774","1534-6307"],"issn-type":[{"value":"1523-3774","type":"print"},{"value":"1534-6307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6,20]]},"assertion":[{"value":"20 June 2007","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}