{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:28:29Z","timestamp":1790227709863,"version":"4.1.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Curr Rheumatol Rep"],"published-print":{"date-parts":[[2008,8]]},"DOI":"10.1007\/s11926-008-0053-2","type":"journal-article","created":{"date-parts":[[2008,10,15]],"date-time":"2008-10-15T16:10:48Z","timestamp":1224087048000},"page":"333-340","source":"Crossref","is-referenced-by-count":58,"title":["Autoantibodies and their significance in myositis"],"prefix":"10.1007","volume":"10","author":[{"given":"Ira N.","family":"Targoff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,10,16]]},"reference":[{"key":"53_CR1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/0090-1229(76)90145-8","volume":"5","author":"M. Reichlin","year":"1976","unstructured":"Reichlin M, Mattioli M: Description of a serological reaction characteristic of polymyositis. Clin Immunol Immunopathol 1976, 5: 12\u201320.","journal-title":"Clin Immunol Immunopathol"},{"key":"53_CR2","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1007\/s11926-996-0025-3","volume":"8","author":"I.N. Targoff","year":"2006","unstructured":"Targoff IN: Myositis specific autoantibodies. Curr Rheumatol Rep 2006, 8: 196\u2013203.","journal-title":"Curr Rheumatol Rep"},{"key":"53_CR3","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/S0889-857X(02)00032-7","volume":"28","author":"I.N. Targoff","year":"2002","unstructured":"Targoff IN: Laboratory testing in the diagnosis and management of idiopathic inflammatory myopathies. Rheum Dis Clin North Am 2002, 28: 859\u2013890.","journal-title":"Rheum Dis Clin North Am"},{"key":"53_CR4","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1002\/art.10794","volume":"47","author":"I. Marie","year":"2002","unstructured":"Marie I, Hachulla E, Cherin P, et al.: Interstitial lung disease in polymyositis and dermatomyositis. Arthritis Rheum 2002, 47: 614\u2013622.","journal-title":"Arthritis Rheum"},{"key":"53_CR5","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/art.23571","volume":"59","author":"M. Fathi","year":"2008","unstructured":"Fathi M, Vikgren J, Boijsen M, et al.: Interstitial lung disease in polymyositis and dermatomyositis: longitudinal evaluation by pulmonary function and radiology. Arthritis Care Res 2008, 59: 677\u2013685.","journal-title":"Arthritis Care Res"},{"key":"53_CR6","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1080\/08916930600622884","volume":"39","author":"H. Yoshifuji","year":"2006","unstructured":"Yoshifuji H, Fujii T, Kobayashi S, et al.: Anti-aminoacyl-tRNA synthetase antibodies in clinical course prediction of interstitial lung disease complicated with idiopathic inflammatory myopathies. Autoimmun 2006, 39: 233\u2013241.","journal-title":"Autoimmun"},{"key":"53_CR7","first-page":"1012","volume":"34","author":"T. Matsushita","year":"2007","unstructured":"Matsushita T, Hasegawa M, Fujimoto M, et al.: Clinical evaluation of anti-aminoacyl tRNA synthetase antibodies in Japanese patients with dermatomyositis. J Rheumatol 2007, 34: 1012\u20131018.","journal-title":"J Rheumatol"},{"key":"53_CR8","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0049-0172(96)80026-6","volume":"26","author":"A.W. Friedman","year":"1996","unstructured":"Friedman AW, Targoff IN, Arnett FC: Interstitial lung disease with autoantibodies against aminoacyl-tRNA synthetases in the absence of clinically apparent myositis. Semin Arthritis Rheum 1996, 26: 459\u2013467.","journal-title":"Semin Arthritis Rheum"},{"key":"53_CR9","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1093\/rheumatology\/kel435","volume":"46","author":"S. Sato","year":"2007","unstructured":"Sato S, Kuwana M, Hirakata M: Clinical characteristics of Japanese patients with anti-OJ (anti-isoleucyl-tRNA synthetase) autoantibodies. Rheumatology (Oxford) 2007, 46: 842\u2013845.","journal-title":"Rheumatology (Oxford)"},{"key":"53_CR10","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1002\/art.22506","volume":"56","author":"M. Hirakata","year":"2007","unstructured":"Hirakata M, Suwa A, Takada T, et al.: Clinical and immunogenetic features of patients with autoantibodies to asparaginyl-transfer RNA synthetase. Arthritis Rheum 2007, 56: 1295\u20131303.","journal-title":"Arthritis Rheum"},{"key":"53_CR11","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1136\/thx.2006.069237","volume":"63","author":"I. Tillie-Leblond","year":"2008","unstructured":"Tillie-Leblond I, Wislez M, Valeyre D, et al.: Interstitial lung disease and anti-Jo-1 antibodies: difference between acute and gradual onset. Thorax 2008, 63: 53\u201359.","journal-title":"Thorax"},{"key":"53_CR12","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s100670070030","volume":"19","author":"W.A. Schmidt","year":"2000","unstructured":"Schmidt WA, Wetzel W, Friedlander R, et al.: Clinical and serological aspects of patients with anti-Jo-1 antibodies-an evolving spectrum of disease manifestations. Clin Rheumatol 2000, 19: 371\u2013377.","journal-title":"Clin Rheumatol"},{"key":"53_CR13","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1164\/ajrccm.164.7.2103110","volume":"164","author":"W.W. Douglas","year":"2001","unstructured":"Douglas WW, Tazelaar HD, Hartman TE, et al.: Polymyositisdermatomyositis-associated interstitial lung disease. Am J Respir Crit Care Med 2001, 164: 1182\u20131185.","journal-title":"Am J Respir Crit Care Med"},{"key":"53_CR14","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1002\/art.22237","volume":"55","author":"A. Selva-O\u2019Callaghan","year":"2006","unstructured":"Selva-O\u2019Callaghan A, Labrador-Horrillo M, Solans-Laque R, et al.: Myositis-specific and myositis-associated antibodies in a series of eighty-eight Mediterranean patients with idiopathic inflammatory myopathy. Arthritis Rheum 2006, 55: 791\u2013798.","journal-title":"Arthritis Rheum"},{"key":"53_CR15","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1002\/art.11090","volume":"48","author":"S. Okada","year":"2003","unstructured":"Okada S, Weatherhead E, Targoff IN, et al.: Global surface ultraviolet radiation intensity may modulate the clinical and immunologic expression of autoimmune muscle disease. Arthritis Rheum 2003, 48: 2285\u20132293.","journal-title":"Arthritis Rheum"},{"key":"53_CR16","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1002\/art.22865","volume":"56","author":"K.B. Stone","year":"2007","unstructured":"Stone KB, Oddis CV, Fertig N, et al.: Anti-Jo-1 antibody levels correlate with disease activity in idiopathic inflammatory myopathy. Arthritis Rheum 2007, 56: 3125\u20133131.","journal-title":"Arthritis Rheum"},{"key":"53_CR17","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.jaad.2007.08.024","volume":"57","author":"R.Q. Klein","year":"2007","unstructured":"Klein RQ, Teal V, Taylor L, et al.: Number, characteristics, and classification of patients with dermatomyositis seen by dermatology and rheumatology departments at a large tertiary medical center. J Am Acad Dermatol 2007, 57: 937\u2013943.","journal-title":"J Am Acad Dermatol"},{"key":"53_CR18","first-page":"169","volume":"35","author":"D. Legault","year":"2008","unstructured":"Legault D, McDermott J, Crous-Tsanaclis AM, Boire G: Cancer-associated myositis in the presence of anti-Jo1 autoantibodies and the antisynthetase syndrome. J Rheumatol 2008, 35: 169\u2013171.","journal-title":"J Rheumatol"},{"key":"53_CR19","first-page":"151","volume":"71","author":"G. Respicio","year":"2007","unstructured":"Respicio G, Shwaiki W, Abeles M: A 58-year-old man with anti-Jo-1 syndrome and renal cell carcinoma: a case report and discussion. Conn Med 2007, 71: 151\u2013153.","journal-title":"Conn Med"},{"key":"53_CR20","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.7326\/0003-4819-134-12-200106190-00008","volume":"134","author":"R. Buchbinder","year":"2001","unstructured":"Buchbinder R, Forbes A, Hall S, et al.: Incidence of malignant disease in biopsy-proven inflammatory myopathy. A population-based cohort study. Ann Intern Med 2001, 134: 1087\u20131095.","journal-title":"Ann Intern Med"},{"key":"53_CR21","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1056\/NEJM199202063260602","volume":"326","author":"B. Sigurgeirsson","year":"1992","unstructured":"Sigurgeirsson B, Lindelof B, Edhag O, Allander E: Risk of cancer in patients with dermatomyositis or polymyositis: A population-based study. N Engl J Med 1992, 326: 363\u2013367.","journal-title":"N Engl J Med"},{"key":"53_CR22","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1097\/01.rhu.0000209894.43413.67","volume":"12","author":"N. Mogulkoc","year":"2006","unstructured":"Mogulkoc N, Kabasakal Y, Ekren PK, Bishop PW: An unusual presentation of anti-Jo-1 syndrome, mimicking lung metastases, with massive pleural and pericardial effusions. J Clin Rheumatol 2006, 12: 90\u201392.","journal-title":"J Clin Rheumatol"},{"key":"53_CR23","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1172\/JCI114461","volume":"85","author":"F.W. Miller","year":"1990","unstructured":"Miller FW, Twitty SA, Biswas T, Plotz PH: Origin and regulation of a disease-specific autoantibody response: Antigenic epitopes, spectrotype stability, and isotype restriction of anti-Jo-1 antibodies. J Clin Invest 1990, 85: 468\u2013475.","journal-title":"J Clin Invest"},{"key":"53_CR24","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.jaut.2007.07.005","volume":"29","author":"Y. Katsumata","year":"2007","unstructured":"Katsumata Y, Ridgway WM, Oriss T, et al.: Species-specific immune responses generated by histidyl-tRNA synthetase immunization are associated with muscle and lung inflammation. J Autoimmun 2007, 29: 174\u2013186.","journal-title":"J Autoimmun"},{"key":"53_CR25","doi-asserted-by":"crossref","first-page":"9209","DOI":"10.1073\/pnas.97.16.9209","volume":"97","author":"K. Nagaraju","year":"2000","unstructured":"Nagaraju K, Raben N, Loeffler L, et al.: Conditional up-regulation of MHC class I in skeletal muscle leads to self-sustaining autoimmune myositis and myositis-specific autoantibodies. Proc Natl Acad Sci U S A 2000, 97: 9209\u20139214.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"53_CR26","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.1002\/art.22790","volume":"56","author":"S.M. Levine","year":"2007","unstructured":"Levine SM, Raben N, Xie D, et al.: Novel conformation of histidyl-transfer RNA synthetase in the lung: the target tissue in Jo-1 autoantibody-associated myositis. Arthritis Rheum 2007, 56: 2729\u20132739.","journal-title":"Arthritis Rheum"},{"key":"53_CR27","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1084\/jem.190.6.815","volume":"190","author":"L. Casciola-Rosen","year":"1999","unstructured":"Casciola-Rosen L, Andrade F, Ulanet D, et al.: Cleavage by granzyme B is strongly predictive of autoantigen status: implications for initiation of autoimmunity. J Exp Med 1999, 190: 815\u2013826.","journal-title":"J Exp Med"},{"key":"53_CR28","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1084\/jem.20041367","volume":"201","author":"L. Casciola-Rosen","year":"2005","unstructured":"Casciola-Rosen L, Nagaraju K, Plotz P, et al.: Enhanced autoantigen expression in regenerating muscle cells in idiopathic inflammatory myopathy. J Exp Med 2005, 201: 591\u2013601.","journal-title":"J Exp Med"},{"key":"53_CR29","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1002\/art.21883","volume":"54","author":"Y. Yamasaki","year":"2006","unstructured":"Yamasaki Y, Yamada H, Nozaki T, et al.: Unusually high frequency of autoantibodies to PL-7 associated with milder muscle disease in Japanese patients with polymyositis\/dermatomyositis. Arthritis Rheum 2006, 54: 2004\u20132009.","journal-title":"Arthritis Rheum"},{"key":"53_CR30","doi-asserted-by":"crossref","first-page":"2556","DOI":"10.1172\/JCI116493","volume":"91","author":"I.N. Targoff","year":"1993","unstructured":"Targoff IN, Trieu EP, Miller FW: Reaction of anti-OJ autoantibodies with components of the multi-enzyme complex of aminoacyl-tRNA synthetases in addition to isoleucyl-tRNA synthetase. J Clin Invest 1993, 91: 2556\u20132564.","journal-title":"J Clin Invest"},{"key":"53_CR31","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1093\/rheumatology\/kem045","volume":"46","author":"Z. Betteridge","year":"2007","unstructured":"Betteridge Z, Gunawardena H, North J, et al.: Anti-synthetase syndrome: a new autoantibody to phenylalanyl transfer RNA synthetase (anti-Zo) associated with polymyositis and interstitial pneumonia. Rheumatology (Oxford) 2007, 46: 1005\u20131008.","journal-title":"Rheumatology (Oxford)"},{"key":"53_CR32","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/art.11484","volume":"50","author":"A.H. Kao","year":"2004","unstructured":"Kao AH, Lacomis D, Lucas M, et al.: Anti-signal recognition particle autoantibody in patients with and patients without idiopathic inflammatory myopathy. Arthritis Rheum 2004, 50: 209\u2013215.","journal-title":"Arthritis Rheum"},{"key":"53_CR33","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1136\/jnnp.73.4.420","volume":"73","author":"T. Miller","year":"2002","unstructured":"Miller T, Al Lozi MT, Lopate G, Pestronk A: Myopathy with antibodies to the signal recognition particle: clinical and pathological features. J Neurol Neurosurg Psychiatry 2002, 73: 420\u2013428.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"53_CR34","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1136\/ard.2006.052191","volume":"65","author":"G.J. Hengstman","year":"2006","unstructured":"Hengstman GJ, ter Laak HJ, Vree Egberts WT, et al.: Anti-signal recognition particle autoantibodies: marker of a necrotising myopathy. Ann Rheum Dis 2006, 65: 1635\u20131638.","journal-title":"Ann Rheum Dis"},{"key":"53_CR35","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/mus.20693","volume":"35","author":"D. Dimitri","year":"2007","unstructured":"Dimitri D, Andre C, Roucoules J, et al.: Myopathy associated with anti-signal recognition peptide antibodies: clinical heterogeneity contrasts with stereotyped histopathology. Muscle Nerve 2007, 35: 389\u2013395.","journal-title":"Muscle Nerve"},{"key":"53_CR36","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1002\/art.1780271011","volume":"27","author":"M. Reichlin","year":"1984","unstructured":"Reichlin M, Arnett FC: Multiplicity of antibodies in myositis sera. Arthritis Rheum 1984, 27: 1150\u20131156.","journal-title":"Arthritis Rheum"},{"key":"53_CR37","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1056\/NEJM197502132920706","volume":"292","author":"A. Bohan","year":"1975","unstructured":"Bohan A, Peter JB: Polymyositis and dermatomyositis. Parts 1 and 2. N Engl J Med 1975, 292: 344\u2013347; 403\u2013407.","journal-title":"N Engl J Med"},{"key":"53_CR38","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1046\/j.1365-2249.1997.4081308.x","volume":"109","author":"S.A. Rutjes","year":"1997","unstructured":"Rutjes SA, Vree Egberts WT, Jongen P, et al.: Anti-Ro52 antibodies frequently co-occur with anti-Jo-1 antibodies in sera from patients with idiopathic inflammatory myopathy. Clin Exp Immunol 1997, 109: 32\u201340.","journal-title":"Clin Exp Immunol"},{"key":"53_CR39","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1006\/jaut.1998.0265","volume":"12","author":"M.B. Frank","year":"1999","unstructured":"Frank MB, McCubbin VR, Trieu EP, et al.: The association of anti-Ro52 autoantibodies with myositis and scleroderma autoantibodies. J Autoimmun 1999, 12: 137\u2013142.","journal-title":"J Autoimmun"},{"key":"53_CR40","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1097\/01.md.0000173991.74008.b0","volume":"84","author":"Y. Troyanov","year":"2005","unstructured":"Troyanov Y, Targoff IN, Tremblay JL, et al.: Novel classification of idiopathic inflammatory myopathies based on overlap syndrome features and autoantibodies: analysis of 100 French Canadian patients. Medicine 2005, 84: 231\u2013249.","journal-title":"Medicine"},{"key":"53_CR41","doi-asserted-by":"crossref","first-page":"R78","DOI":"10.1186\/ar2276","volume":"9","author":"M. Koenig","year":"2007","unstructured":"Koenig M, Fritzler MJ, Targoff IN, et al.: Heterogeneity of autoantibodies in 100 patients with autoimmune myositis: insights into clinical features and outcomes. Arthritis Res Ther 2007, 9: R78.","journal-title":"Arthritis Res Ther"},{"key":"53_CR42","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.semarthrit.2005.03.005","volume":"35","author":"V.D. Steen","year":"2005","unstructured":"Steen VD: Autoantibodies in systemic sclerosis. Semin Arthritis Rheum 2005, 35: 35\u201342.","journal-title":"Semin Arthritis Rheum"},{"key":"53_CR43","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1093\/rheumatology\/kel161","volume":"46","author":"K. Kaji","year":"2007","unstructured":"Kaji K, Fujimoto M, Hasegawa M, et al.: Identification of a novel autoantibody reactive with 155 and 140 kDa nuclear proteins in patients with dermatomyositis: an association with malignancy. Rheumatology 2007, 46: 25\u201328.","journal-title":"Rheumatology"},{"key":"53_CR44","doi-asserted-by":"crossref","first-page":"3682","DOI":"10.1002\/art.22164","volume":"54","author":"I.N. Targoff","year":"2006","unstructured":"Targoff IN, Mamyrova G, Trieu EP, et al.: A novel autoantibody to a 155-kd protein is associated with dermatomyositis. Arthritis Rheum 2006, 54: 3682\u20133689.","journal-title":"Arthritis Rheum"},{"key":"53_CR45","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1136\/ard.2006.068502","volume":"66","author":"H. Chinoy","year":"2007","unstructured":"Chinoy H, Fertig N, Oddis CV, et al.: The diagnostic utility of myositis autoantibody testing for predicting the risk of cancer-associated myositis. Ann Rheum Dis 2007, 66: 1345\u20131349.","journal-title":"Ann Rheum Dis"},{"key":"53_CR46","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1093\/rheumatology\/kem359","volume":"47","author":"H. Gunawardena","year":"2008","unstructured":"Gunawardena H, Wedderburn LR, North J, et al.: Clinical associations of autoantibodies to a p155\/140 kDa doublet protein in juvenile dermatomyositis. Rheumatology (Oxford) 2008, 47: 324\u2013328.","journal-title":"Rheumatology (Oxford)"},{"key":"53_CR47","doi-asserted-by":"crossref","first-page":"3132","DOI":"10.1002\/art.22862","volume":"56","author":"Z. Betteridge","year":"2007","unstructured":"Betteridge Z, Gunawardena H, North J, et al.: Identification of a novel autoantibody directed against small ubiquitin-like modifier activating enzyme in dermatomyositis. Arthritis Rheum 2007, 56: 3132\u20133137.","journal-title":"Arthritis Rheum"}],"container-title":["Current Rheumatology Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11926-008-0053-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11926-008-0053-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11926-008-0053-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T00:49:49Z","timestamp":1559436589000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11926-008-0053-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8]]},"references-count":47,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["53"],"URL":"https:\/\/doi.org\/10.1007\/s11926-008-0053-2","relation":{},"ISSN":["1523-3774","1534-6307"],"issn-type":[{"value":"1523-3774","type":"print"},{"value":"1534-6307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,8]]}}}