{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:53:57Z","timestamp":1787320437452,"version":"build-2736575974"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2010,8,28]],"date-time":"2010-08-28T00:00:00Z","timestamp":1282953600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Curr Rheumatol Rep"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1007\/s11926-010-0128-8","type":"journal-article","created":{"date-parts":[[2010,8,26]],"date-time":"2010-08-26T23:57:22Z","timestamp":1282867042000},"page":"443-447","source":"Crossref","is-referenced-by-count":105,"title":["Orbital Inflammatory Pseudotumors: Etiology, Differential Diagnosis, and Management"],"prefix":"10.1007","volume":"12","author":[{"given":"Gabriela M.","family":"Espinoza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,8,28]]},"reference":[{"key":"128_CR1","first-page":"347","volume":"13","author":"D Jacobs","year":"2002","unstructured":"Jacobs D, Galetta S: Diagnosis and management of orbital pseudotumor. Ophthalmology 2002, 13:347\u2013351.","journal-title":"Ophthalmology"},{"key":"128_CR2","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S0039-6257(97)81996-0","volume":"41","author":"I Mombaerts","year":"1996","unstructured":"Mombaerts I, Goldschmeding R, Schlingemann RO, Koornneef L: What is orbital pseudotumor? Surv Ophthalmol 1996, 41:66\u201378.","journal-title":"Surv Ophthalmol"},{"key":"128_CR3","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0896-1549(01)00003-7","volume":"15","author":"SJA Yuen","year":"2002","unstructured":"Yuen SJA, Rubin PAD: Idiopathic orbital inflammation: ocular mechanisms and clinicopathology. Ophthalmol Clin North Am 2002, 15:121\u2013126.","journal-title":"Ophthalmol Clin North Am"},{"key":"128_CR4","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1440-1754.2008.01288.x","volume":"44","author":"M Alshaikh","year":"2008","unstructured":"Alshaikh M, Kakakios AM, Kemp AS: Orbital myositis following streptococcal pharyngitis. J Paediatr Child Health 2008, 44:233\u2013234.","journal-title":"J Paediatr Child Health"},{"key":"128_CR5","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1093\/rheumatology\/keh225","volume":"43","author":"SL Mackie","year":"2004","unstructured":"Mackie SL, Keat A: Poststreptococcal reactive arthritis: what is it and how do we know? Rheumatology 2004, 43:949\u2013954.","journal-title":"Rheumatology"},{"key":"128_CR6","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jneuroim.2005.10.014","volume":"172","author":"RC Dale","year":"2006","unstructured":"Dale RC, Candler PM, Church AJ, et al.: Neuronal surface glycolytic enzymes are autoantigen targets in post-streptococcal autoimmune CNS disease. J Neuroimmunol 2006, 172:187\u2013197.","journal-title":"J Neuroimmunol"},{"key":"128_CR7","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/BF02029359","volume":"154","author":"A Venuta","year":"1995","unstructured":"Venuta A, Ferrari P, Beverelli A, et al.: Acute post-streptococcal polymyalgia: two new cases with a review of the literature. Eur J Pediatr 1995, 154:475\u2013476.","journal-title":"Eur J Pediatr"},{"key":"128_CR8","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1001\/archopht.126.8.1165","volume":"126","author":"JC Nieto","year":"2008","unstructured":"Nieto JC, Kim N, Lucarelli MJ: Dacryoadenitis and orbital myositis associated with lyme disease. Arch Ophthalmol 2008, 126:1165\u20131166.","journal-title":"Arch Ophthalmol"},{"key":"128_CR9","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/S0002-9394(03)00323-4","volume":"136","author":"A Kawasaki","year":"2003","unstructured":"Kawasaki A, Borruat FX: An unusual presentation of herpes zoster ophthalmicus: orbital myositis preceding vesicular eruption. Am J Ophthalmol 2003, 136:574\u2013575.","journal-title":"Am J Ophthalmol"},{"key":"128_CR10","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1097\/IOP.0b013e318137a373","volume":"23","author":"J Badilla","year":"2007","unstructured":"Badilla J, Dolman P: Orbital myositis involving the oblique muscles associated with herpes zoster ophthalmicus. Ophthal Plast Reconstr Surg 2007, 23:411\u2013413.","journal-title":"Ophthal Plast Reconstr Surg"},{"key":"128_CR11","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1001\/archopht.1991.01080040039015","volume":"109","author":"NJ Volpe","year":"1991","unstructured":"Volpe NJ, Shore JW: Orbital myositis associated with herpes zoster. Arch Ophthalmol 1991, 109:471\u2013472.","journal-title":"Arch Ophthalmol"},{"key":"128_CR12","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1001\/archopht.125.7.895","volume":"125","author":"L Sobrin","year":"2007","unstructured":"Sobrin L, Kim E, Christen W, et al.: Infliximab therapy for the treatment of refractory ocular inflammatory disease. Arch Ophthalmol 2007, 125:895\u2013900.","journal-title":"Arch Ophthalmol"},{"key":"128_CR13","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.ajo.2004.06.077","volume":"138","author":"JA Garrity","year":"2004","unstructured":"Garrity JA, Coleman AW, Matteson EL, et al.: Treatment of recalcitrant idiopathic orbital inflammation (chronic orbital myositis) with infliximab. Am J Ophthalmol 2004, 138:925\u2013930.","journal-title":"Am J Ophthalmol"},{"key":"128_CR14","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0161-6420(95)31066-4","volume":"102","author":"C Atabay","year":"1995","unstructured":"Atabay C, Tyutyunikov A, Scalise D, et al.: Serum antibodies reactive with eye muscle membrane antigens are detected in patients with nonspecific orbital inflammation. Ophthalmology 1995, 102:145\u2013153.","journal-title":"Ophthalmology"},{"key":"128_CR15","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1001\/archopht.121.4.491","volume":"121","author":"SJA Yuen","year":"2003","unstructured":"Yuen SJA, Rubin PAD: Idiopathic orbital inflammation: distribution, clinical features, and treatment outcome. Arch Ophthalmol 2003, 121:491\u2013499.","journal-title":"Arch Ophthalmol"},{"key":"128_CR16","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/0360-3016(90)90108-V","volume":"18","author":"R Lanciano","year":"1990","unstructured":"Lanciano R, Fowble B, Sergott RC, et al.: The results of radiotherapy for orbital pseudotumor. Int J Radiat Oncol Biol Phys 1990, 18:407\u2013411.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"128_CR17","doi-asserted-by":"crossref","first-page":"8536","DOI":"10.1001\/archopht.1981.03930010853013","volume":"99","author":"R Sergott","year":"1981","unstructured":"Sergott R, Glaser J, Charyulu K: Radiotherapy for idiopathic inflammatory orbital pseudotumor: indications and results. Arch Ophthalmol 1981, 99:8536.","journal-title":"Arch Ophthalmol"},{"key":"128_CR18","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1136\/bjo.67.9.570","volume":"67","author":"J Orcutt","year":"1983","unstructured":"Orcutt J, Garner A, Henk J, Wright J: Treatment of idiopathic inflammatory orbital pseudotumors by radiotherapy. Br J Ophthalmol 1983, 67:570\u2013574.","journal-title":"Br J Ophthalmol"},{"key":"128_CR19","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S1053-4296(99)80008-3","volume":"9","author":"MC Smitt","year":"1999","unstructured":"Smitt MC, Donaldson SS: Radiation therapy for benign disease of the orbit. Semin Radiat Oncol 1999, 9:179\u2013189.","journal-title":"Semin Radiat Oncol"},{"key":"128_CR20","doi-asserted-by":"crossref","first-page":"260","DOI":"10.3109\/08820530903392639","volume":"24","author":"IP Zacharopoulos","year":"2009","unstructured":"Zacharopoulos IP, Papadaki T, Manor RS, Briscoe D: Treatment of idiopathic orbital inflammatory disease with cyclosporine-A: a case presentation. Semin Ophthalmol 2009, 24:260\u2013261.","journal-title":"Semin Ophthalmol"},{"key":"128_CR21","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1016\/S0161-6420(91)32064-5","volume":"98","author":"L Bielory","year":"1991","unstructured":"Bielory L, Frohman LP: Low-dose cyclosporine therapy of granulomatous optic neuropathy and orbitopathy. Ophthalmology 1991, 98:1732\u20131736.","journal-title":"Ophthalmology"},{"key":"128_CR22","first-page":"741","volume":"7","author":"C Buell","year":"2008","unstructured":"\u2022 Buell C, Koo J: Long-term safety of mycophenolate mofetil and cyclosporine: a review. J Drugs Dermatol 2008, 7:741\u2013748. This was a meta-analysis review of CsA use that examined its safety profile.","journal-title":"J Drugs Dermatol"},{"key":"128_CR23","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/0002-9394(89)90503-5","volume":"107","author":"M Diaz-Llopis","year":"1989","unstructured":"Diaz-Llopis M, Menezo JL: Idiopathic inflammatory orbital pseudotumor and low-dose cyclosporine. Am J Ophthalmol 1989, 107:547\u2013548.","journal-title":"Am J Ophthalmol"},{"key":"128_CR24","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1136\/ard.61.1.93","volume":"61","author":"F Falcini","year":"2002","unstructured":"Falcini F, Simonini G, Resti M, Cimaz R: Recurrent orbital pain and diplopia in a 12\u00a0year old boy. Ann Rheum Dis 2002, 61:93\u201394.","journal-title":"Ann Rheum Dis"},{"key":"128_CR25","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1136\/ard.52.1.84-b","volume":"52","author":"J Sanchez-Roman","year":"1993","unstructured":"Sanchez-Roman J, Varela-Aguilar JM, Bravo-Ferrer J, et al.: Idiopathic orbital myositis: treatment with cyclosporin. Ann Rheum Dis 1993, 52:84\u201385.","journal-title":"Ann Rheum Dis"},{"key":"128_CR26","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1097\/ICL.0b013e3181b4d135","volume":"35","author":"K Gumus","year":"2009","unstructured":"\u2022 Gumus K, Mirza GE, Cavanagh HD, Karakucuk S: Topical cyclosporine A as a steroid-sparing agent in steroid-dependent idiopathic ocular myositis with scleritis: a case report and review of the literature. Eye Contact Lens 2009, 35:275\u2013278. This case report showed topical corticosteroid and CsA use to control orbital inflammation in a patient who did not achieve control and did not tolerate the side effects of oral corticosteroids and oral CsA.","journal-title":"Eye Contact Lens"},{"key":"128_CR27","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1136\/bjo.85.10.1220","volume":"85","author":"JR Smith","year":"2001","unstructured":"Smith JR, Rosenbaum JT: A role for methotrexate in the management of non-infectious orbital inflammatory disease. Br J Ophthalmol 2001, 85:1220\u20131224.","journal-title":"Br J Ophthalmol"},{"key":"128_CR28","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/S0161-6420(92)31790-7","volume":"99","author":"SS Shah","year":"1992","unstructured":"Shah SS, Lowder CY, Schmitt MA, et al.: Low-dose methotrexate therapy for ocular inflammatory disease. Ophthalmology 1992, 99:1419\u20131423.","journal-title":"Ophthalmology"},{"key":"128_CR29","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1111\/j.1442-9071.2009.02188.x","volume":"37","author":"S Osborne","year":"2009","unstructured":"Osborne S, Sims JL, Rosser PM: Short-term use of infliximab in a case of recalcitrant idiopathic orbital inflammatory disease. Clin Experiment Ophthalmol 2009, 37:897\u2013900.","journal-title":"Clin Experiment Ophthalmol"},{"key":"128_CR30","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1111\/j.1755-3768.2008.01320.x","volume":"87","author":"S Sahlin","year":"2009","unstructured":"\u2022 Sahlin S, Lignell B, Williams M, et al.: Treatment of idiopathic sclerosing inflammation of the orbit (myositis) with infliximab. Acta Ophthalmol 2009, 87:906\u2013908. This case report showed successful treatment with infliximab of a very difficult subset of OIP patients.","journal-title":"Acta Ophthalmol"},{"key":"128_CR31","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1097\/IOP.0b013e318182a522","volume":"24","author":"T Miquel","year":"2008","unstructured":"Miquel T, Abad S, Badelon I, et al.: Successful treatment of idiopathic orbital inflammation with infliximab: an alternative to conventional steroid-sparing agents. Ophthal Plast Reconstr Surg 2008, 24:415\u2013417.","journal-title":"Ophthal Plast Reconstr Surg"},{"key":"128_CR32","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1136\/bjo.2006.111666","volume":"92","author":"C Prendiville","year":"2008","unstructured":"Prendiville C, O\u2019Doherty M, Moriarty P, Cassidy L: The use of infliximab in ocular inflammation. Br J Ophthalmol 2008, 92:823\u2013825.","journal-title":"Br J Ophthalmol"},{"key":"128_CR33","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1097\/01.IOP.0000139521.38345.BA","volume":"20","author":"MW Wilson","year":"2004","unstructured":"Wilson MW, Shergy WJ, Haik BG: Infliximab in the treatment of recalcitrant idiopathic orbital inflammation. Ophthal Plast Reconstr Surg 2004, 20:381\u2013383.","journal-title":"Ophthal Plast Reconstr Surg"}],"container-title":["Current Rheumatology Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11926-010-0128-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11926-010-0128-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11926-010-0128-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T20:49:53Z","timestamp":1559422193000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11926-010-0128-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8,28]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["128"],"URL":"https:\/\/doi.org\/10.1007\/s11926-010-0128-8","relation":{},"ISSN":["1523-3774","1534-6307"],"issn-type":[{"value":"1523-3774","type":"print"},{"value":"1534-6307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8,28]]}}}